{"ymdb_id":"YMDB00309","created_at":"2011-05-29T18:04:45.000Z","updated_at":"2016-09-08T18:35:19.000Z","name":"Glycerophosphocholine","cas":"28319-77-9","state":"Solid","melting_point":"142.5 oC","description":"Glycerophosphorylcholine (GPC) is a choline derivative and one of the two major forms of choline storage (along with phosphocholine) in the cytosol.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;extracellular;cell envelope;endoplasmic reticulum;cytoplasm","synthesis_reference":"Evans, Christopher Thomas; McCague, Raymond; Tyrrell, Nicholas David.  Preparation of phospholipid-intermediate glycerophosphocholine by a crystallization process.    PCT Int. Appl.  (1993),     8 pp.","chebi_id":"16870","hmdb_id":"HMDB00086","kegg_id":"C00670","pubchem_id":"439285","cs_id":"64931","foodb_id":null,"wikipedia_link":"Glycerophosphocholine","biocyc_id":"GLYCERYLPHOSPHORYLCHOLINE","iupac":"(2-{[(2S)-2,3-dihydroxypropyl phosphonato]oxy}ethyl)trimethylazanium","traditional_iupac":"Alpha-GPC","logp":"-5.728311425471745","pka":"13.641245557329462","alogps_solubility":"8.96e+00 g/l","alogps_logp":"-2.56","alogps_logs":"-1.54","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"8","polar_surface_area":"99.05000000000001","refractivity":"68.68230000000001","polarizability":"24.420859371997068","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.9689647678822215","pka_strongest_acidic":"1.8553451472945346","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt","a-Glycerophosphorylcholine","a-Glycerylphosphorylcholine","alpha-Glycerophosphorylcholine","alpha-Glycerylphosphorylcholine","Choline Alfoscerate","Choline glycerophosphate","Glycerol 3-phosphocholine","Glycerol phosphorylcholine","Glycerol-3-phosphatidylcholine","Glycerophosphatidylcholine","Glycerophosphocholine","Glycerophosphorylcholine","GPC","GPCho","hydrogen glycerophosphate Choline","L-alpha-Glycerophosphocholine","L-alpha-Glycerophosphorylcholine","L-alpha-Glycerylphosphorylcholine","L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphate inner salt","sn-Glycero-3-phosphocholine"],"pathways":[{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."}],"proteins":[{"created_at":"2011-05-26T17:13:10.000Z","updated_at":"2011-05-29T05:06:20.000Z","name":"Glycerophosphodiester phosphodiesterase GDE1","uniprot_id":"Q02979","uniprot_name":"GDE1_YEAST","enzyme":true,"transporter":false,"gene_name":"GDE1","num_residues":1223,"molecular_weight":"138013.0","theoretical_pi":"6.77","general_function":"Involved in protein binding","specific_function":"Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source","reactions":[{"id":1594,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2465,"direction":"\u003e","locations":"Cytoplasm;Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","altext":"A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14811,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006999","source":"Smpdb"},{"id":14812,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007170","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U43503","genbank_protein_id":"1163103","gene_card_id":"GDE1","chromosome_location":"chromosome 16","locus":"YPL110C","synonyms":[],"enzyme_classes":["3.1.4.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" phospholipase activity"},{"category":"Function","description":" phospholipase C activity"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" glycerophosphodiester phosphodiesterase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" intracellular signaling pathway"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"}],"pfams":[{"name":"GDPD","identifier":"PF03009"},{"name":"SPX","identifier":"PF03105"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGAAGTTCGGAAAAACCTTTGCCAATCATCGCATTCCAGAGTGGTCAAGTCAATATGTTGGCTACAAGTCGTTGAAGAAAATGATTAAAGAAATTACAAGACTTCAAGAAGACATATATAGGGCACATAACAAGAATAGCTATGATGAAGGCAGGCCACCAACAAAAATGAGAGATTCATCTAATAGTGCTCAAAATTATTTGGACTCTCCAAAAATCCAAAAGTTATTGGCGTCGTTTTTCTTTGCAGTTGACAGGGATATTGAGAAGGTTGATACATTTTACAATTCCCAGTATGCGGAATATAAGAAAAGATTTGAGAGATTGCTTTCTTCTAATCAATTCAATGAGATAAAATCAACATTAGTGGTCGATGCCAACAAAGAAGATGCAGTAGCGCAAACCTTACTCACAAAGGATACGAGAGAGATGAATATGCTTTTAAAGGGAACAAGTCAAGCCAGCCGTCTATCTTACCATAAAGATGACTTAATTGAAATTCAGTCTATCTTAGCTGAGTTAAGAAAACAATTTAGAAACTTAAAGTGGTACGCTGAACTAAATAAGAGAGCTTTTGGTAAGATTTTAAAGAAACTGGATAAAAAAGTCGGCACAAATCAGCAAATGTCAACTATGAAAACTAGAATCTTGCCGTTACAATTTGCTAATGATTCTCTTATTACCAAAGATTTGAGTTTGCTAAAAACTATCTGGGAACAAGTGACGTTCAGGATAAATTCTTACGAGAGAGTAATGAGGAGTACCTCGCCGAACGCAAATGCTAATGATAATACAGAATTCTTTAAGATTATTTGCGTTTTTATAGAAGAAGATGATAGCAAAGGATTGATTAGAGAGCTAACAAACCTATATTCGGAATTGTCTTTGATTCCAACAAGAATTATGATAAGTGTTTTAAACAAGGCAGCACTGTCTAAATCACTGGCATGTATTGATGCTATCTTAAAGGTTATTCCGTCTCTAAATGACTCGGAAGATATTAACAGAAGAAATTTTTTCCATCATCACATAATTGCAATCGGGAAGTTAATCAGAAAACAGGAAATTTTAAGTAGGAAAAAGAAGTCACAACCCTCAAAATATACTAATAGTGAGGGAGAAATTGTAACAGATTTAAGAACCCTGCATACGACCCTATCTGCCCCGGCAGAATCAGATAGCATTACAGAGGAGGAAAAAAGTTCGGCCTGTACACTCTCTTATATTTTAGAGGAGTTACCAATTCATTTAAGACCATGCCTTTTTCAGCATGATAATTACAAGAGAACGCCCTTGCATTATTCTTGCCAGTATGGCTTATCTGAAGTTACGAAGTTGATTATCAAGTTAATGAAAGAATGGAATATCTGGAATGAAATCCCTATTGATGACGTTTCCGCGTTCGGAGATGCCGAATCATTGACACCTTTACATTTATGTGTGTTGGGTGCTCATCCCAAAACAACAGAAGTCTTATTGCAATCTTTGGATCCGAACGTGAAATTAAAAAGTTCAAGTTTGTTACATTTGGCCACTGAGTGGAATAACTATCCCCTTTTACATGTTCTCCTATCATCAAAAAGGTTTGATATTAATTATCAAGACAACGAATTACATGAAACACCGCTATATCTTGCTTGTAGATTAAATTTTTTCGAAGCTGCTGTGTGTTTGTTGTACAATGGAGCCGACCTTGAAATAAGAGAAAAACTTTTTGGCTGGACAGCTATCTTCGTTGCAGCAGCAGAAGGGTTTACGGACATTGTAAAGCTCTTGATAGCCAACAACGCGAACTTTGATATTGAAGATGAAGGTGGGTGGACGCCGATGGAGCACGCGGTATTGCGCGGTCATTTGCACATTGCTGATATGGTTCAAATCAGAGACGAACTGGTCACGCATCCCCATTCACAGTTGAACAGTGGTAGCGAAGAGAAAGAACCACTAAACGAAATTAGTGCCGGAGAATTAAATGAGAGAAATGAAAATGGAAACGGAGGTAATAAAGGGTCCTTGGGAAAACTGGCCGGACCAATAAAGTCATATGGACACAGATTCCTGGATAATAATGAATCACTTATACTAATAACATTGGGAAGTAATGACACAAGAAACAAAAGCCCTTCAATTTCATTAAGCTCGGAAGCACTAGCAAAAGTTATTGGGTTGGAAACAGATTGTGCATTATCGTTAGTAATTTCATGCAATGATTCAATTGATAAATCTTCTGTAATCTTAGATTTACCATTAGATGATAATGTGGACGCAGTAGACTTCAAAGTGCCTTTCAAAGTTGATTATTCTCATACATTATATTTTGATATTGTGCCAACATATGGAACACGCTCGTTGGAGACCCATAATAGAATAGATTGTCAAAAAAATAACAATAATTACGTAATGGCAAGGGGTGTTTCCATGTTGAATAAGTCGTACAGCTCAGTGGGAGTTAATAGAAGTATATTAAATGGTAGCGTGACGGTCCCCATCATCGCTAATCATACACTGGAGATACTTGGGACGCTGAAATTTGAATATATTATTATCACACCATTTGAACATCCACAACTGCCCTTAGAAAGAACAGAAACGTACTGGAAATCCTTAGTGTCCACTCGTGTTATAGGACATAGAGGCCTGGGTAAAAATAATCCTAATAAATCATTACAAATTGGAGAGAACACAGTCGAGTCTTTCATCATGGCAGCCTCATTGGGAGCATCGTATGTAGAGTTTGATGTTCAGTTGACGAAGGATAACGTACCAGTGGTATATCACGATTTTCTCGTAGCTGAAACAGGTGTCGATATCCCCATGCATGAATTGACGCTGGAACAGTTTTTAGATTTGAACAATGCCGATAAAGAGCACATTCAACGTGGAGCAGGTCACTCACCTCATCATGTAAATGGAGCAGATACAGCACTACAAAAATATAGAGGGCGTTCGGTAGATGATTCAGACGTTAGTACATTGAGGAGAGCTTGGGATTTACACGACAACGACCCGAATGGGAAGTCCAACAATGCTCATTGGTCTGACAATCGAATGAGGCTAACCAAAACATTTAAAAAGAACAATTTTAAGGGAAACGCTAGAGGACATTCAATAGCTTCATCATTTGTTACCTTGAAAGAACTATTCAAGAAAATCCCTGCCAACGTTGGGTTTAACATAGAATGTAAGTTTCCCATGCTTGATGAGGCAGAAGAGGAAGAGTTAGGGCAAATAATGATGGAAATGAACCATTGGGTTGACACCGTGTTAAAAGTAGTTTTTGACAATGCGAATGGTAGGGACATCATTTTTTCGTCATTTCATCCGGATATTTGCATCATGCTTTCGTTAAAGCAACCGGTTATTCCGATCTTGTTCCTGACGGAAGGTGGAAGTGAACAGATGGCCGATTTGAGAGCCTCATCGTTACAAAACGGTATAAGATTTGCTAAGAAGTGGAATTTATTGGGGATTGTATCTGCTGCAGCACCCATTTTAAAGGCCCCACGGTTGGTGCAAGTGGTTAAGTCTAATGGGCTGGTATGTGTCACTTACGGTGTGGACAACAATGATCCCGAAAATGCCAGTATACAAATTGAAGCAGGTGTAGATGCCGTGATCGTCGATAGTGTATTGGCAATTAGACGTGGGTTAACCAAAAAGAATGAAAAGTAA","protein_sequence":"MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDINRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAESDSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLLHLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADMVQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSYGHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSIDKSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNNYVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDAVIVDSVLAIRRGLTKKNEK"},{"created_at":"2011-05-26T17:15:04.000Z","updated_at":"2011-05-26T17:15:04.000Z","name":"Probable glycerophosphodiester phosphodiesterase YPL206C","uniprot_id":"Q08959","uniprot_name":"YP206_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":321,"molecular_weight":"37069.39844","theoretical_pi":"8.93","general_function":"Involved in glycerophosphodiester phosphodiesterase activity","specific_function":"Probable glycerophosphocholine glycerophosphodiesterase which may be responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis","reactions":[{"id":1842,"direction":"\u003c\u003e","locations":"mitochondrion;lipid particle","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2465,"direction":"\u003e","locations":"Cytoplasm;Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","altext":"A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"297-315","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential).","genbank_gene_id":"Z73562","genbank_protein_id":"1370428","gene_card_id":null,"chromosome_location":null,"locus":"YPL206C","synonyms":[],"enzyme_classes":["3.1.4.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" glycerophosphodiester phosphodiesterase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"}],"pfams":[{"name":"GDPD","identifier":"PF03009"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGGTTGAAATTGTGGGCCACAGAGCTTTTAAAGCAAGATATCCTGAAAATACGCTACTAGCATTTGAGAAGGCTTATGCAGCAGGTGCTGATGTAATAGAAACGGATTTACAAATGACCAGCGATGGTATGGTGGTGGTAAACCATGACTCAGACACTGGTCGGATGTGGGATAAGAACTTGGTGATTGGCGAGTCGACTTGGGAGGAGGTTAAGCGATTGCGCTGCAAAGAGGATGGTTCCTTAGCAATGATGACATTGAAGGAAATTCTAACATGGGCAGTGTGCCATCCAGGAGCTAAATTGATGTTGGACATCAAATTTACCAACGAGAAAATCATCATGATCAAGACCTTTGTTATCATGTTAGAGGTTAAGAATGATCTTAAATTTTGGCAGGAGAGGATCACGTGGGGGCTTTGGTTGCTGGATTGGTACGATTTCGGTATTGAAACTGGTGTTCTGAAGGATTTCAAAGTTATTGTGATAAGTCTGTCTTTAGATATCGCCTCGCAATTTGTGAAGCGCTCTTTGACACTGAATGATCCTCACTATAAACTTTTTGGTATCAGCGTCCATTTTGTCTCCTCGTGGACAAGCCAATTTAGATTGAGATTACTACCTGTGCTTATGAAGAATGATATCAAGGTCTATTTATGGACTGTCAACAAACCTATAGATTTCAAATATCTGTGCGAATTGCCTATCCATGGTGCTATCACGGATGATCCGATCAAGGCAAGAAAGTTATGCGATGGTCATACCGTGGCGAAGAAGCCTACTGCTGAAAAAAAGTTTGTTGCGCCCAGTCTGGCATCTGTAGATGGGCTAAGATTCCATGCTTTTATCAAAGTTTATAACATCCTTTGCACGCTTCTATATTCCAAATGGGTCCATATTAAGTTGTGCGGTTGGTCTATTGCTTATGTGATTTTTTTGTTCCTTCGAACCATTCATTTTCTTTGA","protein_sequence":"MVEIVGHRAFKARYPENTLLAFEKAYAAGADVIETDLQMTSDGMVVVNHDSDTGRMWDKNLVIGESTWEEVKRLRCKEDGSLAMMTLKEILTWAVCHPGAKLMLDIKFTNEKIIMIKTFVIMLEVKNDLKFWQERITWGLWLLDWYDFGIETGVLKDFKVIVISLSLDIASQFVKRSLTLNDPHYKLFGISVHFVSSWTSQFRLRLLPVLMKNDIKVYLWTVNKPIDFKYLCELPIHGAITDDPIKARKLCDGHTVAKKPTAEKKFVAPSLASVDGLRFHAFIKVYNILCTLLYSKWVHIKLCGWSIAYVIFLFLRTIHFL"},{"created_at":"2011-05-27T06:40:43.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Lysophospholipase 3","uniprot_id":"Q08108","uniprot_name":"PLB3_YEAST","enzyme":true,"transporter":false,"gene_name":"PLB3","num_residues":686,"molecular_weight":"75076.20313","theoretical_pi":"4.63","general_function":"Involved in metabolic process","specific_function":"Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine \u003e phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate","reactions":[{"id":1869,"direction":"\u003c\u003e","locations":"extracellular;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2793,"direction":"\u003e","locations":" Lipid-anchor, GPI-anchor (Potential); Lipid-anchor, GPI-anchor.;Endoplasmic reticulum membrane;Cell membrane; Multi-pass membrane protein;Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor (Probable)","altext":"2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-26","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Lipid-anchor, GPI-anchor (Potential)","genbank_gene_id":"Z74753","genbank_protein_id":"1419781","gene_card_id":"PLB3","chromosome_location":"chromosome 15","locus":"YOL011W","synonyms":["Phospholipase B 3"],"enzyme_classes":["3.1.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" phospholipase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid catabolic process"}],"pfams":[{"name":"PLA2_B","identifier":"PF01735"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGATACGTCCATTATGTTCAAAAATTATTATCAGTTACATATTCGCAATTTCTCAGTTTCTACTGGCCGCTAATGCGTGGTCGCCCACAGATAGTTATGTTCCTGGCACCGTGTCGTGTCCCGATGACATAAATCTGGTAAGAGAGGCTACGTCTATATCTCAGAATGAGAGCGCATGGTTGGAAAAGAGGAATAAAGTCACTAGTGTAGCTTTAAAAGATTTCTTGACTAGGGCTACTGCAAATTTTTCAGATAGCTCAGAAGTTTTGTCGAAGCTATTTAATGATGGCAACAGCGAAAACCTGCCGAAAATTGCTGTCGCCGTTTCAGGTGGGGGCTATCGGTCCATGCTAACAGGTGCGGGTGTTCTAGCAGCAATGGATAACAGAACTGAAGGTGCTTATGAGCATGGGCTGGGTGGACTTTTACAAAGCACAACATATTTATCTGGTGCCTCGGGCGGCAACTGGCTAGTTGGTACATTAGCCTTGAACAATTGGACATCCGTGCAAGACATTCTTAATAATATGCAGAACGACGATTCTATTTGGGATTTGTCAGATTCTATTGTTACCCCCGGCGGCATTAATATATTCAAAACAGCCAAAAGGTGGGATCATATCTCTAATGCTGTCGAATCTAAGCAGAACGCCGATTACAATACTTCTTTGGCCGATATTTGGGGCAGAGCCTTGGCGTATAATTTTTTCCCTTCTCTAAATAGAGGGGGTATAGGCCTGACTTGGTCTTCCATTAGGGATTTCCCAGTGTTTCAAAATGCTGAAATGCCTTTTCCAATTTCTGTTGCGGACGGTAGGTATCCTGGAACAAAAGTCATCAATTTGAACGCAACGGTTTTTGAATTTAATCCCTTTGAAATGGGATCCTGGGATCCCTCTTTGAACTCTTTTGCCAACGTTAAGTACCTTGGAACGAATGTCTCCAATGGTGTACCATTGGAAAGGGGAAAATGTACCGCAGGCTTTGATAATGCAGGTTTTATCATGGGTACTTCCTCCACCTTATTTAACCAGTTTCTTTTGAGAATAAACTCCACTCACTTACCTAGTTTCATCACAAGATTAGCAAGACATTTTCTAAAGGATTTATCTCAAGATTTTAATGATATCGCTGTTTACAGTCCTAATCCATTTAAAGACACGAAGTTTTTGGATAGTGACTATACGACAAGTATTGTTGATTCAGACAGCCTATTCTTAGTTGACGGCGGTGAAGACGACGAAAATGTTCCTGTGTTACCGCTTATACAAAAGGAACGTGATGTGGACATTATTTTTGCGGTAGATAATTCTGCCGATATGAGATTGGCTTGGCCTGACGGTTCTTCTTTAGTCCATACCTATGAGCGTCAATTCGTTAAGCAAGGTCAAGGTATGTCCTTCCCATATGTTCCAGATACGAATACATTCGTTAATTTGGGTTTGAACAAGAAACCAACCTTCTTCGGTTGCGATGCTAATAATTTGACCGATCTTCAATATATTCCACCTCTAGTTGTTTATCTGCCAAATGCAGAATACTCTTTCAATAGTAATCAGAGCGCGTTCAAGCTATCATATTCCGAATCCCAAAGAAGAAGTATGATTCAAAACGGGTTTGAAATTGCAACTAGGAACAACTTCACTGATGATCCTGAATTCATGGGCTGCGTCGGCTGCGCCATCATTAGACGTAAGCAACAAGCTTTGAATATTACTTTGCCTCCGGAATGTGAAACCTGTTTTAAAAATTATTGCTGGAATGGTACCCTGGATACTACCCCATTACCAGATGTTGAAAAGGATGTTCACCACTCCTTTATCAACGTCAATAGCTTCAACAGCTCCATAGGACAAGAAGAAAGTCTTTACGCCGGATCTTCAGCTTCCCAGTCATCGTCTTCATCATCGTCTTCATCTTCGTCTTCGGAAATTCCTTCGGCTACTGCAACCCTTGAGAAAAAGGCAGCTACTAATTCTGGATCACATTTATCTGGCATAAGTGTAAAGTTCTCTGCTATGATTATGCTTACTTTATTGATGTTTACCGGAGCAGTATAA","protein_sequence":"MIRPLCSKIIISYIFAISQFLLAANAWSPTDSYVPGTVSCPDDINLVREATSISQNESAWLEKRNKVTSVALKDFLTRATANFSDSSEVLSKLFNDGNSENLPKIAVAVSGGGYRSMLTGAGVLAAMDNRTEGAYEHGLGGLLQSTTYLSGASGGNWLVGTLALNNWTSVQDILNNMQNDDSIWDLSDSIVTPGGINIFKTAKRWDHISNAVESKQNADYNTSLADIWGRALAYNFFPSLNRGGIGLTWSSIRDFPVFQNAEMPFPISVADGRYPGTKVINLNATVFEFNPFEMGSWDPSLNSFANVKYLGTNVSNGVPLERGKCTAGFDNAGFIMGTSSTLFNQFLLRINSTHLPSFITRLARHFLKDLSQDFNDIAVYSPNPFKDTKFLDSDYTTSIVDSDSLFLVDGGEDDENVPVLPLIQKERDVDIIFAVDNSADMRLAWPDGSSLVHTYERQFVKQGQGMSFPYVPDTNTFVNLGLNKKPTFFGCDANNLTDLQYIPPLVVYLPNAEYSFNSNQSAFKLSYSESQRRSMIQNGFEIATRNNFTDDPEFMGCVGCAIIRRKQQALNITLPPECETCFKNYCWNGTLDTTPLPDVEKDVHHSFINVNSFNSSIGQEESLYAGSSASQSSSSSSSSSSSSEIPSATATLEKKAATNSGSHLSGISVKFSAMIMLTLLMFTGAV"},{"created_at":"2011-05-27T06:41:25.000Z","updated_at":"2011-05-29T05:06:44.000Z","name":"Lysophospholipase 1","uniprot_id":"P39105","uniprot_name":"PLB1_YEAST","enzyme":true,"transporter":false,"gene_name":"PLB1","num_residues":664,"molecular_weight":"71666.60156","theoretical_pi":"4.3","general_function":"Involved in metabolic process","specific_function":"Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine \u003e phosphatidylinositol \u003e\u003e phosphatidylcholine \u003e phosphatidylethanolamine","reactions":[{"id":1870,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1871,"direction":"\u003c\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2793,"direction":"\u003e","locations":" Lipid-anchor, GPI-anchor (Potential); Lipid-anchor, GPI-anchor.;Endoplasmic reticulum membrane;Cell membrane; Multi-pass membrane protein;Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor (Probable)","altext":"2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-22","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Lipid-anchor, GPI-anchor (Probable)","genbank_gene_id":"AY692788","genbank_protein_id":"51013027","gene_card_id":"PLB1","chromosome_location":"chromosome 13","locus":"YMR008C","synonyms":["Phospholipase B 1"],"enzyme_classes":["3.1.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" phospholipase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid catabolic process"}],"pfams":[{"name":"PLA2_B","identifier":"PF01735"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGAAGTTGCAGAGTTTGTTGGTTTCTGCTGCAGTTTTGACTTCTCTAACAGAGAACGTTAACGCTTGGTCACCAAATAACAGTTACGTCCCTGCGAACGTAACCTGTGATGATGATATTAACTTAGTCAGAGAAGCATCTGGTTTGTCAGATAACGAAACAGAATGGCTGAAAAAAAGAGATGCATACACCAAGGAGGCTTTGCATTCTTTTTTGAATAGGGCCACTTCGAATTTCAGTGACACTTCCTTGCTATCCACTCTTTTTGGTAGCAACCCTTCCAATATGCCTAAGATTGCCGTCGCCTGTTCTGGTGGTGGTTACCGTGCCATGTTGTCTGGTGCTGGTATGCTTGCTGCTATGGACAATCGTACTGATGGCGCAAATGAGCATGGTCTTGGTGGGCTGCTGCAAGGTGCAACTTACTTGGCAGGTCTGTCGGGTGGTAACTGGTTAACAAGTACTTTGGCTTGGAACAACTGGACGTCTGTGCAAGCTATCGTGGATAATACAACAGAATCTAACTCAATTTGGGACATCTCTCATTCAATTCTTACCCCAGACGGCATTAACATCTTTAAGACTGGGAGTAGATGGGACGACATATCAGATGACGTTCAGGATAAAAAAGACGCCGGTTTCAACATCTCTTTGGCGGATGTTTGGGGCCGTGCTCTTGCGTACAATTTTTGGCCAAGCTTACACCGTGGTGGTGTAGGGTACACATGGTCAACTTTAAGGGAAGCTGATGTCTTCAAGAATGGAGAAATGCCCTTCCCTATCACTGTTGCAGACGGTAGATACCCAGGTACCACCGTGATAAACTTGAATGCCACTCTTTTCGAATTTAATCCCTTTGAAATGGGTTCATGGGACCCCACTTTGAACGCATTTACGGATGTGAAGTATTTAGGTACCAACGTTACAAACGGTAAACCAGTTAATAAAGGCCAATGCATTGCCGGGTTTGATAACACTGGTTTCATAACAGCCACTTCATCTACGTTGTTTAACCAATTTTTACTAAGATTGAATTCTACCGATTTACCTTCATTTATTGCTAACTTAGCCACCGATTTCCTGGAAGATTTATCCGACAATAGTGACGATATTGCAATTTACGCCCCAAATCCATTCAAGGAAGCTAATTTTCTTCAAAAGAACGCAACCTCCAGTATTATCGAATCAGAATATCTATTTTTGGTTGATGGTGGTGAAGATAACCAAAATATTCCTTTAGTTCCATTGTTGCAAAAGGAACGTGAACTAGATGTTATTTTTGCATTAGACAATTCTGCTGATACTGACGACTATTGGCCAGATGGTGCTTCATTAGTTAACACTTATCAGCGTCAATTTGGCAGCCAAGGTCTCAATTTGTCTTTCCCATATGTTCCAGATGTGAACACATTTGTCAACTTGGGGTTGAACAAAAAGCCAACCTTTTTTGGTTGTGATGCAAGAAATTTGACAGACTTGGAGTACATTCCACCATTAATTGTTTACATTCCAAATTCAAGACATTCATTTAATGGTAACCAAAGTACTTTTAAGATGTCATACTCCGATTCAGAACGTCTTGGTATGATTAAGAATGGGTTTGAAGCTGCCACAATGGGTAATTTTACTGATGATTCTGATTTCTTGGGCTGTGTTGGTTGCGCCATTATCAGACGTAAGCAACAAAACTTGAATGCTACATTGCCCTCTGAATGCAGCCAGTGTTTTACCAACTACTGCTGGAACGGTACTATTGACAGCAGGTCAGTCTCAGGTGTAGGAAATGATGATTATTCTTCTTCTGCTTCCTTGTCTGCCTCCGCCGCTGCTGCCTCTGCCTCTGCCTCTGCCTCTGCTTCCGCCTCTGCCTCTGCTTCTGGGTCTTCCACTCATAAGAAAAATGCGGGCAATGCTTTGGTGAATTATTCTAACTTAAACACTAACACTTTTATTGGTGTCTTAAGTGTCATTAGTGCCGTCTTCGGTCTAATTTAG","protein_sequence":"MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVACSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINLNATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSSTLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSSIIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQRQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRHSFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNATLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASASASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI"},{"created_at":"2011-05-27T06:42:08.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Lysophospholipase NTE1","uniprot_id":"Q04958","uniprot_name":"NTE1_YEAST","enzyme":true,"transporter":false,"gene_name":"NTE1","num_residues":1679,"molecular_weight":"187131.0","theoretical_pi":"8.24","general_function":"Involved in metabolic process","specific_function":"Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium","reactions":[{"id":1870,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2793,"direction":"\u003e","locations":" Lipid-anchor, GPI-anchor (Potential); Lipid-anchor, GPI-anchor.;Endoplasmic reticulum membrane;Cell membrane; Multi-pass membrane protein;Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor (Probable)","altext":"2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":14803,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006998","source":"Smpdb"},{"id":14804,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047263","source":"Smpdb"},{"id":14805,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047295","source":"Smpdb"},{"id":14806,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047311","source":"Smpdb"},{"id":14807,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047317","source":"Smpdb"},{"id":14808,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047328","source":"Smpdb"},{"id":14809,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047334","source":"Smpdb"},{"id":14810,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047345","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"50-70;104-124","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z46729","genbank_protein_id":"577137","gene_card_id":"NTE1","chromosome_location":"chromosome 13","locus":"YML059C","synonyms":["Intracellular phospholipase B","Neuropathy target esterase homolog"],"enzyme_classes":["3.1.1.5"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" endoplasmic reticulum membrane"},{"category":"Function","description":" carboxylesterase activity"},{"category":"Function","description":" lysophospholipase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphatidylcholine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"}],"pfams":[{"name":"cNMP_binding","identifier":"PF00027"},{"name":"Patatin","identifier":"PF01734"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGCGTTCAATGAATTGCACTACGAACAACACCAACAATACCGGCCAAAACACGAAAAACAGTCTTGGCTCCAGCTTTAATTCCAGTAATTATACTTCTTATAGATTCCAGACATGTCTCACCGACCAGATTATTTCTGAGGCGCAGACGTGGTCACTTTCATCCCTCTTCAACTTCTCGTGGGTTGTGTCCTACTTTGTTATGGGTGCCTCTCGTATGATCTTCAGGTACGGTTGGTATCTGGCAACTTTATCGCTTTTAAGGATTCCGAAGTGGATCTTCTTCAAGTTACACCATGTTCAGTTCACTCTTTCCTTTTGGCTGATCCTGTTTGCCCTAGCCGTCATAGTCTTTGTGACTTACACCATCATGAAGGAGAGAATTCTATCCCAGTACAAGAGGCTGACCCCGGAGTTCTTGCCGCTGGAAAATACAGGTAAATCTGGCTCCAGCGCCAATATCAATGCAGCTTCCACTCAGTCAGCCAACGCGCCACCCGCCATAGGTTCCTCTACCACGGGTGCAAGCTCGATTATAGACTCAAAAAAGCATTCATTGAAAGATGGCAACGAAAACGAAACCTTTCTTTCATCTTACCTTGACCAATTTCTCAGCGCCATCAAAATCTTTGGCTATCTGGAAAAACCAGTCTTCCATGACCTGACCAAGAATATGAAAACTCAAAAAATGGATGAGGGTGAGATTTTACTGTTGGACAGTACTATTGGGTTTGCCATCGTCGTTGAAGGCACCCTGCAGTTATATCATGAAGTAGATCATTCAGATAAGGACCATGGCGATGAAACTGACCACAGTGACACGGATGGTCTTGACGACCAGGATAGAGATGAAGAAGACGAAGAAGAAGATGATGACATTGATAACTACGACACCAAATCTTGTTCTTCTAACCTCATCGATGAAGAAGATGAATCCGTTGGTTACATTCATCTGAAAAATGGACTGGGAAATTTTCAACTGCTAAATACAGTCAAGCCAGGAAACCCGCTGACCTCCCTCGTGAGCATTTTAAACTTATTCACGCATTCCATGTCCTCGTATGGCAACAGTAACTTTCCCTCTGAGTTATCGTCACCTATAGACACAACGGTGTCGGTCAACAATATGTTCTGCTCATCAGAGCAGAACTTCTCCAACACAGATTCCATGACAAACTCCACCAACAGCTTTCCAACGTTCCCCTCTTCAATGCCTAAACTTGTCGCCCGTGCGGCTACAGACTGCACAATTGGTATTATCCCACCTCAATCGTTTGCCAAATTAACCGCAAAATACCCACGGTCTGCTTCCCATATCATACAGATGGTTCTCACCAAGCTATACCATGTTACGTTCCAAACTGCTCACGACTACTTAGGTTTAACAAAGGAGATCATGGATATCGAAGTTTTACTAAATAAATCCATCGTTTATGAATTGCCTTATTATTTGAAAGAGGCCGTTATTCGTAAGTTTAAAACTGTAGATAAGTCGAGCGGATCGGCTGATTTAGAACCGAAACCCAAAAATAGTAATGCTTCCTCTAAATTGAAGAAACCGCCCAAAGCGAAGCCATCTGATGGTATCATTCAATCGCTTAAGATTGCTAACGCCAACGCTAACACAAGTTCGAATTCCCTTTCACTGAAACCAGAATTCACCCACCATCCAAGTTCGAGACATGTCGTACTGGGTTCAAGAGACCAATTTAATCCTGGTGATTTACTGTCAAATGTCCCACTGTCTAGAACTATGGATATTCTGTCACCCAACCCAATCCATAATAACAACCGCAATAAATCAAACGGTATTAACACTTCTACCTCTAACCAACATAAGCGATCTTCTAGGAGTAGCAGTAACAATGCTTCCGTACACTCTAAGAAGTTTTCTTCTTTGTCCCCAGAATTGCGCAACGCACAACTTAGTACATCGCCCTTGTCCTTGGATAATACTTCTGTTCATGACCATATCCACCCAAGTCCCGTTCATTTGAAGGGACGGGTCTCTCCAAGACCTAATTTACTGCCCACAACATCCTTTTCTGCTGCCCAGGAAGAAACCGAGGACTCTGCTTTAAGAATGGCTTTAGTTGAGGCAATGTTAACATACTTGGGTGTAAACAAAAGCAATATGTCCGTTTCATCTTCTTCGATAGCAAATATGTCTTCTTTAAACTCTCCTCAACTTAATGAAATGTATAGCCGCCGTCCAAGTAACGCAAGTTTTCTGATGTCCCCTCACTGTACACCATCTGACATTTCCGTAGCTTCATCATTTGCCTCTCCTCAAACTCAACCGACAATGTTAAGAATCCTACCCAAAGAATACACTATCAGCAATAAAAGGCATAATAAAAGTAAAAGCCAGGACAAAAAAAAACCTAGAGCTTACAAAGAGGAGTTGACACCCAATTTGGATTTCGAAGATGTCAAGAAAGACTTTGCACAAGGCATTCAGTTGAAGTTCTTTAAAAAGGGCACCACAATTGTTGAGCAGAACGCTCGTGGTAAAGGCCTATTCTATATCATTTCCGGGAAAGTTAATGTGACAACAAATTCGTCCTCGTCAGTAGTATCATCAATGTCTAAACCAGAGCAGGTTTCAGCCCAAAGTTCACACAAGGGTGAAAATCCTCATCATACTCAACATTTGTTATACTCTGTAGGATCTGGTGGTATTGTGGGCTACTTGTCCTCTCTAATTGGTTACAAATCATTTGTTAATATCGTTGCCAAGAGCGATGTCTATGTTGGATTTTTATCTAGTGCAACCTTAGAAAGATTGTTTGATAAATATTTCCTAATCTACTTACGGATTTCTGATTCATTAACCAAATTGCTATCTTCAAGGTTATTAAAGCTCGACCATGCTTTAGAATGGGTTCACTTGAGGGCTTCTGAAACTCTATTTTCACAAGGTGACTCGGCTAACGGTATTTATGTTGTCCTGAATGGTAGACTAAGGCAGCTACAACAGCAGTCATTGTCAAACTCCAATACAAGTTCCGAAGAAGTTGAAACTCAGAACATTATTCTAGGAGAACTGGCCCAGGGGGAGAGTTTTGGTGAAGTTGAAGTGCTTACCGCTATGAATAGATATTCAACGATAGTGGCAGTGAGGGATTCTGAATTAGCGAGAATTCCGAGAACATTATTCGAACTATTAGCTCTTGAACATCCATCTATCATGATTAGAGTTTCCAGATTAGTTGCTAAAAAAATTGTCGGAGATAGAACTGTTCCAGCATTAACAGGCGATCCATTATCTATAAAGGAAAACGACTTCACTTCTTTAATACCTCCAACGAAAGCGTCTTACTCTAGCTCTTTAAGTCATAAACCCCAAAATATTACTTCTGGCACAATTACTTTTAGAACCATCACTATCTTACCAATTACCAGTGGACTACCTGTAGAAGCATTTGCTATGAAGTTAGTGCAAGCTTTCAAACAGGTAGGAAGGACCACGATTGGTTTAAATCAAAGAACTACCCTAACACATTTAGGTCGTCATGCATTTGACAGATTGTCCAAATTAAAACAAAGTGGTTACTTTGCTGAACTAGAAGAAATGTACCAGACTGTTGTTTATATATCAGATACACCAGTTAAATCTAATTGGACAAGAACCTGTATTGCGCAAGGTGATTGTATTCTCTTACTAGCAGATGCTAGATCTCCATCAGCCGAAATAGGAGAATATGAAAAGTTATTACTAAATTCAAAGACTACCGCAAGGACCGAGTTAATTCTTCTACACCCTGAAAGGTATGTGGAACCAGGACTAACCCATAAGTGGTTACGCTATAGGCCATGGGTTCATTCGCATCATCACATTCAATTTAGTTTGACAGGAACAACCTTGATGAACGAAGGCAAAATGCACGTTTTGAATAATGGTGCCTTGGCATTAATGGATAAGTTGATTCAAACAGAATTCAGTAGAAAAACTCAACAGAATATATCAAAACTACTTCCAGATTCTATCAAGAACACCGTAGAAAACTTTTCTTCAAGATTCATGAAAAGTAAAAGACAATATTACACACCAGTTCATAGGCATAAAAATGATTTTCTAAGATTGGCTAGAATTCTTTCTGGACAAGCTATTGGACTTGTCCTCGGAGGAGGAGGTGCGAGAGGTATTAGTCATTTGGGTGTCATTCAAGCTATTGAAGAACAAGGTATTCCGGTCGACGTTATTGGAGGAACATCGATTGGTTCCTTTGTTGGCGGTTTGTACGCGAAGGATTATGATTTGGTGCCAATTTACGGCCGCGTGAAGAAGTTTGCTGGTCGAATTTCCTCTATATGGAGAATGTTAACAGATTTAACCTGGCCGGTTACTTCTTATACTACTGGTCACGAATTTAATAGAGGTATTTGGAAAACTTTCGGGGATACAAGAATTGAAGACTTCTGGATCCAGTATTATTGTAATTCTACTAATATAACCGATTCGGTTCAAGAAATACATTCCTTTGGTTATGCGTGGAGGTACATCAGAGCTTCGATGTCTCTTGCTGGTCTTTTACCTCCTTTGGAAGAGAACGGGTCTATGTTACTGGATGGTGGTTATGTTGATAATTTACCAGTAACTGAGATGAGAGCGCGTGGTTGCCAAACTATATTTGCAGTAGATGTAGGTTCTGCAGATGATAGAACGCCTATGGAATATGGTGACTCCCTAAATGGGTTTTGGATCATTTTCAATAGATGGAATCCATTTTCTTCTCATCCAAACATACCCAATATGGCAGAGATTCAAGTTAGATTGGGTTACGTCGCATCAGTAAATGCTTTAGAGAAAGCGAAAAATACACCAGGTGTCGTTTATGTGAGACCACCTATTGAAGAATATGCCACATTAGACTTTAGCAAGTTCGAAGAAATTTATCATGTGGGTGTAGACTATGGTCGTATCTTTTTGCAAGGGCTTATTGACGACGACAAGATGCCATATATACCTGGTTCACAAGAAACCACTTTGAATTCTCAAGTTCCTGAGTTTTTATTACATAGAAGAAATAGTATTTGA","protein_sequence":"MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLAGLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLHRRNSI"},{"created_at":"2011-05-27T06:42:45.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Lysophospholipase 2","uniprot_id":"Q03674","uniprot_name":"PLB2_YEAST","enzyme":true,"transporter":false,"gene_name":"PLB2","num_residues":706,"molecular_weight":"75454.60156","theoretical_pi":"4.28","general_function":"Involved in metabolic process","specific_function":"Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine \u003e phosphatidylinositol \u003e phosphatidylcholine \u003e phosphatidylethanolamine","reactions":[{"id":1869,"direction":"\u003c\u003e","locations":"extracellular;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2793,"direction":"\u003e","locations":" Lipid-anchor, GPI-anchor (Potential); Lipid-anchor, GPI-anchor.;Endoplasmic reticulum membrane;Cell membrane; Multi-pass membrane protein;Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor (Probable)","altext":"2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-19","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.","genbank_gene_id":"AF129165","genbank_protein_id":"4732121","gene_card_id":"PLB2","chromosome_location":"chromosome 13","locus":"YMR006C","synonyms":["Phospholipase B 2"],"enzyme_classes":["3.1.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" phospholipase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid catabolic process"}],"pfams":[{"name":"PLA2_B","identifier":"PF01735"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGCAATTACGGAACATATTACAGGCTAGCTCGCTAATTTCTGGACTTTCGCTCGCTGCAGATTCGTCGTCCACTACTGGTGATGGTTATGCTCCATCAATAATTCCTTGTCCCAGTGATGATACCTCTTTAGTTAGAAACGCGTCTGGCTTATCTACCGCTGAAACTGATTGGTTAAAGAAAAGAGATGCGTACACTAAAGAAGCTTTACATTCCTTCTTAAGCAGAGCTACTTCTAACTTCAGTGACACTTCTTTGCTATCCACTCTTTTCAGTAGTAACTCTTCCAATGTACCCAAAATTGGTATTGCATGCTCTGGTGGTGGTTATCGTGCCATGTTGGGTGGTGCTGGTATGATTGCTGCTATGGACAATCGTACTGATGGTGCTAACGAGCATGGTCTTGGTGGTTTACTACAAAGTTCCACGTATCTATCGGGTTTGTCCGGTGGTAACTGGTTGACTGGTACTTTGGCATGGAACAATTGGACCTCTGTACAGGAAATTGTAGACCATATGAGTGAGAGCGATTCCATCTGGAATATCACGAAATCCATTGTGAACCCTGGTGGCTCTAATTTGACCTACACAATTGAAAGATGGGAGTCCATTGTACAAGAAGTGCAGGCTAAGTCTGATGCAGGCTTCAATATATCTTTGTCGGATTTGTGGGCCCGTGCACTTTCTTACAACTTCTTTCCAAGCTTGCCAGATGCTGGCTCCGCTTTGACTTGGTCCTCTTTGAGAGATGTTGATGTGTTCAAAAACGGTGAAATGCCTTTACCAATTACTGTTGCAGATGGTAGATACCCAGGTACCACCGTGATAAACTTGAATGCCACTCTTTTCGAGTTCACTCCATTTGAAATGGGTTCTTGGGATCCTTCTTTGAACGCTTTTACGGATGTGAAATATCTAGGTACCAACGTTACAAATGGTAAACCGGTCAACAAGGATCAATGCGTTTCTGGTTACGATAATGCTGGATTTGTAATTGCCACATCCGCCAGTTTATTCAACGAATTTTCCCTGGAAGCTTCCACTTCGACCTATTATAAAATGATTAATAGTTTTGCCAACAAGTACGTTAACAACCTATCCCAAGATGACGATGATATTGCAATTTACGCTGCAAATCCATTCAAGGATACAGAATTTGTTGACCGCAATTACACTTCCAGTATTGTTGATGCCGATGATTTGTTTTTAGTTGATGGTGGTGAGGACGGCCAAAATTTGCCGTTGGTTCCACTAATCAAGAAGGAACGTGACTTGGATGTGGTGTTCGCATTGGATATATCCGACAATACTGATGAATCATGGCCAAGTGGTGTGTGCATGACGAACACTTATGAGCGCCAGTATTCTAAGCAAGGTAAAGGAATGGCTTTCCCATATGTTCCAGACGTTAACACCTTCCTTAACTTGGGCTTAACTAATAAGCCAACGTTTTTTGGTTGTGATGCAAAAAATTTGACGGACTTGGAGTATATTCCACCTTTAGTTGTATATATCCCAAACACAAAACATTCATTCAATGGTAACCAAAGTACTTTGAAGATGAACTACAATGTTACAGAACGTCTTGGAATGATCAGAAATGGTTTTGAAGCTGCTACAATGGGCAACTTTACGGATGACTCTAACTTTTTAGGTTGCATAGGTTGTGCCATCATTAGACGTAAGCAAGAAAGCCTAAATGCCACCTTGCCCCCTGAATGTACCAAATGTTTTGCGGATTACTGCTGGAACGGCACACTAAGTACCTCAGCTAATCCTGAACTATCGGGAAATAGTACGTATCAAAGCGGTGCTATTGCCTCTGCAATCTCTGAGGCTACTGACGGTATTCCAATAACGGCTCTCTTAGGTTCATCAACCTCCGGAAATACTACATCAAACTCAACAACCTCGACTTCATCAAATGTCACTTCTAACTCAAACTCTTCGTCAAATACAACTTTAAACTCAAATTCTTCATCCTCTTCAATTTCTTCCTCTACAGCTCGTTCTTCTTCCTCTACGGCAAACAAAGCGAATGCTGCGGCTATTTCCTATGCGAACACTAATACTCTAATGAGTTTGTTAGGTGCCATAACAGCATTATTTGGACTAATTTAG","protein_sequence":"MQLRNILQASSLISGLSLAADSSSTTGDGYAPSIIPCPSDDTSLVRNASGLSTAETDWLKKRDAYTKEALHSFLSRATSNFSDTSLLSTLFSSNSSNVPKIGIACSGGGYRAMLGGAGMIAAMDNRTDGANEHGLGGLLQSSTYLSGLSGGNWLTGTLAWNNWTSVQEIVDHMSESDSIWNITKSIVNPGGSNLTYTIERWESIVQEVQAKSDAGFNISLSDLWARALSYNFFPSLPDAGSALTWSSLRDVDVFKNGEMPLPITVADGRYPGTTVINLNATLFEFTPFEMGSWDPSLNAFTDVKYLGTNVTNGKPVNKDQCVSGYDNAGFVIATSASLFNEFSLEASTSTYYKMINSFANKYVNNLSQDDDDIAIYAANPFKDTEFVDRNYTSSIVDADDLFLVDGGEDGQNLPLVPLIKKERDLDVVFALDISDNTDESWPSGVCMTNTYERQYSKQGKGMAFPYVPDVNTFLNLGLTNKPTFFGCDAKNLTDLEYIPPLVVYIPNTKHSFNGNQSTLKMNYNVTERLGMIRNGFEAATMGNFTDDSNFLGCIGCAIIRRKQESLNATLPPECTKCFADYCWNGTLSTSANPELSGNSTYQSGAIASAISEATDGIPITALLGSSTSGNTTSNSTTSTSSNVTSNSNSSSNTTLNSNSSSSSISSSTARSSSSTANKANAAAISYANTNTLMSLLGAITALFGLI"}]}