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Identification |
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Name | Mevalonate kinase |
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Synonyms | - MK
- MvK
- Ergosterol biosynthesis protein 12
- Regulation of autonomous replication protein 1
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Gene Name | ERG12 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in ATP binding |
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Specific Function | RAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids |
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Cellular Location | Cytoplasm |
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SMPDB Pathways | Cholesterol biosynthesis and metabolism CE(10:0) | PW002545 | | Cholesterol biosynthesis and metabolism CE(12:0) | PW002548 | | Cholesterol biosynthesis and metabolism CE(14:0) | PW002544 | | Cholesterol biosynthesis and metabolism CE(16:0) | PW002550 | | Cholesterol biosynthesis and metabolism CE(18:0) | PW002551 | |
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KEGG Pathways | Terpenoid backbone biosynthesis | ec00900 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00064 | CDP | Show | YMDB00109 | Adenosine triphosphate | Show | YMDB00181 | Mevalonic acid-5P | Show | YMDB00257 | Guanosine diphosphate | Show | YMDB00279 | Cytidine triphosphate | Show | YMDB00307 | Uridine 5'-diphosphate | Show | YMDB00310 | 22b-Hydroxycholesterol | Show | YMDB00326 | Uridine triphosphate | Show | YMDB00558 | GTP | Show | YMDB00707 | (R)-Mevalonic acid | Show | YMDB00862 | hydron | Show | YMDB00914 | ADP | Show | YMDB01039 | (R)-Mevalonate | Show |
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GO Classification | Component |
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cell part | intracellular part | cytoplasm | Function |
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transferase activity, transferring phosphorus-containing groups | binding | mevalonate kinase activity | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | adenyl ribonucleotide binding | ATP binding | kinase activity | phosphotransferase activity, alcohol group as acceptor | catalytic activity | transferase activity | Process |
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phosphate metabolic process | metabolic process | phosphorylation | lipid metabolic process | cellular lipid metabolic process | cellular metabolic process | isoprenoid metabolic process | primary metabolic process | isoprenoid biosynthetic process | phosphorus metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 13 |
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Locus | YMR208W |
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Gene Sequence | >1332 bp
ATGTCATTACCGTTCTTAACTTCTGCACCGGGAAAGGTTATTATTTTTGGTGAACACTCT
GCTGTGTACAACAAGCCTGCCGTCGCTGCTAGTGTGTCTGCGTTGAGAACCTACCTGCTA
ATAAGCGAGTCATCTGCACCAGATACTATTGAATTGGACTTCCCGGACATTAGCTTTAAT
CATAAGTGGTCCATCAATGATTTCAATGCCATCACCGAGGATCAAGTAAACTCCCAAAAA
TTGGCCAAGGCTCAACAAGCCACCGATGGCTTGTCTCAGGAACTCGTTAGTCTTTTGGAT
CCGTTGTTAGCTCAACTATCCGAATCCTTCCACTACCATGCAGCGTTTTGTTTCCTGTAT
ATGTTTGTTTGCCTATGCCCCCATGCCAAGAATATTAAGTTTTCTTTAAAGTCTACTTTA
CCCATCGGTGCTGGGTTGGGCTCAAGCGCCTCTATTTCTGTATCACTGGCCTTAGCTATG
GCCTACTTGGGGGGGTTAATAGGATCTAATGACTTGGAAAAGCTGTCAGAAAACGATAAG
CATATAGTGAATCAATGGGCCTTCATAGGTGAAAAGTGTATTCACGGTACCCCTTCAGGA
ATAGATAACGCTGTGGCCACTTATGGTAATGCCCTGCTATTTGAAAAAGACTCACATAAT
GGAACAATAAACACAAACAATTTTAAGTTCTTAGATGATTTCCCAGCCATTCCAATGATC
CTAACCTATACTAGAATTCCAAGGTCTACAAAAGATCTTGTTGCTCGCGTTCGTGTGTTG
GTCACCGAGAAATTTCCTGAAGTTATGAAGCCAATTCTAGATGCCATGGGTGAATGTGCC
CTACAAGGCTTAGAGATCATGACTAAGTTAAGTAAATGTAAAGGCACCGATGACGAGGCT
GTAGAAACTAATAATGAACTGTATGAACAACTATTGGAATTGATAAGAATAAATCATGGA
CTGCTTGTCTCAATCGGTGTTTCTCATCCTGGATTAGAACTTATTAAAAATCTGAGCGAT
GATTTGAGAATTGGCTCCACAAAACTTACCGGTGCTGGTGGCGGCGGTTGCTCTTTGACT
TTGTTACGAAGAGACATTACTCAAGAGCAAATTGACAGCTTCAAAAAGAAATTGCAAGAT
GATTTTAGTTACGAGACATTTGAAACAGACTTGGGTGGGACTGGCTGCTGTTTGTTAAGC
GCAAAAAATTTGAATAAAGATCTTAAAATCAAATCCCTAGTATTCCAATTATTTGAAAAT
AAAACTACCACAAAGCAACAAATTGACGATCTATTATTGCCAGGAAACACGAATTTACCA
TGGACTTCATAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 443 |
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Protein Molecular Weight | 48458.89844 |
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Protein Theoretical pI | 5.28 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Mevalonate kinase
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN
KTTTKQQIDDLLLPGNTNLPWTS |
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References |
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External Links | |
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General Reference | - Kearsey, S. E., Edwards, J. (1987). "Mutations that increase the mitotic stability of minichromosomes in yeast: characterization of RAR1." Mol Gen Genet 210:509-517.3323847
- Oulmouden, A., Karst, F. (1991). "Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase." Curr Genet 19:9-14.1645230
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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