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Identification |
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Name | Glycerol-3-phosphate dehydrogenase, mitochondrial |
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Synonyms | |
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Gene Name | GUT2 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in oxidoreductase activity |
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Specific Function | sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol |
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Cellular Location | Mitochondrion inner membrane |
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SMPDB Pathways | |
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KEGG Pathways | Glycerophospholipid metabolism | ec00564 | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00073 | Glycerol 3-phosphate | Show | YMDB00155 | Quinone | Show | YMDB00296 | FAD | Show | YMDB00322 | Dihydroxyacetone phosphate | Show | YMDB00597 | FADH2 | Show |
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GO Classification | Component |
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macromolecular complex | protein complex | glycerol-3-phosphate dehydrogenase complex | Function |
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oxidoreductase activity | oxidoreductase activity, acting on CH-OH group of donors | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor | glycerol-3-phosphate dehydrogenase activity | catalytic activity | Process |
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metabolic process | oxidation reduction | small molecule metabolic process | alcohol metabolic process | polyol metabolic process | alditol metabolic process | glycerol metabolic process | glycerol-3-phosphate metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 9 |
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Locus | YIL155C |
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Gene Sequence | >1950 bp
ATGTTTTCGGTAACGAGAAGAAGAGCTGCCGGTGCAGCTGCTGCCATGGCCACAGCCACG
GGGACGCTGTACTGGATGACTAGCCAAGGTGATAGGCCGTTAGTGCACAATGACCCGAGC
TACATGGTGCAATTCCCCACCGCCGCTCCACCGCAGGTCTCTAGACGAGACCTGCTGGAC
CGTCTGGCCAAGACGCATCAATTCGACGTGTTGATCATCGGTGGCGGGGCCACGGGGACA
GGATGTGCCCTAGATGCTGCGACCAGGGGACTCAATGTGGCCCTTGTTGAAAAGGGGGAT
TTTGCCTCGGGAACGTCGTCCAAATCTACCAAGATGATTCACGGTGGGGTGCGGTACTTA
GAGAAGGCCTTCTGGGAGTTCTCCAAGGCACAACTGGATCTGGTCATCGAGGCACTCAAC
GAGCGTAAACATCTTATCAACACTGCCCCTCACCTGTGCACGGTGCTACCAATTCTGATC
CCCATCTACAGCACCTGGCAGGTCCCGTACATCTATATGGGCTGTAAATTCTACGATTTC
TTTGCCGGTTCCCAAAACTTGAAAAAATCATACCTACTGTCCAAATCCGCCACCGTGGAG
AAGGCTCCCATGCTTACCACAGACAATTTAAAGGCCTCGCTTGTGTACCATGATGGGTCC
TTTAACGACTCGCGTTTGAACGCCACTTTAGCCATCACGGCTGTGGAGAACGGCGCTACC
GTCTTGAACTATGTCGAGGTACAAAAATTGATCAAAGACCCAACTTCTGGTAAGGTTATC
GGTGCCGAGGCCCGGGACGTTGAGACTAATGAGCTTGTCAGAATCAACGCTAAATGTGTG
GTCAATGCCACGGGCCCATACAGTGACGCCATTTTGCAAATGGACCGCAACCCATCCGGT
CTGCCGGACTCCCCGCTAAACGACAACTCCAAGATCAAGTCGACTTTCAATCAAATCGCC
GTCATGGACCCGAAAATGGTCATCCCATCTATTGGCGTTCACATCGTATTGCCCTCTTTT
TACTGCCCGAAGGATATGGGTTTGTTGGACGTCAGAACCTCTGATGGCAGAGTGATGTTC
TTTTTACCTTGGCAGGGCAAAGTCCTTGCCGGCACCACAGACATCCCACTAAAGCAAGTC
CCAGAAAACCCTATGCCTACAGAGGCTGATATTCAAGATATCTTGAAAGAACTACAGCAC
TATATCGAATTCCCCGTGAAAAGAGAAGACGTGCTAAGTGCATGGGCTGGTGTCAGACCT
TTGGTCAGAGATCCACGTACAATCCCCGCAGACGGGAAGAAGGGCTCTGCCACTCAGGGC
GTGGTAAGATCCCACTTCTTGTTCACTTCGGATAATGGCCTAATTACTATTGCAGGTGGT
AAATGGACTACTTACAGACAAATGGCTGAGGAAACAGTCGACAAAGTTGTCGAAGTTGGC
GGATTCCACAACCTGAAACCTTGTCACACAAGAGATATTAAGCTTGCTGGTGCAGAAGAA
TGGACGCAAAACTATGTGGCTTTATTGGCTCAAAACTACCATTTATCATCAAAAATGTCC
AACTACTTGGTTCAAAACTACGGAACCCGTTCCTCTATCATTTGCGAATTTTTCAAAGAA
TCCATGGAAAATAAACTGCCTTTGTCCTTAGCCGACAAGGAAAATAACGTAATCTACTCT
AGCGAGGAGAACAACTTGGTCAATTTTGATACTTTCAGATATCCATTCACAATCGGTGAG
TTAAAGTATTCCATGCAGTACGAATATTGTAGAACTCCCTTGGACTTCCTTTTAAGAAGA
ACAAGATTCGCCTTCTTGGACGCCAAGGAAGCTTTGAATGCCGTGCATGCCACCGTCAAA
GTTATGGGTGATGAGTTCAATTGGTCGGAGAAAAAGAGGCAGTGGGAACTTGAAAAAACT
GTGAACTTCATCAAGACGTTTGGTGTCTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 649 |
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Protein Molecular Weight | 72388.29688 |
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Protein Theoretical pI | 8.01 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Glycerol-3-phosphate dehydrogenase, mitochondrial
MFSVTRRRAAGAAAAMATATGTLYWMTSQGDRPLVHNDPSYMVQFPTAAPPQVSRRDLLD
RLAKTHQFDVLIIGGGATGTGCALDAATRGLNVALVEKGDFASGTSSKSTKMIHGGVRYL
EKAFWEFSKAQLDLVIEALNERKHLINTAPHLCTVLPILIPIYSTWQVPYIYMGCKFYDF
FAGSQNLKKSYLLSKSATVEKAPMLTTDNLKASLVYHDGSFNDSRLNATLAITAVENGAT
VLNYVEVQKLIKDPTSGKVIGAEARDVETNELVRINAKCVVNATGPYSDAILQMDRNPSG
LPDSPLNDNSKIKSTFNQIAVMDPKMVIPSIGVHIVLPSFYCPKDMGLLDVRTSDGRVMF
FLPWQGKVLAGTTDIPLKQVPENPMPTEADIQDILKELQHYIEFPVKREDVLSAWAGVRP
LVRDPRTIPADGKKGSATQGVVRSHFLFTSDNGLITIAGGKWTTYRQMAEETVDKVVEVG
GFHNLKPCHTRDIKLAGAEEWTQNYVALLAQNYHLSSKMSNYLVQNYGTRSSIICEFFKE
SMENKLPLSLADKENNVIYSSEENNLVNFDTFRYPFTIGELKYSMQYEYCRTPLDFLLRR
TRFAFLDAKEALNAVHATVKVMGDEFNWSEKKRQWELEKTVNFIKTFGV |
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References |
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External Links | |
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General Reference | - Ronnow, B., Kielland-Brandt, M. C. (1993). "GUT2, a gene for mitochondrial glycerol 3-phosphate dehydrogenase of Saccharomyces cerevisiae." Yeast 9:1121-1130.8256521
- Churcher, C., Bowman, S., Badcock, K., Bankier, A., Brown, D., Chillingworth, T., Connor, R., Devlin, K., Gentles, S., Hamlin, N., Harris, D., Horsnell, T., Hunt, S., Jagels, K., Jones, M., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Rowley, N., Skelton, J., Smith, V., Barrell, B., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Nature 387:84-87.9169870
- Grandier-Vazeille, X., Bathany, K., Chaignepain, S., Camougrand, N., Manon, S., Schmitter, J. M. (2001). "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex." Biochemistry 40:9758-9769.11502169
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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