{"ymdb_id":"YMDB00104","created_at":"2011-05-29T15:57:03.000Z","updated_at":"2016-09-08T18:35:01.000Z","name":"L-Homoserine","cas":"672-15-1","state":"Solid","melting_point":"203 oC","description":"L-Homoserine is an alpha-amino acid. L-Homoserine is derived from L-aspartate in the homoserine biosynthesis pathway. It is the precursor in homocysteine biosynthesis pathway and in threonine biosynthesis from homoserine pathway. In certain organisms, including the yeast Saccharomyces cerevisiae S288c and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine. [Biocyc HOMOSERSYN-PWY and PWY-5344 and HOMOSER-THRESYN-PWY]","experimental_water_solubility":"1000 mg/mL at 30 oC [BEILSTEIN]","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Kokusenya, Yoshio; Matsuoka, Manabu.  Synthesis of amino acids by electrochemical reduction.  I.  Synthesis of L-homoserine by electrochemical reduction of L-asparagine.    Denki Kagaku oyobi Kogyo Butsuri Kagaku  (1987),  55(2),  174-5.","chebi_id":"15699","hmdb_id":"HMDB00719","kegg_id":"C00263","pubchem_id":"12647","cs_id":"12126","foodb_id":null,"wikipedia_link":"Homoserine","biocyc_id":"HOMO-SER","iupac":"(2S)-2-amino-4-hydroxybutanoic acid","traditional_iupac":"L-homoserine","logp":"-3.8277325124850385","pka":"15.933083327320805","alogps_solubility":"4.23e+02 g/l","alogps_logp":"-3.31","alogps_logs":"0.55","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"83.55000000000001","refractivity":"26.906399999999998","polarizability":"11.439148714602187","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.159110100742131","pka_strongest_acidic":"2.223319649729163","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(S)-2-amino-4-hydroxy-Butanoate","(S)-2-amino-4-hydroxy-Butanoic acid","(S)-2-Amino-4-hydroxybutanoate","(S)-2-Amino-4-hydroxybutanoic acid","(S)-Homoserine","2-amino-4-hydroxy-Butyrate","2-amino-4-hydroxy-Butyric acid","2-amino-4-hydroxy-L-Butyrate","2-amino-4-hydroxy-L-Butyric acid","2-Amino-4-hydroxybutanoate","2-Amino-4-hydroxybutanoic acid","2-Amino-4-hydroxybutyrate","2-Amino-4-hydroxybutyric acid","Homoserine","L-Homoserine"],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"threonine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12325384,"citation":"Wiebers, J. L., Garner, H. R. (1967). \"Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli.\" J Biol Chem 242:5644-5649."},{"pubmed_id":6035500,"citation":"Robichon-Szulmajster, H., Cherest, H. (1967). \"Regulation of homoserine O-transacetylase, first step in methionine biosyntheis in Saccharomyces cerevisiae.\" Biochem Biophys Res Commun 28:256-262."},{"pubmed_id":5764336,"citation":"Cherest, H., Eichler, F., Robichon-Szulmajster, H. (1969). \"Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.\" J Bacteriol 97:328-336."},{"pubmed_id":8973190,"citation":"Huo, X., Viola, R. E. (1996). \"Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli.\" Biochemistry 35:16180-16185."},{"pubmed_id":16232856,"citation":"Kosuge, T., Gao, D., Hoshino, T. (2000). \"Analysis of the methionine biosynthetic pathway in the extremely thermophilic eubacterium Thermus thermophilus.\" J Biosci Bioeng 90:271-279."},{"pubmed_id":8500624,"citation":"Thomas, D., Barbey, R., Surdin-Kerjan, Y. (1993). \"Evolutionary relationships between yeast and bacterial homoserine dehydrogenases.\" FEBS Lett 323:289-293."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T21:17:06.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Homoserine O-acetyltransferase","uniprot_id":"P08465","uniprot_name":"MET2_YEAST","enzyme":true,"transporter":false,"gene_name":"MET2","num_residues":486,"molecular_weight":"53659.0","theoretical_pi":"5.35","general_function":"Involved in O-acetyltransferase activity","specific_function":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L- homoserine","reactions":[{"id":1642,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2377,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.","export":false,"pw_reaction_id":null,"source":null},{"id":3774,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006296","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z71553","genbank_protein_id":"1302344","gene_card_id":"MET2","chromosome_location":"chromosome 14","locus":"YNL277W","synonyms":["Homoserine O-trans-acetylase"],"enzyme_classes":["2.3.1.31"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" homoserine O-acetyltransferase activity"},{"category":"Function","description":" O-acyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" O-acetyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Abhydrolase_1","identifier":"PF00561"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCGCATACTTTAAAATCGAAAACGCTCCAAGAGCTGGACATTGAGGAGATTAAGGAAACTAACCCATTGCTCAAACTAGTTCAAGGGCAGAGGATTGTTCAAGTTCCGGAACTAGTGCTTGAGTCTGGCGTGGTCATAAATAATTTCCCTATTGCTTATAAGACGTGGGGTACACTGAATGAAGCTGGTGATAATGTTCTGGTAATTTGTCATGCCTTGACTGGGTCCGCAGATGTTGCTGACTGGTGGGGCCCTCTTCTGGGTAACGACTTAGCATTCGACCCATCAAGGTTTTTTATCATATGTTTAAACTCTATGGGCTCTCCATATGGGTCTTTTTCGCCATTAACGATAAATGAGGAGACGGGCGTTAGATATGGACCCGAATTCCCATTATGTACTGTGCGCGATGACGTTAGAGCTCACAGAATTGTTCTGGATTCTCTGGGAGTAAAGTCAATAGCCTGTGTTATTGGTGGCTCTATGGGGGGGATGCTGAGTTTGGAATGGGCTGCCATGTATGGTAAGGAATATGTGAAGAATATGGTTGCTCTGGCGACATCAGCAAGACATTCTGCCTGGTGCATATCGTGGTCTGAGGCTCAAAGACAATCGATTTACTCAGATCCCAACTACTTGGACGGGTACTATCCGGTAGAGGAGCAACCTGTGGCCGGACTATCGGCTGCACGTATGTCTGCATTGTTGACGTACAGGACAAGAAACAGTTTCGAGAACAAATTCTCCAGAAGATCTCCTTCAATAGCACAACAACAAAAAGCTCAAAGGGAGGAGACACGCAAACCATCTACTGTCAGCGAACACTCCCTACAAATCCACAATGATGGGTATAAAACAAAAGCCAGCACTGCCATCGCTGGCATTTCTGGGCAAAAAGGTCAAAGCGTGGTGTCCACCGCATCTTCTTCGGATTCATTGAATTCTTCAACATCGATGACTTCGGTAAGTTCTGTAACGGGTGAAGTGAAGGACATAAAGCCTGCGCAGACGTATTTTTCTGCACAAAGTTACTTGAGGTACCAGGGCACAAAGTTCATCAATAGGTTCGACGCCAATTGTTACATTGCCATCACACGTAAACTGGATACGCACGATTTGGCAAGAGACAGAGTAGATGACATCACTGAGGTCCTTTCTACCATCCAACAACCATCCCTGATCATCGGTATCCAATCTGATGGACTGTTCACATATTCAGAACAAGAATTTTTGGCTGAGCACATACCGAAGTCGCAATTAGAAAAAATTGAATCTCCCGAAGGCCACGATGCCTTCCTATTGGAGTTTAAGCTGATAAACAAACTGATAGTACAATTTTTAAAAACCAACTGCAAGGCCATTACCGATGCCGCTCCAAGAGCTTGGGGAGGTGACGTTGGTAACGATGAAACGAAGACGTCTGTCTTTGGTGAGGCCGAAGAAGTTACCAACTGGTAG","protein_sequence":"MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW"},{"created_at":"2011-05-26T19:28:04.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Homoserine kinase","uniprot_id":"P17423","uniprot_name":"KHSE_YEAST","enzyme":true,"transporter":false,"gene_name":"THR1","num_residues":357,"molecular_weight":"38712.0","theoretical_pi":"5.05","general_function":"Involved in ATP binding","specific_function":"Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate","reactions":[{"id":1641,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2569,"direction":"\u003e","locations":null,"altext":"ATP + L-homoserine = ADP + O-phospho-L-homoserine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M37692","genbank_protein_id":"172978","gene_card_id":"THR1","chromosome_location":"chromosome 8","locus":"YHR025W","synonyms":["HK","HSK"],"enzyme_classes":["2.7.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" homoserine kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" phosphorus metabolic process"},{"category":"Process","description":" phosphate metabolic process"},{"category":"Process","description":" phosphorylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"}],"pfams":[{"name":"GHMP_kinases_N","identifier":"PF00288"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"}],"gene_sequence":"ATGGTTCGTGCCTTCAAAATTAAAGTTCCAGCTTCTTCCGCCAATATCGGCCCTGGTTATGATGTTCTTGGTGTCGGTCTTTCTCTATTCTTGGAGTTAGATGTCACCATCGACTCCAGCCAAGCTCAGGAAACAAACGACGATCCCAACAACTGCAAGCTGTCTTACACTAAAGAAAGTGAAGGCTATTCTACGGTCCCATTGCGTTCTGATGCTAACCTGATTACCAGGACTGCGTTATATGTGTTGCGTTGCAACAATATTAGAAACTTCCCCTCCGGAACCAAAGTTCACGTCTCCAACCCAATCCCACTTGGCCGTGGATTGGGTTCCTCTGGTGCAGCAGTTGTGGCAGGTGTTATTTTAGGTAACGAAGTGGCCCAATTGGGTTTCTCTAAGCAACGTATGTTGGACTACTGTTTGATGATTGAACGTCATCCAGACAACATAACCGCTGCTATGATGGGAGGCTTTTGCGGTTCATTCCTAAGGGACTTGACCCCACAAGAGGTGGAAAGACGTGAGATTCCATTGGCTGAGGTGCTTCCAGAACCTTCTGGTGGTGAAGATACCGGTCTGGTTCCCCCATTACCTCCCACCGATATCGGTAGACATGTCAAATACCAATGGAACCCCGCCATTAAATGTATTGCGATCATCCCACAGTTCGAGTTGTCCACCGCCGACTCCAGAGGCGTTCTTCCAAAAGCCTACCCAACCCAGGACTTGGTTTTCAATCTACAAAGATTGGCCGTCTTGACCACAGCTTTGACCATGGACCCACCTAATGCCGACTTAATCTACCCTGCTATGCAAGATCGTGTCCACCAACCTTATAGAAAGACATTGATCCCAGGTCTCACGGAAATCTTATCATGTGTCACCCCATCCACATACCCTGGCCTATTGGGTATCTGCTTGTCAGGTGCAGGCCCAACTATCTTGGCTTTGGCCACTGAGAATTTCGAAGAAATCTCTCAAGAAATTATCAACAGGTTCGCCAAAAACGGCATCAAGTGCTCCTGGAAACTACTGGAGCCTGCCTACGATGGTGCTAGCGTCGAACAGCAATGA","protein_sequence":"MVRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSQAQETNDDPNNCKLSYTKESEGYSTVPLRSDANLITRTALYVLRCNNIRNFPSGTKVHVSNPIPLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGFCGSFLRDLTPQEVERREIPLAEVLPEPSGGEDTGLVPPLPPTDIGRHVKYQWNPAIKCIAIIPQFELSTADSRGVLPKAYPTQDLVFNLQRLAVLTTALTMDPPNADLIYPAMQDRVHQPYRKTLIPGLTEILSCVTPSTYPGLLGICLSGAGPTILALATENFEEISQEIINRFAKNGIKCSWKLLEPAYDGASVEQQ"},{"created_at":"2011-05-26T21:12:09.000Z","updated_at":"2011-07-22T17:54:13.000Z","name":"Aspartokinase","uniprot_id":"P10869","uniprot_name":"AK_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM3","num_residues":527,"molecular_weight":"58109.19922","theoretical_pi":"6.64","general_function":"Involved in amino acid binding","specific_function":"ATP + L-aspartate = ADP + 4-phospho-L- aspartate","reactions":[{"id":1333,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2606,"direction":"\u003e","locations":null,"altext":"ATP + L-aspartate = ADP + 4-phospho-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3783,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006304","source":"Smpdb"},{"id":3854,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006375","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03526","genbank_protein_id":"171693","gene_card_id":"HOM3","chromosome_location":"chromosome 5","locus":"YER052C","synonyms":["Aspartate kinase"],"enzyme_classes":["2.7.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Function","description":" aspartate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"ACT","identifier":"PF01842"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCAATGGATTTCCAACCTACATCAAGTCATTCGAACTGGGTCGTGCAAAAGTTCGGTGGTACATCTGTCGGTAAATTTCCCGTCCAAATAGTGGATGACATTGTGAAGCACTATTCTAAACCTGACGGCCCAAACAATAATGTCGCTGTCGTTTGTTCCGCCCGTTCTTCATACACCAAGGCTGAAGGTACCACTTCTCGTCTTTTGAAATGTTGTGATTTGGCTTCGCAAGAATCTGAATTTCAAGACATTATCGAAGTTATCAGACAAGACCATATCGATAATGCCGACCGCTTCATTCTCAATCCTGCCTTGCAAGCCAAGTTAGTGGATGATACCAATAAAGAACTTGAACTGGTCAAGAAATATTTAAATGCTTCAAAAGTTTTGGGTGAAGTGAGTTCACGTACAGTAGATCTGGTGATGTCATGTGGTGAGAAGTTGAGTTGTTTGTTCATGACTGCTTTATGTAATGACCGTGGCTGTAAGGCCAAATATGTGGATTTGAGCCACATTGTTCCCTCTGATTTCAGTGCCAGCGCTTTGGATAACAGTTTCTACACTTTCCTGGTTCAAGCATTGAAAGAAAAATTGGCCCCCTTTGTAAGTGCTAAAGAGCGTATCGTTCCAGTCTTTACAGGGTTTTTTGGTTTAGTTCCAACTGGTCTTCTGAATGGTGTTGGTCGTGGCTATACCGATTTATGTGCCGCTTTGATAGCAGTTGCTGTAAATGCTGATGAACTACAAGTTTGGAAGGAAGTTGATGGTATATTTACTGCTGATCCTCGTAAGGTTCCTGAAGCACGTTTGCTAGACAGTGTTACTCCAGAAGAAGCTTCTGAATTAACATATTATGGTTCCGAAGTTATACATCCTTTTACGATGGAACAAGTTATTAGGGCTAAGATTCCTATTAGAATCAAGAATGTTCAAAATCCATTAGGTAACGGTACCATTATCTACCCAGATAATGTAGCAAAGAAGGGTGAATCTACTCCACCACATCCTCCTGAGAACTTATCCTCATCTTTCTATGAAAAGAGAAAGAGAGGTGCCACTGCTATCACCACCAAAAATGACATTTTCGTCATCAACATTCATTCCAATAAGAAAACCCTATCCCATGGTTTCCTAGCTCAAATATTTACCATCCTGGATAAGTACAAGTTAGTCGTAGATTTAATATCTACTTCTGAAGTTCATGTTTCGATGGCTTTGCCCATTCCAGATGCAGACTCATTAAAATCTCTGAGACAAGCTGAGGAAAAATTGAGAATTTTAGGTTCTGTTGATATCACAAAGAAGTTGTCTATTGTTTCATTAGTTGGTAAACATATGAAACAATACATCGGCATTGCTGGTACCATGTTTACTACTCTTGCTGAAGAAGGCATCAACATTGAAATGATTTCTCAAGGGGCAAATGAAATAAACATATCCTGCGTTATCAATGAATCTGACTCCATAAAAGCGCTACAATGTATTCATGCCAAGTTACTAAGTGAGCGGACAAATACTTCAAACCAATTTGAACATGCCATTGATGAACGTTTAGAACAATTGAAAAGACTTGGAATTTAA","protein_sequence":"MPMDFQPTSSHSNWVVQKFGGTSVGKFPVQIVDDIVKHYSKPDGPNNNVAVVCSARSSYTKAEGTTSRLLKCCDLASQESEFQDIIEVIRQDHIDNADRFILNPALQAKLVDDTNKELELVKKYLNASKVLGEVSSRTVDLVMSCGEKLSCLFMTALCNDRGCKAKYVDLSHIVPSDFSASALDNSFYTFLVQALKEKLAPFVSAKERIVPVFTGFFGLVPTGLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRKVPEARLLDSVTPEEASELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDNVAKKGESTPPHPPENLSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTILDKYKLVVDLISTSEVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITKKLSIVSLVGKHMKQYIGIAGTMFTTLAEEGINIEMISQGANEINISCVINESDSIKALQCIHAKLLSERTNTSNQFEHAIDERLEQLKRLGI"},{"created_at":"2011-05-27T16:56:20.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Homoserine dehydrogenase","uniprot_id":"P31116","uniprot_name":"DHOM_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM6","num_residues":359,"molecular_weight":"38501.69922","theoretical_pi":"7.71","general_function":"Involved in oxidoreductase activity","specific_function":"L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H","reactions":[{"id":1639,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1640,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2833,"direction":"\u003e","locations":null,"altext":"L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3781,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006302","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1Q7G","cellular_location":null,"genbank_gene_id":"X64457","genbank_protein_id":"3797","gene_card_id":"HOM6","chromosome_location":"chromosome 10","locus":"YJR139C","synonyms":["HDH"],"enzyme_classes":["1.1.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"Homoserine_dh","identifier":"PF00742"},{"name":"NAD_binding_3","identifier":"PF03447"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGAGCACTAAAGTTGTTAATGTTGCCGTTATCGGTGCCGGTGTTGTTGGTTCAGCTTTCTTGGATCAATTGTTAGCCATGAAGTCTACCATTACTTACAATCTAGTTCTTTTGGCTGAAGCTGAGCGTTCTTTAATCTCCAAGGACTTTTCTCCATTAAATGTTGGTTCTGATTGGAAGGCTGCTTTAGCAGCCTCCACTACTAAAACGTTGCCTTTGGATGATTTAATTGCTCATTTGAAGACTTCACCTAAGCCAGTCATTTTGGTTGATAACACTTCCAGCGCTTACATTGCTGGTTTTTACACTAAGTTTGTCGAAAATGGTATTTCCATTGCTACTCCAAACAAGAAGGCCTTTTCCTCTGATTTGGCTACCTGGAAGGCTCTTTTCTCAAATAAGCCAACTAACGGTTTTGTCTATCATGAAGCTACCGTCGGTGCTGGTTTGCCTATCATCAGTTTCTTAAGAGAAATTATTCAAACCGGTGACGAAGTTGAAAAAATTGAAGGTATCTTCTCTGGTACTCTATCTTATATTTTCAACGAGTTCTCCACTAGTCAAGCTAACGACGTCAAATTCTCTGATGTTGTCAAAGTTGCTAAAAAATTGGGTTATACTGAACCAGATCCAAGAGATGATTTGAATGGGTTGGATGTTGCTAGAAAGGTTACCATTGTTGGTAGGATATCTGGTGTGGAAGTTGAATCTCCAACTTCCTTCCCTGTCCAGTCTTTGATTCCAAAACCATTGGAATCTGTCAAGTCTGCTGATGAATTCTTGGAAAAATTATCTGATTACGATAAAGATTTGACTCAATTGAAGAAGGAAGCTGCCACTGAAAATAAGGTATTGAGATTCATTGGTAAAGTCGATGTTGCCACCAAATCTGTGTCTGTAGGAATTGAAAAGTACGATTACTCACACCCATTCGCATCATTGAAGGGATCAGATAACGTTATTTCCATCAAGACTAAGCGTTACACCAATCCTGTTGTCATTCAAGGTGCCGGTGCCGGTGCTGCCGTTACTGCCGCTGGTGTTTTGGGTGATGTTATCAAGATTGCTCAAAGACTTTAG","protein_sequence":"MSTKVVNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERSLISKDFSPLNVGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSDLATWKALFSNKPTNGFVYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFNEFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIAQRL"}]}