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Putative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W (Q06137)

Identification
NamePutative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W
Synonyms
  • 6-phosphofructo-2-kinase
  • Fructose-2,6-bisphosphatase
Gene NameNot Available
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionSynthesis and degradation of fructose 2,6-bisphosphate
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG Pathways
Fructose and mannose metabolismec00051 Map00051
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00011D-Fructose 2,6-bisphosphateShow
YMDB00078Fructose 6-phosphateShow
YMDB00109Adenosine triphosphateShow
YMDB00890waterShow
YMDB00907phosphateShow
YMDB00914ADPShow
GO Classification
Component
Not Available
Function
transferase activity, transferring phosphorus-containing groups
binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
phosphotransferase activity, alcohol group as acceptor
catalytic activity
phosphofructokinase activity
transferase activity
6-phosphofructo-2-kinase activity
Process
fructose 2,6-bisphosphate metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
metabolic process
fructose metabolic process
Gene Properties
Chromosome LocationNot Available
LocusYLR345W
Gene Sequence>1530 bp ATGCCAAATGTGCTTTCTGATGATGAAGAGCTCCTTAATGGACTAGGAAGTGAGATTATG AAACCCTCTAGACAAGGTAACCATATGGCAAGGACCGTCAAAAGGTGGGTAAATAAAGAA CGTGCTACCACAGCCGATCTGAAAAATGTTAATATTGATGGAGTTCATGGACCGGTAAAT ACCGAAAGTTATATATCACCAGGACAGCTTTACTCCACTGACTCGGGCAATTTATTTCAT GCTGGAAGAATCCTTGTCGTTCTAGTCGGTCTTCCAGCAACATCAAAGACACTATTGTCA GTAGCGATTACAAGATATACAAGATGGTTAGGAGTTAGGACGAAATCGTTCCATTTTTCA GAATATAAAGAATCAGCTAAAAATATACCCTCAGACTATTTTTGCGTAGTGCCAACGTCA AAAGAAGGTGTAGCGTTTGTTGAAAAGCTTCGCATGCAGATGTTGAATGATATACTGGCA TTTTTCAACGACTTGTCAGGTCAGCTGGCCATTTATGATGCCCTAAACATCCGTAAAATT GACAGAAAGAATTTGGAGACAACGTTTTCTGAAATTGGAGTTAAAGTACTCTTCATAGAA TCAATCGTGTCTGATCAAGAAATCATGAATAGAAACATAGCTCTTGCACTGGAGTCGAAC GATTACAAGGGACTTTCAACTGATGAAGCCATTGACGAATATATGAGACGTTTATCAGTG AACGAACCATACTATGAAATGATGACACATGACGAAGAATTATCGTACATTAAATATATA AATTTGGGAAAGCAGATAATTGTGAAAGATAACATACATGGTTATTTGGTCAACAAAATA GTATTTTTCTTAATGAATTTGAGGCAGAAAAAGGGGTGTGTATATTTTGCTCGCTGTGGC ACCAGCGATAAAGACAACTACATACATGATGAGGAACTAAACGAGGAGGGAATCCATTAC TCTCAAGTTCTCAAGGATTTTGTCCTCCAACGAATTAAACAGAAGAGACAGGCCAAAAAA AATTCGGATTCCTTAGTCGAAGTAATAGATGGAAGTCATGATGAAGATTTGAAGACTTCC TTGATAGTTTGGACAGGTCCCAGGAAAAGAACCCACGATACTGCACTCTTTTTTTCAAAA GAAGGTATTAAAGTTCAGCAACGGTCAGAGTTGAGACAGTTGAACCCAGGAAGTATTGCT GATCTTACTGATCAACAGATAATGGACAAATTTCCATCAGAATATAAAGAATCATTAAAA GACCCATATCATTTTCGATTCCCTAGGGCGGAATCTTACCATGACTTAGCCGTTCGTATG GAACCTTTACTATTAGAAATGGAGCATACGAGCAAGGACATTCTCATCATTGCACATGAG TCAACATTAAGAGTATTATATGGCTATTTAATGGCTTGCACCTGCGTAGAGTTACCAAAT CTAAATTTCACAAGAGACAAATTAGTTGAAATTTCATTCAGCCCTTTCTGTAATACTGTA GAGTTACTGAACATTCCTTTAACTAGCTAA
Protein Properties
Pfam Domain Function
Protein Residues509
Protein Molecular Weight58385.19922
Protein Theoretical pI6.4
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Putative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W MPNVLSDDEELLNGLGSEIMKPSRQGNHMARTVKRWVNKERATTADLKNVNIDGVHGPVN TESYISPGQLYSTDSGNLFHAGRILVVLVGLPATSKTLLSVAITRYTRWLGVRTKSFHFS EYKESAKNIPSDYFCVVPTSKEGVAFVEKLRMQMLNDILAFFNDLSGQLAIYDALNIRKI DRKNLETTFSEIGVKVLFIESIVSDQEIMNRNIALALESNDYKGLSTDEAIDEYMRRLSV NEPYYEMMTHDEELSYIKYINLGKQIIVKDNIHGYLVNKIVFFLMNLRQKKGCVYFARCG TSDKDNYIHDEELNEEGIHYSQVLKDFVLQRIKQKRQAKKNSDSLVEVIDGSHDEDLKTS LIVWTGPRKRTHDTALFFSKEGIKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLK DPYHFRFPRAESYHDLAVRMEPLLLEMEHTSKDILIIAHESTLRVLYGYLMACTCVELPN LNFTRDKLVEISFSPFCNTVELLNIPLTS
References
External Links
ResourceLink
Saccharomyces Genome Database YLR345W
Uniprot IDQ06137
Uniprot NameYL345_YEAST
GenBank Gene IDU19028
Genebank Protein ID609382
General Reference
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Zaim, J., Speina, E., Kierzek, A. M. (2005). "Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae." J Biol Chem 280:28-37.15494396
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956