{"ymdb_id":"YMDB00355","created_at":"2011-05-29T18:09:05.000Z","updated_at":"2016-09-08T18:35:23.000Z","name":"O-Phospho-4-hydroxy-L-threonine","cas":null,"state":"Solid","melting_point":"","description":"O-Phospho-4-hydroxy-L-threonine is involved in the vitamin B6 metabolism system. O-Phospho-4-hydroxy-L-threonine is a precursor for pyridoxine. O-Phospho-4-hydroxy-L-threonine can be converted to 4-hydroxy-L-threonine and 2-amino-3-oxo-4-phosphonooxybutyrate by threonine synthase [EC:4.2.3.1] and 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262], respectively.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"18336","hmdb_id":"HMDB06802","kegg_id":"C06055","pubchem_id":"1006","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S,3S)-2-amino-3-hydroxy-4-(phosphonooxy)butanoic acid","traditional_iupac":"4-(phosphonooxy)-L-threonine","logp":"-3.876164191197906","pka":"2.0740868709070774","alogps_solubility":"2.27e+01 g/l","alogps_logp":"-2.40","alogps_logs":"-0.98","acceptor_count":"7","donor_count":"5","rotatable_bond_count":"5","polar_surface_area":"150.31","refractivity":"38.876400000000004","polarizability":"16.597838646165975","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"8.926715134721942","pka_strongest_acidic":"1.313786360081051","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["4-(Phosphonooxy)-L-threonine","4-(Phosphonooxy)-threonine","4-phosphonooxy-L-threonine","O-Phospho-4-hydroxy-L-threonine"],"pathways":[{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"Vitamin B6","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8082795,"citation":"Ramos, C., Calderon, I. L. (1994). \"Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase.\" FEBS Lett 351:357-359."}],"proteins":[{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine","reactions":[{"id":1800,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1894,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2474,"direction":"\u003e","locations":null,"altext":"O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2475,"direction":"\u003e","locations":null,"altext":"4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3842,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006365","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L20917","genbank_protein_id":"311153","gene_card_id":"SER1","chromosome_location":"chromosome 15","locus":"YOR184W","synonyms":["PSAT","Phosphohydroxythreonine aminotransferase"],"enzyme_classes":["2.6.1.52"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTTGGAAAGAGAGGAACCACAACATTTCGGAGCAGGGCCAGCTCAAATGCCTACACCAGTTTTGCAACAAGCTGCTAAAGACTTAATCAATTTCAATGACATAGGTTTGGGTATCGGTGAAATTTCTCACCGTTCGAAGGATGCCACCAAAGTGATTGAAGACTCTAAGAAGCACTTAATCGAACTGCTAAATATTCCTGACACTCATGAAGTGTTCTACTTGCAAGGTGGTGGCACTACTGGTTTTTCTTCCGTTGCTACTAATTTGGCAGCTGCATATGTGGGTAAGCATGGGAAGATTGCACCTGCCGGTTATTTAGTCACCGGTAGTTGGTCTCAGAAATCTTTTGAAGAGGCAAAGAGATTGCACGTTCCTGCTGAAGTTATCTTCAACGCTAAAGATTATAACAATGGCAAATTTGGTAAAATTCCGGATGAATCCCTTTGGGAAGATAAAATCAAAGGTAAGGCTTTCTCATACGTGTACCTATGTGAGAATGAAACTGTTCATGGTGTTGAATGGCCAGAATTACCAAAATGTTTAGTAAACGACCCCAACATCGAAATTGTTGCTGACTTATCCAGCGACATTTTGTCTCGTAAGATTGACGTTTCTCAATACGGTGTCATCATGGCAGGCGCCCAAAAAAACATTGGTTTAGCAGGCTTAACCCTATACATTATCAAGAAATCCATCCTTAAGAATATTTCTGGCGCTTCTGATGAAACATTACATGAATTGGGAGTACCAATCACCCCTATTGCATTCGACTATCCAACGGTGGTGAAGAACAACTCAGCCTATAATACAATTCCAATTTTCACTTTACATGTTATGGATCTCGTGTTCCAACATATTTTGAAGAAGGGTGGTGTTGAAGCGCAACAGGCTGAAAATGAAGAAAAGGCCAAGATATTATATGAGGCATTGGATGCAAATTCAGATTTTTACAACGTTCCAGTGGATCCAAAGTGTAGATCAAAAATGAATGTCGTTTTCACCCTTAAAAAGGACGGCCTTGATGACCAGTTTCTAAAAGAGGCAGCTGCTCGTCATTTAACCGGTTTGAAAGGACATCGTTCAGTTGGTGGGTTCAGAGCCTCCATCTATAACGCGCTTTCAGTGAAAGCTGTACAAAACTTGGTAGATTTTATCAAGGAATTTGCTGAGAAAAACGCTTAA","protein_sequence":"MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA"},{"created_at":"2011-05-27T04:03:47.000Z","updated_at":"2011-07-22T17:53:49.000Z","name":"Threonine synthase","uniprot_id":"P16120","uniprot_name":"THRC_YEAST","enzyme":true,"transporter":false,"gene_name":"THR4","num_residues":514,"molecular_weight":"57473.69922","theoretical_pi":"5.3","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine","reactions":[{"id":1193,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2009,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2755,"direction":"\u003e","locations":null,"altext":"O-phospho-L-homoserine + H(2)O = L-threonine + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006379","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1KL7","cellular_location":null,"genbank_gene_id":"X17256","genbank_protein_id":"4616","gene_card_id":"THR4","chromosome_location":"chromosome 3","locus":"YCR053W","synonyms":["TS"],"enzyme_classes":["4.2.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" carbon-oxygen lyase activity, acting on phosphates"},{"category":"Function","description":" threonine synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"},{"category":"Process","description":" threonine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTAACGCTTCCCAAGTTTACAGATCTACCAGATCCAGCTCTCCAAAGACAATCTCTTTTGAAGAGGCTATCATTCAAGGTCTGGCCACTGACGGTGGTCTTTTCATTCCACCAACTATTCCACAAGTGGACCAAGCCACTCTTTTCAATGATTGGTCAAAGCTCTCCTTCCAAGACTTAGCCTTTGCTATCATGAGACTATACATTGCCCAAGAAGAGATTCCAGATGCTGATCTAAAGGACTTGATCAAGAGATCTTATTCTACTTTCCGTTCTGATGAAGTCACCCCCTTGGTGCAAAACGTCACTGGTGACAAGGAGAATTTGCACATTTTAGAATTATTCCACGGTCCTACCTACGCTTTCAAAGACGTTGCTTTACAATTTGTCGGTAATCTTTTTGAATACTTCTTACAAAGAACCAACGCCAATTTACCTGAAGGCGAGAAAAAGCAAATCACTGTGGTCGGTGCTACTTCCGGTGACACTGGTTCTGCAGCCATCTACGGTTTAAGAGGCAAAAAGGACGTTTCCGTTTTCATCTTATATCCAACCGGTAGAATTTCCCCAATTCAAGAAGAACAAATGACCACCGTTCCAGATGAAAACGTCCAGACTTTGTCTGTTACCGGTACTTTCGACAACTGTCAAGATATCGTCAAAGCTATTTTCGGTGACAAAGAATTCAACTCTAAACACAACGTCGGTGCTGTTAACTCCATCAACTGGGCAAGAATCTTGGCCCAAATGACCTATTACTTTTATTCATTCTTCCAAGCCACCAACGGTAAGGACTCCAAGAAGGTCAAGTTCGTTGTGCCAAGTGGGAACTTCGGTGATATATTGGCCGGTTATTTTGCCAAGAAAATGGGTTTGCCTATTGAAAAACTGGCCATCGCTACCAATGAAAACGACATTTTGGACAGATTTTTGAAATCTGGTCTATACGAAAGATCAGACAAGGTTGCTGCTACTTTATCCCCAGCAATGGATATCTTAATCTCTTCTAACTTTGAAAGACTACTATGGTACCTAGCTCGTGAATACCTAGCTAATGGTGATGATTTGAAAGCCGGTGAAATCGTCAACAATTGGTTCCAGGAATTGAAGACCAACGGTAAGTTCCAAGTTGACAAATCCATCATTGAAGGCGCATCAAAGGACTTTACATCAGAAAGAGTTTCCAATGAAGAAACATCTGAAACAATCAAGAAGATCTACGAATCATCTGTAAATCCAAAACATTACATCTTAGATCCTCACACAGCTGTCGGTGTTTGCGCCACAGAAAGATTGATTGCAAAAGATAATGACAAGTCCATCCAATACATTTCTCTATCTACCGCTCACCCAGCTAAATTTGCCGATGCTGTAAACAATGCATTGTCTGGATTTTCCAATTATTCATTTGAAAAGGATGTTTTGCCTGAGGAATTGAAGAAACTATCCACATTAAAGAAGAAATTAAAATTCATCGAAAGAGCTGACGTTGAATTGGTCAAAAACGCTATTGAAGAAGAACTTGCTAAAATGAAATTATAA","protein_sequence":"MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQATLFNDWSKLSFQDLAFAIMRLYIAQEEIPDADLKDLIKRSYSTFRSDEVTPLVQNVTGDKENLHILELFHGPTYAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVNSINWARILAQMTYYFYSFFQATNGKDSKKVKFVVPSGNFGDILAGYFAKKMGLPIEKLAIATNENDILDRFLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDDLKAGEIVNNWFQELKTNGKFQVDKSIIEGASKDFTSERVSNEETSETIKKIYESSVNPKHYILDPHTAVGVCATERLIAKDNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEELKKLSTLKKKLKFIERADVELVKNAIEEELAKMKL"}]}