{"ymdb_id":"YMDB00379","created_at":"2011-05-29T18:11:09.000Z","updated_at":"2016-10-18T17:11:28.000Z","name":"Iron(2+)","cas":"15438-31-0","state":null,"melting_point":null,"description":"Iron(2+), also called ferrous iron, is iron in the +2 oxidation state. In animals, plants, and fungi, iron is often the metal ion incorporated into the heme complex. Heme is an essential component of cytochrome proteins, which mediate redox reactions, and of oxygen carrier proteins such as hemoglobin, myoglobin, and leghemoglobin. Inorganic iron also contributes to redox reactions in the iron-sulfur clusters of many enzymes, such as nitrogenase (involved in the synthesis of ammonia from nitrogen and hydrogen) and hydrogenase. Non-heme iron proteins include the enzymes methane monooxygenase (oxidizes methane to methanol), ribonucleotide reductase (reduces ribose to deoxyribose; DNA biosynthesis), hemerythrins (oxygen transport and fixation in Marine invertebrates) and purple acid phosphatase (hydrolysis of phosphate esters). [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"29033","hmdb_id":null,"kegg_id":"C14818","pubchem_id":"27284","cs_id":"25946211","foodb_id":null,"wikipedia_link":"Ferrous","biocyc_id":"FE+2","iupac":"lambda2-iron(2+) ion","traditional_iupac":"lambda2-iron(2+) ion","logp":"-0.77","pka":"5.46","alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"0","donor_count":"0","rotatable_bond_count":"0","polar_surface_area":"0.0","refractivity":"0.0","polarizability":"1.7784","formal_charge":"2","physiological_charge":"2","pka_strongest_basic":null,"pka_strongest_acidic":"4.58","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["FE (II) ION","Fe(2+)","Fe(II)","Fe2+","Ferrous ion","iron ion(2+)","Iron(2+)"],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"growth_conditions":[{"growth_media":"hops, malted barley","concentration":"4.0","concentration_units":"\u0026#181;M","error":"1.0"},{"growth_media":"grape juice","concentration":"82.0","concentration_units":"\u0026#181;M","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":null,"citation":"Alcoholic beverage, wine, table, red - U.S. Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. \u003ca href = http://www.ars.usda.gov/ba/bhnrc/ndl\u003eNutrient Data Laboratory Home Page\u003c/a\u003e"},{"pubmed_id":11980703,"citation":"Schubert, H. L., Raux, E., Brindley, A. A., Leech, H. K., Wilson, K. S., Hill, C. P., Warren, M. J. (2002). \"The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.\" EMBO J 21:2068-2075."}],"proteins":[{"created_at":"2011-05-24T21:11:28.000Z","updated_at":"2011-07-22T17:55:05.000Z","name":"Ferrochelatase, mitochondrial","uniprot_id":"P16622","uniprot_name":"HEMH_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM15","num_residues":393,"molecular_weight":"44595.80078","theoretical_pi":"9.46","general_function":"Involved in ferrochelatase activity","specific_function":"Catalyzes the ferrous insertion into protoporphyrin IX","reactions":[{"id":1538,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2366,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.","altext":"Protoheme + 2 H(+) = protoporphyrin + Fe(2+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1LBQ","cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.","genbank_gene_id":"J05395","genbank_protein_id":"171660","gene_card_id":"HEM15","chromosome_location":"chromosome 15","locus":"YOR176W","synonyms":["Heme synthase","Protoheme ferro-lyase"],"enzyme_classes":["4.99.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ferrochelatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" heme biosynthetic process"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"}],"pfams":[{"name":"Ferrochelatase","identifier":"PF00762"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGCTTTCCAGAACAATCCGTACACAAGGTTCCTTCCTAAGAAGATCACAACTGACCATTACAAGATCATTTTCGGTTACATTCAACATGCAGAATGCACAAAAGAGATCACCCACAGGAATTGTTTTGATGAACATGGGTGGCCCCTCTAAAGTTGAGGAAACATATGATTTTTTGTATCAATTATTTGCCGATAATGACCTAATTCCCATTAGTGCTAAGTATCAGAAGACAATTGCTAAATATATTGCTAAGTTTCGTACCCCCAAGATAGAGAAGCAATATAGGGAAATTGGTGGGGGCTCCCCAATCCGGAAATGGTCTGAGTATCAAGCCACTGAGGTCTGTAAAATCTTAGATAAAACCTGTCCAGAAACGGCGCCTCATAAGCCTTACGTGGCGTTTCGTTACGCAAAGCCGCTAACCGCAGAAACTTATAAACAAATGCTAAAAGATGGCGTGAAGAAGGCAGTGGCCTTTTCTCAATATCCTCATTTCTCTTATTCCACTACCGGGTCATCCATCAACGAATTGTGGAGACAGATTAAGGCATTGGACTCCGAGAGATCTATATCTTGGTCGGTTATTGATCGTTGGCCTACAAATGAAGGTCTAATCAAGGCCTTCTCCGAAAATATCACCAAAAAACTACAAGAGTTTCCGCAACCTGTCAGAGACAAGGTTGTTTTATTGTTTTCCGCACATTCTCTACCCATGGATGTTGTTAACACCGGTGATGCCTACCCAGCTGAGGTAGCTGCGACGGTTTACAACATCATGCAAAAATTAAAGTTTAAAAACCCTTATAGGTTGGTTTGGCAATCCCAAGTTGGACCAAAACCATGGTTGGGAGCGCAGACAGCTGAAATTGCGGAATTTTTAGGCCCCAAAGTTGATGGCCTAATGTTTATTCCTATCGCCTTTACCTCTGATCATATTGAAACATTGCATGAAATTGACTTAGGCGTCATTGGGGAATCGGAATATAAGGATAAATTTAAGAGATGCGAATCTTTAAATGGCAACCAGACCTTTATTGAAGGCATGGCAGATCTCGTCAAAAGCCACTTACAGAGTAACCAACTCTATTCTAATCAACTACCTCTTGATTTTGCACTTGGCAAGTCCAATGATCCTGTAAAGGACCTTTCATTGGTATTTGGCAATCACGAATCTACTTGA","protein_sequence":"MLSRTIRTQGSFLRRSQLTITRSFSVTFNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGPKVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFKRCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPLDFALGKSNDPVKDLSLVFGNHEST"},{"created_at":"2011-05-27T01:49:14.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Probable ferric reductase transmembrane component 8","uniprot_id":"Q12209","uniprot_name":"FRE8_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE8","num_residues":686,"molecular_weight":"78947.70313","theoretical_pi":"9.43","general_function":"Involved in iron ion binding","specific_function":"Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis","reactions":[{"id":2644,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein","altext":"2 Fe(2+) + NAD(+) = 2 Fe(3+) + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"36-56;90-110;129-149;158-178;187-207;217-237;268-288;403-423","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X94607","genbank_protein_id":"1181268","gene_card_id":"FRE8","chromosome_location":"chromosome 12","locus":"YLR047C","synonyms":["Ferric-chelate reductase 8"],"enzyme_classes":["1.16.1.7"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"}],"pathways":[],"gene_sequence":"ATGAATTTAAAGTCCATCGTTAGCTGGTTCAAGGAACATCTTCCCAGTTTTGATGTCGACGTGGACAAGCATTTTAGAACTTTAAGAGTCCGCAAATATTCTCAGATATGTCTTTTAATTTCTTTCATTATAATATGTGTTATTATACCCTTAATGAATTATTTGTTGCTAACTGACAAATTCTTCAAAATATGTCACCATTTAAAGCATCATGTTTTCAACAGAAGATCATGGGTTCACAAAACACATATGTATCACAAACAGTCACTACAACTATGTTTAATATGCTTTGTTTTCACCTCGTTTTTTGTTATACAAGGCGCTAACGGAGATCTGTTAGAAATTACTAAGCGAATGGGGAGAATTTCCGTTGCTTTGATGCCACCTTTACTATTTCTAACGTTGAGGCCATCACCGTTACCTCACACGTTATACTTAGCATTGTTACCTCTCCACAAATGGATTTCCAGAATTGTTGTGCTTGAATCTATTCTACACACGTGGTTCTATCTCTATTACATGTACATTAATGATACGTTATACGTGAAAATGAGAAAACTACCCAACATTTATGGGGTTATTGCCCTCGGCCTTTTCCTACTGATTGCCATCACCTCTGTGAGATATGCCAGACGATGGAGCTACAGAGTTTTTTACTATGTTCACTATGTAAGCACATGGCTTATTTTGGTGTTTCTACATTATCACGCTCGCCCAGGAATTTCATATTATACCACTTTAAATGTGCTCATATTAACGGGACAAATCGTCTATAGGCTCCATATCACCAATGTTACGAGAGTTACGATAGTACCCATTTCTTCATCATTGTCTCTTTTGGAGTTCCCATTAACCGATTTACCCAAAAAGCCCATCCTACCAGGAGGGCATCTAAGGATCAACATTTACCATAGAAATTTTTTAAGGAGGTTTTTCTCCCATTTGATACCCTTCCAACATCCTTTTACTATTGCTAGTATTCCAAGTGATAATTTGGTCAGGTTAATTATTAGAAACGGGCATTTTCCATTGCGTACAAATGAAAAGTATTACATTACAGGGGCTTTTGAACCTGAGTTGAGTTTCATTTCTAAACCTACTGTTCCTTTTAATATTACCACGAAATCTTCCAAGAATCCATTTCGAAACAATTCTTCTGCACTAATAAATTCGCCTTTAAATTTTCTAATTAAAGCGCAAAGAGTGTTTATGTGTGTTGGAGGTTCAGGAATTTCCTTTGGCTTACCACTACTTCGTATTCTAAACTTCAACGGTGTAAACGTTAGGCTCCTTTGGGTTTCTAGAGATTATAAGGATCTGGAAGTATTGAACCACTTCAAAAACAATTTTGAAGGTATGGAGATATATATTAGTGGCACCGAAGGCAACGAACAGGACATAGAAATTGATTATATTGACTATCATGACTGCGCTGCTGATATTAATGATGAAGTCAGGAGTATTTCTTCGAGCGGCCGAGTTTCAGAACTGGGAGATAATTCCATGTTATCAGATGGAAATCCCCAACCTACGGAGCCCAATGAGAACACAGCCCTTCTAAGTAAGAAATCTACCTTGAGAAACCATCACCCACCAAAAACAAGTGATATACCTGACATCAATGCTGATGACGAGATAGATTTTACATATGCTTTTAGCAGATCCAAATCAAGGAAAAATACTGCACAAGGAACTCTAACTACACATTCTTCGTTTAACGGATCGAGCGTTTTCAGACAACCAAAGATCATTGAGCCACCTGCCCAAGATCCTTGTTTAGAGGCGGCGCCTAAAAAGATCAGAATTCCCGCAGGTGTTAAAGTGTTCTTTGGCAGGCCTACACTTGGAGATAAGGATTATGAATGGTGTCTGCAAACCGAATGTGATGCAGAGACGGATTCTATTCAATGTTGCAGGTGGGCGAATCAAGGCAGAGACCATGCTGAATATTTGTCACAAGTATGGGTTCTCGCTGCAGGCCCTAGAGGCTTAATTGAAAGCACCAAAAGATGGGCGACAGATGGTGGTTTACACTTTCACGGAGAAAGTTTTGCATTATAA","protein_sequence":"MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDKFFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMGRISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTLYVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPGISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRINIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPELSFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRILNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAADINDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDINADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKIRIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAGPRGLIESTKRWATDGGLHFHGESFAL"},{"created_at":"2011-05-27T01:53:37.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Siroheme biosynthesis protein MET8","uniprot_id":"P15807","uniprot_name":"MET8_YEAST","enzyme":true,"transporter":false,"gene_name":"MET8","num_residues":274,"molecular_weight":"31917.40039","theoretical_pi":"6.26","general_function":"Involved in binding","specific_function":"Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin- 2 into sirohydrochlorin and its subsequent ferrochelation into siroheme","reactions":[{"id":1967,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1968,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2646,"direction":"\u003e","locations":null,"altext":"Precorrin-2 + NAD(+) = sirohydrochlorin + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2647,"direction":"\u003e","locations":null,"altext":"Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1KYQ","cellular_location":null,"genbank_gene_id":"X17271","genbank_protein_id":"3934","gene_card_id":"MET8","chromosome_location":"chromosome 2","locus":"YBR213W","synonyms":["Precorrin-2 dehydrogenase","Sirohydrochlorin ferrochelatase"],"enzyme_classes":["1.3.1.76","4.99.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"}],"pfams":[],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGGTCAAATCGCTACAGCTAGCCCATCAATTAAAAGACAAGAAAATACTACTAATCGGAGGCGGAGAAGTCGGCTTGACAAGGTTATATAAGCTGATACCTACAGGTTGCAAGCTGACTTTAGTATCTCCTGACCTACACAAATCCATTATTCCGAAGTTTGGAAAATTCATCCAGAACGAGGATCAGCCCGACTACAGAGAAGACGCTAAACGCTTTATCAATCCGAACTGGGACCCCACGAAGAATGAAATTTACGAGTACATCCGCAGTGACTTCAAAGACGAATACCTCGACCTAGAAGACGAGAACGACGCGTGGTACATAATAATGACCTGTATACCCGACCACCCTGAAAGCGCAAGAATATATCACCTTTGTAAGGAAAGATTCGGTAAGCAGCAGCTGGTCAATGTGGCGGACAAACCTGATCTCTGTGACTTTTATTTCGGCGCCAACCTGGAGATAGGAGACCGTCTACAGATTCTGATCTCTACCAACGGCCTTTCTCCGCGCTTTGGCGCTCTAGTAAGAGATGAGATCCGTAACTTATTCACACAAATGGGGGATCTGGCGCTGGAGGACGCTGTCGTCAAACTAGGTGAGCTGAGAAGAGGAATTAGGCTGCTGGCACCAGACGACAAGGATGTCAAGTACCGCATGGATTGGGCCAGACGCTGCACAGACCTCTTCGGCATTCAGCACTGCCACAACATCGACGTAAAACGTCTGCTGGATCTTTTCAAGGTCATGTTTCAAGAACAGAACTGTTCCTTGCAGTTCCCTCCCAGAGAACGGTTGCTTAGCGAGTACTGCTCGTCTTGA","protein_sequence":"MVKSLQLAHQLKDKKILLIGGGEVGLTRLYKLIPTGCKLTLVSPDLHKSIIPKFGKFIQNEDQPDYREDAKRFINPNWDPTKNEIYEYIRSDFKDEYLDLEDENDAWYIIMTCIPDHPESARIYHLCKERFGKQQLVNVADKPDLCDFYFGANLEIGDRLQILISTNGLSPRFGALVRDEIRNLFTQMGDLALEDAVVKLGELRRGIRLLAPDDKDVKYRMDWARRCTDLFGIQHCHNIDVKRLLDLFKVMFQEQNCSLQFPPRERLLSEYCSS"},{"created_at":"2011-05-27T03:24:30.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric/cupric reductase transmembrane component 1","uniprot_id":"P32791","uniprot_name":"FRE1_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE1","num_residues":686,"molecular_weight":"78853.0","theoretical_pi":"9.49","general_function":"Involved in oxidoreductase activity","specific_function":"Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-22","transmembrane_regions":"149-169;216-236;260-280;297-317;329-349;359-378;384-401","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"M86908","genbank_protein_id":"171521","gene_card_id":"FRE1","chromosome_location":"chromosome 12","locus":"YLR214W","synonyms":["Ferric-chelate reductase 1"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGGTTAGAACCCGTGTATTATTCTGCTTATTTATATCTTTTTTTGCTACGGTTCAATCGAGTGCTACACTTATTAGCACTTCATGTATTTCCCAAGCTGCGCTATACCAATTTGGATGTTCTAGTAAATCTAAAAGTTGCTACTGTAAAAACATCAATTGGCTGGGTTCAGTGACAGCATGTGCCTATGAGAATTCCAAATCTAACAAAACACTAGACAGCGCCTTAATGAAGTTAGCATCCCAATGTTCAAGCATCAAAGTTTATACTTTAGAGGACATGAAGAATATTTATTTAAATGCGTCAAATTATTTGAGAGCACCTGAGAAAAGTGATAAAAAAACCGTGGTTAGTCAACCGCTCATGGCGAACGAGACAGCGTATCATTATTATTATGAGGAAAATTATGGTATCCATCTTAACCTAATGCGCTCTCAATGGTGCGCTTGGGGTCTCGTCTTCTTCTGGGTGGCTGTGCTTACTGCAGCCACTATCTTGAACATTCTGAAAAGGGTGTTTGGTAAGAACATCATGGCAAACTCCGTCAAAAAATCACTTATTTATCCTTCTGTTTACAAAGATTATAATGAACGAACTTTTTATTTATGGAAGCGTCTACCATTTAATTTTACAACTCGAGGCAAGGGTCTCGTCGTATTAATTTTTGTTATTTTGACTATATTATCTCTCAGTTTTGGTCATAATATTAAACTTCCACACCCATATGATAGGCCCAGATGGAGAAGAAGTATGGCCTTTGTGAGTCGTAGAGCAGACTTGATGGCCATTGCACTTTTCCCAGTAGTCTATCTATTCGGAATAAGAAATAATCCCTTCATCCCTATAACAGGGCTTTCCTTTTCTACATTTAATTTCTATCATAAATGGTCTGCCTACGTTTGTTTCATGTTGGCCGTTGTACACTCAATTGTCATGACCGCCTCGGGAGTGAAAAGAGGTGTGTTTCAAAGTCTGGTTAGGAAATTTTACTTTAGGTGGGGTATAGTGGCAACGATATTAATGTCTATTATTATTTTCCAAAGTGAAAAAGTATTTAGAAATAGAGGGTATGAGATATTCCTTCTTATTCATAAAGCGATGAATATTATGTTCATTATTGCCATGTACTACCATTGTCACACCCTGGGCTGGATGGGTTGGATTTGGTCAATGGCTGGTATTTTATGCTTTGATAGATTCTGCAGGATTGTTAGAATAATCATGAATGGTGGCTTGAAAACTGCTACTTTGAGTACCACTGATGATTCTAATGTTATTAAAATTTCAGTAAAAAAACCAAAGTTTTTCAAGTACCAAGTAGGAGCTTTCGCATACATGTATTTCTTATCACCAAAAAGTGCATGGTTCTATAGTTTCCAATCACATCCATTTACAGTATTATCGGAACGACACCGTGATCCAAACAATCCAGATCAATTGACGATGTACGTAAAGGCAAATAAAGGTATCACTCGAGTTTTGTTATCGAAAGTTCTAAGTGCTCCAAATCATACTGTTGATTGTAAAATATTCCTTGAAGGCCCATATGGTGTAACGGTTCCACATATCGCTAAGCTAAAAAGAAATCTGGTAGGTGTAGCCGCTGGTTTGGGTGTTGCGGCTATTTATCCGCACTTTGTCGAATGTTTACGGTTACCATCTACTGATCAACTTCAGCATAAATTTTACTGGATTGTTAATGACCTATCCCATTTGAAATGGTTTGAAAATGAATTGCAATGGTTAAAGGAGAAAAGTTGTGAAGTCTCAGTCATATATACTGGTTCCAGTGTTGAGGACACAAATTCAGATGAGAGTACAAAAGGTTTTGATGATAAAGAAGAAAGCGAAATCACTGTTGAATGTCTCAATAAAAGACCTGATTTGAAAGAACTAGTGCGCTCGGAAATAAAACTCTCAGAACTAGAGAATAATAATATTACCTTTTATTCCTGCGGGCCAGCAACGTTTAACGACGATTTTAGAAATGCAGTGGTCCAAGGTATAGACTCTTCCTTGAAGATTGACGTTGAACTAGAAGAAGAAAGTTTTACATGGTAA","protein_sequence":"MVRTRVLFCLFISFFATVQSSATLISTSCISQAALYQFGCSSKSKSCYCKNINWLGSVTACAYENSKSNKTLDSALMKLASQCSSIKVYTLEDMKNIYLNASNYLRAPEKSDKKTVVSQPLMANETAYHYYYEENYGIHLNLMRSQWCAWGLVFFWVAVLTAATILNILKRVFGKNIMANSVKKSLIYPSVYKDYNERTFYLWKRLPFNFTTRGKGLVVLIFVILTILSLSFGHNIKLPHPYDRPRWRRSMAFVSRRADLMAIALFPVVYLFGIRNNPFIPITGLSFSTFNFYHKWSAYVCFMLAVVHSIVMTASGVKRGVFQSLVRKFYFRWGIVATILMSIIIFQSEKVFRNRGYEIFLLIHKAMNIMFIIAMYYHCHTLGWMGWIWSMAGILCFDRFCRIVRIIMNGGLKTATLSTTDDSNVIKISVKKPKFFKYQVGAFAYMYFLSPKSAWFYSFQSHPFTVLSERHRDPNNPDQLTMYVKANKGITRVLLSKVLSAPNHTVDCKIFLEGPYGVTVPHIAKLKRNLVGVAAGLGVAAIYPHFVECLRLPSTDQLQHKFYWIVNDLSHLKWFENELQWLKEKSCEVSVIYTGSSVEDTNSDESTKGFDDKEESEITVECLNKRPDLKELVRSEIKLSELENNNITFYSCGPATFNDDFRNAVVQGIDSSLKIDVELEEESFTW"},{"created_at":"2011-05-27T03:25:21.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric reductase transmembrane component 4","uniprot_id":"P53746","uniprot_name":"FRE4_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE4","num_residues":719,"molecular_weight":"82014.60156","theoretical_pi":"9.48","general_function":"Involved in oxidoreductase activity","specific_function":"Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-18","transmembrane_regions":"157-177;229-249;268-288;305-325;347-367;374-394;396-416","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"Z71675","genbank_protein_id":"1302584","gene_card_id":"FRE4","chromosome_location":"chromosome 14","locus":"YNR060W","synonyms":["Ferric-chelate reductase 4"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGTTGTTGGTACATATTATATCTTTCCTTCTGTTCTTCCAGCTTTCGGCCGCAAAGGCCCCACCCAGTAAAACGTCTCTAATAAATACTCATGAGAGAAGGTCGATATATTCATGCTACGTTGGTTTACGTAAAGAAACATGGGGGTTCAATGGGTCCGCTATATGTCGGTATGAACCAGCAATCCAATCGATGCTTTACTGTCTTTACGAAGACACGCATGAGAAAGGGTATTCAAATAAAACTTTGGAGAAAGGTTTTGAAGAAATGAGACAATTTTGCTATACACCAAAGTTTTTGAACATGACTGATGCCGAGTTTTACACCTCATTGGATAATGGAACATACTATATACAAGATCAACCTAAAGCTGGCATCAATATCACTTATCCTATCAGACTGAACACTACACTAAGAAAAGCATACTATGATGCATACTATGGTTACTACTATAACCATGACATTCCGTATTATTTCGGGGGCATTATCTGTGCATACTTTGTGGGTGTCATGTTGCTTGCAGGTTTAATTCGTTTTTTGAATTATACCCCAATAAAAAAGATTATGTTTCAGCAAAAGCTAGTCAATTACGTGAGAGGTTATACTACTCTACCCACTCTTTATGAAAAGCATGCAGAGCCCTTCTCGTACTTAAAAGTGATAACAGGCTATCTTCCTACTAGGTTTGAAACGTTGGTTATTTTAGGCTACCTCATACTTCATACCATTTTCATGGCCTACAAATATCAATATGATCCATACCACATCATATTTGCCGCTCATAGAGCAGAAGTGGCACATTTTGTTGCGTACAGAAGCGGTATACTTTCTTTTGCACACCTGCCACTCATTGTTTTATTTGCGGGAAGAAATAACTTTCTCCAACTTATTTCTGGCTTGAAGCATACCTCATTCATTGTGTTCCATAAGTGGCTGGGAAGAATGATGTTTCTTGATGCAATAATTCATGCTGCCGGCTTTACGAACTATTATTTGTATTATAAAAAATGGAATACGGTTAGATTAAGAGTCTACTGGAAATTCGGTATTGCTACCACCTGTTTAGCGGGAATGTTAATTTTCTTTTCCATCGCAGCATTTAGAAGACACTACTATGAAACGTTTATGGCCCTCCATATAGTATTCGCAGCACTATTTCTCTATACTTGTTGGGAGCATGTTACTAACTTCAGCGGTATCGAATGGATTTACGCGGCAATAGCAATTTGGGGAGTTGATAGAATTGTACGTATCACCAGAATTGCACTCTTAGGATTTCCTAAAGCAGATCTACAACTGGTTGGATCTGATTTGGTCCGTGTAACGGTTAAAAAACCAAAGAAGTTTTGGAAGGCAAAACCAGGCCAATACGTTTTCGTTTCCTTCTTGCGTCCATTGTGCTTCTGGCAGTCGCATCCATTTACAGTGATGGATTCTTGCGTAAACGATAGAGAATTGGTCATCGTTCTGAAAGCAAAGAAAGGTGTGACAAAACTGGTAAGAAACTTTGTTGAACGTAAAGGCGGCAAGGCATCCATGAGATTAGCTATCGAAGGCCCTTATGGCTCCAAGTCCACCGCCCATCGCTTTGATAATGTATTATTGTTGGCAGGTGGCTCAGGGCTTCCCGGTCCAATTTCTCATGCCCTTGAATTAGGAAAGACAACAGCTGCAAGCGGTAAAAACTTTGTACAGTTAGTCATAGCAGTAAGAGGACTAGACATGCTCAACGCGTGTAAGAAAGAACTAATGGCATTAAAGGGCTTGAATGTTCAAGTTCACATTTATAATTCTAAGCAAGAGCTAGCTTCGGCTGAAAAAATTTCCTCAAATGAAGTCAAAAACGGTGAAACGACAGCAGAGAAGGCCCCATCTAGTCTAAGCAATTCAGAAAAAGCTCCTTCTGAAAGTGAAAATACAGAACTACCTCTTTCCCTGAATGACACGTCTATCTCCGATTTAGAATTTGCCACTTTCCATGTTGGAAGGCCAAATGTTGAAGAAATACTAAATGAATCTGTTAACCATTCTGGTTCACTTGCCGTCGTATGTTGCGGACCACCTATTTTCGTCGACACCGCTAGAAATCAAACTGCCAAAGCTGTTATCAGAAACCCATCAAGAATGATTGAATACTTGGAGGAATACCAAGCCTGGTGA","protein_sequence":"MLLVHIISFLLFFQLSAAKAPPSKTSLINTHERRSIYSCYVGLRKETWGFNGSAICRYEPAIQSMLYCLYEDTHEKGYSNKTLEKGFEEMRQFCYTPKFLNMTDAEFYTSLDNGTYYIQDQPKAGINITYPIRLNTTLRKAYYDAYYGYYYNHDIPYYFGGIICAYFVGVMLLAGLIRFLNYTPIKKIMFQQKLVNYVRGYTTLPTLYEKHAEPFSYLKVITGYLPTRFETLVILGYLILHTIFMAYKYQYDPYHIIFAAHRAEVAHFVAYRSGILSFAHLPLIVLFAGRNNFLQLISGLKHTSFIVFHKWLGRMMFLDAIIHAAGFTNYYLYYKKWNTVRLRVYWKFGIATTCLAGMLIFFSIAAFRRHYYETFMALHIVFAALFLYTCWEHVTNFSGIEWIYAAIAIWGVDRIVRITRIALLGFPKADLQLVGSDLVRVTVKKPKKFWKAKPGQYVFVSFLRPLCFWQSHPFTVMDSCVNDRELVIVLKAKKGVTKLVRNFVERKGGKASMRLAIEGPYGSKSTAHRFDNVLLLAGGSGLPGPISHALELGKTTAASGKNFVQLVIAVRGLDMLNACKKELMALKGLNVQVHIYNSKQELASAEKISSNEVKNGETTAEKAPSSLSNSEKAPSESENTELPLSLNDTSISDLEFATFHVGRPNVEEILNESVNHSGSLAVVCCGPPIFVDTARNQTAKAVIRNPSRMIEYLEEYQAW"},{"created_at":"2011-05-27T03:26:09.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric reductase transmembrane component 3","uniprot_id":"Q08905","uniprot_name":"FRE3_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE3","num_residues":711,"molecular_weight":"80588.5","theoretical_pi":"7.1","general_function":"Involved in oxidoreductase activity","specific_function":"Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-20","transmembrane_regions":"167-187;238-258;281-301;322-341;354-374;377-397;399-419","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z75289","genbank_protein_id":"1420821","gene_card_id":"FRE3","chromosome_location":"chromosome 15","locus":"YOR381W","synonyms":["Ferric-chelate reductase 3"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGTATTGGGTCCTCCTTTGTGGTTCTATTTTGTTATGCTGCTTGTCAGGAGCAAGCGCCTCCCCTGCTAAGACAAAAATGTACGGCAAGTTACCACTGGTTTTGACAGATGCCTGCATGGGAGTTCTCGGCGAAGTAACCTGGGAGTATAGTAGTGACGATTTATATTCCTCACCAGCATGTACATATGAACCGGCATTACAGTCAATGTTGTATTGTATTTACGAATCATTGAATGAAAAGGGTTATTCCAATAGAACCTTTGAAAAAACCTTTGCTGCTATCAAAGAAGACTGCGCATATTACACTGATAACCTTCAGAATATGACTAATGCAGATTTCTATAATATGCTGAATAATGGAACAACATACATAATACAGTATTCTGAAGGTAGCGCGAATCTTACGTATCCAATCGAGATGGATGCCCAAGTGAGAGAAAACTATTATTATTCTTACCATGGTTTCTACGCCAACTACGACATTGGTCATACTTATGGTGGTATTATTTGCGCCTATTTTGTAGGTGTTATGATTCTTGCCAGCATACTCCATTATCTAAGTTACACTCCGTTTAAAACTGCCTTATTTAAACAAAGACTTGTAAGATATGTGAGAAGATATTTGACAATACCTACTATCTGGGGTAAACATGCGTCGAGCTTTTCTTACCTTAAAATTTTTACAGGCTTCCTTCCCACACGATCTGAAGGCGTCATTATACTTGGATACCTCGTGCTTCATACAGTTTTTCTGGCATACGGGTATCAATATGATCCTTACAACTTAATTTTCGACTCTCGTAGAGAACAGATTGCTCGATACGTGGCAGATAGAAGTGGTGTCCTGGCATTTGCACATTTTCCCCTAATAGCTCTTTTCGCAGGAAGGAACAATTTTCTAGAATTCATTTCTGGAGTAAAATATACCTCTTTCATAATGTTTCATAAGTGGTTGGGAAGAATGATGTTTTTAGATGCTGTGATTCATGGCGCTGCTTATACCAGTTATTCCGTATTCTACAAAGATTGGGCAGCAAGCAAGGAAGAGACATATTGGCAATTTGGAGTAGCTGCTCTTTGTATAGTTGGTGTTATGGTGTTTTTTTCTTTGGCAATGTTCAGAAAGTTTTTCTATGAAGCCTTCTTATTTCTCCATATTGTGCTTGGCGCATTGTTCTTTTATACGTGTTGGGAGCACGTCGTAGAATTGAGTGGGATTGAGTGGATATACGCTGCTATTGCTATCTGGACTATTGATAGGCTAATTCGAATTGTTAGAGTATCTTATTTCGGTTTCCCTAAGGCTTCCTTACAGTTAGTTGGCGATGACATCATTCGAGTCACAGTCAAACGACCAGTAAGGCTATGGAAAGCCAAACCAGGACAGTATGTTTTCGTTTCATTCCTACACCACCTGTATTTTTGGCAGTCACATCCTTTCACAGTCTTAGATTCAATTATCAAAGATGGTGAGCTGACTATTATCCTGAAGGAAAAAAAGGGAGTAACAAAACTTGTCAAAAAGTATGTGTGTTGCAATGGAGGTAAGGCATCTATGAGACTAGCTATAGAAGGTCCATATGGCTCTTCATCTCCAGTCAATAATTATGATAACGTCTTGCTACTTACGGGAGGTACTGGTTTGCCAGGGCCCATTGCACACGCCATTAAACTTGGAAAAACGTCAGCGGCAACTGGAAAACAATTCATAAAATTAGTGATTGCAGTTAGAGGGTTTAACGTACTCGAGGCTTACAAGCCGGAGCTGATGTGTCTAGAAGATCTTAATGTACAGCTTCACATCTACAATACAATGGAAGTTCCGGCATTAACTCCTAATGATAGTTTGGAAATTTCTCAACAAGACGAGAAGGCCGATGGAAAAGGTGTTGTTATGGCAACTACCCTAGAACAGTCACCTAATCCAGTTGAATTTGATGGTACTGTTTTTCATCATGGAAGACCCAATGTTGAAAAGCTTCTGCATGAAGTTGGTGACCTAAATGGATCGTTAGCTGTGGTTTGTTGTGGGCCTCCTGTTTTCGTTGACGAAGTAAGGGATCAAACGGCAAATCTTGTTCTAGAGAAGCCTGCAAAGGCAATCGAATACTTTGAAGAATACCAAAGTTGGTAA","protein_sequence":"MYWVLLCGSILLCCLSGASASPAKTKMYGKLPLVLTDACMGVLGEVTWEYSSDDLYSSPACTYEPALQSMLYCIYESLNEKGYSNRTFEKTFAAIKEDCAYYTDNLQNMTNADFYNMLNNGTTYIIQYSEGSANLTYPIEMDAQVRENYYYSYHGFYANYDIGHTYGGIICAYFVGVMILASILHYLSYTPFKTALFKQRLVRYVRRYLTIPTIWGKHASSFSYLKIFTGFLPTRSEGVIILGYLVLHTVFLAYGYQYDPYNLIFDSRREQIARYVADRSGVLAFAHFPLIALFAGRNNFLEFISGVKYTSFIMFHKWLGRMMFLDAVIHGAAYTSYSVFYKDWAASKEETYWQFGVAALCIVGVMVFFSLAMFRKFFYEAFLFLHIVLGALFFYTCWEHVVELSGIEWIYAAIAIWTIDRLIRIVRVSYFGFPKASLQLVGDDIIRVTVKRPVRLWKAKPGQYVFVSFLHHLYFWQSHPFTVLDSIIKDGELTIILKEKKGVTKLVKKYVCCNGGKASMRLAIEGPYGSSSPVNNYDNVLLLTGGTGLPGPIAHAIKLGKTSAATGKQFIKLVIAVRGFNVLEAYKPELMCLEDLNVQLHIYNTMEVPALTPNDSLEISQQDEKADGKGVVMATTLEQSPNPVEFDGTVFHHGRPNVEKLLHEVGDLNGSLAVVCCGPPVFVDEVRDQTANLVLEKPAKAIEYFEEYQSW"},{"created_at":"2011-05-27T03:26:33.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Frataxin homolog, mitochondrial","uniprot_id":"Q07540","uniprot_name":"FRDA_YEAST","enzyme":true,"transporter":false,"gene_name":"YFH1","num_residues":174,"molecular_weight":"19490.0","theoretical_pi":"5.63","general_function":"Involved in ferroxidase activity","specific_function":"Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain","reactions":[{"id":2724,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY558160","genbank_protein_id":"45270210","gene_card_id":"YFH1","chromosome_location":"chromosome 4","locus":"YDL120W","synonyms":["Frataxin homolog intermediate form"],"enzyme_classes":["1.16.3.1"],"go_classes":[],"pfams":[{"name":"Frataxin_Cyay","identifier":"PF01491"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGATTAAGCGGTCTCTCGCAAGTTTAGTTCGAGTCAGCTCTGTAATGGGCAGAAGATATATGATAGCAGCGGCAGGAGGAGAACGTGCCAGATTTTGTCCAGCTGTAACAAATAAAAAGAATCATACTGTAAATACTTTTCAGAAGAGATTTGTAGAATCCTCGACAGATGGTCAAGTTGTGCCTCAAGAAGTGTTAAACTTACCGCTTGAAAAATACCATGAAGAGGCAGATGACTACCTAGACCATTTACTAGATAGCTTAGAAGAACTGAGTGAGGCTCATCCGGATTGTATACCTGATGTAGAGCTAAGCCATGGCGTAATGACATTGGAAATTCCAGCTTTTGGAACGTATGTAATAAACAAACAGCCTCCAAATAAGCAAATTTGGTTGGCATCACCATTGTCCGGGCCTAACAGATTTGACCTTCTCAATGGGGAGTGGGTTTCGTTAAGAAATGGCACAAAGCTAACAGATATACTTACTGAAGAAGTTGAGAAGGCCATTTCTAAAAGCCAATAA","protein_sequence":"MIKRSLASLVRVSSVMGRRYMIAAAGGERARFCPAVTNKKNHTVNTFQKRFVESSTDGQVVPQEVLNLPLEKYHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPAFGTYVINKQPPNKQIWLASPLSGPNRFDLLNGEWVSLRNGTKLTDILTEEVEKAISKSQ"},{"created_at":"2011-05-27T03:27:25.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric reductase transmembrane component 5","uniprot_id":"Q08908","uniprot_name":"FRE5_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE5","num_residues":694,"molecular_weight":"80291.70313","theoretical_pi":"8.84","general_function":"Involved in oxidoreductase activity","specific_function":"Cell surface metalloreductase","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-19","transmembrane_regions":"164-184;223-243;268-288;312-334;348-368;372-392;404-424","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"AY692958","genbank_protein_id":"51013367","gene_card_id":"FRE5","chromosome_location":"chromosome 15","locus":"YOR384W","synonyms":["Ferric-chelate reductase 5"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGCTTTTCGCTAGATTAGTGCTGCTGTTGGTGTATTTGGCACCAGGTTCTTTAGCAAAACCAGCATCAACTAAGAAAAGAACGCAATGGGACCAGATAGCAATTGATGCTTGTGCTAAAGAATTGGAATCACACAAATTTGACACGGATGTGAAGGGTCGGCACGCTACTCTTTGCACTTATGAACCAGCACTAGGGTCTTGGTTACATTGCGCGAAGGATGTTCTCGACAGTAGGAAGAAAAGTAAAAAAATATTCGAAAAAACGTTTAGCAAAATTAATCAGTATTGCCACGATTATCACAAAGATGAGGTCGTCAGCAATGAGGAGTATTATCGAATTTTTGCCAATGCATCCCTTTTCATCCGGCCTCTTGATGAGGTAAAGGAAAACATACGATATCCCGTCACTCCCAATAAAGCCTCTCTAGATAGGTGGGTATGGGCTTATTTTGGGCCCCTGGATAATATAGACAAAGGAAATGTTTATGGAGTGACGATTTGCTTATACTGGATAGGAGTTCTGTTTATTGCAGCTGTATATCACTTCTTGAACTTTTCTCGACTTAAACAAACGGTGTTCAAAAACAAGGTGTCTGCTTTCTTAAGAGGCCACTATGTTCTTCCAGCGCTTGTTCATAACCATGCTATGTCAGTGGGAAGGTGGTTTTTCATCGGTCTGGTCCCTACCAGGTTAGAGACCCTTGTCCTATTCGGTTACGTTTTGTTGCACGGGTTCTTGTTGAGTAGTTACAATTTTGACCATAATGAGTTGCTCAGTGATCGCAGAAGCCAAGTGCTTATCTTCCTTTCCGACAGGGCAGGGATCCTGGCATTCGCACATTTTCCTTTGATAGTTCTCTTTGGCGGTAAAAACAGCACAATGACTTGGCTCACAGGTATAAGATATACCGCATTCATTACTTACCACAAATGGTTAGGAAGATTCATGTTAGTAGACTGTACGATCCATGCAATAGGATACACCTACCATGCATACATAGAAAATTACTGGAAATACGTGAAGTATAGTGATCTATGGACATCCGGAAGACATGCCATGATCATTGTTGGAATACTTGTGTTTTTTTCGTTCTTCTTCTTTAGACGACATTATTACGAATTGTTTGTTATTACGCACATTATCTTAGCAATAGGATTTTTCCATGCGTGCTGGAAACATTGCTATAAACTTGGATGGGGTGAATGGATAATGGCGTGTGCACTGTTTTGGATTGCTGACCGTATTCTGCGGCTAATAAAGATTGCAATTTTTGGAATGCCATGGGCTAAATTGAAACTGTGTGGCGAGTCCATGATAGAAGTGAGAATCTCAAAAAGCTCCAAATGGTGGAAAGCAGAACCTGGCCAATATATATATCTGTACTTCTTAAGACCAAAAATATTCTGGCAATCACATCCATTCACGGTCATGGATTCTTTGGTTGAGGATGGTGAGTTGGTAGTTGTGATAACAGTGAAAAATGGGCTAACCAAAAAATTACAGGAATACCTTTTAGAGAGCGAAGGGTACACGGAAATGCGAGTACTAGCAGAAGGACCTTATGGACAAAGCACGCGAACACATTTGTTCGAAAGCCTCCTGTTTATTGCCGGAGGGGCGGGTGTTCCTGGACCTCTGTCGATGGCAATAAAGGCAGGTCGCCAGGTCAAAAGCAACGATTCTCATCAAATGATCAAATTTGTGTGGAGTGTACGTAACCTTGATCTCTTAGAAGTGTATCGCAAAGAGATAATGGTGCTAAAAGAGTTGAACATAGACACAAAAATTTACTTCACAGGAGAGCGAAAAGATGAATCGAACACGGAGGAGGGAGCAATTGCTAATATGAGCACGGAAGGCAGACTGCTGACGACATCGAAATCAGCGGAAATGATTACTGATTTTGGACGACCAAATATCGATGAGATAATTGAAGAAGCAGTAAGTGGTGCAAAATCTTTGTTGGTCACTTGTTGCGGGTCAGAGGGCTTTGTAGACAAGACACGAGAGTTGACGGCAAAAAGAGTTCTTGAACACGGTGACAAATGGATAGAATACGTGGAGGAATTCCAGAATTGGTAG","protein_sequence":"MLFARLVLLLVYLAPGSLAKPASTKKRTQWDQIAIDACAKELESHKFDTDVKGRHATLCTYEPALGSWLHCAKDVLDSRKKSKKIFEKTFSKINQYCHDYHKDEVVSNEEYYRIFANASLFIRPLDEVKENIRYPVTPNKASLDRWVWAYFGPLDNIDKGNVYGVTICLYWIGVLFIAAVYHFLNFSRLKQTVFKNKVSAFLRGHYVLPALVHNHAMSVGRWFFIGLVPTRLETLVLFGYVLLHGFLLSSYNFDHNELLSDRRSQVLIFLSDRAGILAFAHFPLIVLFGGKNSTMTWLTGIRYTAFITYHKWLGRFMLVDCTIHAIGYTYHAYIENYWKYVKYSDLWTSGRHAMIIVGILVFFSFFFFRRHYYELFVITHIILAIGFFHACWKHCYKLGWGEWIMACALFWIADRILRLIKIAIFGMPWAKLKLCGESMIEVRISKSSKWWKAEPGQYIYLYFLRPKIFWQSHPFTVMDSLVEDGELVVVITVKNGLTKKLQEYLLESEGYTEMRVLAEGPYGQSTRTHLFESLLFIAGGAGVPGPLSMAIKAGRQVKSNDSHQMIKFVWSVRNLDLLEVYRKEIMVLKELNIDTKIYFTGERKDESNTEEGAIANMSTEGRLLTTSKSAEMITDFGRPNIDEIIEEAVSGAKSLLVTCCGSEGFVDKTRELTAKRVLEHGDKWIEYVEEFQNW"},{"created_at":"2011-05-27T03:28:16.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric reductase transmembrane component 6","uniprot_id":"Q12473","uniprot_name":"FRE6_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE6","num_residues":712,"molecular_weight":"81988.29688","theoretical_pi":"9.13","general_function":"Involved in oxidoreductase activity","specific_function":"Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-17","transmembrane_regions":"168-188;245-265;288-308;329-349;361-381;388-408;417-437","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z47973","genbank_protein_id":"642333","gene_card_id":"FRE6","chromosome_location":"chromosome 12","locus":"YLL051C","synonyms":["Ferric-chelate reductase 6"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGCATAGAACGCTTCTGTTTTTAACGTGGCTGATATCTTTAACAAAGGCTTTTAATATAAAATTACCACACACTGAAAAAAAAGACCATTTGGAATCCAACGCTGTGCTGGCATGCGCATCCTATATAAATACTCTGAAGTGGTCATTTGATAGCTCCGTCGTACCGGGTTTCTATTCTACCATATGCTCTTATTCACCAGCGTTTGATACTTGGTCACTTTGTATCTTCAATTCGCTTACAGACCAGATTATTCCCATGGACAACACAAGTTTCGAAGAAAGCTTGGGTAACGTACGAAAAACGTGCTCGTTTGTCGATAAAAAGTTTAGCAATATTTCACTGGAGCAATACTACTCATCTTTAAATAATGCTTCTTCTCACGCTTTGGAAGACTATGGTTCTATTGAAAGTTTATCGACATCCATTCGAGTCGATCGTGAGACAAGATCTAGATGGATACGAGCTTTTCATGCGCATGCCTATAATTTAGATATCAGCAGTGTTTATGGTGCATATTTAACTTACTACTTCGTCATAGTGGGTATTATCGCCGTCTTCTTCCATATGAGTCACTATAACGGCCTGAATCGAGCGCTATTTGCAAGCCGGTTCGTCAATTATATTCGGGGCCATTTTGTGTTGCCTACGTTTTTAGTAGATAAGCACGCTAATCACTTCAAGTTTCTAAACGTGGAAGTCTTTACGGGACTGATGCCGAATTCCTTGGAGGCATGGATCATTTTTGGATACACATTGGCGAACATCATATTTTTGTCCATAAGTTACATCATAGACCCATATAACCTCATTTTCAACAGTCACCTGTCGCAGTTTACAAGACTGTTGGCTGATAGATCTGGGATACTGGCGTTTACTCAGTTCCCTCTCATTATCATTTTTACGGCAAGGAATAGTTTTCTCGAATTTTTAACAGGAGTCAAGTTCAATTCCTTTATTAGTTTCCATAAATGGATCGGTAGAATCATGGTCTTAAACGCAACGATACATTCGCTTTCTTATTCATTATTCGCAATTATCAACCATGCCTTCAAAATAAGCAACAAACAGCTCTATTGGAAGTTTGGTATTGCATCCATAACAGTGCTTTGCGTTCTACTAGTTCTATCGCTCGGAATAGTAAGGAAAAGACATTACGAATTTTTCCTGTACACCCACATCATACTAGCCCTTTTGTTCTTTTACTGTTGTTGGCAACACGTCAAAATTTTCAACGGTTGGAAAGAATGGATAGTGGTATCCTTGCTCATTTGGGGGCTGGAAAAGCTTTTCAGAATATGGAACATTTTGCAGTTTAGATTTCCGAAAGCAACACTAATCAATTTGAACACCAGCAACAACCCGCACGATGAAATGTTTAAAGTAATCATACCCAAATATAACCGGAGATGGCATTCGAAACCGGGTCAATATTGTTTCATTTATTTTTTACATCCATTGGTATTTTGGCAATGCCATCCATTTACCATTATCGACGAAGGTGAGAAGTGTGTTTTAGTGATCAAACCTAAAAGTGGTCTCACTAGATTCATTTATAACCATATTTTGCAATCTTTAAATGGTAAATTACAACTCCGAGTGGCCATTGAGGGACCTTATGGGCCCAGTAATCTTCACCTCGATAAATTCGACCATTTGCTGTTACTAAGTGGAGGAACAGGCTTGCCTGGTCCATTAGATCATGCCATTAAGCTGTCACGAAACCCTGATAAACCCAAGAGTATAGATTTGATCATGGCGATCAAAAATCCTTCTTTTCTTAACGGCTATAAATCCGAGATACTAGAGCTAAAAAATAGCCGATCCCACGTCAACGTGCAGGTTTACCTTACACAGAAAACAGCTGTTACAAAGGCAGCAAACGCACGAGACCAATTAATACATTTTGATGATATAATGACCGAACTGACAAGCTTCGCCCACATCGGCAATGCAAGACCTAATTTTAGCAATGTAATTGAAAACGCAATAAAAAGTACGCCGCCTGGAGATTCATTAGCGGTCGTGTGCTGCGGCCCTCCTGTTCTGGTGGACGATGTTAGAAACACCGTTTCTCAAAAACTCCTCGGTTACCCAGAGAGAATTATAGAGTATTTCGAGGAATATCAGTGTTGGTAA","protein_sequence":"MHRTLLFLTWLISLTKAFNIKLPHTEKKDHLESNAVLACASYINTLKWSFDSSVVPGFYSTICSYSPAFDTWSLCIFNSLTDQIIPMDNTSFEESLGNVRKTCSFVDKKFSNISLEQYYSSLNNASSHALEDYGSIESLSTSIRVDRETRSRWIRAFHAHAYNLDISSVYGAYLTYYFVIVGIIAVFFHMSHYNGLNRALFASRFVNYIRGHFVLPTFLVDKHANHFKFLNVEVFTGLMPNSLEAWIIFGYTLANIIFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFISFHKWIGRIMVLNATIHSLSYSLFAIINHAFKISNKQLYWKFGIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLIWGLEKLFRIWNILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHSKPGQYCFIYFLHPLVFWQCHPFTIIDEGEKCVLVIKPKSGLTRFIYNHILQSLNGKLQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLIMAIKNPSFLNGYKSEILELKNSRSHVNVQVYLTQKTAVTKAANARDQLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLVDDVRNTVSQKLLGYPERIIEYFEEYQCW"},{"created_at":"2011-05-27T03:29:08.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Ferric/cupric reductase transmembrane component 2","uniprot_id":"P36033","uniprot_name":"FRE2_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE2","num_residues":711,"molecular_weight":"80071.5","theoretical_pi":"9.39","general_function":"Involved in oxidoreductase activity","specific_function":"Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-23","transmembrane_regions":"165-185;236-256;281-301;318-340;354-374;378-398;401-423","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"X75950","genbank_protein_id":"473129","gene_card_id":"FRE2","chromosome_location":"chromosome 11","locus":"YKL220C","synonyms":["Ferric-chelate reductase 2"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGCATTGGACGTCCATCTTGAGCGCTATTTTGCTTTTCTGCCTGTCAGGAGCAAGAGCATCACCTGCAAAGACAGTTATTCGTAACAAGGTGCCCTTGCTTGTCACTAATGCCTGCACGAGGATTTTTCAAAAAGTTACTTGGGAGTATACCAGCAAGTCTAAGCGTTCATCACCAGTATGTTCTTACGAACCAGCGTTTCAATCAATGCTGTATTGTATCTATGAAACGTTGGATGAAAAAGGTTATTCGAATAAAACCTTAGAAAAAACATTTAGTACCATCAAAAAAAACTGTGCAAGTTATAGTGATGCTCTTCAGAACATGACTAATTCTGAGTTTTATGACGTTCTAAACAACGGAACGAGGCATATGACGCCCTATGTCAAAGGCAGTGCAAACCTAACATATCCAGTTGAAATGGATACACAGTTAAGAAAAGCCTACTATCATGCATTGCATGGTTTCTATGCTAACTTAGATGTCGGAAACATATATGGTGGCATTATATGTGCTTATTTTGTCGCTATCATGGCTTTTGCAGGCGTTCTTCATTGCATGAATTACACTCCCTTTAAAACTGTTCTATTGAAGCAAAAGCTTGTGGGATATGTAAGGGGATACCTCACTCTACCTACCATTGGAAGCAAACATGCGTCAGATTTCTCTTATTTTAGAATATTCACAGGATATTTACCTACAAGATTAGAGGGTATCATTATTCTTGGATATCTCGTGCTTCATACCGTTTTTTTGGCATACGGTTATGAATACGATCCTGAAAATATAATATTCAAGTCTCGTAGAGTTCAAGTTGCTCGATATGTGGCAGACAGAAGTGGTGTACTCGCATTCGCACACTTTCCATTAATAGTTCTTTTCGCGGGAAGAAACAACTTTCTCGAGTATATTTCTGGGGTTAAATATACTTCCTTCATTATGTTTCACAAATGGTTGGGAAGAATGATGTTTTTGGATGCTATGATTCATGGCTCTGCATATACTAGTTATACGGTAGCGAATAAAACTTGGGCAACAAGTAAAAACCGATTATATTGGCAATTCGGGGTGGCAGCACTTTGTTTAGCTGGCACAATGGTTTTCTTTTCCTTTGCAGTATTCAGGAAGTATTTTTATGAAGCCTTTCTTTTTCTTCATATCGTCCTTGGTGCAATGTTCTTTTATGCATGTTGGGAGCATGTTGTTAGTTTAAGTGGCATTGAGTGGATATACACTGCTATTGCGATTTGGATCGTTGACCGGATTATTAGAATTATCAAAGCTTCTTATTTTGGTTTCCCCAAAGCTTCCCTACAACTAATCGGGGATGATCTCATTCGTTTAACAGTTAAAAAACCGGCAAGGCCATGGAGGGCCAAACCTGGGCAATATGTTTTCGTTTCGTTTTTACATCCACTGTACTTCTGGCAGTCACATCCATTTACTGTTTTGGATTCAGTAAGCAAGAATGGTGAACTGGTTATTATCCTGAAAGAAAAAAAGGGAGTAACAAGACTTGTCAAAAAGTATGTGTGTCGCAATGGAGGTAAGACATCTATGAGACTAGCTATAGAAGGTCCATATGGTTCTTCATCTCCGGTCAATAATTACAATAATGTATTGTTACTCACTGGAGGTACCGGTTTGCCTGGACCTATTGCACATGCAATTAAACTTGGAAAGACGTCAGCGGCTGCTGGAAAACAATCTGTAAAATTAGTGATTGCAGTTAGAGGATTCGACGTACTCGAGGCTTATAAGCCGGAGTTGATGTGTTTAGAAAATCTGAATGTACAGCTTCACATCTACAACACAATGGAAGTCCCATCATTAACCCCTAGTGATAGTTTAGATATTTCTCAACAGGATGAGAAGGCTGATGAAAAAGGCACTGTTGTGGCAACTACTTTAGAAAAGTCTGCCAATCCACTTGGTTTTGATGGTGTTGTTTTCCATTGCGGGCGACCAAATGTTAAGGAACTTCTACATGAAGCGGCTGAATTGAGTGGCTCATTATCTGTGGTTTGCTGTGGACCTCCTATTTTTGTTGACAAAGTGAGGAATGAAACCGCAAAAATAGTTTTAGATAAGTCTGCAAAAGCCATTGAGTACTTTGAAGAGTATCAATGCTGGTGA","protein_sequence":"MHWTSILSAILLFCLSGARASPAKTVIRNKVPLLVTNACTRIFQKVTWEYTSKSKRSSPVCSYEPAFQSMLYCIYETLDEKGYSNKTLEKTFSTIKKNCASYSDALQNMTNSEFYDVLNNGTRHMTPYVKGSANLTYPVEMDTQLRKAYYHALHGFYANLDVGNIYGGIICAYFVAIMAFAGVLHCMNYTPFKTVLLKQKLVGYVRGYLTLPTIGSKHASDFSYFRIFTGYLPTRLEGIIILGYLVLHTVFLAYGYEYDPENIIFKSRRVQVARYVADRSGVLAFAHFPLIVLFAGRNNFLEYISGVKYTSFIMFHKWLGRMMFLDAMIHGSAYTSYTVANKTWATSKNRLYWQFGVAALCLAGTMVFFSFAVFRKYFYEAFLFLHIVLGAMFFYACWEHVVSLSGIEWIYTAIAIWIVDRIIRIIKASYFGFPKASLQLIGDDLIRLTVKKPARPWRAKPGQYVFVSFLHPLYFWQSHPFTVLDSVSKNGELVIILKEKKGVTRLVKKYVCRNGGKTSMRLAIEGPYGSSSPVNNYNNVLLLTGGTGLPGPIAHAIKLGKTSAAAGKQSVKLVIAVRGFDVLEAYKPELMCLENLNVQLHIYNTMEVPSLTPSDSLDISQQDEKADEKGTVVATTLEKSANPLGFDGVVFHCGRPNVKELLHEAAELSGSLSVVCCGPPIFVDKVRNETAKIVLDKSAKAIEYFEEYQCW"},{"created_at":"2011-05-27T07:11:58.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Low-affinity Fe(2+) transport protein","uniprot_id":"P40988","uniprot_name":"FET4_YEAST","enzyme":false,"transporter":true,"gene_name":"FET4","num_residues":552,"molecular_weight":"62791.5","theoretical_pi":"5.16","general_function":"Involved in transmembrane transport","specific_function":"Required for Fe(2+) ion low affinity uptake","reactions":[],"signal_regions":"None","transmembrane_regions":"98-118;226-246;272-292;355-375;384-404;466-486;494-514","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"L34837","genbank_protein_id":"567911","gene_card_id":"FET4","chromosome_location":"chromosome 13","locus":"YMR319C","synonyms":["Low-affinity Fe(II) transport protein"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Iron_permease","identifier":"PF04120"}],"pathways":[],"gene_sequence":"ATGGGTAAAATTGCAGAGTTTCTCGGGAATCCAGGTGCTAGGCCTGACGTTCATCATAGAGCACCTACTGTTGACTGCAAACAGTACGAAGAATTCGGTGATTCTAACGATTACAAAAATGATGATGTGGTCAGAGTAGTCAGCCATAGCGATGAGAGTACTGATGACGAACTTTGTAATGTGAATTTAACAGAAACAGGGGCAATCTTCACGAGTAAAGGTTTTACCGGGTTAAGCAAAGGTTTCACAGATAAGACCCTGGATTTCCTGGTACGAGTGGCCGGTTCGCAGGCGGTTTTTTTTATTGTTTGGATCATCCTCATAATTTGGGTGGTTATTGGTATTGTTTATAACGCACCTTTCAATTGGCAAGTTGTTATGCAGGACGGACAGTCCATTCAAAGTTATGTTTGGGACACACTGTTGATGAGACAACAGTTGATGAGTACGCATGAACAAATTTTGATCTGCGGTAGATTGAAGTCGAGATTGGCTTCCTTCAAAAACTATCTAACAAGAAGCACCCCAGAGGAAGAAAAAGCAGACTGCACAGTTGAAGCTAATGAAGTCAGCTCTGTTGAAAATCATATAGACCCATCTGCCATTAACGGAGAACTGCCTGTGGAAAATTGGTACGACCGTTTATCTAATGTAGCAAGTAGGTATATGGGTTCAATTGCAGCAATGGTGATATTTTGGATAGGTATTTTCGTTTGGATTGGTTGCGGTGCTATCCCAAAAGATGCGGGCAACACTCCACCTTACACCGGAGAAACTACAGGTAGTAATCCAAGATTGAAAAAGTTCAGTGACGCTTGGCAGATGTATATTAACACTGCAGTTGCAATTTCCCTTCTAATTTGCACTACTTTCTTACAAAATATAAGGGCCAGACATGATTATTTCACGGGGAGGTTTTTAGTTGATATCTTTGATATGGACGAGAAAATCGACTATCGTATAAGAAAGCATTTTAACGATTTTGAAACACCTCACCCAGTTGTTACCATTGAGTCTAAAAAAAGGTCGACAGGGAGAAAGATGATTGATTGGTATGCTGATATTATTGGTACTGGTATTGGTGTCCTGATCGGTGTGGCAGTGTTCGCTACATGGATTGGTATTGGTTCGCCAATGAAGTGGGATGATAATTGGTGGTTGATTATCGGTACATACACAGGTTTAATTGGGTTTTTGGACGGTTTCGTTTTGAGAGAAGTGTACTTCCGAATCGTTCAACATGAAGAGAAAAATTATTCTGATGTGGCTAAAGAAGACCTTGAATTATTCCAAGAATTAGGTATTGAATGTCCCGAAGAACTTAGTGGTAAAGCTCCTGAAATTAACATTATTGGTTACAGAACATCCCAATATATTAATAGGATCTGCTCAACTCCATGGAGTGTTCTTGTATCCGTCATCATCATCATTGGTTTAATTTGTATTGCTTCCGGTTTGCGTTGGAGTACAACAGGTCAATTGATTGCTAACACGCCAACTATGATTATCGAAGAATTTTTCTTGCTAGTTTTGTTGCAAGCACATAATTGGGCCGATCGTCAAAGAAGAGTGGAGGTTACCGCTTTGTACGCACGTAGGCGCATACTTCTATCATACGTAGAAAAGCGTTTCCCAGAGGTTATGATGTTGGAAAAATAG","protein_sequence":"MGKIAEFLGNPGARPDVHHRAPTVDCKQYEEFGDSNDYKNDDVVRVVSHSDESTDDELCNVNLTETGAIFTSKGFTGLSKGFTDKTLDFLVRVAGSQAVFFIVWIILIIWVVIGIVYNAPFNWQVVMQDGQSIQSYVWDTLLMRQQLMSTHEQILICGRLKSRLASFKNYLTRSTPEEEKADCTVEANEVSSVENHIDPSAINGELPVENWYDRLSNVASRYMGSIAAMVIFWIGIFVWIGCGAIPKDAGNTPPYTGETTGSNPRLKKFSDAWQMYINTAVAVSLLICTTFLQNIRARHDYFTGRFLVDIFDMDEKIDYRIRKHFNDFETPHPVVTIESKKRSTGRKMIDWYADIIGTGIGVLIGVAVFATWIGIGSPMKWDDNWWLIIGTYTGLIGFLDGFVLREVYFRIVQHEEKNYSDVAKEDLELFQELGIECPEEFSGKAPEINTIGYRTSQYINRICSTPWSVLVSVIIIIGLICIASGLRWSTTGQLIANTPTMIIEEFFLLVLLQAHNWADRQRRVEVTALYARRRILLSYVEKRFPEVMMLEK"},{"created_at":"2011-05-29T04:04:20.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Ferric/cupric reductase transmembrane component 7","uniprot_id":"Q12333","uniprot_name":"FRE7_YEAST","enzyme":true,"transporter":false,"gene_name":"FRE7","num_residues":620,"molecular_weight":"70904.70313","theoretical_pi":"8.79","general_function":"Involved in oxidoreductase activity","specific_function":"Cell surface metalloreductase. May be involved in copper homeostasis","reactions":[{"id":2723,"direction":"\u003e","locations":"Cell membrane; Multi-pass membrane protein;Vacuole membrane; Multi-pass membrane protein (Probable)","altext":"2 Fe(2+) + NADP(+) = 2 Fe(3+) + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"46-66;108-128;168-188;195-215;238-258;266-286;293-313","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"FRE7","chromosome_location":"chromosome 15","locus":"YOL152W","synonyms":["Ferric-chelate reductase 7"],"enzyme_classes":["1.16.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ferric_reduct","identifier":"PF01794"},{"name":"FAD_binding_8","identifier":"PF08022"},{"name":"NAD_binding_6","identifier":"PF08030"}],"pathways":[],"gene_sequence":"ATGATTGAAGAAAGAGATTTGGTTTTAAGCAATGGTATCCATTGTATTGCTGACATCCACTCCGAACTATACGCCAGGTTAAAAAAAGAATCGCAGGCAGCGACACCATGGGTGTACCAAAAACAATACGGAAAATTCGTCACTTACTTTGTCGCTGTGATAATTTTTTTGTCTTTGATAAAAAAGCTGGCATTTATGTATTATGATTCCAGTGAGGAATTTCTTCCAGAAAAGAAGAACTCGCCGACTACCCCTTCTGTATTCCTTGCTCGAATAATGACGAAACTTGTCGCATTCAACAGATACATTTGCTACAGGAAATTTCCCACGTTGATATTTTCTTATTTAGGTATTCCGACATCTGTGGGTACTTTTTTAGTAGTAATGGCTACCACTTTATACACACTTCTATACTGCTTTGTTCCTCATCCATTCTACAGACCTTGTGCAGGATTTGGTTCGCCGCCTTTGTCTGTTCGTGCAGGCATAATGGCAATATCTTTGGTTCCGTTTGTATTCTCACTTTCCGGGAAGATCAACGTTATAGGTTGGTTGGTTGGGCTTTCGTATGAAAAAATCAACATATACCACCAATGGGCATCCATTCTTTGTTTATTCTTTAGCTGGGTTCATGTCATTCCCTTCCTACGTCAAGCACGACATGAGGGAGGATATGAAAGAATGCATCAACGGTGGAAGGCATCCGACATGTGGAGGAGTGGTGTCCCACCCATCTTATTTTTGAATCTGCTATGGTTATCTTCGCTGCCTATTGCTAGAAGACATTTTTATGAGATTTTTTTGCAACTTCATTGGATTTTAGCTGTTGGATTTTACATTAGTTTGTTCTATCATGTATATCCCGAATTGAATTCCCATATGTATCTGGTTGCTACAATTGTGGTTTGGTTTGCACAACTGTTTTACAGACTAGCTGTGAAGGGTTATTTAAGACCTGGTAGAAGTTTCATGGCCTCGACCATTGCAAATGTCAGCATAGTCGGCGAAGGATGCGTAGAATTGATCGTCAAAGATGTGGAAATGGCCTATTCCCCAGGTCAACACATATTCGTGAGAACTATTGATAAGGGCATCATTTCCAACCATCCATTTTCTATCTTTCCGAGTGCAAAGTATCCCGGAGGAATAAAAATGCTGATTAGAGCCCAGAAAGGGTTTTCTAAAAGGCTATACGAAAGTAATGACGACATGAAGAAAATTCTTATTGATGGGCCTTATGGTGGAATCGAGAGAGATATTAGAAGTTTTACCAATGTCTACTTGATTTGCTCTGGTTCAGGTATATCTACATGCTTACCTTTCCTGCAAAAATATGGCCCCATACTCCATAAGACAAACTTAGAAGTTATTACATTGGACTGGGTGGTAAGACATAGGGAGGATATATCATGGATTAGAGATGAAATGTGTACCCTCTCAAATAATTTGCGCCAGTTATTTTTAGATGGGAAAATTGTGGTTAGAATTTACGTCTGCTCGGACAGTACCGTCCCTGGTATTATTAAAACTTTCCCTCAAACAATAGACACCGCCAGTGACCAATCTGATTTAGCTAAAAGAGAAAAAGATACCGAATTCGGCCAGGATGATACTGAGTCAAATTCAACTTTCGACAAATCCAATAACGAATATAAAGGTCTCATCACCATTATTCCTTCCAAACCTGATTTGAATCAGGTCATTAATGATTACCAAATTGGGTTCAGGAACTGCTTCATTTGTTCAGGTTCTGACAGCCTAAGGTATACCGTCGGAAATTCCGTGGCAGGTTTACAGGCCAAGGTTTTTTCTAACAAAAATGTCGAAGAGTGCTATTTACACAGCGAGAGTTTTGGCTACTAG","protein_sequence":"MIEERDLVLSNGIHCIADIHSELYARLKKESQAATPWVYQKQYGKFVTYFVAVIIFLSLIKKLAFMYYDSSEEFLPEKKNSPTTPSVFLARIMTKLVAFNRYICYRKFPTLIFSYLGIPTSVGTFLVVMATTLYTLLYCFVPHPFYRPCAGFGSPPLSVRAGIMAISLVPFVFSLSGKINVIGWLVGLSYEKINIYHQWASILCLFFSWVHVIPFLRQARHEGGYERMHQRWKASDMWRSGVPPILFLNLLWLSSLPIARRHFYEIFLQLHWILAVGFYISLFYHVYPELNSHMYLVATIVVWFAQLFYRLAVKGYLRPGRSFMASTIANVSIVGEGCVELIVKDVEMAYSPGQHIFVRTIDKGIISNHPFSIFPSAKYPGGIKMLIRAQKGFSKRLYESNDDMKKILIDGPYGGIERDIRSFTNVYLICSGSGISTCLPFLQKYGPILHKTNLEVITLDWVVRHREDISWIRDEMCTLSNNLRQLFLDGKIVVRIYVCSDSTVPGIIKTFPQTIDTASDQSDLAKREKDTEFGQDDTESNSTFDKSNNEYKGLITIIPSKPDLNQVINDYQIGFRNCFICSGSDSLRYTVGNSVAGLQAKVFSNKNVEECYLHSESFGY"}]}