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| Identification |
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| Name | 6-phosphogluconolactonase 3 |
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| Synonyms | |
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| Gene Name | SOL3 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in 6-phosphogluconolactonase activity |
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| Specific Function | Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate |
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| Cellular Location | Cytoplasm. Nucleus |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00140 | 6-Phosphonoglucono-D-lactone | Show | | YMDB00218 | 6-Phosphogluconic acid | Show | | YMDB00862 | hydron | Show | | YMDB00890 | water | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| 6-phosphogluconolactonase activity | | catalytic activity | | hydrolase activity | | hydrolase activity, acting on ester bonds | | carboxylesterase activity | | Process |
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| metabolic process | | primary metabolic process | | carbohydrate metabolic process | | small molecule metabolic process | | alcohol metabolic process | | monosaccharide metabolic process | | hexose metabolic process | | glucose metabolic process | | glucose catabolic process | | pentose-phosphate shunt |
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| Gene Properties |
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| Chromosome Location | chromosome 8 |
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| Locus | YHR163W |
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| Gene Sequence | >YHR163W SOL3 SGDID:S000001206, Chr VIII from 423724-424473, Verified ORF, "6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p"
ATGGTGACAGTCGGTGTGTTTTCTGAGAGGGCTAGTTTGACCCATCAATTGGGGGAATTC
ATCGTCAAGAAACAAGATGAGGCGCTGCAAAAGAAGTCAGACTTTAAAGTTTCCGTTAGC
GGTGGCTCTTTGATCGATGCTCTGTATGAAAGTTTAGTAGCGGACGAATCACTATCTTCT
CGAGTGCAATGGTCTAAATGGCAAATCTACTTCTCTGATGAAAGAATTGTGCCACTGACG
GACGCTGACAGCAATTATGGTGCCTTCAAGAGAGCTGTTCTAGATAAATTACCCTCGACT
AGTCAGCCAAACGTTTATCCCATGGACGAGTCCTTGATTGGCAGCGATGCTGAATCTAAC
AACAAAATTGCTGCAGAGTACGAGCGTATCGTACCTCAAGTGCTTGATTTGGTACTGTTG
GGCTGTGGTCCTGATGGACACACTTGTTCCTTATTCCCTGGAGAAACACATAGGTACTTG
CTGAACGAAACAACCAAAAGAGTTGCTTGGTGCCACGATTCTCCCAAGCCTCCAAGTGAC
AGAATCACCTTCACTCTGCCTGTGTTGAAAGACGCCAAAGCCCTGTGTTTTGTGGCTGAG
GGCAGTTCCAAACAAAATATAATGCATGAGATCTTTGACTTGAAAAACGATCAATTGCCA
ACCGCATTGGTTAACAAATTATTTGGTGAAAAAACATCCTGGTTCGTTAATGAGGAAGCT
TTTGGAAAAGTTCAAACGAAAACTTTTTAG |
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| Protein Properties |
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| Pfam Domain Function | Not Available |
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| Protein Residues | 249 |
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| Protein Molecular Weight | 27784.19922 |
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| Protein Theoretical pI | 5.17 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >6-phosphogluconolactonase 3
MVTVGVFSERASLTHQLGEFIVKKQDEALQKKSDFKVSVSGGSLIDALYESLVADESLSS
RVQWSKWQIYFSDERIVPLTDADSNYGAFKRAVLDKLPSTSQPNVYPMDESLIGSDAESN
NKIAAEYERIVPQVLDLVLLGCGPDGHTCSLFPGETHRYLLNETTKRVAWCHDSPKPPSD
RITFTLPVLKDAKALCFVAEGSSKQNIMHEIFDLKNDQLPTALVNKLFGEKTSWFVNEEA
FGKVQTKTF |
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| References |
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| External Links | |
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| General Reference | - Shen, W. C., Stanford, D. R., Hopper, A. K. (1996). "Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family." Genetics 143:699-712.8725220
- Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
- Kellis, M., Patterson, N., Endrizzi, M., Birren, B., Lander, E. S. (2003). "Sequencing and comparison of yeast species to identify genes and regulatory elements." Nature 423:241-254.12748633
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Stanford, D. R., Whitney, M. L., Hurto, R. L., Eisaman, D. M., Shen, W. C., Hopper, A. K. (2004). "Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism." Genetics 168:117-127.15454531
- Zhang, Z., Dietrich, F. S. (2005). "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE." Nucleic Acids Res 33:2838-2851.15905473
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