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Identification |
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Name | Homoserine kinase |
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Synonyms | |
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Gene Name | THR1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in ATP binding |
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Specific Function | Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate |
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Cellular Location | Not Available |
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SMPDB Pathways | Not Available |
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KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00104 | L-Homoserine | Show | YMDB00109 | Adenosine triphosphate | Show | YMDB00258 | O-Phosphohomoserine | Show | YMDB00862 | hydron | Show | YMDB00914 | ADP | Show |
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GO Classification | Component |
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Not Available | Function |
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phosphotransferase activity, alcohol group as acceptor | catalytic activity | transferase activity | transferase activity, transferring phosphorus-containing groups | homoserine kinase activity | binding | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | adenyl ribonucleotide binding | ATP binding | kinase activity | Process |
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phosphorus metabolic process | phosphate metabolic process | metabolic process | phosphorylation | aspartate family amino acid metabolic process | threonine metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 8 |
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Locus | YHR025W |
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Gene Sequence | >1074 bp
ATGGTTCGTGCCTTCAAAATTAAAGTTCCAGCTTCTTCCGCCAATATCGGCCCTGGTTAT
GATGTTCTTGGTGTCGGTCTTTCTCTATTCTTGGAGTTAGATGTCACCATCGACTCCAGC
CAAGCTCAGGAAACAAACGACGATCCCAACAACTGCAAGCTGTCTTACACTAAAGAAAGT
GAAGGCTATTCTACGGTCCCATTGCGTTCTGATGCTAACCTGATTACCAGGACTGCGTTA
TATGTGTTGCGTTGCAACAATATTAGAAACTTCCCCTCCGGAACCAAAGTTCACGTCTCC
AACCCAATCCCACTTGGCCGTGGATTGGGTTCCTCTGGTGCAGCAGTTGTGGCAGGTGTT
ATTTTAGGTAACGAAGTGGCCCAATTGGGTTTCTCTAAGCAACGTATGTTGGACTACTGT
TTGATGATTGAACGTCATCCAGACAACATAACCGCTGCTATGATGGGAGGCTTTTGCGGT
TCATTCCTAAGGGACTTGACCCCACAAGAGGTGGAAAGACGTGAGATTCCATTGGCTGAG
GTGCTTCCAGAACCTTCTGGTGGTGAAGATACCGGTCTGGTTCCCCCATTACCTCCCACC
GATATCGGTAGACATGTCAAATACCAATGGAACCCCGCCATTAAATGTATTGCGATCATC
CCACAGTTCGAGTTGTCCACCGCCGACTCCAGAGGCGTTCTTCCAAAAGCCTACCCAACC
CAGGACTTGGTTTTCAATCTACAAAGATTGGCCGTCTTGACCACAGCTTTGACCATGGAC
CCACCTAATGCCGACTTAATCTACCCTGCTATGCAAGATCGTGTCCACCAACCTTATAGA
AAGACATTGATCCCAGGTCTCACGGAAATCTTATCATGTGTCACCCCATCCACATACCCT
GGCCTATTGGGTATCTGCTTGTCAGGTGCAGGCCCAACTATCTTGGCTTTGGCCACTGAG
AATTTCGAAGAAATCTCTCAAGAAATTATCAACAGGTTCGCCAAAAACGGCATCAAGTGC
TCCTGGAAACTACTGGAGCCTGCCTACGATGGTGCTAGCGTCGAACAGCAATGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 357 |
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Protein Molecular Weight | 38712.0 |
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Protein Theoretical pI | 5.05 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Homoserine kinase
MVRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSQAQETNDDPNNCKLSYTKES
EGYSTVPLRSDANLITRTALYVLRCNNIRNFPSGTKVHVSNPIPLGRGLGSSGAAVVAGV
ILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGFCGSFLRDLTPQEVERREIPLAE
VLPEPSGGEDTGLVPPLPPTDIGRHVKYQWNPAIKCIAIIPQFELSTADSRGVLPKAYPT
QDLVFNLQRLAVLTTALTMDPPNADLIYPAMQDRVHQPYRKTLIPGLTEILSCVTPSTYP
GLLGICLSGAGPTILALATENFEEISQEIINRFAKNGIKCSWKLLEPAYDGASVEQQ |
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References |
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External Links | |
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General Reference | - Mannhaupt, G., Pohlenz, H. D., Seefluth, A. K., Pilz, U., Feldmann, H. (1990). "Yeast homoserine kinase. Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism." Eur J Biochem 191:115-122.2165904
- Schultes, N. P., Ellington, A. D., Cherry, J. M., Szostak, J. W. (1990). "Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases." Gene 96:177-180.2176637
- Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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