Inositol monophosphatase 1 (P38710)

Identification
NameInositol monophosphatase 1
Synonyms
  • IMP 1
  • IMPase 1
  • Inositol-1(or 4)-monophosphatase 1
Gene NameINM1
Enzyme Class
Biological Properties
General FunctionInvolved in inositol or phosphatidylinositol phosphatase activity
Specific FunctionResponsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides
Cellular LocationCytoplasm. Nucleus
SMPDB Pathways
Inositol MetabolismPW002498 ThumbThumb?image type=greyscaleThumb?image type=simple
Inositol phosphate metabolismPW002495 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Inositol phosphate metabolismec00562 Map00562
SMPDB Reactions
D-Myo-inositol 4-phosphate + water → Myoinositol + phosphate
1D-myo-inositol 3-phosphate + water → Myoinositol + phosphate
1D-myo-inositol 3-phosphate + water → Myoinositol + phosphate
D-Myo-inositol 4-phosphate + water → Myoinositol + Phosphoric acid
KEGG Reactions
1D-myo-inositol 1-phosphate + water → Myoinositol + phosphate
Metabolites
YMDB IDNameView
YMDB00173MyoinositolShow
YMDB007141D-myo-inositol 1-phosphateShow
YMDB007151D-myo-inositol 3-phosphateShow
YMDB00792Myo-inositol 1-phosphateShow
YMDB00890waterShow
YMDB00907phosphateShow
YMDB16136D-Myo-inositol 4-phosphateShow
YMDB16145Phosphoric acidShow
GO Classification
Component
Not Available
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 8
LocusYHR046C
Gene Sequence>YHR046C INM1 SGDID:S000001088, Chr VIII from 198285-197398, reverse complement, Verified ORF, "Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of ATGACCATTGATCTAGCTTCTATCGAGAAATTCCTCTGTGAACTGGCTACTGAAAAAGTA GGACCAATCATCAAATCCAAGTCCGGCACTCAAAAGGATTATGACTTGAAGACTGGCTCC AGGAGCGTTGATATTGTAACTGCTATCGATAAACAGGTCGAAAAGTTAATTTGGGAATCG GTAAAAACCCAATATCCAACTTTCAAGTTTATTGGAGAGGAAAGTTATGTGAAAGGGGAG ACCGTGATTACTGATGATCCTACCTTTATTATTGATCCAATTGATGGGACTACAAACTTT GTTCATGATTTCCCATTTAGCTGTACCTCTCTTGGGCTCACAGTAAACAAAGAGCCCGTA GTAGGCGTTATATATAATCCTCACATTAATCTTCTGGTATCCGCTTCTAAAGGAAATGGG ATGAGAGTTAACAACAAGGACTATGACTATAAATCAAAATTGGAATCTATGGGTTCTCTA ATACTAAATAAATCCGTAGTGGCATTACAGCCAGGTTCCGCTAGAGAGGGAAAGAATTTT CAGACAAAAATGGCCACATATGAAAAATTACTATCATGTGATTACGGTTTTGTTCATGGA TTCAGAAATTTAGGATCATCTGCAATGACAATGGCATATATTGCTATGGGGTACCTTGAT AGTTATTGGGATGGTGGTTGCTATTCGTGGGACGTGTGTGCTGGATGGTGTATTTTGAAA GAAGTGGGCGGTCGTGTAGTAGGTGCCAATCCAGGTGAATGGAGTATTGATGTCGACAAT AGGACATATTTGGCTGTGAGGGGAACAATTAATAACGAAAGTGACGAACAAACAAAATAT ATCACAGACTTTTGGAACTGTGTTGATGGCCATTTGAAATATGACTGA
Protein Properties
Pfam Domain Function
Protein Residues295
Protein Molecular Weight32823.0
Protein Theoretical pI4.92
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Inositol monophosphatase 1 MTIDLASIEKFLCELATEKVGPIIKSKSGTQKDYDLKTGSRSVDIVTAIDKQVEKLIWES VKTQYPTFKFIGEESYVKGETVITDDPTFIIDPIDGTTNFVHDFPFSCTSLGLTVNKEPV VGVIYNPHINLLVSASKGNGMRVNNKDYDYKSKLESMGSLILNKSVVALQPGSAREGKNF QTKMATYEKLLSCDYGFVHGFRNLGSSAMTMAYIAMGYLDSYWDGGCYSWDVCAGWCILK EVGGRVVGANPGEWSIDVDNRTYLAVRGTINNESDEQTKYITDFWNCVDGHLKYD
References
External Links
ResourceLink
Saccharomyces Genome Database INM1
Uniprot IDP38710
Uniprot NameINM1_YEAST
General Reference
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Lopez, F., Leube, M., Gil-Mascarell, R., Navarro-Avino, J. P., Serrano, R. (1999). "The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair." Mol Microbiol 31:1255-1264.10096091
  • Navarro-Avino, J. P., Belles, J. M., Serrano, R. (2003). "Yeast inositol mono- and trisphosphate levels are modulated by inositol monophosphatase activity and nutrients." Biochem Biophys Res Commun 302:41-45.12593845
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106