{"ymdb_id":"YMDB00597","created_at":"2011-05-29T18:34:21.000Z","updated_at":"2016-09-08T18:35:40.000Z","name":"FADH2","cas":"1910-41-4","state":"Solid","melting_point":null,"description":"Flavin adenine dinucleotide (FAD) is a redox cofactor involved in several important reactions in metabolism; it can exist in two different redox states (FAD and FADH2). The molecule consists of a riboflavin moiety (vitamin B2) bound to the phosphate group of an ADP molecule. The flavin group is bound to ribitol, a sugar alcohol, by a carbon-nitrogen bond.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":"Kavakli I Halil; Sancar Aziz  Analysis of the role of intraprotein electron transfer in photoreactivation by DNA photolyase in vivo.    Biochemistry  (2004),  43(48),  15103-10.","chebi_id":"17877","hmdb_id":"HMDB01197","kegg_id":"C01352","pubchem_id":"446013","cs_id":"25057974","foodb_id":null,"wikipedia_link":"FAD","biocyc_id":"FADH2","iupac":"{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-1H,2H,3H,4H,5H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"fadh(.)","logp":"-4.754266277947068","pka":"3.1874000191902","alogps_solubility":"3.39e+00 g/l","alogps_logp":"-0.23","alogps_logs":"-2.37","acceptor_count":"18","donor_count":"11","rotatable_bond_count":"13","polar_surface_area":"355.7599999999999","refractivity":"188.7976","polarizability":"69.68624254083198","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.009017835067944","pka_strongest_acidic":"1.8536781846381398","bioavailability":"0","number_of_rings":"6","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["1,5-dihydro-FAD","1,5-dihydro-P-5-ester with adenosine","Adenosine 5-(trihydrogen pyrophosphate)","Dihydro-FAD","Dihydroflavine-adenine dinucleotide","FAD","FADH2","FDA","flavin adenine dinucleotide (reduced form)","Flavin adenine dinucleotide (reduced)","flavin adenine dinucleotide reduced","Reduced flavine adenine dinucleotide"],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null},{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9587404,"citation":"Muratsubaki, H., Enomoto, K. (1998). \"One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene.\" Arch Biochem Biophys 352:175-181."}],"proteins":[{"created_at":"2011-05-26T17:16:17.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Glycerol-3-phosphate dehydrogenase, mitochondrial","uniprot_id":"P32191","uniprot_name":"GPDM_YEAST","enzyme":true,"transporter":false,"gene_name":"GUT2","num_residues":649,"molecular_weight":"72388.29688","theoretical_pi":"8.01","general_function":"Involved in oxidoreductase activity","specific_function":"sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol","reactions":[{"id":1590,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2469,"direction":"\u003e","locations":"Mitochondrion inner membrane","altext":"sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane","genbank_gene_id":"Z38059","genbank_protein_id":"557768","gene_card_id":"GUT2","chromosome_location":"chromosome 9","locus":"YIL155C","synonyms":["GPD-M","GPDH-M"],"enzyme_classes":["1.1.5.3"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" glycerol-3-phosphate dehydrogenase complex"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor"},{"category":"Function","description":" glycerol-3-phosphate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" alditol metabolic process"},{"category":"Process","description":" glycerol metabolic process"},{"category":"Process","description":" glycerol-3-phosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"}],"pfams":[{"name":"DAO","identifier":"PF01266"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGTTTTCGGTAACGAGAAGAAGAGCTGCCGGTGCAGCTGCTGCCATGGCCACAGCCACGGGGACGCTGTACTGGATGACTAGCCAAGGTGATAGGCCGTTAGTGCACAATGACCCGAGCTACATGGTGCAATTCCCCACCGCCGCTCCACCGCAGGTCTCTAGACGAGACCTGCTGGACCGTCTGGCCAAGACGCATCAATTCGACGTGTTGATCATCGGTGGCGGGGCCACGGGGACAGGATGTGCCCTAGATGCTGCGACCAGGGGACTCAATGTGGCCCTTGTTGAAAAGGGGGATTTTGCCTCGGGAACGTCGTCCAAATCTACCAAGATGATTCACGGTGGGGTGCGGTACTTAGAGAAGGCCTTCTGGGAGTTCTCCAAGGCACAACTGGATCTGGTCATCGAGGCACTCAACGAGCGTAAACATCTTATCAACACTGCCCCTCACCTGTGCACGGTGCTACCAATTCTGATCCCCATCTACAGCACCTGGCAGGTCCCGTACATCTATATGGGCTGTAAATTCTACGATTTCTTTGCCGGTTCCCAAAACTTGAAAAAATCATACCTACTGTCCAAATCCGCCACCGTGGAGAAGGCTCCCATGCTTACCACAGACAATTTAAAGGCCTCGCTTGTGTACCATGATGGGTCCTTTAACGACTCGCGTTTGAACGCCACTTTAGCCATCACGGCTGTGGAGAACGGCGCTACCGTCTTGAACTATGTCGAGGTACAAAAATTGATCAAAGACCCAACTTCTGGTAAGGTTATCGGTGCCGAGGCCCGGGACGTTGAGACTAATGAGCTTGTCAGAATCAACGCTAAATGTGTGGTCAATGCCACGGGCCCATACAGTGACGCCATTTTGCAAATGGACCGCAACCCATCCGGTCTGCCGGACTCCCCGCTAAACGACAACTCCAAGATCAAGTCGACTTTCAATCAAATCGCCGTCATGGACCCGAAAATGGTCATCCCATCTATTGGCGTTCACATCGTATTGCCCTCTTTTTACTGCCCGAAGGATATGGGTTTGTTGGACGTCAGAACCTCTGATGGCAGAGTGATGTTCTTTTTACCTTGGCAGGGCAAAGTCCTTGCCGGCACCACAGACATCCCACTAAAGCAAGTCCCAGAAAACCCTATGCCTACAGAGGCTGATATTCAAGATATCTTGAAAGAACTACAGCACTATATCGAATTCCCCGTGAAAAGAGAAGACGTGCTAAGTGCATGGGCTGGTGTCAGACCTTTGGTCAGAGATCCACGTACAATCCCCGCAGACGGGAAGAAGGGCTCTGCCACTCAGGGCGTGGTAAGATCCCACTTCTTGTTCACTTCGGATAATGGCCTAATTACTATTGCAGGTGGTAAATGGACTACTTACAGACAAATGGCTGAGGAAACAGTCGACAAAGTTGTCGAAGTTGGCGGATTCCACAACCTGAAACCTTGTCACACAAGAGATATTAAGCTTGCTGGTGCAGAAGAATGGACGCAAAACTATGTGGCTTTATTGGCTCAAAACTACCATTTATCATCAAAAATGTCCAACTACTTGGTTCAAAACTACGGAACCCGTTCCTCTATCATTTGCGAATTTTTCAAAGAATCCATGGAAAATAAACTGCCTTTGTCCTTAGCCGACAAGGAAAATAACGTAATCTACTCTAGCGAGGAGAACAACTTGGTCAATTTTGATACTTTCAGATATCCATTCACAATCGGTGAGTTAAAGTATTCCATGCAGTACGAATATTGTAGAACTCCCTTGGACTTCCTTTTAAGAAGAACAAGATTCGCCTTCTTGGACGCCAAGGAAGCTTTGAATGCCGTGCATGCCACCGTCAAAGTTATGGGTGATGAGTTCAATTGGTCGGAGAAAAAGAGGCAGTGGGAACTTGAAAAAACTGTGAACTTCATCAAGACGTTTGGTGTCTAA","protein_sequence":"MFSVTRRRAAGAAAAMATATGTLYWMTSQGDRPLVHNDPSYMVQFPTAAPPQVSRRDLLDRLAKTHQFDVLIIGGGATGTGCALDAATRGLNVALVEKGDFASGTSSKSTKMIHGGVRYLEKAFWEFSKAQLDLVIEALNERKHLINTAPHLCTVLPILIPIYSTWQVPYIYMGCKFYDFFAGSQNLKKSYLLSKSATVEKAPMLTTDNLKASLVYHDGSFNDSRLNATLAITAVENGATVLNYVEVQKLIKDPTSGKVIGAEARDVETNELVRINAKCVVNATGPYSDAILQMDRNPSGLPDSPLNDNSKIKSTFNQIAVMDPKMVIPSIGVHIVLPSFYCPKDMGLLDVRTSDGRVMFFLPWQGKVLAGTTDIPLKQVPENPMPTEADIQDILKELQHYIEFPVKREDVLSAWAGVRPLVRDPRTIPADGKKGSATQGVVRSHFLFTSDNGLITIAGGKWTTYRQMAEETVDKVVEVGGFHNLKPCHTRDIKLAGAEEWTQNYVALLAQNYHLSSKMSNYLVQNYGTRSSIICEFFKESMENKLPLSLADKENNVIYSSEENNLVNFDTFRYPFTIGELKYSMQYEYCRTPLDFLLRRTRFAFLDAKEALNAVHATVKVMGDEFNWSEKKRQWELEKTVNFIKTFGV"},{"created_at":"2011-05-26T17:56:42.000Z","updated_at":"2011-05-26T17:56:42.000Z","name":"Fumarate reductase","uniprot_id":"P32614","uniprot_name":"FRDS_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":470,"molecular_weight":"50843.69922","theoretical_pi":"6.26","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2498,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm","altext":"Succinate + NAD(+) = fumarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"U18779","genbank_protein_id":"603632","gene_card_id":null,"chromosome_location":null,"locus":"YEL047C","synonyms":["FAD-dependent oxidoreductase FRDS","NADH","NADH-dependent fumarate reductase"],"enzyme_classes":["1.3.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTCTCTCTCTCCCGTTGTTGTTATTGGAACCGGTTTGGCCGGGCTGGCTGCTGCCAATGAATTGGTTAACAAGTATAACATCCCTGTAACCATCCTCGAAAAGGCTTCCTCGATCGGTGGGAACTCTATCAAGGCCTCCAGTGGTATTAACGGTGCTTGCACCGAGACTCAACGTCACTTCCACATCGAGGACTCCCCACGCTTATTTGAAGATGACACCATCAAGTCTGCTAAAGGTAAAGGTGTCCAAGAATTAATGGCTAAGTTGGCCAATGATTCTCCCCTGGCTATTGAATGGTTGAAAAACGAATTTGATTTGAAATTGGACCTATTGGCTCAATTGGGTGGCCACTCTGTGGCAAGAACTCACAGATCGTCTGGGAAGTTGCCTCCAGGTTTCGAAATTGTTTCTGCCTTATCTAACAATTTGAAGAAATTAGCTGAGACTAAACCAGAGTTAGTTAAGATTAACTTAGACAGTAAAGTCGTAGACATCCATGAAAAGGATGGCTCCATTTCTGCTGTAGTGTACGAGGACAAGAATGGCGAAAAGCACATGGTGAGTGCTAACGATGTCGTTTTTTGTTCTGGAGGGTTTGGCTTTTCTAAGGAAATGCTTAAAGAATACGCACCCGAACTGGTGAACTTGCCAACAACAAACGGGCAACAAACAACTGGTGATGGTCAAAGGCTTCTGCAGAAGTTAGGCGCTGATCTGATTGACATGGACCAAATTCAAGTTCATCCAACTGGGTTCATTGATCCAAATGACCGTAGCTCAAGCTGGAAATTCTTGGCTGCCGAATCCTTAAGAGGTCTTGGTGGTATCCTATTAAACCCTATTACCGGTAGAAGATTTGTCAACGAATTGACCACAAGAGATGTAGTCACTGCAGCTATTCAAAAGGTTTGTCCTCAAGAGGATAACAGAGCACTATTGGTTATGGGCGAAAAAATGTACACAGATTTGAAGAATAATTTAGATTTTTACATGTTCAAGAAACTTGTACAGAAATTGACATTATCTCAAGTTGTTTCTGAATATAATTTACCAATCACTGTCGCCCAATTATGCGAGGAATTGCAAACATACTCTTCCTTCACTACCAAGGCTGATCCGTTGGGACGTACCGTTATTCTCAACGAATTTGGCTCTGACGTTACTCCAGAAACTGTGGTTTTTATTGGTGAAGTAACACCGGTTGTCCATTTCACCATGGGTGGTGCTAGAATCAATGTCAAGGCTCAAGTCATTGGCAAGAACGACGAAAGGCTACTAAAAGGCCTGTACGCGGCCGGTGAAGTTTCTGGCGGTGTTCATGGCGCCAATAGGTTGGGTGGTTCAAGTTTGTTAGAATGCGTTGTCTTTGGGAGAACCGCAGCTGAATCTATTGCCAATGACCGCAAGTAA","protein_sequence":"MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK"},{"created_at":"2011-05-26T17:57:08.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Osmotic growth protein 1","uniprot_id":"P21375","uniprot_name":"OSM1_YEAST","enzyme":true,"transporter":false,"gene_name":"OSM1","num_residues":501,"molecular_weight":"55064.80078","theoretical_pi":"9.51","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3732,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006258","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Probable)","genbank_gene_id":"L26347","genbank_protein_id":"695798","gene_card_id":"OSM1","chromosome_location":"chromosome 10","locus":"YJR051W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[],"gene_sequence":"ATGATTAGATCTGTGAGAAGGGTTTTCATTTACGTCTCAATATTCGTATTGATAATAGTTTTGAAAAGAACATTAAGTGGCACAGATCAAACGTCAATGAAACAACCAGTGGTGGTCATTGGCTCTGGTTTGGCAGGCTTAACCACAAGTAATCGTCTCATTAGTAAATACAGAATTCCTGTTGTGCTTTTGGATAAGGCGGCTTCTATTGGTGGGAATTCTATAAAGGCTTCTAGTGGTATTAATGGTGCTCACACAGACACTCAACAAAATTTAAAGGTAATGGACACTCCCGAATTGTTTTTGAAAGATACTTTGCATTCGGCTAAAGGCAGAGGGGTTCCATCACTGATGGATAAGTTGACTAAGGAATCCAAGAGTGCTATCAGGTGGTTGCAAACAGAATTCGATTTGAAATTAGACCTCCTTGCGCAATTGGGCGGTCACTCTGTTCCAAGGACCCATAGATCTTCTGGCAAATTACCACCAGGTTTTGAAATCGTGCAAGCGTTATCAAAAAAACTAAAGGATATCTCTTCCAAAGATTCCAATCTCGTGCAGATTATGCTAAACAGTGAAGTAGTGGATATCGAGCTTGATAATCAAGGTCATGTTACTGGTGTAGTATATATGGACGAGAACGGAAACCGTAAAATCATGAAGTCACACCATGTCGTGTTTTGCTCAGGTGGATTTGGTTACTCTAAGGAAATGTTGAAAGAGTACTCACCAAATTTGATTCACTTGCCAACTACTAATGGCAAACAGACTACAGGTGATGGTCAAAAAATCCTTTCAAAGTTGGGTGCCGAATTGATTGATATGGATCAAGTGCAGGTACACCCTACCGGCTTCATTGATCCAAATGACCGTGAAAATAACTGGAAGTTTTTGGCTGCAGAGGCATTGAGGGGTTTAGGCGGCATCTTATTGCATCCCACCACTGGAAGAAGGTTTACAAATGAATTGAGCACCAGAGATACAGTAACCATGGAAATACAGTCTAAATGTCCGAAAAATGATAATAGAGCACTTTTGGTAATGAGCGACAAAGTCTACGAGAACTATACGAATAACATAAACTTTTATATGTCCAAAAACTTAATCAAAAAAGTGTCAATCAACGATCTGATCCGACAATATGACCTACAAACTACAGCTTCTGAACTGGTAACTGAACTGAAGAGCTATTCCGATGTTAATACTAAGGATACGTTTGATAGGCCATTGATTATCAATGCCTTTGATAAAGATATTTCGACTGAATCAACTGTTTATGTTGGGGAAGTTACACCAGTTGTTCATTTCACAATGGGTGGTGTGAAAATTAATGAGAAATCTCAGGTAATTAAGAAAAATTCGGAAAGCGTTCTATCTAATGGGATATTTGCTGCTGGTGAAGTTTCGGGTGGTGTTCATGGAGCCAACAGATTGGGTGGATCTAGTTTGTTAGAGTGTGTTGTCTTTGGAAAGACAGCTGCGGATAACATAGCAAAATTGTACTGA","protein_sequence":"MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY"},{"created_at":"2011-05-26T18:00:13.000Z","updated_at":"2011-06-05T02:21:17.000Z","name":"Mitochondrial FAD carrier protein FLX1","uniprot_id":"P40464","uniprot_name":"FLX1_YEAST","enzyme":false,"transporter":true,"gene_name":"FLX1","num_residues":311,"molecular_weight":"34408.89844","theoretical_pi":"10.42","general_function":"Involved in binding","specific_function":"Transport of FAD from the cytosol to the mitochondrial matrix","reactions":[],"signal_regions":"None","transmembrane_regions":"13-33;77-97;129-149;183-203;230-250;266-286","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"AY692757","genbank_protein_id":"51012965","gene_card_id":"FLX1","chromosome_location":"chromosome 9","locus":"YIL134W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGGTCGATCACCAGTGGACGCCACTGCAGAAGGAGGTTATCTCAGGTCTGTCCGCGGGATCCGTCACCACATTGGTAGTGCATCCATTAGATTTACTGAAGGTTCGTTTGCAATTATCCGCTACAAGCGCACAAAAGGCCCATTACGGCCCATTTATGGTAATCAAAGAGATTATACGTTCGTCGGCGAATAGTGGACGTAGTGTTACGAACGAACTGTATCGCGGATTAAGCATAAATTTGTTTGGAAATGCCATTGCATGGGGAGTTTATTTCGGTTTATATGGTGTCACGAAAGAATTGATATACAAGTCAGTGGCAAAGCCAGGGGAAACACAGCTTAAAGGTGTTGGGAACGACCACAAAATGAATTCGCTTATTTATTTGTCTGCCGGTGCTTCCAGTGGGTTGATGACAGCTATCCTAACAAACCCTATCTGGGTTATAAAGACCAGGATAATGTCTACAAGTAAAGGCGCCCAAGGAGCGTACACTTCTATGTACAACGGTGTCCAACAACTGTTACGAACTGATGGCTTCCAGGGCCTATGGAAGGGCCTTGTACCCGCACTGTTTGGTGTTTCGCAAGGTGCCTTATATTTTGCAGTTTACGATACCTTAAAGCAAAGAAAATTGCGACGGAAGAGGGAAAATGGGCTTGACATCCATTTAACAAATCTTGAAACCATTGAAATCACATCGTTGGGAAAAATGGTCTCCGTCACTTTGGTTTACCCTTTTCAATTATTGAAATCAAACTTACAAAGTTTCAGGGCCAATGAGCAAAAATTTAGGCTCTTTCCTTTGATAAAATTAATCATTGCTAATGATGGTTTTGTTGGACTTTATAAGGGCCTATCTGCAAACTTAGTACGGGCCATTCCATCCACTTGCATTACCTTTTGTGTATACGAGAACCTTAAGCATAGGCTTTAG","protein_sequence":"MVDHQWTPLQKEVISGLSAGSVTTLVVHPLDLLKVRLQLSATSAQKAHYGPFMVIKEIIRSSANSGRSVTNELYRGLSINLFGNAIAWGVYFGLYGVTKELIYKSVAKPGETQLKGVGNDHKMNSLIYLSAGASSGLMTAILTNPIWVIKTRIMSTSKGAQGAYTSMYNGVQQLLRTDGFQGLWKGLVPALFGVSQGALYFAVYDTLKQRKLRRKRENGLDIHLTNLETIEITSLGKMVSVTLVYPFQLLKSNLQSFRANEQKFRLFPLIKLIIANDGFVGLYKGLSANLVRAIPSTCITFCVYENLKHRL"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"}]}