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Identification |
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Name | Probable phospholipid-transporting ATPase DNF3 |
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Synonyms | Not Available |
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Gene Name | DNF3 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in nucleotide binding |
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Specific Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential) |
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Cellular Location | Membrane; Multi-pass membrane protein |
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SMPDB Pathways | Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z)) | PW002785 | | Lysolipid incorporation into ER PC(18:0/18:0) | PW002787 | | Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z)) | PW002788 | | Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z)) | PW002789 | | Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) | PW002790 | |
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KEGG Pathways | Not Available |
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SMPDB Reactions | Not Available |
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KEGG Reactions | Not Available |
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Metabolites | YMDB ID | Name | View |
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YMDB00109 | Adenosine triphosphate | Show | YMDB00890 | water | Show | YMDB00907 | phosphate | Show | YMDB00914 | ADP | Show |
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GO Classification | Component |
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cell part | membrane | membrane part | intrinsic to membrane | integral to membrane | Function |
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substrate-specific transporter activity | metal ion binding | lipid transporter activity | transporter activity | phospholipid transporter activity | transmembrane transporter activity | phospholipid-translocating ATPase activity | hydrolase activity | substrate-specific transmembrane transporter activity | ion transmembrane transporter activity | binding | magnesium ion binding | catalytic activity | nucleoside binding | ATPase activity, coupled to transmembrane movement of ions | purine nucleoside binding | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | adenyl nucleotide binding | hydrolase activity, acting on acid anhydrides | adenyl ribonucleotide binding | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | ATP binding | ion binding | cation binding | Process |
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nitrogen compound metabolic process | cellular nitrogen compound metabolic process | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | nucleobase, nucleoside and nucleotide metabolic process | establishment of localization | lipid transport | nucleoside phosphate metabolic process | transport | phospholipid transport | nucleotide metabolic process | purine nucleotide metabolic process | purine nucleotide biosynthetic process | metabolic process | purine nucleoside triphosphate biosynthetic process | purine ribonucleoside triphosphate biosynthetic process | ATP biosynthetic process |
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Gene Properties |
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Chromosome Location | chromosome 13 |
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Locus | YMR162C |
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Gene Sequence | >4971 bp
ATGGGCATAGCTGATGGGCAAAGAAGAAGATCTTCATCACTACGAACGCAGATGTTCAAC
AAGCATTTGTATGATAAATATCGCGGAAGAACTGATGATGAGATAGAGTTAGAAGATATA
AATGAGAGTAAGACGTTCTCCGGTAGCGATAATAACGATAAAGATGACAGAGATGAAACA
AGCGGCAATTATGCTGCTGAAGAGGATTATGAAATGGAAGAGTATGGTAGTCCTGATGTG
TCATATAGCATTATCACTAAAATACTTGATACTATCCTAGATCGAAGGAGGACGTTCCAT
TCGAAAGACGGTAGACATATTCCGATTATATTAGATCATAATGCAATTGAATACAAACAA
GCTGCTACTAAAAGGGATGGTCATTTGATAGACGAAAGGTTCAACAAGCCTTACTGCGAC
AACCGAATAACTTCATCAAGATATACATTCTATTCCTTTTTGCCTAGACAGTTGTATGCA
CAATTTTCAAAGTTAGCCAATACTTATTTTTTCATTGTCGCAGTATTACAAATGATACCT
GGATGGTCTACAACTGGTACTTATACAACTATTATCCCCTTATGTGTATTTATGGGTATA
TCCATGACAAGAGAGGCTTGGGACGATTTCAGGAGACATCGTTTAGATAAGGAAGAGAAC
AATAAACCAGTGGGAGTGTTGGTTAAAGATGGAAATAATGACGCACAAGAAGTTTATACA
CTACCAAGTAGTGTTGTCTCATCCACTGCATATCTAACTAAATCGGCCGCTGCTGAAAAT
AATCCACCTTTAAACGATGATCGGAACTCCTCTCAAGGACACTTCTTAGACACGCACTTC
AATAACTTTGAACTACTCAAGAATAAATACAATGTTCATATTCATCAAAAGAAGTGGGAA
AAACTTCGTGTTGGAGACTTCGTACTTCTCACACAAGATGATTGGGTACCTGCAGATCTG
CTTTTATTGACATGTGACGGCGAAAATAGCGAATGTTTCGTTGAAACGATGGCTTTAGAT
GGCGAAACAAATTTGAAAAGTAAACAACCCCATCCAGAATTAAATAAGTTAACCAAAGCC
GCATCAGGTCTTGCAAATATTAATGCTCAAGTTACCGTGGAAGATCCCAATATTGATTTA
TATAATTTTGAAGGTAATCTTGAATTGAAAAACCATCGCAATGATACCATAATGAAATAC
CCTCTAGGTCCTGATAATGTCATTTATCGTGGTAGTATTTTGAGGAATACTCAAAATGTT
GTTGGTATGGTCATTTTCAGTGGTGAGGAAACAAAAATCAGAATGAATGCTTTAAAAAAC
CCAAGAACGAAAGCCCCTAAGCTACAAAGGAAGATAAATATGATTATCGTGTTTATGGTG
TTTGTCGTTGCCACAATATCTTTATTTTCTTATCTTGGCCATGTTTTGCATAAGAAAAAA
TATATCGACCAGAACAAAGCATGGTATCTATTTCAGGCAGATGCTGGCGTAGCACCCACA
ATAATGTCTTTTATCATCATGTATAACACTGTGATTCCTTTGTCCCTATATGTAACAATG
GAAATTATCAAGGTAGTCCAAAGTAAAATGATGGAATGGGACATAGACATGTACCATGCA
GAAACGAACACGCCATGCGAATCGAGAACTGCCACCATTCTGGAGGAATTGGGGCAAGTA
TCTTATATTTTTAGTGATAAAACCGGAACGCTGACGGATAATAAGATGATATTTCGGAAA
TTTTCTTTATGTGGATCATCTTGGCTGCATAATGTAGATCTCGGTAATTCTGAGGATAAC
TTTGAAGACAACAGAGACAATACGAACTCCTTGAGACTACCACCAAAAGCTCACAACGGC
TCTAGTATAGACGTTGTTTCCATTGGAGATCAAAATGTTCTTGATCGGTTAGGATTTTCG
GACGCACCAATTGAAAAAGGGCATCGTCCATCTTTGGACAACTTTCCTAAATCTAGGAAT
TCTATTGAATATAAGGGAAATTCATCAGCAATTTATACAGGCCGTCCCAGTATGAGATCA
CTTTTTGGGAAAGATAATTCACATCTAAGTAAACAAGCTTCGGTTATTTCACCCTCCGAG
ACATTTTCGGAGAACATTAAAAGTTCGTTTGATTTAATTCAGTTTATTCAAAGATATCCG
ACCGCCCTGTTTTCTCAAAAGGCTAAATTTTTCTTCTTATCATTAGCTCTTTGTCATAGC
TGTCTTCCCAAAAAAACTCATAACGAATCAATAGGAGAAGACTCCATAGAGTATCAGTCT
TCATCTCCAGATGAATTAGCACTAGTAACCGCTGCTAGAGACCTTGGTTATATTGTATTG
AATAGAAATGCACAGATTTTGACCATTAAAACTTTTCCAGACGGTTTTGACGGTGAAGCA
AAATTGGAAAATTATGAAATTTTGAACTATATTGACTTCAATTCTCAAAGAAAGAGAATG
TCTGTTCTTGTACGTATGCCAAATCAACCAAATCAAGTTCTTTTAATTTGCAAAGGTGCT
GATAACGTTATTATGGAGCGTTTACATGATCGCGAATTGGCTGCCAAAAAAATGGCAGAC
ATATGCACCAGTACCAAAGAACGTAAAGACGCAGAAGCAGAGCTGGTTCTCCAGCAAAGA
AAGTCTCTGGAAAGAATGGTAGATGAAGAGGCTATGGCCAGGACCTCATTGAGAAATTCT
TTGTCTAGCGTACCGAGAGCAAGTTTATCATTGCAGGCAGTGAGAAAAAGTCTTTCAATG
AAGAACAGCAGGACCCGTGATCCAGAGAAACAAATTGACTCCATTGATCAATTTCTAGAA
ACGGTCAAGAAATCTGATCAGGAGATTGGCAGCGTTGTAAATAAAAGCAGGAAGTCACTC
CATAAGCAACAAATAGAAAAATATGGGCCGCGAATTTCGATAGATGGAACACATTTTCCG
AACAACAATGTCCCAATAGACACAAGAAAAGAAGGACTACAGCATGATTACGATACAGAA
ATTTTGGAGCACATTGGAAGCGATGAGTTAATTTTGAATGAAGAGTATGTTATTGAAAGA
ACTTTGCAAGCCATCGATGAGTTTTCGACTGAAGGCTTAAGAACTCTGGTCTATGCTTAC
AAATGGATCGATATTGGGCAGTATGAAAATTGGAATAAACGCTATCACCAAGCCAAAACC
TCCCTTACTGATAGAAAAATCAAAGTCGATGAGGCAGGTGCAGAAATCGAGGATGGTTTA
AATCTGTTAGGGGTAACTGCAATCGAAGACAAGTTACAAGACGGCGTTTCAGAAGCTATA
GAAAAGATCAGAAGAGCCGGTATAAAAATGTGGATGCTAACAGGGGATAAAAGGGAAACG
GCTATAAATATAGGGTATTCGTGTATGTTAATCAAAGATTATTCTACGGTAGTCATTTTA
ACTACTACTGATGAAAATATTATATCAAAGATGAATGCGGTTTCTCAAGAAGTTGATTCC
GGAAACATAGCACACTGCGTTGTTGTAATTGACGGTGCCACGATGGCCATGTTTGAAGGA
AATCCTACATACATGTCTGTATTTGTTGAGCTTTGCACTAAAACAGACTCGGTAATATGT
TGCCGTGCTTCACCTTCTCAAAAAGCCCTTATGGTTTCCAACATAAGAAATACCGATCCA
AACTTAGTCACGTTGGCAATAGGTGATGGTGCGAATGATATTGCCATGATACAATCTGCC
GATATAGGTGTTGGAATAGCCGGTAAGGAGGGATTGCAAGCATCTAGAGTATCTGATTAT
TCTATTGGCCAATTTCGGTTTCTCTTGAAATTGTTATTTGTTCATGGGCGTTATAACTAT
ATTCGCACCTCCAAGTTTATGCTTTGCACGTTTTACAAAGAAATTACGTTTTACTTTACG
CAGTTGATATATCAAAGATATACAATGTTTTCAGGCTCCTCTCTATATGAGCCATGGTCA
TTGTCCATGTTCAATACTCTATTCACATCACTACCGGTTCTATGTATTGGTATGTTTGAG
AAAGACTTGAAACCAATGACTCTACTAACAGTCCCTGAATTATATTCGTACGGGCGCCTT
TCACAAGGTTTTAATTGGTTAATATTCATGGAGTGGGTTATCTTGGCAACTACGAATTCT
CTTATCATTACATTTTTAAATGTTGTAATGTGGGGTATGAGTTCTCTTTCAGATAACACT
ATGTATCCTCTAGGTCTCATCAATTTCACAGCCATTGTTGCCTTAATTAACGTTAAATCC
CAATTTGTTGAAATGCACAATAGGAATTGGCTGGCTTTTACTTCTGTAGTTCTATCCTGT
GGAGGTTGGTTAGTGTGGTGTTGTGCCCTTCCTATTTTGAATAATACTGACCAAATATAT
GATGTAGCATATGGCTTTTACAATCATTTTGGTAAAGACATTACATTCTGGTGTACTAGC
TTGGTGTTGGCACTGTTACCTATCACTTTAGATATAGTTTACAAAACATTCAAAGTTATG
ATATGGCCATCAGATTCTGATATTTTTGCTGAGCTGGAACAAAAAAGTGATATCAGAAAG
AAGCTGGAACTAGGAGCCTATAGCGAAATGAGGCAAGGATGGACGTGGGATAAAGATCCC
AGTACTTTCACAAGGTACACAGACAAAGTTCTTTCAAGGCCAAGAACTAATTCACGTGCA
AGTGCAAAAACTCATAACAGCAGCATATATTCAATGTCAAATGGGAATGTAGACCATTCC
TCAAAAAAAAATTTCTTTGGAAACTCTTCTAAAAAGAGCTCTGAACGATACGAGGTATTA
CCTAGTGGCAAGTTAATCAAGCGACCATCCTTGAAAACACAAAGCAGTAAAGACAGTATT
GGCGGCAATATAACTACTAAACTGACGAAGAAACTGAAGCTTCCATCGAGGAATGTGGAA
GATGAAGATGTGAACCAGATTATTCAGGCAAGGCTAAAGGATCTGGAGTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 1656 |
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Protein Molecular Weight | 188318.0 |
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Protein Theoretical pI | 6.74 |
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Signalling Regions | |
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Transmembrane Regions | - 165-185
- 452-472
- 496-516
- 1158-1178
- 1319-1339
- 1366-1386
- 1396-1416
- 1433-1453
- 1474-1494
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Protein Sequence | >Probable phospholipid-transporting ATPase DNF3
MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDET
SGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQ
AATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIP
GWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYT
LPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWE
KLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKA
ASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNV
VGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKK
YIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHA
ETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDN
FEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRN
SIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYP
TALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVL
NRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGA
DNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNS
LSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSL
HKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIER
TLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGL
NLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVIL
TTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVIC
CRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDY
SIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWS
LSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNS
LIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSC
GGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVM
IWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRA
SAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSI
GGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE |
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References |
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External Links | |
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General Reference | - Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
- Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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