Showing Reaction 1148

Acetyl-CoA + Alpha-Ketoisovaleric acid + water → 2-Isopropylmalic acid + hydron + Coenzyme A
Thumb+Thumb+Thumb→Thumb+Thumb+Thumb

Enzymes

  1. 2-isopropylmalate synthase
  2. 2-isopropylmalate synthase 2, mitochondrial

Cellular Locations

  • mitochondrion
  • cytoplasm

References

  • Mo, M. L., Palsson, B. O., Herrgard, M. J. (2009). "Connecting extracellular metabolomic measurements to intracellular flux states in yeast." BMC Syst Biol 3:37.19321003
  • Chang, L. F., Cunningham, T. S., Gatzek, P. R., Chen, W. J., Kohlhaw, G. B. (1984). "Cloning and characterization of yeast Leu4, one of two genes responsible for alpha-isopropylmalate synthesis." Genetics 108:91-106.6090272