| Identification |
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| Name | Cytochrome c oxidase assembly protein COX15 |
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| Synonyms | Not Available |
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| Gene Name | COX15 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in protein complex assembly |
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| Specific Function | Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase |
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| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00110 | NAD | Show | | YMDB00143 | NADH | Show | | YMDB00412 | NAD(+) | Show | | YMDB00882 | Heme A | Show | | YMDB00890 | water | Show | | YMDB00900 | oxygen | Show |
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| GO Classification | | Component |
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| cell part | | membrane | | Function |
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| Not Available | | Process |
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| cellular component organization or biogenesis | | cellular component organization | | cellular component assembly | | macromolecular complex assembly | | protein complex assembly |
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| Gene Properties |
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| Chromosome Location | chromosome 5 |
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| Locus | YER141W |
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| Gene Sequence | >1461 bp
ATGCTTTTCAGAAACATAGAAGTGGGCAGGCAGGCAGCTAAGCTATTAACGAGAACCTCG
AGTCGTTTGGCCTGGCAAAGTATTGGGGCCTCAAGGAATATTTCTACCATCAGACAACAA
ATCAGAAAGACTCAACTATATAATTTTAAGAAAACTGTGAGCATCCGTCCATTTTCTCTC
TCCTCCCCTGTTTTTAAACCACATGTTGCTTCAGAATCAAACCCTATAGAATCACGTTTG
AAGACCTCGAAGAATGTTGCTTACTGGTTAATAGGTACATCCGGTTTGGTATTTGGTATT
GTTGTTCTTGGTGGGTTGACTAGACTAACAGAATCGGGGCTGAGTATTACCGAATGGAAA
CCTGTCACAGGTACTTTGCCCCCTATGAACCAGAAGGAATGGGAAGAAGAATTTATCAAG
TATAAGGAATCACCAGAATTTAAATTGTTGAATTCTCACATTGATTTAGACGAGTTCAAG
TTTATATTTTTTATGGAGTGGATTCATAGATTGTGGGGTCGTGCTATCGGCGCTGTTTTT
ATATTACCTGCAGTTTATTTCGCTGTATCTAAAAAAACTTCAGGCCATGTCAATAAGAGG
TTGTTTGGTCTCGCAGGTTTATTAGGATTACAAGGATTTGTTGGTTGGTGGATGGTGAAG
TCTGGTCTTGATCAAGAGCAACTAGACGCAAGAAAATCAAAGCCTACCGTTTCTCAATAT
AGACTTACTACGCATTTGGGTACCGCCTTCTTTTTATACATGGGTATGCTCTGGACTGGT
TTGGAAATATTGAGAGAATGTAAATGGATTAAGAACCCTGTTCAAGCCATTAGTCTCTTC
AAAAAATTAGATAATCCCGCAATTGGCCCAATGAGAAAGATTTCTTTAGCTTTGTTAGCG
GTGTCTTTCCTTACCGCTATGAGTGGCGGTATGGTTGCCGGTTTGGATGCTGGTTGGGTC
TATAACACCTGGCCAAAAATGGGTGAACGATGGTTCCCTAGTTCTCGTGAATTAATGGAC
GAAAACTTCTGTAGAAGAGAGGACAAGAAAGATCTGTGGTGGAGGAATTTGCTAGAAAAC
CCGGTTACAGTTCAGTTGGTCCATAGGACATGTGCGTACGTTGCGTTTACATCAGTACTA
GCTGCTCATATGTACGCTATCAAAAAGAAGGCCGTAATTCCAAGGAACGCGATGACCTCT
TTGCATGTTATGATGGGCGTCGTTACTTTACAAGCAACACTTGGTATTTTAACTATATTG
TACCTAGTCCCAATATCGTTAGCTTCTATCCATCAAGCTGGTGCTTTGGCGTTGCTAACA
AGTTCTTTGGTGTTTGCCTCTCAATTAAGGAAGCCAAGAGCTCCGATGAGAAACGTAATC
ATTACCTTGCCACATTCAAGCAAAGTAACTAGCGGTAAAATTTTAAGTGAAGCGTCGAAG
TTAGCCTCGAAACCATTATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 486 |
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| Protein Molecular Weight | 54657.89844 |
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| Protein Theoretical pI | 10.83 |
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| Signalling Regions | |
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| Transmembrane Regions | - 86-106
- 171-191
- 201-221
- 244-264
- 294-314
- 403-423
- 425-445
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| Protein Sequence | >Cytochrome c oxidase assembly protein COX15
MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSL
SSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWK
PVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVF
ILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQY
RLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLA
VSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLEN
PVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTIL
YLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASK
LASKPL |
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| References |
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| External Links | |
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| General Reference | - Glerum, D. M., Muroff, I., Jin, C., Tzagoloff, A. (1997). "COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase." J Biol Chem 272:19088-19094.9228094
- Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
- Barros, M. H., Carlson, C. G., Glerum, D. M., Tzagoloff, A. (2001). "Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O." FEBS Lett 492:133-138.11248251
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