| Identification |
|---|
| Name | Probable ferric reductase transmembrane component 8 |
|---|
| Synonyms | - Ferric-chelate reductase 8
|
|---|
| Gene Name | FRE8 |
|---|
| Enzyme Class | |
|---|
| Biological Properties |
|---|
| General Function | Involved in iron ion binding |
|---|
| Specific Function | Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis |
|---|
| Cellular Location | Membrane; Multi-pass membrane protein |
|---|
| SMPDB Pathways | Not Available |
|---|
| KEGG Pathways | Not Available |
|---|
| SMPDB Reactions | Not Available |
|---|
| KEGG Reactions | Not Available |
|---|
| Metabolites | | YMDB ID | Name | View |
|---|
| YMDB00110 | NAD | Show | | YMDB00143 | NADH | Show | | YMDB00194 | Iron(3+) | Show | | YMDB00379 | Iron(2+) | Show |
|
|---|
| GO Classification | | Component |
|---|
| cell part | | membrane part | | intrinsic to membrane | | integral to membrane | | Function |
|---|
| metal ion binding | | transition metal ion binding | | iron ion binding | | catalytic activity | | oxidoreductase activity | | electron carrier activity | | binding | | nucleoside binding | | purine nucleoside binding | | adenyl nucleotide binding | | FAD or FADH2 binding | | ion binding | | cation binding | | Process |
|---|
| Not Available |
|
|---|
| Gene Properties |
|---|
| Chromosome Location | chromosome 12 |
|---|
| Locus | YLR047C |
|---|
| Gene Sequence | >2061 bp
ATGAATTTAAAGTCCATCGTTAGCTGGTTCAAGGAACATCTTCCCAGTTTTGATGTCGAC
GTGGACAAGCATTTTAGAACTTTAAGAGTCCGCAAATATTCTCAGATATGTCTTTTAATT
TCTTTCATTATAATATGTGTTATTATACCCTTAATGAATTATTTGTTGCTAACTGACAAA
TTCTTCAAAATATGTCACCATTTAAAGCATCATGTTTTCAACAGAAGATCATGGGTTCAC
AAAACACATATGTATCACAAACAGTCACTACAACTATGTTTAATATGCTTTGTTTTCACC
TCGTTTTTTGTTATACAAGGCGCTAACGGAGATCTGTTAGAAATTACTAAGCGAATGGGG
AGAATTTCCGTTGCTTTGATGCCACCTTTACTATTTCTAACGTTGAGGCCATCACCGTTA
CCTCACACGTTATACTTAGCATTGTTACCTCTCCACAAATGGATTTCCAGAATTGTTGTG
CTTGAATCTATTCTACACACGTGGTTCTATCTCTATTACATGTACATTAATGATACGTTA
TACGTGAAAATGAGAAAACTACCCAACATTTATGGGGTTATTGCCCTCGGCCTTTTCCTA
CTGATTGCCATCACCTCTGTGAGATATGCCAGACGATGGAGCTACAGAGTTTTTTACTAT
GTTCACTATGTAAGCACATGGCTTATTTTGGTGTTTCTACATTATCACGCTCGCCCAGGA
ATTTCATATTATACCACTTTAAATGTGCTCATATTAACGGGACAAATCGTCTATAGGCTC
CATATCACCAATGTTACGAGAGTTACGATAGTACCCATTTCTTCATCATTGTCTCTTTTG
GAGTTCCCATTAACCGATTTACCCAAAAAGCCCATCCTACCAGGAGGGCATCTAAGGATC
AACATTTACCATAGAAATTTTTTAAGGAGGTTTTTCTCCCATTTGATACCCTTCCAACAT
CCTTTTACTATTGCTAGTATTCCAAGTGATAATTTGGTCAGGTTAATTATTAGAAACGGG
CATTTTCCATTGCGTACAAATGAAAAGTATTACATTACAGGGGCTTTTGAACCTGAGTTG
AGTTTCATTTCTAAACCTACTGTTCCTTTTAATATTACCACGAAATCTTCCAAGAATCCA
TTTCGAAACAATTCTTCTGCACTAATAAATTCGCCTTTAAATTTTCTAATTAAAGCGCAA
AGAGTGTTTATGTGTGTTGGAGGTTCAGGAATTTCCTTTGGCTTACCACTACTTCGTATT
CTAAACTTCAACGGTGTAAACGTTAGGCTCCTTTGGGTTTCTAGAGATTATAAGGATCTG
GAAGTATTGAACCACTTCAAAAACAATTTTGAAGGTATGGAGATATATATTAGTGGCACC
GAAGGCAACGAACAGGACATAGAAATTGATTATATTGACTATCATGACTGCGCTGCTGAT
ATTAATGATGAAGTCAGGAGTATTTCTTCGAGCGGCCGAGTTTCAGAACTGGGAGATAAT
TCCATGTTATCAGATGGAAATCCCCAACCTACGGAGCCCAATGAGAACACAGCCCTTCTA
AGTAAGAAATCTACCTTGAGAAACCATCACCCACCAAAAACAAGTGATATACCTGACATC
AATGCTGATGACGAGATAGATTTTACATATGCTTTTAGCAGATCCAAATCAAGGAAAAAT
ACTGCACAAGGAACTCTAACTACACATTCTTCGTTTAACGGATCGAGCGTTTTCAGACAA
CCAAAGATCATTGAGCCACCTGCCCAAGATCCTTGTTTAGAGGCGGCGCCTAAAAAGATC
AGAATTCCCGCAGGTGTTAAAGTGTTCTTTGGCAGGCCTACACTTGGAGATAAGGATTAT
GAATGGTGTCTGCAAACCGAATGTGATGCAGAGACGGATTCTATTCAATGTTGCAGGTGG
GCGAATCAAGGCAGAGACCATGCTGAATATTTGTCACAAGTATGGGTTCTCGCTGCAGGC
CCTAGAGGCTTAATTGAAAGCACCAAAAGATGGGCGACAGATGGTGGTTTACACTTTCAC
GGAGAAAGTTTTGCATTATAA |
|---|
| Protein Properties |
|---|
| Pfam Domain Function | |
|---|
| Protein Residues | 686 |
|---|
| Protein Molecular Weight | 78947.70313 |
|---|
| Protein Theoretical pI | 9.43 |
|---|
| Signalling Regions | |
|---|
| Transmembrane Regions | - 36-56
- 90-110
- 129-149
- 158-178
- 187-207
- 217-237
- 268-288
- 403-423
|
|---|
| Protein Sequence | >Probable ferric reductase transmembrane component 8
MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDK
FFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMG
RISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTL
YVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPG
ISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRI
NIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPEL
SFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRI
LNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAAD
INDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDI
NADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKI
RIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAG
PRGLIESTKRWATDGGLHFHGESFAL |
|---|
| References |
|---|
| External Links | |
|---|
| General Reference | - Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
- De Freitas, J. M., Kim, J. H., Poynton, H., Su, T., Wintz, H., Fox, T., Holman, P., Loguinov, A., Keles, S., van der Laan, M., Vulpe, C. (2004). "Exploratory and confirmatory gene expression profiling of mac1Delta." J Biol Chem 279:4450-4458.14534306
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
|
|---|