You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Identification |
---|
Name | Threonine synthase |
---|
Synonyms | |
---|
Gene Name | THR4 |
---|
Enzyme Class | |
---|
Biological Properties |
---|
General Function | Involved in catalytic activity |
---|
Specific Function | Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine |
---|
Cellular Location | Not Available |
---|
SMPDB Pathways | |
---|
KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | | Vitamin B6 metabolism | ec00750 | |
|
---|
SMPDB Reactions | |
---|
KEGG Reactions | |
---|
Metabolites | YMDB ID | Name | View |
---|
YMDB00214 | L-Threonine | Show | YMDB00258 | O-Phosphohomoserine | Show | YMDB00355 | O-Phospho-4-hydroxy-L-threonine | Show | YMDB00494 | 4-Hydroxy-L-threonine | Show | YMDB00890 | water | Show | YMDB00907 | phosphate | Show |
|
---|
GO Classification | Component |
---|
Not Available | Function |
---|
binding | cofactor binding | pyridoxal phosphate binding | carbon-oxygen lyase activity | carbon-oxygen lyase activity, acting on phosphates | threonine synthase activity | catalytic activity | lyase activity | Process |
---|
aspartate family amino acid metabolic process | threonine metabolic process | threonine biosynthetic process | metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process |
|
---|
Gene Properties |
---|
Chromosome Location | chromosome 3 |
---|
Locus | YCR053W |
---|
Gene Sequence | >1545 bp
ATGCCTAACGCTTCCCAAGTTTACAGATCTACCAGATCCAGCTCTCCAAAGACAATCTCT
TTTGAAGAGGCTATCATTCAAGGTCTGGCCACTGACGGTGGTCTTTTCATTCCACCAACT
ATTCCACAAGTGGACCAAGCCACTCTTTTCAATGATTGGTCAAAGCTCTCCTTCCAAGAC
TTAGCCTTTGCTATCATGAGACTATACATTGCCCAAGAAGAGATTCCAGATGCTGATCTA
AAGGACTTGATCAAGAGATCTTATTCTACTTTCCGTTCTGATGAAGTCACCCCCTTGGTG
CAAAACGTCACTGGTGACAAGGAGAATTTGCACATTTTAGAATTATTCCACGGTCCTACC
TACGCTTTCAAAGACGTTGCTTTACAATTTGTCGGTAATCTTTTTGAATACTTCTTACAA
AGAACCAACGCCAATTTACCTGAAGGCGAGAAAAAGCAAATCACTGTGGTCGGTGCTACT
TCCGGTGACACTGGTTCTGCAGCCATCTACGGTTTAAGAGGCAAAAAGGACGTTTCCGTT
TTCATCTTATATCCAACCGGTAGAATTTCCCCAATTCAAGAAGAACAAATGACCACCGTT
CCAGATGAAAACGTCCAGACTTTGTCTGTTACCGGTACTTTCGACAACTGTCAAGATATC
GTCAAAGCTATTTTCGGTGACAAAGAATTCAACTCTAAACACAACGTCGGTGCTGTTAAC
TCCATCAACTGGGCAAGAATCTTGGCCCAAATGACCTATTACTTTTATTCATTCTTCCAA
GCCACCAACGGTAAGGACTCCAAGAAGGTCAAGTTCGTTGTGCCAAGTGGGAACTTCGGT
GATATATTGGCCGGTTATTTTGCCAAGAAAATGGGTTTGCCTATTGAAAAACTGGCCATC
GCTACCAATGAAAACGACATTTTGGACAGATTTTTGAAATCTGGTCTATACGAAAGATCA
GACAAGGTTGCTGCTACTTTATCCCCAGCAATGGATATCTTAATCTCTTCTAACTTTGAA
AGACTACTATGGTACCTAGCTCGTGAATACCTAGCTAATGGTGATGATTTGAAAGCCGGT
GAAATCGTCAACAATTGGTTCCAGGAATTGAAGACCAACGGTAAGTTCCAAGTTGACAAA
TCCATCATTGAAGGCGCATCAAAGGACTTTACATCAGAAAGAGTTTCCAATGAAGAAACA
TCTGAAACAATCAAGAAGATCTACGAATCATCTGTAAATCCAAAACATTACATCTTAGAT
CCTCACACAGCTGTCGGTGTTTGCGCCACAGAAAGATTGATTGCAAAAGATAATGACAAG
TCCATCCAATACATTTCTCTATCTACCGCTCACCCAGCTAAATTTGCCGATGCTGTAAAC
AATGCATTGTCTGGATTTTCCAATTATTCATTTGAAAAGGATGTTTTGCCTGAGGAATTG
AAGAAACTATCCACATTAAAGAAGAAATTAAAATTCATCGAAAGAGCTGACGTTGAATTG
GTCAAAAACGCTATTGAAGAAGAACTTGCTAAAATGAAATTATAA |
---|
Protein Properties |
---|
Pfam Domain Function | |
---|
Protein Residues | 514 |
---|
Protein Molecular Weight | 57473.69922 |
---|
Protein Theoretical pI | 5.3 |
---|
PDB File | show |
---|
Signalling Regions | |
---|
Transmembrane Regions | |
---|
Protein Sequence | >Threonine synthase
MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQATLFNDWSKLSFQD
LAFAIMRLYIAQEEIPDADLKDLIKRSYSTFRSDEVTPLVQNVTGDKENLHILELFHGPT
YAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSV
FILYPTGRISPIQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVN
SINWARILAQMTYYFYSFFQATNGKDSKKVKFVVPSGNFGDILAGYFAKKMGLPIEKLAI
ATNENDILDRFLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDDLKAG
EIVNNWFQELKTNGKFQVDKSIIEGASKDFTSERVSNEETSETIKKIYESSVNPKHYILD
PHTAVGVCATERLIAKDNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEEL
KKLSTLKKKLKFIERADVELVKNAIEEELAKMKL |
---|
References |
---|
External Links | |
---|
General Reference | - Aas, S. F., Rognes, S. E. (1990). "Nucleotide sequence of the yeast THR4 gene encoding threonine synthase." Nucleic Acids Res 18:665.2408022
- Mannhaupt, G., van der Linden, G., Vetter, I., Maurer, K., Pilz, U., Planta, R., Feldmann, H. (1990). "Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae." Yeast 6:353-361.2204248
- Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
|
---|