Formate dehydrogenase 1 (Q08911)

Identification
NameFormate dehydrogenase 1
Synonyms
  • NAD-dependent formate dehydrogenase 1
Gene NameFDH1
Enzyme Class
Biological Properties
General FunctionInvolved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific FunctionFormate + NAD(+) = CO(2) + NADH
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG Pathways
Glyoxylate and dicarboxylate metabolismec00630 Map00630
Methane metabolismec00680 Map00680
SMPDB ReactionsNot Available
KEGG Reactions
NAD + Formic acid → NADH + Carbon dioxide
Metabolites
YMDB IDNameView
YMDB00110NADShow
YMDB00143NADHShow
YMDB00385Formic acidShow
YMDB00412NAD(+)Show
YMDB00912Carbon dioxideShow
GO Classification
Component
Not Available
Function
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
NAD or NADH binding
catalytic activity
binding
nucleotide binding
oxidoreductase activity
cofactor binding
Process
metabolic process
Gene Properties
Chromosome Locationchromosome 15
LocusYOR388C
Gene Sequence>1131 bp ATGTCGAAGGGAAAGGTTTTGCTGGTTCTTTACGAAGGTGGTAAGCATGCTGAAGAGCAG GAAAAGTTATTGGGGTGTATTGAAAATGAACTTGGTATCAGAAATTTCATTGAAGAACAG GGATACGAGTTGGTTACTACCATTGACAAGGACCCTGAGCCAACCTCAACGGTAGACAGG GAGTTGAAAGACGCTGAAATTGTCATTACTACGCCCTTTTTCCCCGCCTACATCTCGAGA AACAGGATTGCAGAAGCTCCTAACCTGAAGCTCTGTGTAACCGCTGGCGTCGGTTCAGAC CATGTCGATTTAGAAGCTGCAAATGAACGGAAAATCACGGTCACCGAAGTTACTGGTTCT AACGTCGTTTCTGTCGCAGAGCACGTTATGGCCACAATTTTGGTTTTGATAAGAAACTAT AATGGTGGTCATCAACAAGCAATTAATGGTGAGTGGGATATTGCCGGCGTGGCTAAAAAT GAGTATGATCTGGAAGACAAAATAATTTCAACGGTAGGTGCCGGTAGAATTGGATATAGG GTTCTGGAAAGATTGGTCGCATTTAATCCGAAGAAGTTACTGTACTACGACTACCAGGAA CTACCTGCGGAAGCAATCAATAGATTGAACGAGGCCAGCAAGCTTTTCAATGGCAGAGGT GATATTGTTCAGAGAGTAGAGAAATTGGAGGATATGGTTGCTCAGTCAGATGTTGTTACC ATCAACTGTCCATTGCACAAGGACTCAAGGGGTTTATTCAATAAAAAGCTTATTTCCCAC ATGAAAGATGGTGCATACTTGGTGAATACCGCTAGAGGTGCTATTTGTGTCGCAGAAGAT GTTGCCGAGGCAGTCAAGTCTGGTAAATTGGCTGGCTATGGTGGTGATGTCTGGGATAAG CAACCAGCACCAAAAGACCATCCCTGGAGGACTATGGACAATAAGGACCACGTGGGAAAC GCAATGACTGTTCATATCAGTGGCACATCTCTGGATGCTCAAAAGAGGTACGCTCAGGGA GTAAAGAACATCCTAAATAGTTACTTTTCCAAAAAGTTTGATTACCGTCCACAGGATATT ATTGTGCAGAATGGTTCTTATGCCACCAGAGCTTATGGACAGAAGAAATAA
Protein Properties
Pfam Domain Function
Protein Residues376
Protein Molecular Weight41714.0
Protein Theoretical pI6.43
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Formate dehydrogenase 1 MSKGKVLLVLYEGGKHAEEQEKLLGCIENELGIRNFIEEQGYELVTTIDKDPEPTSTVDR ELKDAEIVITTPFFPAYISRNRIAEAPNLKLCVTAGVGSDHVDLEAANERKITVTEVTGS NVVSVAEHVMATILVLIRNYNGGHQQAINGEWDIAGVAKNEYDLEDKIISTVGAGRIGYR VLERLVAFNPKKLLYYDYQELPAEAINRLNEASKLFNGRGDIVQRVEKLEDMVAQSDVVT INCPLHKDSRGLFNKKLISHMKDGAYLVNTARGAICVAEDVAEAVKSGKLAGYGGDVWDK QPAPKDHPWRTMDNKDHVGNAMTVHISGTSLDAQKRYAQGVKNILNSYFSKKFDYRPQDI IVQNGSYATRAYGQKK
References
External Links
ResourceLink
Saccharomyces Genome Database FDH1
Uniprot IDQ08911
Uniprot NameFDH1_YEAST
GenBank Gene IDZ75296
Genebank Protein ID1420835
General Reference
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • van den Berg, M. A., Steensma, H. Y. (1997). "Expression cassettes for formaldehyde and fluoroacetate resistance, two dominant markers in Saccharomyces cerevisiae." Yeast 13:551-559.9178506
  • Overkamp, K. M., Kotter, P., van der Hoek, R., Schoondermark-Stolk, S., Luttik, M. A., van Dijken, J. P., Pronk, J. T. (2002). "Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae." Yeast 19:509-520.11921099