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Identification
YMDB IDYMDB00005
NameSulfate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionA sulfate (SO42- or inorganic sulfate) is a salt of sulfuric acid (H2SO4). Inorganic sulfate is involved in the sulfate activation for sulfonation pathway. The sulfonation of biological compounds (sulfoconjugation) is a fundamental metabolic process, in which a sulfate group is added to an oxygen moiety to form a sulfate ester bond. Inorganic sulfate is also involved in the sulfate reduction (assimilatory) pathway which reduces sulfate to hydrogen sulfide, the required form for sulfur assimilation into biosynthetic pathways. [Biocyc PWY-5340 and SO4ASSIM-PWY]
Structure
Thumb
Synonyms
  • [SO4](2-)
  • SO4(2-)
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
  • Sulfate ion (SO42-)
  • Sulfate ion(2-)
  • Sulfate(2-)
  • Sulfuric acid
  • Sulfuric acid anion(2-)
  • Sulfuric acid dianion
  • Sulfuric acid ion
  • Sulfuric acid ion(2-)
  • Sulfuric acid(2-)
  • Sulphate
  • Sulphate anion(2-)
  • Sulphate dianion
  • Sulphate ion
  • Sulphate ion(2-)
  • Sulphate(2-)
  • Sulphuric acid
  • Sulphuric acid anion(2-)
  • Sulphuric acid dianion
  • Sulphuric acid ion
  • Sulphuric acid ion(2-)
  • Sulphuric acid(2-)
  • [S(OH)2O2]
  • [SO2(OH)2]
  • Acide sulfurique
  • Acido sulfurico
  • Acidum sulfuricum
  • H2SO4
  • Schwefelsaeureloesungen
  • Acide sulphurique
  • Acido sulphurico
  • Acidum sulphuricum
  • Sulfate
CAS number14808-79-8
WeightAverage: 96.063
Monoisotopic: 95.951729178
InChI KeyQAOWNCQODCNURD-UHFFFAOYSA-L
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
IUPAC Namesulfuric acid
Traditional IUPAC Namesulfuric acid
Chemical FormulaO4S
SMILES[O-]S([O-])(=O)=O
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as non-metal sulfates. These are inorganic non-metallic compounds containing a sulfate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal sulfates
Direct ParentNon-metal sulfates
Alternative Parents
Substituents
  • Non-metal sulfate
  • Sulfuric acid
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.6 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.77 m³·mol⁻¹ChemAxon
Polarizability6.51 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • extracellular
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB Pathways
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Cysteine and methionine metabolismec00270 Map00270
Purine metabolismec00230 Map00230
Sulfur metabolismec00920 Map00920
SMPDB Reactions
3-O-Sulfogalactosylceramide (d18:1/24:0) + water → Galactosylceramide (d18:1/16:0) + Sulfate
Adenosine triphosphate + hydron + SulfateAdenosine phosphosulfate + Pyrophosphate
ThiosulfateSulfate
Adenosine triphosphate + water + SulfateADP + phosphate + hydron + Sulfate
Adenosine triphosphate + water + SulfateADP + phosphate + hydron + Sulfate
KEGG Reactions
Adenosine triphosphate + hydron + SulfatePyrophosphate + Adenosine phosphosulfate
hydron + Sulfate + ADPAdenosine phosphosulfate + phosphate
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). "The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism." BMC Syst Biol 2:71.18687109
  • Plateau, P., Fromant, M., Schmitter, J. M., Buhler, J. M., Blanquet, S. (1989). "Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase." J Bacteriol 171:6437-6445.2556364
  • Masselot, M., Surdin-Kerjan, Y. (1977). "Methionine biosynthesis in Saccharomyces cerevisiae. II. Gene-enzyme relationships in the sulfate assimilation pathway." Mol Gen Genet 154:23-30.197388
  • Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). "Growth control of the eukaryote cell: a systems biology study in yeast." J Biol 6:4.17439666
Synthesis Reference:Zhang, Qiu-Ju; Wang, Xiao; Chen, Jian-Min; Zhuang, Guo-Shun. Formation of Fe(II) (aq) and sulfate via heterogeneous reaction of SO2 with Fe2O3. Gaodeng Xuexiao Huaxue Xuebao (2006), 27(7), 1347-1350.
External Links:
ResourceLink
CHEBI ID16189
HMDB IDHMDB01448
Pubchem Compound ID1117
Kegg IDC00059
ChemSpider ID1085
FOODB IDFDB022629
WikipediaSulfate
BioCyc IDNH42SO4

Enzymes

General function:
Involved in sulfate adenylyltransferase (ATP) activity
Specific function:
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids
Gene Name:
MET3
Uniprot ID:
P08536
Molecular weight:
57724.0
Reactions
ATP + sulfate → diphosphate + adenylyl sulfate.
General function:
Involved in ATP adenylyltransferase activity
Specific function:
Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP
Gene Name:
APA1
Uniprot ID:
P16550
Molecular weight:
36492.19922
Reactions
ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.
ADP + sulfate → phosphate + adenylyl sulfate.
Adenylylsulfate + ATP → P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate.
General function:
Involved in iron ion binding
Specific function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Gene Name:
CYC1
Uniprot ID:
P00044
Molecular weight:
12181.90039
Reactions
General function:
Involved in iron ion binding
Specific function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Gene Name:
CYC7
Uniprot ID:
P00045
Molecular weight:
12532.2998
Reactions

Transporters

General function:
Involved in secondary active sulfate transmembrane transporter activity
Specific function:
High affinity uptake of sulfate into the cell
Gene Name:
SUL2
Uniprot ID:
Q12325
Molecular weight:
99649.79688
General function:
Involved in secondary active sulfate transmembrane transporter activity
Specific function:
High affinity uptake of sulfate into the cell
Gene Name:
SUL1
Uniprot ID:
P38359
Molecular weight:
95950.0