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| Identification |
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| Name | Inorganic pyrophosphatase, mitochondrial |
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| Synonyms | - Pyrophosphate phospho-hydrolase
- PPase
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| Gene Name | PPA2 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in magnesium ion binding |
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| Specific Function | Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis |
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| Cellular Location | Mitochondrion |
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| SMPDB Pathways | |
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| KEGG Pathways | |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00219 | Pyrophosphate | Show | | YMDB00862 | hydron | Show | | YMDB00890 | water | Show | | YMDB00907 | phosphate | Show |
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| GO Classification | | Component |
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| cell part | | intracellular part | | cytoplasm | | Function |
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| binding | | ion binding | | cation binding | | metal ion binding | | hydrolase activity | | magnesium ion binding | | hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | catalytic activity | | pyrophosphatase activity | | inorganic diphosphatase activity | | Process |
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| cellular metabolic process | | phosphorus metabolic process | | phosphate metabolic process | | metabolic process |
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| Gene Properties |
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| Chromosome Location | chromosome 13 |
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| Locus | YMR267W |
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| Gene Sequence | >933 bp
ATGAATTTATTACGAATGAATGCTTTAACAAGCAAGGCTAGGTCAATAGAACGGTTAAAA
CAAACATTGAATATTTTATCCATTCGTAATCATAGACAATTCAGCACCATTCAACAAGGC
AGCAAATATACCCTCGGGTTTAAGAAATACTTGACATTATTAAATGGAGAGGTTGGTTCT
TTTTTCCATGATGTCCCTTTAGATTTGAATGAACATGAAAAGACCGTAAATATGATTGTT
GAAGTACCAAGATGGACAACTGGAAAATTTGAAATATCCAAAGAACTTAGGTTCAATCCG
ATCGTTCAAGATACGAAGAATGGCAAGCTTAGGTTCGTGAACAATATCTTTCCCTATCAC
GGCTATATACACAACTATGGTGCTATTCCCCAAACATGGGAAGATCCCACAATTGAACAT
AAACTGGGGAAGTGTGACGTGGCTTTGAAAGGTGACAATGATCCTCTTGATTGTTGCGAA
ATCGGTTCGGATGTTTTGGAAATGGGTTCCATTAAAAAGGTCAAGGTATTAGGATCACTC
GCTTTAATTGATGATGGAGAATTGGATTGGAAGGTCATAGTGATCGACGTAAATGATCCT
TTATCCTCTAAAATAGATGACTTGGAAAAAATTGAGGAGTACTTTCCTGGGATTCTAGAT
ACGACTAGGGAGTGGTTTAGAAAGTATAAAGTTCCAGCAGGGAAGCCATTAAATAGTTTC
GCCTTTCATGAACAGTATCAAAATTCCAATAAAACCATCCAAACTATAAAGAAATGTCAC
AATTCGTGGAAAAACCTCATTTCAGGATCACTCCAGGAGAAGTATGACAACCTGCCTAAT
ACAGAAAGGGCTGGTAATGGTGTCACACTTGAAGATAGTGTTAAACCCCCTTCTCAAATA
CCGCCTGAGGTGCAAAAATGGTATTACGTTTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 310 |
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| Protein Molecular Weight | 35572.39844 |
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| Protein Theoretical pI | 7.6 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Inorganic pyrophosphatase, mitochondrial
MNLLRMNALTSKARSIERLKQTLNILSIRNHRQFSTIQQGSKYTLGFKKYLTLLNGEVGS
FFHDVPLDLNEHEKTVNMIVEVPRWTTGKFEISKELRFNPIVQDTKNGKLRFVNNIFPYH
GYIHNYGAIPQTWEDPTIEHKLGKCDVALKGDNDPLDCCEIGSDVLEMGSIKKVKVLGSL
ALIDDGELDWKVIVIDVNDPLSSKIDDLEKIEEYFPGILDTTREWFRKYKVPAGKPLNSF
AFHEQYQNSNKTIQTIKKCHNSWKNLISGSLQEKYDNLPNTERAGNGVTLEDSVKPPSQI
PPEVQKWYYV |
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| References |
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| External Links | |
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| General Reference | - Lundin, M., Baltscheffsky, H., Ronne, H. (1991). "Yeast PPA2 gene encodes a mitochondrial inorganic pyrophosphatase that is essential for mitochondrial function." J Biol Chem 266:12168-12172.1648084
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Vihinen, M., Lundin, M., Baltscheffsky, H. (1992). "Computer modeling of two inorganic pyrophosphatases." Biochem Biophys Res Commun 186:122-128.1321599
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