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Identification
NameProbable glycerophosphodiester phosphodiesterase YPL206C
SynonymsNot Available
Gene NameNot Available
Enzyme Class
Biological Properties
General FunctionInvolved in glycerophosphodiester phosphodiesterase activity
Specific FunctionProbable glycerophosphocholine glycerophosphodiesterase which may be responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis
Cellular LocationEndoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).
SMPDB Pathways
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycerophospholipid metabolismec00564 Map00564
SMPDB ReactionsNot Available
KEGG Reactions
water + phosphatidylglycerol ↔ Glycerol 3-phosphate + DG(16:0/16:0/0:0)
Metabolites
YMDB IDNameView
YMDB00073Glycerol 3-phosphateShow
YMDB00227CholineShow
YMDB00309GlycerophosphocholineShow
YMDB00890waterShow
YMDB00988sn-glycerol 3-phosphateShow
GO Classification
Component
Not Available
Function
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
catalytic activity
phosphoric diester hydrolase activity
glycerophosphodiester phosphodiesterase activity
Process
polyol metabolic process
alditol metabolic process
glycerol metabolic process
metabolic process
lipid metabolic process
primary metabolic process
small molecule metabolic process
alcohol metabolic process
Gene Properties
Chromosome LocationNot Available
LocusYPL206C
Gene Sequence>966 bp ATGGTTGAAATTGTGGGCCACAGAGCTTTTAAAGCAAGATATCCTGAAAATACGCTACTA GCATTTGAGAAGGCTTATGCAGCAGGTGCTGATGTAATAGAAACGGATTTACAAATGACC AGCGATGGTATGGTGGTGGTAAACCATGACTCAGACACTGGTCGGATGTGGGATAAGAAC TTGGTGATTGGCGAGTCGACTTGGGAGGAGGTTAAGCGATTGCGCTGCAAAGAGGATGGT TCCTTAGCAATGATGACATTGAAGGAAATTCTAACATGGGCAGTGTGCCATCCAGGAGCT AAATTGATGTTGGACATCAAATTTACCAACGAGAAAATCATCATGATCAAGACCTTTGTT ATCATGTTAGAGGTTAAGAATGATCTTAAATTTTGGCAGGAGAGGATCACGTGGGGGCTT TGGTTGCTGGATTGGTACGATTTCGGTATTGAAACTGGTGTTCTGAAGGATTTCAAAGTT ATTGTGATAAGTCTGTCTTTAGATATCGCCTCGCAATTTGTGAAGCGCTCTTTGACACTG AATGATCCTCACTATAAACTTTTTGGTATCAGCGTCCATTTTGTCTCCTCGTGGACAAGC CAATTTAGATTGAGATTACTACCTGTGCTTATGAAGAATGATATCAAGGTCTATTTATGG ACTGTCAACAAACCTATAGATTTCAAATATCTGTGCGAATTGCCTATCCATGGTGCTATC ACGGATGATCCGATCAAGGCAAGAAAGTTATGCGATGGTCATACCGTGGCGAAGAAGCCT ACTGCTGAAAAAAAGTTTGTTGCGCCCAGTCTGGCATCTGTAGATGGGCTAAGATTCCAT GCTTTTATCAAAGTTTATAACATCCTTTGCACGCTTCTATATTCCAAATGGGTCCATATT AAGTTGTGCGGTTGGTCTATTGCTTATGTGATTTTTTTGTTCCTTCGAACCATTCATTTT CTTTGA
Protein Properties
Pfam Domain Function
Protein Residues321
Protein Molecular Weight37069.39844
Protein Theoretical pI8.93
Signalling Regions
  • None
Transmembrane Regions
  • 297-315
Protein Sequence>Probable glycerophosphodiester phosphodiesterase YPL206C MVEIVGHRAFKARYPENTLLAFEKAYAAGADVIETDLQMTSDGMVVVNHDSDTGRMWDKN LVIGESTWEEVKRLRCKEDGSLAMMTLKEILTWAVCHPGAKLMLDIKFTNEKIIMIKTFV IMLEVKNDLKFWQERITWGLWLLDWYDFGIETGVLKDFKVIVISLSLDIASQFVKRSLTL NDPHYKLFGISVHFVSSWTSQFRLRLLPVLMKNDIKVYLWTVNKPIDFKYLCELPIHGAI TDDPIKARKLCDGHTVAKKPTAEKKFVAPSLASVDGLRFHAFIKVYNILCTLLYSKWVHI KLCGWSIAYVIFLFLRTIHFL
References
External Links
ResourceLink
Saccharomyces Genome Database YPL206C
Uniprot IDQ08959
Uniprot NameYP206_YEAST
GenBank Gene IDZ73562
Genebank Protein ID1370428
General Reference
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Beilharz, T., Egan, B., Silver, P. A., Hofmann, K., Lithgow, T. (2003). "Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae." J Biol Chem 278:8219-8223.12514182
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Fisher, E., Almaguer, C., Holic, R., Griac, P., Patton-Vogt, J. (2005). "Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae." J Biol Chem 280:36110-36117.16141200
  • Fernandez-Murray, J. P., McMaster, C. R. (2005). "Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway." J Biol Chem 280:38290-38296.16172116