Eukaryotic peptide chain release factor GTP-binding subunit (P05453)

Identification
NameEukaryotic peptide chain release factor GTP-binding subunit
Synonyms
  • ERF-3
  • ERF2
  • G1 to S phase transition protein 1
  • Omnipotent suppressor protein 2
  • PSI no more protein 2
  • Polypeptide release factor 3
  • Translation release factor 3
  • ERF3
Gene NameSUP35
Enzyme ClassNot Available
Biological Properties
General Functiontranslational termination
Specific FunctionInvolved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.
Cellular LocationNot Available
SMPDB Pathways
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sulfur metabolismec00920 Map00920
SMPDB Reactions
Adenosine triphosphate + hydron + Sulfate → Adenosine phosphosulfate + Pyrophosphate
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00005SulfateShow
YMDB00109Adenosine triphosphateShow
YMDB00219PyrophosphateShow
YMDB00256Adenosine phosphosulfateShow
YMDB00862hydronShow
GO Classification
Function
GTP binding
GTPase activity
translation release factor activity
cytoplasmic translational termination
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
translational termination
cytosol
cytoplasmic stress granule
translation release factor complex
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2058 bp ATGTCGGATTCAAACCAAGGCAACAATCAGCAAAACTACCAGCAATACAGCCAGAACGGT AACCAACAACAAGGTAACAACAGATACCAAGGTTATCAAGCTTACAATGCTCAAGCCCAA CCTGCAGGTGGGTACTACCAAAATTACCAAGGTTATTCTGGGTACCAACAAGGTGGCTAT CAACAGTACAATCCCGACGCCGGTTACCAGCAACAGTATAATCCTCAAGGAGGCTATCAA CAGTACAATCCTCAAGGCGGTTATCAGCAGCAATTCAATCCACAAGGTGGCCGTGGAAAT TACAAAAACTTCAACTACAATAACAATTTGCAAGGATATCAAGCTGGTTTCCAACCACAG TCTCAAGGTATGTCTTTGAACGACTTTCAAAAGCAACAAAAGCAGGCCGCTCCCAAACCA AAGAAGACTTTGAAGCTTGTCTCCAGTTCCGGTATCAAGTTGGCCAATGCTACCAAGAAG GTTGGCACAAAACCTGCCGAATCTGATAAGAAAGAGGAAGAGAAGTCTGCTGAAACCAAA GAACCAACTAAAGAGCCAACAAAGGTCGAAGAACCAGTTAAAAAGGAGGAGAAACCAGTC CAGACTGAAGAAAAGACGGAGGAAAAATCGGAACTTCCAAAGGTAGAAGACCTTAAAATC TCTGAATCAACACATAATACCAACAATGCCAATGTTACCAGTGCTGATGCCTTGATCAAG GAACAGGAAGAAGAAGTGGATGACGAAGTTGTTAACGATATGTTTGGTGGTAAAGATCAC GTTTCTTTAATTTTCATGGGTCATGTTGATGCCGGTAAATCTACTATGGGTGGTAATCTA CTATACTTGACTGGCTCTGTGGATAAGAGAACTATTGAGAAATATGAAAGAGAAGCCAAG GATGCAGGCAGACAAGGTTGGTACTTGTCATGGGTCATGGATACCAACAAAGAAGAAAGA AATGATGGTAAGACTATCGAAGTTGGTAAGGCCTACTTTGAAACTGAAAAAAGGCGTTAT ACCATATTGGATGCTCCTGGTCATAAAATGTACGTTTCCGAGATGATCGGTGGTGCTTCT CAAGCTGATGTTGGTGTTTTGGTCATTTCCGCCAGAAAGGGTGAGTACGAAACCGGTTTT GAGAGAGGTGGTCAAACTCGTGAACACGCCCTATTGGCCAAGACCCAAGGTGTTAATAAG ATGGTTGTCGTCGTAAATAAGATGGATGACCCAACCGTTAACTGGTCTAAGGAACGTTAC GACCAATGTGTGAGTAATGTCAGCAATTTCTTGAGAGCAATTGGTTACAACATTAAGACA GACGTTGTATTTATGCCAGTATCCGGCTACAGTGGTGCAAATTTGAAAGATCACGTAGAT CCAAAAGAATGCCCATGGTACACCGGCCCAACTCTGTTAGAATATCTGGATACAATGAAC CACGTCGACCGTCACATCAATGCTCCATTCATGTTGCCTATTGCCGCTAAGATGAAGGAT CTAGGTACCATCGTTGAAGGTAAAATTGAATCCGGTCATATCAAAAAGGGTCAATCCACC CTACTGATGCCTAACAAAACCGCTGTGGAAATTCAAAATATTTACAACGAAACTGAAAAT GAAGTTGATATGGCTATGTGTGGTGAGCAAGTTAAACTAAGAATCAAAGGTGTTGAAGAA GAAGACATTTCACCAGGTTTTGTACTAACATCGCCAAAGAACCCTATCAAGAGTGTTACC AAGTTTGTAGCTCAAATTGCTATTGTAGAATTAAAATCTATCATAGCAGCCGGTTTTTCA TGTGTTATGCATGTTCATACAGCAATTGAAGAGGTACATATTGTTAAGTTATTGCACAAA TTAGAAAAGGGTACCAACCGTAAGTCAAAGAAACCACCTGCTTTTGCTAAGAAGGGTATG AAGGTCATCGCTGTTTTAGAAACTGAAGCTCCAGTTTGTGTGGAAACTTACCAAGATTAC CCTCAATTAGGTAGATTCACTTTGAGAGATCAAGGTACCACAATAGCAATTGGTAAAATT GTTAAAATTGCCGAGTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues685
Protein Molecular Weight76550.76
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Eukaryotic peptide chain release factor GTP-binding subunit MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGY QQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQ SQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVGTKPAESDKKEEEKSAETK EPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIK EQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAK DAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGAS QADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERY DQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMN HVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETEN EVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFS CVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDY PQLGRFTLRDQGTTIAIGKIVKIAE
References
External Links
ResourceLink
Saccharomyces Genome Database SUP35
Uniprot IDP05453
Uniprot NameSUP35
PDB ID
1YJO
General ReferenceNot Available