{"ymdb_id":"YMDB00792","created_at":"2011-05-29T18:53:26.000Z","updated_at":"2016-09-08T18:35:54.000Z","name":"Myo-inositol 1-phosphate","cas":"573-35-3","state":"Solid","melting_point":"195 oC","description":"1D-Myo-Inositol 1-phosphate is involved in the sphingolipid metabolism. 1D-Myo-Inositol 1-phosphate is the constituent of phospholipids and inositol polyphosphates. [Biocyc SPHINGOLIPID-SYN-PWY]","experimental_water_solubility":"333 mg/mL [MERCK INDEX (1996)]","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":"Klyashchitskii, B. A.; Pimenova, V. V.; Shvets, V. I.; Sokolov, S. D.; Preobrazhenskii, N. A.  Total synthesis of sn-myoinositol 1-phosphate.    Zhurnal Obshchei Khimii  (1969),  39(10),  2373.","chebi_id":"18297","hmdb_id":"HMDB00213","kegg_id":"C01177","pubchem_id":"107737","cs_id":"24808130","foodb_id":null,"wikipedia_link":"Myo-inositol_1-phosphate","biocyc_id":"1-L-MYO-INOSITOL-1-P","iupac":"{[(1R,2S,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid","traditional_iupac":"myo-inositol 1-phosphate","logp":"-3.9055756833333333","pka":"6.194111788919007","alogps_solubility":"3.95e+01 g/l","alogps_logp":"-1.98","alogps_logs":"-0.82","acceptor_count":"8","donor_count":"7","rotatable_bond_count":"2","polar_surface_area":"167.91","refractivity":"46.6479","polarizability":"20.634480013236395","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.645813019693807","pka_strongest_acidic":"1.1625722061585555","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-(dihydrogen phosphate) DL-myo-Inositol","1-(dihydrogen phosphate) myo-Inositol","DL-myo-Inositol 1-phosphate","myo-Inositol 1-monophosphate","myo-Inositol 1-phosphate","myo-Inositol-1-phosphate","Myoinositol 1-phosphate","Myoinositol 1-phosphic acid"],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18407956,"citation":"Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). \"A multidimensional chromatography technology for in-depth phosphoproteome analysis.\" Mol Cell Proteomics 7:1389-1396."},{"pubmed_id":17563356,"citation":"Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). \"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.\" Proc Natl Acad Sci U S A 104:10364-10369."},{"pubmed_id":10844654,"citation":"Murray, M., Greenberg, M. L. (2000). \"Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate.\" Mol Microbiol 36:651-661."},{"pubmed_id":12484746,"citation":"Funato, K., Vallee, B., Riezman, H. (2002). \"Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae.\" Biochemistry 41:15105-15114."},{"pubmed_id":9804825,"citation":"Reggiori, F., Conzelmann, A. (1998). \"Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes.\" J Biol Chem 273:30550-30559."}],"proteins":[{"created_at":"2011-05-27T03:10:33.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Inositol monophosphatase 2","uniprot_id":"Q05533","uniprot_name":"INM2_YEAST","enzyme":true,"transporter":false,"gene_name":"INM2","num_residues":292,"molecular_weight":"32092.40039","theoretical_pi":"5.4","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling","reactions":[{"id":1749,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2708,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasmic","altext":"Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY557746","genbank_protein_id":"45269383","gene_card_id":"INM2","chromosome_location":"chromosome 4","locus":"YDR287W","synonyms":["IMP 2","IMPase 2","Inositol-1(or 4)-monophosphatase 2"],"enzyme_classes":["3.1.3.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Inositol_P","identifier":"PF00459"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGGTATTAACGAGGCAAGTACTAGAGGAAGTGGAGAACACATTTATTGAATTACTTAGGAGTAAAATAGGACCTCTCGTAAAATCGCACGCAGGAACAAACTTTTGTTCATATGATGATAAAGCAAATGGCGTAGATTTGGTAACTGCTTTAGACAAACAAATTGAATCTATAATCAAGGAAAATTTAACGGCCAAGTATCCCAGTTTCAAATTTATCGGAGAAGAAACTTATGTAAAAGGTGTCACGAAAATAACTAACGGCCCTACATTTATTGTTGATCCCATCGATGGTACTACTAATTTTATTCACGGTTACCCCTATAGTTGTACATCTCTAGGTTTAGCTGAAATGGGGAAGCCGGTTGTTGGTGTGGTTTTCAATCCTCACTTAAACCAACTATTCCATGCTTCCAAAGGCAATGGAGCTTTCTTAAATGATCAGGAGATAAAGGTTTCAAAAAGGCCATTGATTTTGCAAAAATCCTTAATTGCTTTAGAAGGAGGTTCGGAAAGAACTGAAGGTTCCCAAGGAAACTTTGATAAGAAAATGAATACTTATAAAAACTTACTAAGTGAGTCCGGCGCCTTTGTTCACGGGTTCAGAAGTGCAGGAAGTGCTGCCATGAACATATGCTACGTAGCGAGCGGCATGCTTGATGCTTATTGGGAAGGTGGCTGCTGGGCTTGGGATGTTTGTGCCGGTTGGTGTATTCTTGAGGAAGCAGGAGGAATAATGGTTGGCGGAAATTGTGGAGAATGGAACATTCCATTAGACAGAAGATGTTACTTGGCTATTAGAGGTGGATGTGAGTCGATGGAGCAGAAGCGATTTGCAGAATCGTTTTGGCCTCACGTTGCGGGTGAGTTAGAATACTAA","protein_sequence":"MVLTRQVLEEVENTFIELLRSKIGPLVKSHAGTNFCSYDDKANGVDLVTALDKQIESIIKENLTAKYPSFKFIGEETYVKGVTKITNGPTFIVDPIDGTTNFIHGYPYSCTSLGLAEMGKPVVGVVFNPHLNQLFHASKGNGAFLNDQEIKVSKRPLILQKSLIALEGGSERTEGSQGNFDKKMNTYKNLLSESGAFVHGFRSAGSAAMNICYVASGMLDAYWEGGCWAWDVCAGWCILEEAGGIMVGGNCGEWNIPLDRRCYLAIRGGCESMEQKRFAESFWPHVAGELEY"},{"created_at":"2011-05-29T04:10:26.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Inositol monophosphatase 1","uniprot_id":"P38710","uniprot_name":"INM1_YEAST","enzyme":true,"transporter":false,"gene_name":"INM1","num_residues":295,"molecular_weight":"32823.0","theoretical_pi":"4.92","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides","reactions":[{"id":1749,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2708,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasmic","altext":"Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14846,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007023","source":"Smpdb"},{"id":14847,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007024","source":"Smpdb"},{"id":14848,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007027","source":"Smpdb"},{"id":14849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007040","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"INM1","chromosome_location":"chromosome 8","locus":"YHR046C","synonyms":["IMP 1","IMPase 1","Inositol-1(or 4)-monophosphatase 1"],"enzyme_classes":["3.1.3.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Inositol_P","identifier":"PF00459"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACCATTGATCTAGCTTCTATCGAGAAATTCCTCTGTGAACTGGCTACTGAAAAAGTAGGACCAATCATCAAATCCAAGTCCGGCACTCAAAAGGATTATGACTTGAAGACTGGCTCCAGGAGCGTTGATATTGTAACTGCTATCGATAAACAGGTCGAAAAGTTAATTTGGGAATCGGTAAAAACCCAATATCCAACTTTCAAGTTTATTGGAGAGGAAAGTTATGTGAAAGGGGAGACCGTGATTACTGATGATCCTACCTTTATTATTGATCCAATTGATGGGACTACAAACTTTGTTCATGATTTCCCATTTAGCTGTACCTCTCTTGGGCTCACAGTAAACAAAGAGCCCGTAGTAGGCGTTATATATAATCCTCACATTAATCTTCTGGTATCCGCTTCTAAAGGAAATGGGATGAGAGTTAACAACAAGGACTATGACTATAAATCAAAATTGGAATCTATGGGTTCTCTAATACTAAATAAATCCGTAGTGGCATTACAGCCAGGTTCCGCTAGAGAGGGAAAGAATTTTCAGACAAAAATGGCCACATATGAAAAATTACTATCATGTGATTACGGTTTTGTTCATGGATTCAGAAATTTAGGATCATCTGCAATGACAATGGCATATATTGCTATGGGGTACCTTGATAGTTATTGGGATGGTGGTTGCTATTCGTGGGACGTGTGTGCTGGATGGTGTATTTTGAAAGAAGTGGGCGGTCGTGTAGTAGGTGCCAATCCAGGTGAATGGAGTATTGATGTCGACAATAGGACATATTTGGCTGTGAGGGGAACAATTAATAACGAAAGTGACGAACAAACAAAATATATCACAGACTTTTGGAACTGTGTTGATGGCCATTTGAAATATGACTGA","protein_sequence":"MTIDLASIEKFLCELATEKVGPIIKSKSGTQKDYDLKTGSRSVDIVTAIDKQVEKLIWESVKTQYPTFKFIGEESYVKGETVITDDPTFIIDPIDGTTNFVHDFPFSCTSLGLTVNKEPVVGVIYNPHINLLVSASKGNGMRVNNKDYDYKSKLESMGSLILNKSVVALQPGSAREGKNFQTKMATYEKLLSCDYGFVHGFRNLGSSAMTMAYIAMGYLDSYWDGGCYSWDVCAGWCILKEVGGRVVGANPGEWSIDVDNRTYLAVRGTINNESDEQTKYITDFWNCVDGHLKYD"}]}