{"ymdb_id":"YMDB00592","created_at":"2011-05-29T18:33:52.000Z","updated_at":"2016-10-18T17:11:32.000Z","name":"L-Arginine","cas":"74-79-3","state":"Solid","melting_point":"222 oC","description":"Arginine (abbreviated as Arg or R) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a polar, basic amino acid, because of the positively charged nature of the guanidino-alkyl side chain.  With a pKa of 12.5, arginine is a positively amino acid at all physiological pHs.  The first five steps of arginine biosynthesis in S. cerevisiae take place in the mitochondrion. This part of the pathway is known as the acetylated derivatives cycle because the acetyl group that is added to L-glutamate in the first step of the pathway is recycled via N-acetylglutamate generated in the fifth step. The enzymes that catalyze the second and third steps are encoded by a single gene (ARG5,6) that is translated into a pre-protein which is imported into mitochondria and cleaved there to yield two enzymes, N-acetylglutamate kinase and N-acetylglutamyl-phosphate reductase. These enzymes form a complex with each other and with N-acetylglutamate synthase, the first enzyme in the pathway, which may have implications for regulation of their activity. The mitochondrial steps of the arginine biosynthesis pathway result in the formation of ornithine, which is exported to the cytoplasm by the transporter Ort1p. In the cytoplasm, L-ornithine is converted to L-arginine in three reactions mediated by ornithine carbamoyltransferase, arginosuccinate synthase, and argininosuccinate lyase. The catabolism of arginine begins within the context of the urea cycle. It is hydrolyzed to urea and ornithine by arginase.","experimental_water_solubility":"182 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-4.20 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":"Meyer, Helmut E.; Swiderek, Kristine; Hoffmann-Posorske, Edeltraut; Korte, Horst; Heilmeyer, Ludwig M. G., Jr. Quantitative determination of phosphoserine by high-performance liquid chromatography as the phenylthiocarbamyl-S-ethylcysteine. Application to ","chebi_id":"16467","hmdb_id":"HMDB00517","kegg_id":"C00062","pubchem_id":"6322","cs_id":"6082","foodb_id":null,"wikipedia_link":"Arginine","biocyc_id":"ARG","iupac":"(2S)-2-amino-5-carbamimidamidopentanoic acid","traditional_iupac":"L-arginine","logp":"-3.1559373774200568","pka":null,"alogps_solubility":"2.28e+00 g/l","alogps_logp":"-3.49","alogps_logs":"-1.88","acceptor_count":"6","donor_count":"5","rotatable_bond_count":"5","polar_surface_area":"125.21999999999998","refractivity":"53.9231","polarizability":"17.798401776145056","formal_charge":"0","physiological_charge":"1","pka_strongest_basic":"12.41100429474531","pka_strongest_acidic":"2.4118378885304885","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate","(S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid","(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate","(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid","2-amino-5-guanidinovalerate","2-amino-5-guanidinovaleric acid","5-[(aminoiminomethyl)amino]-L-Norvaline","Arginine","L-(+)-Arginine","L-a-Amino-d-guanidinovalerate","L-a-Amino-d-guanidinovaleric acid","L-alpha-Amino-delta-guanidinovalerate","L-alpha-Amino-delta-guanidinovaleric acid","N5-(aminoiminomethyl)-L-Ornithine"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"16662.06154","concentration_units":"\u0026#181;M","error":"333.12821"},{"growth_media":"YPG media","concentration":"4180.1641","concentration_units":"\u0026#181;M","error":"83.57949"},{"growth_media":"SD media","concentration":"8772.57436","concentration_units":"\u0026#181;M","error":"175.48718"},{"growth_media":"SG media","concentration":"3650.43077","concentration_units":"\u0026#181;M","error":"72.87179"},{"growth_media":"M (molasses)","concentration":"10950.99487","concentration_units":"\u0026#181;M","error":"218.91282"},{"growth_media":"MA (molasses)","concentration":"2355.09744","concentration_units":"\u0026#181;M","error":"46.99487"},{"growth_media":"MB (molasses)","concentration":"5475.49744","concentration_units":"\u0026#181;M","error":"109.45641"},{"growth_media":"MAB (molasses)","concentration":"2708.45128","concentration_units":"\u0026#181;M","error":"54.13333"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"7005.0","concentration_units":"\u0026#181;M","error":"350.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"6020.0","concentration_units":"\u0026#181;M","error":"433.0"},{"growth_media":"Minimal medium  supplemented with ammonium and glucose","concentration":"18000.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium  supplemented with arginine and glucose","concentration":"190000.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium  supplemented with ornithine and glucose","concentration":"750.0","concentration_units":"\u0026#181;M","error":"750.0"},{"growth_media":"Minimal medium  supplemented with citrulline and glucose","concentration":"190000.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium  supplemented with citrulline and glucose","concentration":"110000.0","concentration_units":"\u0026#181;M","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11553611,"citation":"Abadjieva, A., Pauwels, K., Hilven, P., Crabeel, M. (2001). \"A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase.\" J Biol Chem 276:42869-42880."},{"pubmed_id":6370999,"citation":"Eisenstein, E., Osborne, J. C. Jr, Chaiken, I. M., Hensley, P. (1984). \"Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae.\" J Biol Chem 259:5139-5145."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":15572352,"citation":"Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y., Kakinuma, Y. (2005). \"A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae.\" J Biol Chem 280:4851-4857."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:44:45.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Arginase","uniprot_id":"P00812","uniprot_name":"ARGI_YEAST","enzyme":true,"transporter":false,"gene_name":"CAR1","num_residues":333,"molecular_weight":"35661.60156","theoretical_pi":"5.38","general_function":"Involved in arginase activity","specific_function":"L-arginine + H(2)O = L-ornithine + urea","reactions":[{"id":1326,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2269,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-arginine + H(2)O = L-ornithine + urea.","export":false,"pw_reaction_id":null,"source":null},{"id":3740,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006267","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M10110","genbank_protein_id":"171161","gene_card_id":"CAR1","chromosome_location":"chromosome 16","locus":"YPL111W","synonyms":[],"enzyme_classes":["3.5.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"},{"category":"Function","description":" arginase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Arginase","identifier":"PF00491"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAAACAGGACCTCATTACAACTACTACAAAAATCGCGAATTGTCCATCGTTCTGGCTCCATTCAGCGGCGGTCAGGGTAAGCTTGGTGTCGAGAAGGGCCCTAAATACATGCTTAAGCATGGTCTGCAAACAAGCATAGAGGATTTGGGCTGGTCTACGGAATTAGAGCCCTCAATGGACGAGGCCCAATTTGTGGGAAAGTTGAAAATGGAGAAGGACTCCACAACTGGGGGTTCCTCTGTTATGATAGACGGTGTCAAGGCTAAAAGAGCAGATTTGGTTGGTGAAGCCACCAAGTTGGTGTACAACTCCGTGTCGAAAGTGGTCCAGGCGAACAGATTCCCCTTGACCTTGGGTGGTGATCATTCAATAGCCATTGGTACTGTATCCGCGGTTTTGGACAAATACCCCGATGCTGGTCTTTTATGGATAGACGCCCACGCTGATATAAACACCATAGAAAGCACCCCCTCTGGAAACTTGCACGGCTGTCCCGTGTCATTCCTAATGGGTTTGAACAAGGATGTCCCACATTGTCCCGAGTCGCTCAAATGGGTTCCAGGCAACTTGAGCCCAAAAAAGATCGCGTATATTGGGTTGAGAGATGTTGATGCCGGAGAAAAGAAAATCTTGAAAGATCTGGGTATCGCCGCCTTTTCCATGTACCACGTTGACAAATACGGCATCAACGCTGTCATTGAAATGGCAATGAAAGCCGTGCACCCAGAAACAAACGGTGAAGGTCCCATTATGTGCTCCTATGACGTCGATGGTGTAGACCCATTATACATTCCTGCTACAGGTACTCCAGTGAGAGGTGGGTTGACCTTGAGAGAAGGTCTTTTCTTGGTGGAAAGATTGGCCGAATCCGGTAATTTAATTGCGCTAGACGTTGTTGAATGTAACCCTGATCTGGCTATTCATGATATCCATGTTTCAAACACCATCTCTGCAGGTTGCGCCATTGCAAGGTGTGCATTGGGTGAAACCTTATTGTAG","protein_sequence":"METGPHYNYYKNRELSIVLAPFSGGQGKLGVEKGPKYMLKHGLQTSIEDLGWSTELEPSMDEAQFVGKLKMEKDSTTGGSSVMIDGVKAKRADLVGEATKLVYNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPDAGLLWIDAHADINTIESTPSGNLHGCPVSFLMGLNKDVPHCPESLKWVPGNLSPKKIAYIGLRDVDAGEKKILKDLGIAAFSMYHVDKYGINAVIEMAMKAVHPETNGEGPIMCSYDVDGVDPLYIPATGTPVRGGLTLREGLFLVERLAESGNLIALDVVECNPDLAIHDIHVSNTISAGCAIARCALGETLL"},{"created_at":"2011-05-26T16:44:03.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Argininosuccinate lyase","uniprot_id":"P04076","uniprot_name":"ARLY_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG4","num_residues":463,"molecular_weight":"51988.69922","theoretical_pi":"5.48","general_function":"Involved in argininosuccinate lyase activity","specific_function":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine","reactions":[{"id":1327,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2441,"direction":"\u003e","locations":null,"altext":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.","export":false,"pw_reaction_id":null,"source":null},{"id":3738,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006263","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693155","genbank_protein_id":"51013761","gene_card_id":"ARG4","chromosome_location":"chromosome 8","locus":"YHR018C","synonyms":["ASAL","Arginosuccinase"],"enzyme_classes":["4.3.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" amidine-lyase activity"},{"category":"Function","description":" argininosuccinate lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" arginine biosynthetic process via ornithine"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Lyase_1","identifier":"PF00206"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGTCAGACGGCACTCAAAAACTATGGGGTGGGAGATTCACTGGTGAAACCGATCCTTTGATGCACCTTTACAATGCGTCTCTTCCGTATGATTATAAGATGTATAAGGCAGATTTAGAAGGAACTAAAGTATACACAGCGGGCTTGCAGAAGTTGGGTCTTCTAACGGAGACAGAATTGGCAAAGATCCATGAAGGTTTGGCTGAAATCAAAAAAGAATGGGACGCTGACAAATTTGTCCGTCATCCAAACGACGAGGATATCCATACTGCGAATGAAAGACGTCTTGGTGAACTAATTGGCCGCGATATTGCTGGTAAAGTCCACACCGGTAGATCCCGTAATGATCAAGTTGTTACCGATTTGAGAATATACTGTCGTGACATTGTCAATGACACCCTCTTTCCAGCTTTAAAGGGCTTGGTTGAAGTTCTAATTAAGAGGGCCGAAGGTGAGATAGATGTCTTAATGCCAGGCTACACACATTTACAAAGGGCACAACCTATTAGATGGTCTCATTGGTTGAGCTCTTATGCAACATACTTCACCGAAGATTACAAGAGACTGGGTCAAATACTACACAGATTGAATCAATCACCACTGGGTGCAGGCGCTCTTGCTGGTCATCCTTACGGCATTGATAGAGAATTTTTGGCTGAAGGTTTGGGTTTCAATAGTGTAATTGGTAACTCCTTGGTTGCTGTTTCTGATAGAGATTTCATCGTGGAGTTGATGTTTTGGGGAACTTTGTTCATGAACCATATTTCTCGTTTTGCTGAAGATTTGATTATATATTGTACAGCAGAATTTGGTTTCATACAGTTGAGCGACGCCTATTCAACAGGTTCTTCTTTAATGCCTCAGAAGAAGAATGCAGACTCGTTAGAGTTGTTAAGAGGTAAATCCGGTAGAGTATTTGGTGATCTGACAGGATTCTTGATGAGTTTGAAGGGTATCCCATCTACTTATGATAAAGACATGCAAGAAGACAAAGAGCCACTATTCGATTGCTTAACAACTGTAGAGCACTCCATGCTGATTGCCACAGGTGTTATTTCTACCTTAACTGTAAATAAGGAAAAGATGGAAGCTGCTCTCACGATGGATATGCTAGCTACCGACTTGGCAGATTACTTGGTCAGAAAGGGTGTTCCATTCAGAGAGACTCATCACATATCTGGTGAGTGTGTCGCTACTGCTGAAAGACTTGGTCTAAGCGGTATTGATAAATTAACCTTGGAGCAGTATCAAAAGATCGATTCGAGATTCGGACAAGATCTTTTTGAAACTTTTAACTTTGAACAAAGCGTTGAAAGACGAGATGCTACTGGTGGAACCGCTAAATCTGCTGTATTGAAGCAATTGGATAATTTGAAATCCCAATTAAATTAG","protein_sequence":"MSDGTQKLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIKKEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFPALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPLGAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYCTAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDKEPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGECVATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLKSQLN"},{"created_at":"2011-05-26T18:27:27.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Arginyl-tRNA synthetase, mitochondrial","uniprot_id":"P38714","uniprot_name":"SYRM_YEAST","enzyme":true,"transporter":false,"gene_name":"MSR1","num_residues":643,"molecular_weight":"73693.39844","theoretical_pi":"9.84","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)","reactions":[{"id":1329,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2534,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"L39019","genbank_protein_id":"633022","gene_card_id":"MSR1","chromosome_location":"chromosome 8","locus":"YHR091C","synonyms":["Arginine--tRNA ligase","ArgRS"],"enzyme_classes":["6.1.1.19"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" arginine-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" arginyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic 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synthetase, cytoplasmic","uniprot_id":"Q05506","uniprot_name":"SYRC_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":607,"molecular_weight":"69524.39844","theoretical_pi":"6.76","general_function":"Involved in nucleotide binding","specific_function":"Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis","reactions":[{"id":1329,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2534,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1F7V","cellular_location":"Cytoplasm","genbank_gene_id":"U51032","genbank_protein_id":"1230668","gene_card_id":null,"chromosome_location":null,"locus":"YDR341C","synonyms":["Arginine--tRNA ligase","ArgRS"],"enzyme_classes":["6.1.1.19"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" arginine-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein 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process"}],"pfams":[{"name":"Arg_tRNA_synt_N","identifier":"PF03485"},{"name":"DALR_1","identifier":"PF05746"},{"name":"tRNA-synt_1d","identifier":"PF00750"}],"pathways":[],"gene_sequence":"ATGGCTAGCACAGCAAATATGATTTCTCAACTAAAGAAACTATCTATCGCGGAACCTGCGGTTGCCAAGGATTCTCATCCTGATGTAAATATCGTGGATTTGATGAGAAATTACATTTCACAAGAATTAAGCAAGATTTCCGGCGTAGACTCGTCTCTTATTTTTCCAGCATTAGAATGGACAAATACTATGGAGAGAGGCGATTTGTTGATTCCTATCCCAAGATTGAGAATCAAAGGTGCCAATCCAAAGGATTTGGCAGTCCAATGGGCTGAAAAATTTCCATGTGGAGATTTCTTGGAGAAAGTTGAAGCGAATGGCCCGTTCATCCAGTTTTTCTTCAACCCTCAATTTTTAGCAAAACTTGTCATCCCAGATATCTTAACCAGAAAGGAGGATTATGGTTCTTGCAAATTGGTTGAAAACAAGAAAGTTATTATTGAATTCTCCTCTCCCAACATTGCCAAGCCATTTCATGCTGGTCATTTAAGATCCACTATTATTGGTGGCTTTTTGGCCAACCTTTATGAAAAATTAGGTTGGGAGGTTATCAGAATGAACTACCTGGGTGACTGGGGTAAACAATTTGGTCTTTTAGCTGTTGGTTTTGAAAGATACGGTAATGAAGAGGCTTTAGTTAAGGATCCAATTCACCACCTGTTCGATGTTTACGTTCGTATCAACAAGGATATTGAGGAAGAAGGTGACAGTATTCCATTAGAACAATCCACCAATGGAAAAGCTCGTGAATATTTCAAGAGAATGGAAGATGGTGACGAGGAAGCTTTAAAAATTTGGAAGAGATTCCGTGAATTTTCTATTGAAAAATATATTGACACATATGCACGTTTGAACATCAAATATGATGTTTACTCTGGTGAATCTCAAGTTTCTAAAGAATCCATGCTCAAAGCTATCGACCTGTTCAAGGAAAAGGGCTTAACACATGAGGATAAGGGTGCAGTTTTGATCGATTTGACAAAATTTAACAAAAAGTTAGGAAAGGCTATTGTTCAAAAATCGGACGGTACTACGTTATATCTAACTAGAGACGTTGGTGCAGCTATGGACCGTTATGAAAAGTATCATTTTGACAAGATGATTTACGTTATCGCTTCTCAACAAGATTTGCACGCTGCCCAATTCTTCGAAATTTTGAAGCAGATGGGCTTTGAGTGGGCTAAAGATCTACAGCATGTCAACTTTGGTATGGTCCAAGGTATGTCAACAAGAAAAGGTACTGTTGTCTTCTTAGATAATATCTTGGAGGAAACTAAGGAAAAAATGCACGAAGTTATGAAAAAGAATGAGAACAAATACGCGCAAATTGAGCATCCAGAAGAAGTTGCCGATTTAGTTGGTATCTCTGCCGTCATGATTCAAGATATGCAAGGTAAGCGTATCAACAACTACGAGTTTAAATGGGAAAGAATGCTTTCATTCGAAGGTGACACTGGTCCATACCTTCAATATGCTCACTCAAGGTTAAGATCAGTTGAAAGAAATGCTTCTGGTATCACCCAAGAAAAATGGATAAATGCCGATTTTTCGTTATTAAAAGAACCTGCCGCAAAACTGTTGATTAGACTGCTAGGCCAATACCCCGATGTTTTGAGAAATGCAATCAAAACCCACGAGCCAACAACCGTGGTCACATATTTATTCAAATTGACTCACCAGGTTTCTTCTTGTTATGACGTCTTATGGGTTGCTGGTCAAACTGAAGAATTAGCAACTGCCCGTCTGGCTCTATATGGTGCTGCAAGACAAGTTTTATACAACGGTATGCGCTTGTTAGGTTTAACTCCCGTAGAAAGAATGTAA","protein_sequence":"MASTANMISQLKKLSIAEPAVAKDSHPDVNIVDLMRNYISQELSKISGVDSSLIFPALEWTNTMERGDLLIPIPRLRIKGANPKDLAVQWAEKFPCGDFLEKVEANGPFIQFFFNPQFLAKLVIPDILTRKEDYGSCKLVENKKVIIEFSSPNIAKPFHAGHLRSTIIGGFLANLYEKLGWEVIRMNYLGDWGKQFGLLAVGFERYGNEEALVKDPIHHLFDVYVRINKDIEEEGDSIPLEQSTNGKAREYFKRMEDGDEEALKIWKRFREFSIEKYIDTYARLNIKYDVYSGESQVSKESMLKAIDLFKEKGLTHEDKGAVLIDLTKFNKKLGKAIVQKSDGTTLYLTRDVGAAMDRYEKYHFDKMIYVIASQQDLHAAQFFEILKQMGFEWAKDLQHVNFGMVQGMSTRKGTVVFLDNILEETKEKMHEVMKKNENKYAQIEHPEEVADLVGISAVMIQDMQGKRINNYEFKWERMLSFEGDTGPYLQYAHSRLRSVERNASGITQEKWINADFSLLKEPAAKLLIRLLGQYPDVLRNAIKTHEPTTVVTYLFKLTHQVSSCYDVLWVAGQTEELATARLALYGAARQVLYNGMRLLGLTPVERM"},{"created_at":"2011-05-27T06:52:17.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar basic amino acid transporter 2","uniprot_id":"P38358","uniprot_name":"VBA2_YEAST","enzyme":false,"transporter":true,"gene_name":"VBA2","num_residues":474,"molecular_weight":"51676.39844","theoretical_pi":"10.15","general_function":"Involved in transmembrane transport","specific_function":"Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine","reactions":[],"signal_regions":"None","transmembrane_regions":"34-54;63-85;98-118;122-142;168-188;197-217;239-259;274-294;304-324;332-352;376-396;448-468","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"AY692630","genbank_protein_id":"51012711","gene_card_id":"VBA2","chromosome_location":"chromosome 2","locus":"YBR293W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGAGTATTTCAAATTGGATCACCACTGCGTATTTAATTACATCAACATCTTTTCAACCTCTTTATGGGTCATTTTCTGATGCACTTGGTCGAAGAAACTGCCTTTTCTTTGCTAATGGGGCTTTTACCATTGGATGTCTAGCCTGTGGTTTCTCGAAAAACATCTACATGCTTAGTTTTATGAGAGCATTGACAGGCATAGGAGGTGGTGGCTTGATCACACTTTCTACAATCGTAAATTCAGACGTTATTCCAAGTTCGAAAAGAGGAATTTTTCAAGCGTTTCAGAATTTACTTTTGGGATTTGGTGCCATATGTGGAGCGTCTTTCGGTGGCACAATAGCGTCGAGCATTGGTTGGAGGTGGTGTTTTCTCATCCAAGTACCCATATCTGTGATTAGTTCCATATTAATGAATTATTATGTACCTAATCAGAAAGAATATAATCGTCAAAATTCTAGCATATTCCAAAATCCCGGAAAAATACTCAGGGACATAGATGTTATGGGCTCAATTCTTATTATAACTGGTCTCACACTACAGCTTCTTTACCTGAGCCTGGGGTGTTCTACTTCTAAATTATCATGGACCAGCCCTTCTGTGCTACTGCTATTAGTTGGGAGTGTAATAATCCTCTTACTGTTCATATTGCACGAAAGGAAAACAAGTGCTAGAGCGATTATTCCTATGGAGCTGGTCAATTCCTCCTACAGTGTCGTTGTACTTTCGATAAGTATACTTGTTGGTTTTGCCAGCTACGCGTATCTTTTTACTTTACCATTATTCTTTCAGATTGTACTTGGAGATTCCACTGCAAAAGCAGGATTACGTCTTACGATTCCTTCCCTATTTACTCCGGTAGGCAGTCTCATAACAGGATTTTCCATGAGCAAGTACAACTGTCTAAGATTATTACTCTACATTGGTATTTCTTTGATGTTTTTGGGTAACTTTTTATTCCTGTTTATTGAAAAAACTTCTCCGAACTGGTTGATTGGTCTATTTTTGATACCTGCAAATCTAGGACAAGGTATCACTTTTCCTACGACCTTGTTTACTTTCATATTTATGTTCTCTAAGAGTGACCAAGCTACTGCGACATCAACTTTATATTTATTCCGTAGTATTGGATCTGTATGGGGTGTTGCAATTTCAGCTGGCGTCATTCAATTATCTTTCGCAGGTTTATTGCGTAGTAATTTGAAAGGTCTACTGGATGAAAACAAGATAAAGAAACTTATTGTTCAGCTTAGTGCAAACTCCTCATATATTGGATCTTTACATGGCGAAGTTAAAAACACAGTCATAAAGAGTTTTGATGAGGCAACAAAGAGGGCTCATCTAATGTCTACATTACTCTCTTCATTGGCCCTGATACTCTGCATCCTTAAAGACAATCTGGCGAAACCTAAAACAAGAAGATAA","protein_sequence":"MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGWRWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTLQLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVVVLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYNCLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSKSDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSANSSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR"},{"created_at":"2011-05-27T07:45:19.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Basic amino-acid permease","uniprot_id":"P38971","uniprot_name":"ALP1_YEAST","enzyme":false,"transporter":true,"gene_name":"ALP1","num_residues":573,"molecular_weight":"64012.89844","theoretical_pi":"8.0","general_function":"Involved in transport","specific_function":"High-affinity permease for basic amino acids","reactions":[],"signal_regions":"None","transmembrane_regions":"74-93;96-116;154-174;180-200;210-230;266-286;307-327;360-380;404-424;432-452;478-498;511-531","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X92494","genbank_protein_id":"1045240","gene_card_id":"ALP1","chromosome_location":"chromosome 14","locus":"YNL270C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGATGAAACTGTGAACATACAAATGTCCAAGGAAGGTCAGTATGAAATCAATTCTAGCTCTATAATAAAAGAGGAGGAGTTTGTAGATGAACAATATTCTGGGGAGAACGTTACGAAGGCCATCACCACAGAGAGAAAAGTCGAGGATGATGCTGCTAAGGAAACAGAGAGCTCACCACAAGAAAGAAGAGAGGTGAAGCGGAAGTTAAAGCAGCGGCATATAGGGATGATTGCTCTCGGCGGCACCATTGGGACGGGCCTCATAATTGGTATTGGTCCGCCATTGGCACACGCCGGCCCTGTTGGTGCCTTGATATCGTATTTATTTATGGGGACAGTGATTTACTCCGTTACACAATCGTTAGGAGAGATGGTCACTTTTATCCCGGTTACATCTTCATTTTCTGTCTTCGCCCAAAGATTTCTGTCGCCAGCGCTGGGAGCGACTAACGGATATATGTACTGGCTGTCGTGGTGTTTCACCTTCGCACTGGAACTATCCGTTTTGGGGAAAGTTATTCAGTACTGGACAGAAGCAGTGCCTCTAGCGGCTTGGATCGTGATCTTTTGGTGCCTGTTAACTTCAATGAACATGTTTCCCGTAAAGTATTACGGAGAATTTGAGTTTTGTATTGCCTCCATAAAGGTCATCGCGTTGCTCGGTTTTATCATTTTCTCATTCTGTGTTGTGTGTGGTGCGGGACAATCTGATGGACCCATCGGTTTCAGGTACTGGAGAAATCCAGGAGCCTGGGGGCCTGGCATTATCTCCAGTGATAAAAATGAGGGCCGTTTTCTCGGATGGGTTTCCTCTTTGATTAATGCTGCATTTACGTACCAAGGTACTGAACTGGTTGGGATAACCGCTGGTGAAGCGGCTAACCCAAGAAAAGCTCTCCCGAGGGCAATAAAGAAAGTTGTAGTGAGGATTCTAGTCTTTTACATTCTTTCACTATTTTTCATTGGCCTTTTGGTCCCATATAATGACCCAAAGTTGGATAGTGACGGTATATTTGTCTCTTCATCGCCCTTTATGATAAGCATTGAGAATTCAGGCACAAAAGTTCTCCCAGATATATTTAACGCGGTCGTGCTAATCACCATTCTTTCCGCAGGTAACTCTAATGTGTACATTGGCTCAAGAGTACTGTATAGTCTGTCTAAAAATAGCTTGGCGCCAAGGTTCTTGTCTAACGTGACCAGAGGTGGTGTTCCATACTTTTCTGTTCTATCTACATCCGTGTTCGGATTTTTGGCTTTCTTAGAGGTTTCTGCAGGCAGCGGCAAGGCCTTTAACTGGTTATTGAACATAACTGGTGTGGCCGGTTTCTTTGCCTGGCTTTTGATTTCATTTTCTCATATCCGTTTCATGCAAGCCATAAGGAAACGTGGTATATCGAGGGATGACTTACCTTATAAAGCTCAAATGATGCCTTTTTTGGCATATTATGCATCTTTTTTCATCGCTCTAATTGTTCTGATCCAGGGCTTCACCGCTTTCGCACCTACTTTTCAGCCTATAGACTTTGTCGCTGCATATATATCAATATTCCTATTTTTGGCCATATGGTTATCATTCCAAGTTTGGTTTAAGTGCCGCTTACTCTGGAAGCTGCAGGATATCGATATCGATTCTGACCGCCGGCAAATAGAGGAGTTGGTATGGATAGAGCCAGAATGTAAAACAAGGTGGCAACGAGTTTGGGATGTCCTTTCATAA","protein_sequence":"MDETVNIQMSKEGQYEINSSSIIKEEEFVDEQYSGENVTKAITTERKVEDDAAKETESSPQERREVKRKLKQRHIGMIALGGTIGTGLIIGIGPPLAHAGPVGALISYLFMGTVIYSVTQSLGEMVTFIPVTSSFSVFAQRFLSPALGATNGYMYWLSWCFTFALELSVLGKVIQYWTEAVPLAAWIVIFWCLLTSMNMFPVKYYGEFEFCIASIKVIALLGFIIFSFCVVCGAGQSDGPIGFRYWRNPGAWGPGIISSDKNEGRFLGWVSSLINAAFTYQGTELVGITAGEAANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLDSDGIFVSSSPFMISIENSGTKVLPDIFNAVVLITILSAGNSNVYIGSRVLYSLSKNSLAPRFLSNVTRGGVPYFSVLSTSVFGFLAFLEVSAGSGKAFNWLLNITGVAGFFAWLLISFSHIRFMQAIRKRGISRDDLPYKAQMMPFLAYYASFFIALIVLIQGFTAFAPTFQPIDFVAAYISIFLFLAIWLSFQVWFKCRLLWKLQDIDIDSDRRQIEELVWIEPECKTRWQRVWDVLS"},{"created_at":"2011-05-27T08:12:34.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Arginine permease","uniprot_id":"P04817","uniprot_name":"CAN1_YEAST","enzyme":false,"transporter":true,"gene_name":"CAN1","num_residues":590,"molecular_weight":"65784.79688","theoretical_pi":"8.59","general_function":"Involved in transport","specific_function":"High-affinity permease for arginine","reactions":[],"signal_regions":"None","transmembrane_regions":"93-110;230-254;324-343;377-396;420-437;451-469;494-518;525-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"M11724","genbank_protein_id":"171155","gene_card_id":"CAN1","chromosome_location":"chromosome 5","locus":"YEL063C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACAAATTCAAAAGAAGACGCCGACATAGAGGAGAAGCATATGTACAATGAGCCGGTCACAACCCTCTTTCACGACGTTGAAGCTTCACAAACACACCACAGACGTGGGTCAATACCATTGAAAGATGAGAAAAGTAAAGAATTGTATCCATTGCGCTCTTTCCCGACGAGAGTAAATGGCGAGGATACGTTCTCTATGGAGGATGGCATAGGTGATGAAGATGAAGGAGAAGTACAGAACGCTGAAGTGAAGAGAGAGCTTAAGCAAAGACATATTGGTATGATTGCCCTTGGTGGTACTATTGGTACAGGTCTTTTCATTGGTTTATCCACACCTCTGACCAACGCCGGCCCAGTGGGCGCTCTTATATCATATTTATTTATGGGTTCTTTGGCATATTCTGTCACGCAGTCCTTGGGTGAAATGGCTACATTCATCCCTGTTACATCCTCTTTCACAGTTTTCTCACAAAGATTCCTTTCTCCAGCATTTGGTGCGGCCAATGGTTACATGTATTGGTTTTCTTGGGCAATCACTTTTGCCCTGGAACTTAGTGTAGTTGGCCAAGTCATTCAATTTTGGACGTACAAAGTTCCACTGGCGGCATGGATTAGTATTTTTTGGGTAATTATCACAATAATGAACTTGTTCCCTGTCAAATATTACGGTGAATTCGAGTTCTGGGTCGCTTCCATCAAAGTTTTAGCCATTATCGGGTTTCTAATATACTGTTTTTGTATGGTTTGTGGTGCTGGGGTTACCGGCCCAGTTGGATTCCGTTATTGGAGAAACCCAGGTGCCTGGGGTCCAGGTATAATATCTAAGGATAAAAACGAAGGGAGGTTCTTAGGTTGGGTTTCCTCTTTGATTAACGCTGCCTTCACATTTCAAGGTACTGAACTAGTTGGTATCACTGCTGGTGAAGCTGCAAACCCCAGAAAATCCGTTCCAAGAGCCATCAAAAAAGTTGTTTTCCGTATCTTAACCTTCTACATTGGCTCTCTATTATTCATTGGACTTTTAGTTCCATACAATGACCCTAAACTAACACAATCTACTTCCTACGTTTCTACTTCTCCCTTTATTATTGCTATTGAGAACTCTGGTACAAAGGTTTTGCCACATATCTTCAACGCTGTTATCTTAACAACCATTATTTCTGCCGCAAATTCAAATATTTACGTTGGTTCCCGTATTTTATTTGGTCTATCAAAGAACAAGTTGGCTCCTAAATTCCTGTCAAGGACCACCAAAGGTGGTGTTCCATACATTGCAGTTTTCGTTACTGCTGCATTTGGCGCTTTGGCTTACATGGAGACATCTACTGGTGGTGACAAAGTTTTCGAATGGCTATTAAATATCACTGGTGTTGCAGGCTTTTTTGCATGGTTATTTATCTCAATCTCGCACATCAGATTTATGCAAGCTTTGAAATACCGTGGCATCTCTCGTGACGAGTTACCATTTAAAGCTAAATTAATGCCCGGCTTGGCTTATTATGCGGCCACATTTATGACGATCATTATCATTATTCAAGGTTTCACGGCTTTTGCACCAAAATTCAATGGTGTTAGCTTTGCTGCCGCCTATATCTCTATTTTCCTGTTCTTAGCTGTTTGGATCTTATTTCAATGCATATTCAGATGCAGATTTATTTGGAAGATTGGAGATGTCGACATCGATTCCGATAGAAGAGACATTGAGGCAATTGTATGGGAAGATCATGAACCAAAGACTTTTTGGGACAAATTTTGGAATGTTGTAGCATAG","protein_sequence":"MTNSKEDADIEEKHMYNEPVTTLFHDVEASQTHHRRGSIPLKDEKSKELYPLRSFPTRVNGEDTFSMEDGIGDEDEGEVQNAEVKRELKQRHIGMIALGGTIGTGLFIGLSTPLTNAGPVGALISYLFMGSLAYSVTQSLGEMATFIPVTSSFTVFSQRFLSPAFGAANGYMYWFSWAITFALELSVVGQVIQFWTYKVPLAAWISIFWVIITIMNLFPVKYYGEFEFWVASIKVLAIIGFLIYCFCMVCGAGVTGPVGFRYWRNPGAWGPGIISKDKNEGRFLGWVSSLINAAFTFQGTELVGITAGEAANPRKSVPRAIKKVVFRILTFYIGSLLFIGLLVPYNDPKLTQSTSYVSTSPFIIAIENSGTKVLPHIFNAVILTTIISAANSNIYVGSRILFGLSKNKLAPKFLSRTTKGGVPYIAVFVTAAFGALAYMETSTGGDKVFEWLLNITGVAGFFAWLFISISHIRFMQALKYRGISRDELPFKAKLMPGLAYYAATFMTIIIIIQGFTAFAPKFNGVSFAAAYISIFLFLAVWILFQCIFRCRFIWKIGDVDIDSDRRDIEAIVWEDHEPKTFWDKFWNVVA"}]}