Phosphopantothenoylcysteine decarboxylase subunit SIS2 (P36024)

Identification
NamePhosphopantothenoylcysteine decarboxylase subunit SIS2
Synonyms
  • Halotolerance protein HAL3
  • Sit4 suppressor 2
Gene NameSIS2
Enzyme ClassNot Available
Biological Properties
General Functionresponse to salt stress
Specific FunctionComponent of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis. Acts as an inhibitory subunit of protein phosphatase PPZ1, which is involved in many cellular processes such as G1-S transition or salt tolerance. Also modulates the expression of the ENA1 ATPase.
Cellular LocationNot Available
SMPDB Pathways
beta-Alanine metabolismPW002381 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
beta-Alanine metabolismec00410 Map00410
SMPDB Reactions
4-Phosphopantothenoylcysteine + hydron → Carbon dioxide + 4'-phosphopantetheine
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB004004-PhosphopantothenoylcysteineShow
YMDB00862hydronShow
YMDB00912Carbon dioxideShow
YMDB162644'-phosphopantetheineShow
GO Classification
Function
nucleus
cytoplasm
CoA-synthesizing protein complex
phosphopantothenoylcysteine decarboxylase complex
phosphopantothenoylcysteine decarboxylase activity
protein phosphatase inhibitor activity
coenzyme A biosynthetic process
regulation of mitotic cell cycle
response to salt stress
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1689 bp ATGACTGCCGTCGCCTCTACTAGCGGGAAGCAAGATGCTGACCATAACCAGTCTATAGAG TGTCCAAGGTTTTCGCGTGGACAGAAAGAGATTTTGTTGGACCATGAGGATGCGAAGGGG AAGGATTCAATAATCAACTCCCCCGTGTCAGGGAGGCAATCAATAAGCCCTACTTTGTCG AATGCTACTACCACGACTACGAAATCTATTATGAATGCCACCGGCACCTCCGGCGCAGTA GTAAGTAATACTCCGGAGCCTGGTTTGAAGAGAGTCCCCGCCGTCACTTTCAGTGATCTA AAGCAACAGCAAAAGCAGGATAGTCTGACTCAGCTGAAGAACGACTCAGAAAGGACCAAG TCTCCAAATAGTAATCCTGCTCCTGTCTCAAATTCCATTCCTGGCAATCATGCAGTTATA CCGAACCACACCAACACTTCAAGAACAACGCAATTATCTGGGTCTCCACTCGTCAACGAA ATGAAAGATTATGATCCTAAGAAAAAAGACAGTGCTCTTAAAATAGTTGATACCATGAAG CCTGACAAAATCATGGCCACTTCAACGCCAATAAGTAGAGAAAATAATAAGGTAACCGCC AAAGCCCCCACCAGTATTACACTTCGAAAGGAAGATGCACAAGATCAAGCTAACAATGTT TCAGGCCAAATTAATGTGCGTTCTACCCCGGAAGAAACGCCAGTGAAGCAGTCCGTCATT CCTTCCATCATCCCCAAAAGAGAGAACTCCAAGAATTTGGATCCCAGACTACCTCAAGAT GATGGAAAATTGCACGTGTTGTTTGGCGCTACAGGTTCGTTATCGGTATTTAAGATCAAG CCAATGATTAAAAAACTAGAAGAAATATATGGACGTGATAGAATAAGCATTCAAGTTATC CTCACTCAATCAGCAACACAGTTTTTCGAACAAAGATATACCAAGAAAATTATCAAATCT TCAGAAAAACTAAATAAAATGTCGCAGTACGAATCCACTCCGGCAACTCCAGTGACACCA ACACCAGGACAATGCAACATGGCTCAAGTAGTCGAGTTACCCCCACATATTCAACTATGG ACCGACCAAGATGAATGGGACGCATGGAAACAACGAACTGATCCTGTACTTCATATAGAA CTACGTCGCTGGGCGGATATACTGGTAGTAGCTCCATTAACTGCAAACACATTATCAAAA ATTGCTTTGGGCCTGTGCGACAATCTTCTGACAAGTGTCATTAGAGCTTGGAATCCGAGT TATCCCATTCTTTTGGCACCTTCTATGGTGAGTAGCACTTTTAATTCTATGATGACAAAG AAGCAACTACAAACGATAAAGGAGGAAATGTCCTGGGTCACTGTTTTCAAGCCGTCTGAG AAAGTTATGGATATAAATGGTGATATTGGTCTCGGGGGTATGATGGACTGGAATGAGATT GTTAACAAAATCGTTATGAAATTGGGTGGGTACCCAAAAAATAACGAGGAAGAGGACGAT GATGAGGATGAGGAAGAAGACGACGACGAAGAAGAAGATACAGAAGATAAGAACGAAAAC AACAACGATGATGATGACGATGACGACGATGACGACGACGACGACGACGACGACGACGAC GACGACGACGATGATGACGAGGACGAGGACGAAGCAGAAACCCCAGGTATAATAGATAAG CATCAATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues562
Protein Molecular Weight62477.605
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Phosphopantothenoylcysteine decarboxylase subunit SIS2 MTAVASTSGKQDADHNQSIECPRFSRGQKEILLDHEDAKGKDSIINSPVSGRQSISPTLS NATTTTTKSIMNATGTSGAVVSNTPEPGLKRVPAVTFSDLKQQQKQDSLTQLKNDSERTK SPNSNPAPVSNSIPGNHAVIPNHTNTSRTTQLSGSPLVNEMKDYDPKKKDSALKIVDTMK PDKIMATSTPISRENNKVTAKAPTSITLRKEDAQDQANNVSGQINVRSTPEETPVKQSVI PSIIPKRENSKNLDPRLPQDDGKLHVLFGATGSLSVFKIKPMIKKLEEIYGRDRISIQVI LTQSATQFFEQRYTKKIIKSSEKLNKMSQYESTPATPVTPTPGQCNMAQVVELPPHIQLW TDQDEWDAWKQRTDPVLHIELRRWADILVVAPLTANTLSKIALGLCDNLLTSVIRAWNPS YPILLAPSMVSSTFNSMMTKKQLQTIKEEMSWVTVFKPSEKVMDINGDIGLGGMMDWNEI VNKIVMKLGGYPKNNEEEDDDEDEEEDDDEEEDTEDKNENNNDDDDDDDDDDDDDDDDDD DDDDDDEDEDEAETPGIIDKHQ
References
External Links
ResourceLink
Saccharomyces Genome Database SIS2
Uniprot IDP36024
Uniprot NameSIS2
General ReferenceNot Available