{"ymdb_id":"YMDB00227","created_at":"2011-05-29T16:09:02.000Z","updated_at":"2016-10-18T17:11:22.000Z","name":"Choline","cas":"62-49-7","state":"Solid","melting_point":"","description":"Choline is an important head group for phospholipids, which are the major structural components of biological membranes. Choline is a precursor in the phosphatidylcholine biosynthesis pathway. [Biocyc PWY3O-450]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"extracellular;cell envelope;cytoplasm","synthesis_reference":"Hasegawa, Yoichi; Hyoda, Shunji; Sawada, Hirotoshi; Baba, Masakatsu.  Preparation of high-purity organic carboxylic acid choline salts and choline.    Jpn. Kokai Tokkyo Koho  (1999),     9 pp. ","chebi_id":"15354","hmdb_id":"HMDB00097","kegg_id":"C00114","pubchem_id":"305","cs_id":"73580","foodb_id":null,"wikipedia_link":"Choline","biocyc_id":"CPD-563","iupac":"(2-hydroxyethyl)trimethylazanium","traditional_iupac":"choline","logp":"-4.662269162805079","pka":null,"alogps_solubility":"3.61e+00 g/l","alogps_logp":"-3.59","alogps_logs":"-1.59","acceptor_count":"1","donor_count":"1","rotatable_bond_count":"2","polar_surface_area":"20.23","refractivity":"42.194","polarizability":"12.56561305801337","formal_charge":"1","physiological_charge":"1","pka_strongest_basic":"-3.249884462803304","pka_strongest_acidic":"13.968714076810006","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["(2-Hydroxyethyl)trimethyl ammonium","(2-Hydroxyethyl)trimethylammonium","(beta-hydroxyethyl)trimethylammonium","2-hydroxy-N,N,N-trimethyl-ethanaminium","2-hydroxy-N,N,N-trimethylethanaminium","Bilineurine","Biocolina","Biocoline","Choline","Choline cation","Choline ion","Cholinum","Hepacholine","Hormocline","Lipotril","N,N,N-trimethylethanol-ammonium","N,N,N-trimethylethanolammonium","Neocolina","Paresan"],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"growth_conditions":[{"growth_media":"hops, malted barley","concentration":"970.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"grape juice","concentration":"547.0","concentration_units":"\u0026#181;M","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7961735,"citation":"McMaster, C. R., Bell, R. M. (1994). \"Phosphatidylcholine biosynthesis in Saccharomyces cerevisiae. Regulatory insights from studies employing null and chimeric sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases.\" J Biol Chem 269:28010-28016."},{"pubmed_id":null,"citation":"Alcoholic beverage, beer, regular, all - U.S. Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. \u003ca href = http://www.ars.usda.gov/ba/bhnrc/ndl\u003eNutrient Data Laboratory Home Page\u003c/a\u003e"},{"pubmed_id":null,"citation":"Alcoholic beverage, wine, table, red - U.S. Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. \u003ca href = http://www.ars.usda.gov/ba/bhnrc/ndl\u003eNutrient Data Laboratory Home Page\u003c/a\u003e"},{"pubmed_id":8618862,"citation":"Rose, K., Rudge, S. A., Frohman, M. A., Morris, A. J., Engebrecht, J. (1995). \"Phospholipase D signaling is essential for meiosis.\" Proc Natl Acad Sci U S A 92:12151-12155."},{"pubmed_id":16141200,"citation":"Fisher, E., Almaguer, C., Holic, R., Griac, P., Patton-Vogt, J. (2005). \"Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae.\" J Biol Chem 280:36110-36117."},{"pubmed_id":10329685,"citation":"Kim, K., Kim, K. H., Storey, M. K., Voelker, D. R., Carman, G. M. (1999). \"Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase.\" J Biol Chem 274:14857-14866."}],"proteins":[{"created_at":"2011-05-24T19:54:50.000Z","updated_at":"2011-07-22T17:54:40.000Z","name":"Choline kinase","uniprot_id":"P20485","uniprot_name":"KICH_YEAST","enzyme":true,"transporter":false,"gene_name":"CKI1","num_residues":582,"molecular_weight":"66316.0","theoretical_pi":"5.34","general_function":"Involved in phosphotransferase activity, alcohol group as acceptor","specific_function":"Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline","reactions":[{"id":1383,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1479,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2281,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + choline = ADP + O-phosphocholine.","export":false,"pw_reaction_id":null,"source":null},{"id":14813,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007000","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692779","genbank_protein_id":"51013009","gene_card_id":"CKI1","chromosome_location":"chromosome 12","locus":"YLR133W","synonyms":[],"enzyme_classes":["2.7.1.32"],"go_classes":[],"pfams":[{"name":"Choline_kin_N","identifier":"PF04428"},{"name":"Choline_kinase","identifier":"PF01633"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGGTACAAGAATCACGTCCAGGGAGTGTAAGAAGTTACTCGGTCGGTTACCAAGCAAGGTCCAGATCGAGTTCTCAAAGAAGACATTCGTTAACACGCCAACGTTCCTCGCAAAGACTGATTAGAACCATCAGTATCGAGTCTGATGTGTCTAATATTACTGACGATGACGATTTGAGAGCTGTCAATGAGGGAGTAGCGGGTGTGCAACTGGACGTCTCTGAAACCGCAAATAAGGGACCAAGAAGAGCATCAGCAACTGATGTCACAGATAGTTTGGGTTCGACTTCGTCGGAATATATTGAGATTCCCTTTGTTAAGGAAACATTGGATGCAAGTTTACCTTCGGATTATCTGAAGCAGGACATATTAAATCTCATTCAGAGTTTGAAGATATCCAAATGGTATAACAACAAGAAAATCCAACCGGTAGCACAAGATATGAACTTAGTCAAGATCTCTGGTGCGATGACAAACGCAATTTTCAAAGTTGAATACCCTAAGTTACCATCGTTGCTATTGAGAATATACGGACCGAATATTGATAATATCATTGACAGGGAATATGAATTGCAGATTTTGGCTAGGCTTTCATTGAAAAATATAGGTCCTTCCCTTTACGGCTGTTTTGTAAACGGTAGATTTGAGCAGTTTCTGGAGAATTCTAAGACTTTAACAAAAGACGACATTAGAAACTGGAAGAACTCTCAAAGGATTGCAAGGAGAATGAAGGAGTTACATGTAGGTGTTCCTCTCTTGAGTTCAGAAAGGAAGAACGGGTCGGCTTGTTGGCAAAAGATTAACCAGTGGTTGCGCACGATTGAGAAAGTCGACCAATGGGTGGGGGATCCTAAAAACATTGAAAACTCTTTATTATGTGAGAATTGGTCCAAGTTTATGGATATTGTCGATAGATATCACAAGTGGCTTATTTCTCAAGAACAGGGTATAGAGCAAGTCAACAAAAATCTTATATTCTGCCATAATGATGCCCAATACGGCAATTTACTTTTCACTGCTCCTGTGATGAACACACCGAGCCTATACACTGCACCTTCGTCTACATCATTGACTTCCCAATCAAGTTCCTTATTTCCTTCGAGCTCCAATGTCATTGTAGATGATATAATCAACCCGCCAAAGCAGGAGCAAAGCCAAGATTCCAAATTGGTCGTCATTGATTTTGAATATGCAGGTGCCAATCCCGCCGCATATGATTTAGCGAATCATCTTTCCGAGTGGATGTATGATTACAACAATGCTAAGGCCCCACATCAGTGCCACGCTGATAGATATCCCGATAAAGAACAGGTTTTGAATTTCTTATACTCTTATGTTTCGCATCTAAGGGGTGGTGCTAAGGAACCCATAGATGAAGAGGTTCAAAGACTCTATAAGTCAATCATTCAATGGAGACCCACTGTACAACTATTTTGGTCGCTCTGGGCCATCCTACAAAGTGGTAAATTAGAGAAAAAAGAAGCCTCCACTGCCATCACTAGAGAAGAAATTGGACCCAATGGAAAAAAATATATCATCAAGACTGAACCCGAATCCCCTGAAGAAGACTTTGTTGAAAATGACGACGAGCCTGAAGCTGGCGTCAGCATTGACACGTTCGATTATATGGCTTATGGTCGTGACAAGATTGCGGTCTTTTGGGGCGACCTCATTGGCTTAGGCATAATCACCGAAGAAGAATGCAAAAATTTCAGCTCTTTCAAGTTCCTCGATACTAGTTATTTGTAA","protein_sequence":"MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL"},{"created_at":"2011-05-26T17:13:10.000Z","updated_at":"2011-05-29T05:06:20.000Z","name":"Glycerophosphodiester phosphodiesterase GDE1","uniprot_id":"Q02979","uniprot_name":"GDE1_YEAST","enzyme":true,"transporter":false,"gene_name":"GDE1","num_residues":1223,"molecular_weight":"138013.0","theoretical_pi":"6.77","general_function":"Involved in protein binding","specific_function":"Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source","reactions":[{"id":1594,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2465,"direction":"\u003e","locations":"Cytoplasm;Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","altext":"A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14811,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006999","source":"Smpdb"},{"id":14812,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007170","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U43503","genbank_protein_id":"1163103","gene_card_id":"GDE1","chromosome_location":"chromosome 16","locus":"YPL110C","synonyms":[],"enzyme_classes":["3.1.4.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phospholipase activity"},{"category":"Function","description":" phospholipase C activity"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" glycerophosphodiester phosphodiesterase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lipase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" intracellular signaling pathway"},{"category":"Process","description":" lipid metabolic process"}],"pfams":[{"name":"GDPD","identifier":"PF03009"},{"name":"SPX","identifier":"PF03105"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGAAGTTCGGAAAAACCTTTGCCAATCATCGCATTCCAGAGTGGTCAAGTCAATATGTTGGCTACAAGTCGTTGAAGAAAATGATTAAAGAAATTACAAGACTTCAAGAAGACATATATAGGGCACATAACAAGAATAGCTATGATGAAGGCAGGCCACCAACAAAAATGAGAGATTCATCTAATAGTGCTCAAAATTATTTGGACTCTCCAAAAATCCAAAAGTTATTGGCGTCGTTTTTCTTTGCAGTTGACAGGGATATTGAGAAGGTTGATACATTTTACAATTCCCAGTATGCGGAATATAAGAAAAGATTTGAGAGATTGCTTTCTTCTAATCAATTCAATGAGATAAAATCAACATTAGTGGTCGATGCCAACAAAGAAGATGCAGTAGCGCAAACCTTACTCACAAAGGATACGAGAGAGATGAATATGCTTTTAAAGGGAACAAGTCAAGCCAGCCGTCTATCTTACCATAAAGATGACTTAATTGAAATTCAGTCTATCTTAGCTGAGTTAAGAAAACAATTTAGAAACTTAAAGTGGTACGCTGAACTAAATAAGAGAGCTTTTGGTAAGATTTTAAAGAAACTGGATAAAAAAGTCGGCACAAATCAGCAAATGTCAACTATGAAAACTAGAATCTTGCCGTTACAATTTGCTAATGATTCTCTTATTACCAAAGATTTGAGTTTGCTAAAAACTATCTGGGAACAAGTGACGTTCAGGATAAATTCTTACGAGAGAGTAATGAGGAGTACCTCGCCGAACGCAAATGCTAATGATAATACAGAATTCTTTAAGATTATTTGCGTTTTTATAGAAGAAGATGATAGCAAAGGATTGATTAGAGAGCTAACAAACCTATATTCGGAATTGTCTTTGATTCCAACAAGAATTATGATAAGTGTTTTAAACAAGGCAGCACTGTCTAAATCACTGGCATGTATTGATGCTATCTTAAAGGTTATTCCGTCTCTAAATGACTCGGAAGATATTAACAGAAGAAATTTTTTCCATCATCACATAATTGCAATCGGGAAGTTAATCAGAAAACAGGAAATTTTAAGTAGGAAAAAGAAGTCACAACCCTCAAAATATACTAATAGTGAGGGAGAAATTGTAACAGATTTAAGAACCCTGCATACGACCCTATCTGCCCCGGCAGAATCAGATAGCATTACAGAGGAGGAAAAAAGTTCGGCCTGTACACTCTCTTATATTTTAGAGGAGTTACCAATTCATTTAAGACCATGCCTTTTTCAGCATGATAATTACAAGAGAACGCCCTTGCATTATTCTTGCCAGTATGGCTTATCTGAAGTTACGAAGTTGATTATCAAGTTAATGAAAGAATGGAATATCTGGAATGAAATCCCTATTGATGACGTTTCCGCGTTCGGAGATGCCGAATCATTGACACCTTTACATTTATGTGTGTTGGGTGCTCATCCCAAAACAACAGAAGTCTTATTGCAATCTTTGGATCCGAACGTGAAATTAAAAAGTTCAAGTTTGTTACATTTGGCCACTGAGTGGAATAACTATCCCCTTTTACATGTTCTCCTATCATCAAAAAGGTTTGATATTAATTATCAAGACAACGAATTACATGAAACACCGCTATATCTTGCTTGTAGATTAAATTTTTTCGAAGCTGCTGTGTGTTTGTTGTACAATGGAGCCGACCTTGAAATAAGAGAAAAACTTTTTGGCTGGACAGCTATCTTCGTTGCAGCAGCAGAAGGGTTTACGGACATTGTAAAGCTCTTGATAGCCAACAACGCGAACTTTGATATTGAAGATGAAGGTGGGTGGACGCCGATGGAGCACGCGGTATTGCGCGGTCATTTGCACATTGCTGATATGGTTCAAATCAGAGACGAACTGGTCACGCATCCCCATTCACAGTTGAACAGTGGTAGCGAAGAGAAAGAACCACTAAACGAAATTAGTGCCGGAGAATTAAATGAGAGAAATGAAAATGGAAACGGAGGTAATAAAGGGTCCTTGGGAAAACTGGCCGGACCAATAAAGTCATATGGACACAGATTCCTGGATAATAATGAATCACTTATACTAATAACATTGGGAAGTAATGACACAAGAAACAAAAGCCCTTCAATTTCATTAAGCTCGGAAGCACTAGCAAAAGTTATTGGGTTGGAAACAGATTGTGCATTATCGTTAGTAATTTCATGCAATGATTCAATTGATAAATCTTCTGTAATCTTAGATTTACCATTAGATGATAATGTGGACGCAGTAGACTTCAAAGTGCCTTTCAAAGTTGATTATTCTCATACATTATATTTTGATATTGTGCCAACATATGGAACACGCTCGTTGGAGACCCATAATAGAATAGATTGTCAAAAAAATAACAATAATTACGTAATGGCAAGGGGTGTTTCCATGTTGAATAAGTCGTACAGCTCAGTGGGAGTTAATAGAAGTATATTAAATGGTAGCGTGACGGTCCCCATCATCGCTAATCATACACTGGAGATACTTGGGACGCTGAAATTTGAATATATTATTATCACACCATTTGAACATCCACAACTGCCCTTAGAAAGAACAGAAACGTACTGGAAATCCTTAGTGTCCACTCGTGTTATAGGACATAGAGGCCTGGGTAAAAATAATCCTAATAAATCATTACAAATTGGAGAGAACACAGTCGAGTCTTTCATCATGGCAGCCTCATTGGGAGCATCGTATGTAGAGTTTGATGTTCAGTTGACGAAGGATAACGTACCAGTGGTATATCACGATTTTCTCGTAGCTGAAACAGGTGTCGATATCCCCATGCATGAATTGACGCTGGAACAGTTTTTAGATTTGAACAATGCCGATAAAGAGCACATTCAACGTGGAGCAGGTCACTCACCTCATCATGTAAATGGAGCAGATACAGCACTACAAAAATATAGAGGGCGTTCGGTAGATGATTCAGACGTTAGTACATTGAGGAGAGCTTGGGATTTACACGACAACGACCCGAATGGGAAGTCCAACAATGCTCATTGGTCTGACAATCGAATGAGGCTAACCAAAACATTTAAAAAGAACAATTTTAAGGGAAACGCTAGAGGACATTCAATAGCTTCATCATTTGTTACCTTGAAAGAACTATTCAAGAAAATCCCTGCCAACGTTGGGTTTAACATAGAATGTAAGTTTCCCATGCTTGATGAGGCAGAAGAGGAAGAGTTAGGGCAAATAATGATGGAAATGAACCATTGGGTTGACACCGTGTTAAAAGTAGTTTTTGACAATGCGAATGGTAGGGACATCATTTTTTCGTCATTTCATCCGGATATTTGCATCATGCTTTCGTTAAAGCAACCGGTTATTCCGATCTTGTTCCTGACGGAAGGTGGAAGTGAACAGATGGCCGATTTGAGAGCCTCATCGTTACAAAACGGTATAAGATTTGCTAAGAAGTGGAATTTATTGGGGATTGTATCTGCTGCAGCACCCATTTTAAAGGCCCCACGGTTGGTGCAAGTGGTTAAGTCTAATGGGCTGGTATGTGTCACTTACGGTGTGGACAACAATGATCCCGAAAATGCCAGTATACAAATTGAAGCAGGTGTAGATGCCGTGATCGTCGATAGTGTATTGGCAATTAGACGTGGGTTAACCAAAAAGAATGAAAAGTAA","protein_sequence":"MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDINRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAESDSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLLHLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADMVQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSYGHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSIDKSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNNYVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDAVIVDSVLAIRRGLTKKNEK"},{"created_at":"2011-05-26T17:15:04.000Z","updated_at":"2011-05-26T17:15:04.000Z","name":"Probable glycerophosphodiester phosphodiesterase YPL206C","uniprot_id":"Q08959","uniprot_name":"YP206_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":321,"molecular_weight":"37069.39844","theoretical_pi":"8.93","general_function":"Involved in glycerophosphodiester phosphodiesterase activity","specific_function":"Probable glycerophosphocholine glycerophosphodiesterase which may be responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis","reactions":[{"id":1842,"direction":"\u003c\u003e","locations":"mitochondrion;lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2465,"direction":"\u003e","locations":"Cytoplasm;Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","altext":"A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"297-315","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","genbank_gene_id":"Z73562","genbank_protein_id":"1370428","gene_card_id":null,"chromosome_location":null,"locus":"YPL206C","synonyms":[],"enzyme_classes":["3.1.4.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" glycerophosphodiester phosphodiesterase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"},{"category":"Process","description":" lipid metabolic process"}],"pfams":[{"name":"GDPD","identifier":"PF03009"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGGTTGAAATTGTGGGCCACAGAGCTTTTAAAGCAAGATATCCTGAAAATACGCTACTAGCATTTGAGAAGGCTTATGCAGCAGGTGCTGATGTAATAGAAACGGATTTACAAATGACCAGCGATGGTATGGTGGTGGTAAACCATGACTCAGACACTGGTCGGATGTGGGATAAGAACTTGGTGATTGGCGAGTCGACTTGGGAGGAGGTTAAGCGATTGCGCTGCAAAGAGGATGGTTCCTTAGCAATGATGACATTGAAGGAAATTCTAACATGGGCAGTGTGCCATCCAGGAGCTAAATTGATGTTGGACATCAAATTTACCAACGAGAAAATCATCATGATCAAGACCTTTGTTATCATGTTAGAGGTTAAGAATGATCTTAAATTTTGGCAGGAGAGGATCACGTGGGGGCTTTGGTTGCTGGATTGGTACGATTTCGGTATTGAAACTGGTGTTCTGAAGGATTTCAAAGTTATTGTGATAAGTCTGTCTTTAGATATCGCCTCGCAATTTGTGAAGCGCTCTTTGACACTGAATGATCCTCACTATAAACTTTTTGGTATCAGCGTCCATTTTGTCTCCTCGTGGACAAGCCAATTTAGATTGAGATTACTACCTGTGCTTATGAAGAATGATATCAAGGTCTATTTATGGACTGTCAACAAACCTATAGATTTCAAATATCTGTGCGAATTGCCTATCCATGGTGCTATCACGGATGATCCGATCAAGGCAAGAAAGTTATGCGATGGTCATACCGTGGCGAAGAAGCCTACTGCTGAAAAAAAGTTTGTTGCGCCCAGTCTGGCATCTGTAGATGGGCTAAGATTCCATGCTTTTATCAAAGTTTATAACATCCTTTGCACGCTTCTATATTCCAAATGGGTCCATATTAAGTTGTGCGGTTGGTCTATTGCTTATGTGATTTTTTTGTTCCTTCGAACCATTCATTTTCTTTGA","protein_sequence":"MVEIVGHRAFKARYPENTLLAFEKAYAAGADVIETDLQMTSDGMVVVNHDSDTGRMWDKNLVIGESTWEEVKRLRCKEDGSLAMMTLKEILTWAVCHPGAKLMLDIKFTNEKIIMIKTFVIMLEVKNDLKFWQERITWGLWLLDWYDFGIETGVLKDFKVIVISLSLDIASQFVKRSLTLNDPHYKLFGISVHFVSSWTSQFRLRLLPVLMKNDIKVYLWTVNKPIDFKYLCELPIHGAITDDPIKARKLCDGHTVAKKPTAEKKFVAPSLASVDGLRFHAFIKVYNILCTLLYSKWVHIKLCGWSIAYVIFLFLRTIHFL"},{"created_at":"2011-05-27T05:19:19.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Phospholipase D1","uniprot_id":"P36126","uniprot_name":"SPO14_YEAST","enzyme":true,"transporter":false,"gene_name":"SPO14","num_residues":1683,"molecular_weight":"195202.0","theoretical_pi":"7.63","general_function":"Involved in protein binding","specific_function":"Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth","reactions":[{"id":1873,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2768,"direction":"\u003e","locations":null,"altext":"A phosphatidylcholine + H(2)O = choline + a phosphatidate.","export":false,"pw_reaction_id":null,"source":null},{"id":14802,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006997","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z28256","genbank_protein_id":"486463","gene_card_id":"SPO14","chromosome_location":"chromosome 11","locus":"YKR031C","synonyms":["PLD 1","Choline phosphatase 1","Meiosis-specific sporulation-specific protein 14","Phosphatidylcholine-hydrolyzing phospholipase D1"],"enzyme_classes":["3.1.4.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" lipid binding"},{"category":"Function","description":" phospholipid binding"},{"category":"Function","description":" phosphoinositide binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cell communication"}],"pfams":[{"name":"PLDc","identifier":"PF00614"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Choline metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTAACGTGTCAACAGCGTCTGGAACTCACTTCGCTCCACCTCAGGCAGATAGATCGGTGACTGAAGAAGTAGATAGAGTAAATTCGAGACCAGATGAGTTAGAAAACCAAGAAGTATTGCGGCAATTACCTGAGAATGGCAATCTGACTAGCAGTTTACAAAGAGAAAAACGAAGAACTCCCAACGGCAAGGAGGCGGAGAGGAAGCATGCATTGCCCAAATCCTTTGTAGATAGAAACCTGAGTGATGTGTCACCGAACCACTCATTAGACCATATTATGCACTCTAATGAACATGATCCTCGTCGAGGTTCTGATGAGGAAAATATGCACCGGCTCTACAACAATCTCCATAGCAGTAACAATAATGTTCATTCTAAGCGGAATTCTAAAAGAGAGGAAGAAAGAGCCCCTCAAAGGCGTTCTTCTTCTGTAGCTTACACCCAACAGCAGTTCAATGGCTGGAAGAAAGAGTTTGGCCACGCTTTTAAGAAAATCTCTGCTATTGGTAGACTGAAATCCAGCGTAAATTCTCCTACACCGGCTGGAAGCGGCCATCGTCATAACCAGCACCAGCATCAACAAGTAAACGAAGAAGATTTGTACACACAAAGACTAGCCTCTGATTTATTAGATTCGTTATTGGCAGGATGCCCGGCCTCATTGTTCGCAAGCACGCAATTTCTGAGAGACGAACATGGGAAGAGAAGGGCTCCTCTGCTATTAGCTAAACTAGATGTAAGAGTGTCTCCCTTGAAAAATGACAACAACATTTTGGATATTACCAATAGCAACCATAACCATCGTGGTAACAACAACAACAATACTGGCGAGAATTCTGATAGGAGACCCTCTATTCCAAGGAGCTCCAGCATTATAAGCATTTCTTCGAATGTGGCGGAATTTATGTATAGCAGGAACGAAAACTCTTTATTTAGAATACACTTGGAATATGGGATTGATGAAGACAGGCTCAAATGGTCTATTATAAGAAGTTATAAAGATATCAAATCACTACATCACAAATTGAAAATCGTCGCGTTCCAACAACTCACTATAAGCAAGCTTTATAGTGATAACAACAGATATCATTCGTTACAACTTCCGCATTTCCCCCATTATAAAGAAATGGTTAAAGAAAGAAATGTAATGGAGAAAAAAGCAGAAAATAAACCATCCTCTGCAGCCTCAGCTCCTCATACATCGGAAAATAACAATAACGATAATGGCAGCAACATTACATCGTTAGAAACTTTATCATCTTCTGAAATATCTGAGTTTAATATAGATAACGTCAAAATGAAACATTTACAAGACTTAATTGACGAACCTGACGATTTCTCCCAACCGATACATTTGAGGCTAGAAAGGTATTTGAGACTACTGAACATTGCATTATGTTTGAGACCTCATGCAAATAGATTGTTTGAATTTTACGAATTATCTCCCTTAGGCAATTTATTAAGTCGTGAAAGTGGGTTCCAGGGCAAACAGGGGTATTTAGTAATTAGATCTACTGCCAAGGCCCAAGGTTGGAGAGTTTCTCATTTTGGTAAACATGCGTTTAAAGACATGATCGACAGACATACTACCAAATGGTTCCTGGTAAGAAATTCTTACCTAACTTACGTGTCGGATCTTTCTTCGACAACTCCTTTAGACGTATTCTTAATAGATTGGAAATTTAAGGTTAGATTTTCTGGGAACAAGAATAACATACTTGATAACGAAAACGAGATCAACTGGATCATTCATGATCCCAATTTAGAAATAAATGACGAACTAGAAGAGTTCGGTATTGAAAATGATGCCAATAATATCCTAGACAAGAATGGAAAATCGAAAACACACCAAAAGAAGTCCAATATATCTTCAAAACTATTATTATTGACCCTAGAAAACAGTGAAAGGAAACTGAAAATTATTTGCAAATCAGAGAGTTCGTTAAAGCAATGGATGAGTTCAATTATCAAAATGTCTACCTCAACACCTTGGTCGAAACCAAATAGATTTGGTAGTTTCGCACCTGTAAGAACAAATTCGTTTTGCAAATTTTTGGTAGATGGGCGTGATTATTTTTGGTCGTTAAGCGAGGCCCTCTTAATGGCAAAGGATGTCATATATATCCATGATTGGTGGCTATCCCCTGAATTATACTTGCGACGTCCGGTGAAAGGCAACCAGGGATTTAGAATTGATCGTATGCTGAAAAGTTGTGCAGAAAAAGGTATCAAAATTTTTATTGTGATTTATAGGAATGTGGGGAATATTGTTGGGACAGATAGTCTTTGGACCAAGCATTCTATGCTAAATTTACATCCAAATATACATATCATAAGGTCTCCCAATCAATGGCTACAAAATACATATTTTTGGGCACACCACGAGAAGTTTGTCGTTATTGATGAAACATTTGCATTTATTGGTGGTACAGATTTATGTTATGGTAGATATGATACTTTTGAACACGTTCTACGAGATGATGCAGAATCTTTATTAGATCAAAATTTTCCTGGTAAGGATTATTCAAATGCCAGAATTGCTGATTTTCATGATTTAGATAAACCATTCGAATCAATGTATGATAGAAAAGTCATTCCGAGGATGCCATGGCATGATGTGCAAATGATGACTTTGGGTGAGCCAGCAAGAGACTTAGCCCGACATTTTGTTCAAAGATGGAATTACTTATTGAGAGCTAAGAGACCTAGTAGGTTAACTCCATTACTAACCCCGCCTTCAGATTTAACTGCTGAAGAATTGAAGAGTTTGCCGATGTTCGAAATTCTACGCGAAAAATCGACTTGTGAAACTCAAATACTTAGAAGTGCTGGGAACTGGTCTCTTGGGCTAAAGGAAACGGAATGCTCAATTCAAAATGCTTACCTGAAGTTAATTGAACAAAGTGAACACTTTATTTATATTGAGAATCAATTCTTCATTACATCAACTGTCTGGAACGGGACTTGCGTTTTGAATAAAATTGGTGATGCTCTCGTTGATAGGATAGTCAAAGCTAATCAGGAGAAAAAACCTTGGAAAGCCTTTATTCTTATCCCACTAATGCCAGGATTCGATTCTCCAGTAGATACTGCAGAAGCCTCAAGTCTTCGTTTAATTATGCAATTCCAATATCAATCAATTTCAAGAGGTGAACATTCTACATTTAGTAAACTGAAGAAACTAAATATTGACCCAGCTCAATATATTCAGTTCTTTTCACTAAGAAAATGGTCGACTTTTGCGCCTAATGAAAGATTAATCACCGAGCAGCTCTACGTTCATGCTAAAATTCTGATTGCTGATGACAGAAGATGTATTATAGGGTCTGCTAATATTAACGAAAGATCACAACTGGGTAATAGAGATAGTGAGGTGGCAATTCTTATTAGAGACACCGACTTGATAAAGACCAAAATGAATGGTGACGATTACTACGCGGGAAAATTTCCTTGGGAATTAAGGCAGCGATTAATGAGGGAACATTTAGGTTGTGATGTAGATCTTGTTGAGTTTGTTGAAAAGAAATTTGAAAGGTTTGAAAAGTTTGCTGCAAAGAATTATGAAAAACTTCATACCCTAAGTAAGGAGGGAGATAGTGGTAACAATTGGAGCGATCGAGAAATGATCGATTCCGCTATGATTGAGCTAGGTTATCGTGAAATATTTGGTTGTAAATTTAGCCCTCAATGGAAGAGTGGTCATGGAAACAGTGTTGATGATGGAAGCACTCAGTGTGGCATAAATGAAAAAGAAGTGGGAAGAGAAGATGAAAACGTTTATGAAAAATTCTTCAATTCTGTGGACTACGGTAAATCATCACGTAAGAGAACGCCTCTGCCCAAACATAATTTTGCATCTTTAGGGCTAACATTCAACCACAGGGCAGGAATTGAAAATGTCGGTATACGAGACCACAAAGTCTTAAGTACTGATCCAAGATTAAGAAAGAATGATGAACATAAAAAAGAGGTTGATGGCTACGGTCCCGATTGTTGGAAAAAGGAATCCAACAAAAAATTCAAGGCCGATGCAACTGAACAGCTAAAGGAGTGGGCATTGAACTCATTGGCCTCGAAAGTTCTTGACGATAAAGAAATGATAAAATCAGAAATTCCAGAAGGATTTTCAAATTATTTGCCCAATGAGAAAGATCTAGAAATGTATCTCACGGATAAAACTGTTACCAATAGAAACAAATGGAGTATGCTCAAAAGGATATGCTACTTGCAATATTTATCTCATAAACTCGACGAAAGAAAAACACAGAGATTGAAGAAAATCAAAGATATGAGAAGACATTTAAGTTCAAGCACAGAAAGTACCAGAAATGGGTCTAATAGTCTGCCATTAAACGAAAAGAGCAATGAAGGAGAAAGCACTAATGTCGACCAAGATATCGAAGGCGATGAATATCATAGATTGCACGAAGATATTTTGAAAAATCAAGAACTAGATGATGGTTCACTGGACGATCTACTTTCTCAGATAATTCCTAAGATCACTAACTTTAACAGTGGTGAAATTGATGACGCAAAAAAAGAAGAGTTATTGAAACTCAACTTCATTGACCCGTATTCCTTCGAGGATCCTCTTATTTCTTCGTTTTCTGAAGGGCTATGGTTCACTATAGCCTTGAGAAATACATTACTCTATAAATTAGTGTTTCATTGTCAACCCGATAATGCTGTACAAAATTGGAAAGAATATGGAGAATTTACTGAATTAGAACAAGAATTTCAAATAAACCAGGAAAAGTTGATTGACTTAGAGGCTGAAAATATTAATTCTACTACTACAAATGTTGTAGATAAGGATAGGGAAAAGGAAAAAATGAGAAAAGCCGCTGAATTGAGAATGAAGTTATCCGGTAGTTTGCTTTATGGATTCAATCAAAAGGTTTTTGACAAACATACGGCGCAGAGAATCTTGGAAAGGATCCACGGTCATTTGGTCATTTTCCCAACCGAATGGTTAGCTAAAGAAGTTGAGAGTAGAAATTGGATTTTTAACTCGGATAGACTTTCTCCAATGGAAATCTACAATTAA","protein_sequence":"MSNVSTASGTHFAPPQADRSVTEEVDRVNSRPDELENQEVLRQLPENGNLTSSLQREKRRTPNGKEAERKHALPKSFVDRNLSDVSPNHSLDHIMHSNEHDPRRGSDEENMHRLYNNLHSSNNNVHSKRNSKREEERAPQRRSSSVAYTQQQFNGWKKEFGHAFKKISAIGRLKSSVNSPTPAGSGHRHNQHQHQQVNEEDLYTQRLASDLLDSLLAGCPASLFASTQFLRDEHGKRRAPLLLAKLDVRVSPLKNDNNILDITNSNHNHRGNNNNNTGENSDRRPSIPRSSSIISISSNVAEFMYSRNENSLFRIHLEYGIDEDRLKWSIIRSYKDIKSLHHKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSENNNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYLRLLNIALCLRPHANRLFEFYELSPLGNLLSRESGFQGKQGYLVIRSTAKAQGWRVSHFGKHAFKDMIDRHTTKWFLVRNSYLTYVSDLSSTTPLDVFLIDWKFKVRFSGNKNNILDNENEINWIIHDPNLEINDELEEFGIENDANNILDKNGKSKTHQKKSNISSKLLLLTLENSERKLKIICKSESSLKQWMSSIIKMSTSTPWSKPNRFGSFAPVRTNSFCKFLVDGRDYFWSLSEALLMAKDVIYIHDWWLSPELYLRRPVKGNQGFRIDRMLKSCAEKGIKIFIVIYRNVGNIVGTDSLWTKHSMLNLHPNIHIIRSPNQWLQNTYFWAHHEKFVVIDETFAFIGGTDLCYGRYDTFEHVLRDDAESLLDQNFPGKDYSNARIADFHDLDKPFESMYDRKVIPRMPWHDVQMMTLGEPARDLARHFVQRWNYLLRAKRPSRLTPLLTPPSDLTAEELKSLPMFEILREKSTCETQILRSAGNWSLGLKETECSIQNAYLKLIEQSEHFIYIENQFFITSTVWNGTCVLNKIGDALVDRIVKANQEKKPWKAFILIPLMPGFDSPVDTAEASSLRLIMQFQYQSISRGEHSTFSKLKKLNIDPAQYIQFFSLRKWSTFAPNERLITEQLYVHAKILIADDRRCIIGSANINERSQLGNRDSEVAILIRDTDLIKTKMNGDDYYAGKFPWELRQRLMREHLGCDVDLVEFVEKKFERFEKFAAKNYEKLHTLSKEGDSGNNWSDREMIDSAMIELGYREIFGCKFSPQWKSGHGNSVDDGSTQCGINEKEVGREDENVYEKFFNSVDYGKSSRKRTPLPKHNFASLGLTFNHRAGIENVGIRDHKVLSTDPRLRKNDEHKKEVDGYGPDCWKKESNKKFKADATEQLKEWALNSLASKVLDDKEMIKSEIPEGFSNYLPNEKDLEMYLTDKTVTNRNKWSMLKRICYLQYLSHKLDERKTQRLKKIKDMRRHLSSSTESTRNGSNSLPLNEKSNEGESTNVDQDIEGDEYHRLHEDILKNQELDDGSLDDLLSQIIPKITNFNSGEIDDAKKEELLKLNFIDPYSFEDPLISSFSEGLWFTIALRNTLLYKLVFHCQPDNAVQNWKEYGEFTELEQEFQINQEKLIDLEAENINSTTTNVVDKDREKEKMRKAAELRMKLSGSLLYGFNQKVFDKHTAQRILERIHGHLVIFPTEWLAKEVESRNWIFNSDRLSPMEIYN"},{"created_at":"2011-05-27T05:19:55.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Choline transport protein","uniprot_id":"P19807","uniprot_name":"HNM1_YEAST","enzyme":false,"transporter":true,"gene_name":"HNM1","num_residues":563,"molecular_weight":"62055.39844","theoretical_pi":"6.85","general_function":"Involved in transport","specific_function":"Sole choline transporter in yeast","reactions":[],"signal_regions":"None","transmembrane_regions":"58-78;88-108;183-203;206-226;256-276;294-314;343-363;399-417;427-445;466-486;492-512","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723806","genbank_protein_id":"51830315","gene_card_id":"HNM1","chromosome_location":"chromosome 7","locus":"YGL077C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTATACGGAATGATAATGCTTCCGGTGGCTATATGCAGCCGGATCAATCTTCGAACGCTTCTATGCACAAAAGAGACTTAAGAGTTGAGGAGGAAATAAAGCCATTGGATGATATGGATAGCAAGGGTGCTGTAGCAGCAGATGGTGAAGTTCATCTAAGAAAGTCATTTTCGTTGTGGTCAATTCTTGGTGTTGGATTCGGTTTGACTAATTCCTGGTTCGGTATTTCTACATCGATGGTTGCAGGTATATCTTCTGGTGGACCCATGATGATTGTTTACGGTATAATTATTGTTGCCCTGATTTCTATTTGCATTGGTACCTCGTTGGGTGAATTATCTTCCGCATATCCGCACGCCGGTGGTCAGTTTTGGTGGTCTTTGAAGCTTGCCCCTCCTAAGTACAAAAGATTTGCGGCCTACATGTGCGGTTCATTTGCTTACGCAGGATCCGTGTTCACAAGTGCTTCAACTACGTTATCCGTTGCTACCGAAGTGGTTGGTATGTACGCTCTGACGCACCCTGAATTCATCCCAAAGAGATGGCATATATTCGTTTGCTTTGAATTGTTGCATTTGTTCTTGATGTTTTTCAACTGTTACGGTAAATCCTTACCTATCATTTCATCTTCCTCTCTATACATTTCCCTACTATCCTTTTTCACAATTACAATTACTGTATTGGCATGTTCTCATGGAAAGTTCAACGATGCAAAGTTTGTTTTTGCCACATTTAATAATGAAACAGGTTGGAAGAACGGCGGTATCGCCTTTATTGTCGGTTTGATTAACCCAGCTTGGTCATTTTCGTGCCTTGACTGTGCAACCCATATGGCGTTTGAAGTTGAAAAACCAGAAAGAGTTATTCCCATTGCTATCATGGGAACAGTCGCCATTGGGTTTGTCACTTCCTTTTGTTATGTTATCGCTATGTTCTTCTCTATACAAGATCTGGACGCTGTCTTGTCTTCTACAACAGGCGCCCCAATCTTGGACATTTATAATCAGGCATTGGGTAATAAATCAGGTGCGATTTTCCTGGGTTGCTTGATTCTATTTACCTCTTTTGGTTGCGTCATTGCTTGTCACACTTGGCAGGCAAGGTTATGTTGGTCATTTGCCAGGGACAATGGTCTTCCATTATCCCGTTTATGGTCGCAAGTTAACCCACACACTGGTGTACCTTTGAACGCTCATTTAATGTCATGCGCTTGGATAACCCTCATTGGCCTACTTTATTTGGCTTCCAGTACGGCTTTTCAGTCCTTAATTACAGGTTGTATTGCATTTTTATTGTTATCCTACATCATTCCGGTTATATGTTTACTTGCTAAAAAGCGTAACATAGCTCATGGTCCATTCTGGCTTGGAAAATTTGGATTTTTTTCAAACATTGTTCTTTTGGGTTGGACTGTCTTTTCTGTGGTCTTTTTTTCCTTTCCACCAGTTTTACCTGTGACAAAGGATAACATGAACTATGTTTGTGTAGTTATTGTTGGTTATACTGCGTATTCGATTCTTTACTGGAAATACAAGGGTAAGAAGGAATTCCACGCTTTAGAAGAATCTGAGAACGAACAGGCTGAATATAGTAATAACTTCGATACCATTGAAGATAGTCGAGAATTTTCCGTTGCGGCCTCTGACGTTGAACTCGAAAATGAACACGTACCGTGGGGAAAGAAGTGA","protein_sequence":"MSIRNDNASGGYMQPDQSSNASMHKRDLRVEEEIKPLDDMDSKGAVAADGEVHLRKSFSLWSILGVGFGLTNSWFGISTSMVAGISSGGPMMIVYGIIIVALISICIGTSLGELSSAYPHAGGQFWWSLKLAPPKYKRFAAYMCGSFAYAGSVFTSASTTLSVATEVVGMYALTHPEFIPKRWHIFVCFELLHLFLMFFNCYGKSLPIISSSSLYISLLSFFTITITVLACSHGKFNDAKFVFATFNNETGWKNGGIAFIVGLINPAWSFSCLDCATHMAFEVEKPERVIPIAIMGTVAIGFVTSFCYVIAMFFSIQDLDAVLSSTTGAPILDIYNQALGNKSGAIFLGCLILFTSFGCVIACHTWQARLCWSFARDNGLPLSRLWSQVNPHTGVPLNAHLMSCAWITLIGLLYLASSTAFQSLITGCIAFLLLSYIIPVICLLAKKRNIAHGPFWLGKFGFFSNIVLLGWTVFSVVFFSFPPVLPVTKDNMNYVCVVIVGYTAYSILYWKYKGKKEFHALEESENEQAEYSNNFDTIEDSREFSVAASDVELENEHVPWGKK"}]}