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| Identification |
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| YMDB ID | YMDB00385 |
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| Name | Formic acid |
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| Species | Saccharomyces cerevisiae |
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| Strain | Baker's yeast |
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| Description | Formic acid, also known as formate or ameisensaeure, belongs to the class of organic compounds known as carboxylic acids. Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH. Formic acid is a weakly acidic compound (based on its pKa). Formic acid exists in all living species, ranging from bacteria to humans. |
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| Structure | |
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| Synonyms | - Add-F
- Amasil
- Ameisensaeure
- Ameisensaure
- Aminate
- Aminic acid
- Bilorin
- Collo-Bueglatt
- Collo-Didax
- FMT
- Formate
- formic acid
- Formira
- Formisoton
- Formylate
- Formylic acid
- HCO2 anion
- HCOOH
- Hydrogen carboxylate
- Hydrogen carboxylic acid
- hydrogencarboxylic acid
- Kwas metaniowy
- Kyselina mravenci
- Methanoate
- Methanoic acid
- Methanoic acid monomer
- Mierenzuur
- Myrmicyl
- Sodium Formate
- Sybest
- Trisodium phosphonoformate hexahydrate
- Wonderbond Hardener M 600L
- Acide formique
- H-COOH
- HCO2H
- Methoic acid
- Methoate
- Calcium formate
- Cobalt(II) formate dihydrate
- Formic acid, aluminum salt
- Formic acid, copper salt
- Formic acid, cromium (+3) salt
- Lithium formate
- Ammonium formate
- Formic acid, ammonium (4:1) salt
- Formic acid, ammonium salt
- Formic acid, calcium salt
- Formic acid, copper (+2) salt
- Formic acid, lead (+2) salt
- Formic acid, lead salt
- Formic acid, nickel salt
- Formic acid, potassium salt
- Formic acid, strontium salt
- Mafusol
- Ammonium tetraformate
- Formic acid, 14C-labeled
- Formic acid, cobalt (+2) salt
- Formic acid, copper, ammonium salt
- Formic acid, sodium salt
- Formic acid, sodium salt, 14C-labeled
- Formic acid, ammonium (2:1) salt
- Formic acid, cadmium salt
- Formic acid, cesium salt
- Formic acid, copper, nickel salt
- Formic acid, cromium (+3), sodium (4:1:1) salt
- Formic acid, lithium salt
- Formic acid, magnesium salt
- Formic acid, nickel (+2) salt
- Formic acid, rubidium salt
- Formic acid, sodium salt, 13C-labeled
- Formic acid, thallium (+1) salt
- Formic acid, zinc salt
- Nickel formate dihydrate
- Aluminum formate
- Potassium formate
- Strontium formate
- Lead formate
- Nickel formate
- Chromic formate
- Cobaltous formate
- Cupric formate
- Magnesium formate
- Zinc formate
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| CAS number | 64-18-6 |
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| Weight | Average: 46.0254
Monoisotopic: 46.005479308 |
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| InChI Key | BDAGIHXWWSANSR-UHFFFAOYSA-N |
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| InChI | InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3) |
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| IUPAC Name | formic acid |
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| Traditional IUPAC Name | formic acid |
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| Chemical Formula | CH2O2 |
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| SMILES | [H]OC([H])=O |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as carboxylic acids. Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH. |
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| Kingdom | Organic compounds |
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| Super Class | Organic acids and derivatives |
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| Class | Carboxylic acids and derivatives |
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| Sub Class | Carboxylic acids |
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| Direct Parent | Carboxylic acids |
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| Alternative Parents | |
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| Substituents | - Monocarboxylic acid or derivatives
- Carboxylic acid
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | |
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| Physical Properties |
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| State | Liquid |
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| Charge | 0 |
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| Melting point | 8.4 °C |
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| Experimental Properties | | Property | Value | Reference |
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| Water Solubility | 1000 mg/mL at 25 oC [RIDDICK,JA et al. (1986)] | PhysProp | | LogP | -0.54 [HANSCH,C ET AL. (1995)] | PhysProp |
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| Predicted Properties | |
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| Biological Properties |
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| Cellular Locations | - Cytoplasm
- Extracellular
- Mitochondrion
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| Organoleptic Properties | |
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| SMPDB Pathways |
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| KEGG Pathways |
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| SMPDB Reactions |
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| KEGG Reactions |
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| Concentrations |
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| Intracellular Concentrations | | Intracellular Concentration | Substrate | Growth Conditions | Strain | Citation |
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| 14745 ± 737 µM | YEB media with 0.5 mM glucose | aerobic | Baker's yeast | Experimentally Determined
Not Available | | Conversion Details Here |
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| Extracellular Concentrations | Not Available |
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| Spectra |
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| Spectra | | Spectrum Type | Description | Splash Key | View |
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| Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-0002-9000000000-5d27bb312e37a2c8994f | JSpectraViewer | | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive | splash10-0fmi-9200000000-2a89ba98485194acd75a | JSpectraViewer | | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | JSpectraViewer | | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive | Not Available | JSpectraViewer | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 4V, positive | splash10-0002-9000000000-a8fbddf8ca4197b30013 | JSpectraViewer | MoNA | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 5V, positive | splash10-0002-9000000000-98310116f8a2d6a969ce | JSpectraViewer | MoNA | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 6V, positive | splash10-0002-9000000000-ec8753fd9790a3cf0be8 | JSpectraViewer | MoNA | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 7V, positive | splash10-0002-9000000000-121d1a025b72a70e412a | JSpectraViewer | MoNA | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 8V, positive | splash10-0002-9000000000-5f1955dee7ab988e86dd | JSpectraViewer | MoNA | | LC-MS/MS | LC-MS/MS Spectrum - QqQ 9V, positive | splash10-0002-9000000000-f8e14272296ee06d19f4 | JSpectraViewer | MoNA | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0002-9000000000-092f816e62c8d2f5d56e | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0002-9000000000-092f816e62c8d2f5d56e | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0002-9000000000-092f816e62c8d2f5d56e | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0006-9000000000-eb2207f7400e9144fff7 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0006-9000000000-eb2207f7400e9144fff7 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-9000000000-eb2207f7400e9144fff7 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0006-9000000000-d948d5d95ae14e701f57 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0006-9000000000-d948d5d95ae14e701f57 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-9000000000-d948d5d95ae14e701f57 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0002-9000000000-92190863fc6ae28a8789 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0002-9000000000-92190863fc6ae28a8789 | JSpectraViewer | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0002-9000000000-348f481062f48991a0aa | JSpectraViewer | | MS | Mass Spectrum (Electron Ionization) | splash10-004j-9000000000-2e63b0c1e2e417b0d747 | JSpectraViewer | MoNA | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 1H NMR Spectrum | Not Available | JSpectraViewer | | 1D NMR | 13C NMR Spectrum | Not Available | JSpectraViewer | | 2D NMR | [1H,1H] 2D NMR Spectrum | Not Available | JSpectraViewer | | 2D NMR | [1H,13C] 2D NMR Spectrum | Not Available | JSpectraViewer |
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| References |
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| References: | - UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
- Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
- Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
- Jin, C., Barrientos, A., Tzagoloff, A. (2003). "Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration." J Biol Chem 278:14698-14703.12595523
- Subhi, A. L., Diegelman, P., Porter, C. W., Tang, B., Lu, Z. J., Markham, G. D., Kruger, W. D. (2003). "Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites." J Biol Chem 278:49868-49873.14506228
- Panozzo, C., Nawara, M., Suski, C., Kucharczyka, R., Skoneczny, M., Becam, A. M., Rytka, J., Herbert, C. J. (2002). "Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae." FEBS Lett 517:97-102.12062417
- Lamb, D. C., Kelly, D. E., Manning, N. J., Kaderbhai, M. A., Kelly, S. L. (1999). "Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction." FEBS Lett 462:283-288.10622712
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| Synthesis Reference: | Finholt, Albert E.; Jacobson, Eugene C. The reduction of carbon dioxide to formic acid with lithium aluminum hydride. Journal of the American Chemical Society (1952), 74 3943-4. |
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| External Links: | |
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