Thiamine transporter (Q05998)

Identification
NameThiamine transporter
SynonymsNot Available
Gene NameTHI7
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in nucleobase transmembrane transporter activity
Specific FunctionResponsible for intake of thiamine
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00220ThiamineShow
YMDB00862hydronShow
GO Classification
Component
membrane
cell part
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
nucleobase transmembrane transporter activity
Process
transmembrane transport
establishment of localization
transport
nucleobase, nucleoside, nucleotide and nucleic acid transport
Gene Properties
Chromosome Locationchromosome 12
LocusYLR237W
Gene Sequence>1797 bp ATGAGTTTCGGTAGTAAAGTCTCCAGGGCTTTGAGATTTTTGGAAATTCCTGTCAAAGAC AGGGCATCTGTGAGTTTCTTGAAGAACCCGGATTTGCAACCTATTAAGTCGGCTAACCAA ACATGGGGGTTCTGGTCTAATTTTGCATATTGGGGTGTTATGTCCTTTTCAGTGGGTACA TGGATGAGTGCCTCTTCTGCACTAGGTGTTGGATTAAGTTACCCAGAAACCATTGGTACA TTTATCGTCGGTGATGTGTTGACCATTATTTTCACATTGGCAAACTCGTGTCCTGGTTAC GACTGGAAGGTCGGTTTCACTTTGGCCCAAAGATTCGTCTTTGGTATTTACGGTTCTGCC TTCGGTATCATCATCAGAATTTTGATGAGTATTGTCAACTACGGGTCCAACGCTTGGGTG GGAGGTCTTTGTATCAATATGATCTTGGATTCATGGTCTCACCATTATTTGCACCTGCCA AACACCTTATCTTCGAAAGTTGCCATGACCACTAAAGAATTAATTGGTTTTATCATCTTC CACGTCCTTACTGCATTCTGTTACTTAATGAAACCCTACCACATGAACTACATTTTAATT TGGTCGTGTGTTGCTACATTTTTCTCTATGTTGGGTATGGTGATCTATTTAGCTAAACAG GCTCACGGTGTTGGAGAATTGTTTACCTCCACTAAATCCACTGCCACTGGCTCCACCAAA GCTTGGGCTTGGGTTTATATGATCTCGTACTGGTTCGGTTCCGTTTCTCCAGGTTCCACC AACCAAAGTGATTACTCGAGATTTGGTTCCTCCAATTGGGCTATCTGGGCCGGTACCATC TGTGCATTGTTAATTCCAACCACTTTAATCCCAGTTTTTGGTGTTATTGGTGCCTCCACC TGTGACAAACTATACGGTGAACAATATTGGATGCCTATGGATATCTTCAACCATTGGTTG ACAACTAACTATTCTGCAGGTGCTCGTGCCGGTGCGTTCTTCTGTGGTCTTTCATTTGTC CTATCTCAAATGTCCTACACCATCTCCAACTGTGGGTTTGCCAGTGGTATGGATTTGGCC GGTTTATTACCCAAGTATGTCGACATCAAGAGGGGTGCCCTTTTTGCCGCATGTGTCTCC TGGGCTTGTTTGCCATGGAACTTCTACAACTCTTCTTCTACTTTCTTGACTGTCATGAGT TCTTTCGGTGTTGTCATGACTCCTATCATTTCTGTCATGATTTGCGATAACTTCTTGATC AGAAAAAGACAATACTCCATCACTAATGCCTTTATTCTCAAGGGTGAATACTATTTCACT AAGGGTGTTAACTGGAGAGCTATTGTTGCCTGGGTTTGTGGTATGACCCCCGGTCTACCT GGTATTGCTTGGGAAGTCAATAATGACTATTTCCACAACACTGGTATTGTCAATTTCTTT TACGGTGACTCCTTCTTCTCGTTTTTGATCTCCTTTTTCGTCTATTGGGGACTATGCCTC CTCTTCCCATTCAAAATTACTGTCAAACATGATGACAAAGATTATTATGGTGCCTTTACT GACGAAGAAGCAAGAAAGAAGGGCATGGTTCCATACAGTGAAATTTCTGAAGAAGAAATC CGCGCTTACACATTAGGCGAAGGTTACACTACCGGCCACGAGTACAGACCTGAAGGCTCC GACGATGAAATACCTGAGTTGGTCAAAACTAGCTCTGAAAACACCAATGAGTTTGAAATA GTTCATCATAAGAATAATGAAAAGCAATCCTCCACCGCCAGTGAAAAAGCTGCTTAG
Protein Properties
Pfam Domain Function
Protein Residues598
Protein Molecular Weight66903.29688
Protein Theoretical pI7.08
Signalling Regions
  • None
Transmembrane Regions
  • 42-62
  • 74-94
  • 112-132
  • 174-194
  • 198-218
  • 241-261
  • 275-295
  • 333-353
  • 372-392
  • 395-415
  • 447-467
  • 484-504
Protein Sequence>Thiamine transporter MSFGSKVSRALRFLEIPVKDRASVSFLKNPDLQPIKSANQTWGFWSNFAYWGVMSFSVGT WMSASSALGVGLSYPETIGTFIVGDVLTIIFTLANSCPGYDWKVGFTLAQRFVFGIYGSA FGIIIRILMSIVNYGSNAWVGGLCINMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIF HVLTAFCYLMKPYHMNYILIWSCVATFFSMLGMVIYLAKQAHGVGELFTSTKSTATGSTK AWAWVYMISYWFGSVSPGSTNQSDYSRFGSSNWAIWAGTICALLIPTTLIPVFGVIGAST CDKLYGEQYWMPMDIFNHWLTTNYSAGARAGAFFCGLSFVLSQMSYTISNCGFASGMDLA GLLPKYVDIKRGALFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIISVMICDNFLI RKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMTPGLPGIAWEVNNDYFHNTGIVNFF YGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEI RAYTLGEGYTTGHEYRPEGSDDEIPELVKTSSENTNEFEIVHHKNNEKQSSTASEKAA
References
External Links
ResourceLink
Saccharomyces Genome Database THI7
Uniprot IDQ05998
Uniprot NameTHI7_YEAST
GenBank Gene IDD55634
Genebank Protein ID1871134
General Reference
  • Enjo, F., Nosaka, K., Ogata, M., Iwashima, A., Nishimura, H. (1997). "Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae." J Biol Chem 272:19165-19170.9235906
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956