Vacuolar basic amino acid transporter 2 (P38358)

Identification
NameVacuolar basic amino acid transporter 2
SynonymsNot Available
Gene NameVBA2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transport
Specific FunctionTransporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine
Cellular LocationVacuole membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00330L-LysineShow
YMDB00364L-TyrosineShow
YMDB00369L-HistidineShow
YMDB00592L-ArginineShow
YMDB00862hydronShow
GO Classification
Component
Not Available
Function
Not Available
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 2
LocusYBR293W
Gene Sequence>1425 bp ATGAGTATTTCAAATTGGATCACCACTGCGTATTTAATTACATCAACATCTTTTCAACCT CTTTATGGGTCATTTTCTGATGCACTTGGTCGAAGAAACTGCCTTTTCTTTGCTAATGGG GCTTTTACCATTGGATGTCTAGCCTGTGGTTTCTCGAAAAACATCTACATGCTTAGTTTT ATGAGAGCATTGACAGGCATAGGAGGTGGTGGCTTGATCACACTTTCTACAATCGTAAAT TCAGACGTTATTCCAAGTTCGAAAAGAGGAATTTTTCAAGCGTTTCAGAATTTACTTTTG GGATTTGGTGCCATATGTGGAGCGTCTTTCGGTGGCACAATAGCGTCGAGCATTGGTTGG AGGTGGTGTTTTCTCATCCAAGTACCCATATCTGTGATTAGTTCCATATTAATGAATTAT TATGTACCTAATCAGAAAGAATATAATCGTCAAAATTCTAGCATATTCCAAAATCCCGGA AAAATACTCAGGGACATAGATGTTATGGGCTCAATTCTTATTATAACTGGTCTCACACTA CAGCTTCTTTACCTGAGCCTGGGGTGTTCTACTTCTAAATTATCATGGACCAGCCCTTCT GTGCTACTGCTATTAGTTGGGAGTGTAATAATCCTCTTACTGTTCATATTGCACGAAAGG AAAACAAGTGCTAGAGCGATTATTCCTATGGAGCTGGTCAATTCCTCCTACAGTGTCGTT GTACTTTCGATAAGTATACTTGTTGGTTTTGCCAGCTACGCGTATCTTTTTACTTTACCA TTATTCTTTCAGATTGTACTTGGAGATTCCACTGCAAAAGCAGGATTACGTCTTACGATT CCTTCCCTATTTACTCCGGTAGGCAGTCTCATAACAGGATTTTCCATGAGCAAGTACAAC TGTCTAAGATTATTACTCTACATTGGTATTTCTTTGATGTTTTTGGGTAACTTTTTATTC CTGTTTATTGAAAAAACTTCTCCGAACTGGTTGATTGGTCTATTTTTGATACCTGCAAAT CTAGGACAAGGTATCACTTTTCCTACGACCTTGTTTACTTTCATATTTATGTTCTCTAAG AGTGACCAAGCTACTGCGACATCAACTTTATATTTATTCCGTAGTATTGGATCTGTATGG GGTGTTGCAATTTCAGCTGGCGTCATTCAATTATCTTTCGCAGGTTTATTGCGTAGTAAT TTGAAAGGTCTACTGGATGAAAACAAGATAAAGAAACTTATTGTTCAGCTTAGTGCAAAC TCCTCATATATTGGATCTTTACATGGCGAAGTTAAAAACACAGTCATAAAGAGTTTTGAT GAGGCAACAAAGAGGGCTCATCTAATGTCTACATTACTCTCTTCATTGGCCCTGATACTC TGCATCCTTAAAGACAATCTGGCGAAACCTAAAACAAGAAGATAA
Protein Properties
Pfam Domain Function
Protein Residues474
Protein Molecular Weight51676.39844
Protein Theoretical pI10.15
Signalling Regions
  • None
Transmembrane Regions
  • 34-54
  • 63-85
  • 98-118
  • 122-142
  • 168-188
  • 197-217
  • 239-259
  • 274-294
  • 304-324
  • 332-352
  • 376-396
  • 448-468
Protein Sequence>Vacuolar basic amino acid transporter 2 MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSF MRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGW RWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTL QLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVV VLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYN CLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSK SDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSAN SSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR
References
External Links
ResourceLink
Saccharomyces Genome Database VBA2
Uniprot IDP38358
Uniprot NameVBA2_YEAST
GenBank Gene IDAY692630
Genebank Protein ID51012711
General Reference
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y., Kakinuma, Y. (2005). "A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae." J Biol Chem 280:4851-4857.15572352
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258