Myo-inositol transporter 1 (P30605)

Identification
NameMyo-inositol transporter 1
SynonymsNot Available
Gene NameITR1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transporter activity
Specific FunctionMajor transporter for myo-inositol
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00173MyoinositolShow
YMDB00862hydronShow
GO Classification
Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
Function
substrate-specific transmembrane transporter activity
transporter activity
transmembrane transporter activity
Process
transport
transmembrane transport
establishment of localization
Gene Properties
Chromosome Locationchromosome 4
LocusYDR497C
Gene Sequence>1755 bp ATGGGAATACACATACCATATCTCACGTCAAAGACATCGCAATCAAATGTTGGTGATGCC GTTGGCAACGCTGATAGTGTAGAGTTCAACAGTGAGCATGACTCACCTTCAAAGAGAGGT AAAATTCACATTGAGTCACATGAAATACAGAGGGCTCCCGCTAGCGATGATGAAGATAGG ATTCAAATTAAACCCGTGAACGACGAGGATGACACGTCGGTCATGATCACTTTTAACCAA TCTCTTTCGCCCTTCATCATCACTCTGACTTTTGTCGCATCCATATCCGGTTTCATGTTT GGTTACGACACTGGTTATATATCCAGTGCGCTGATCTCGATCGGCACAGATCTGGACCAC AAGGTACTTACTTATGGGGAGAAGGAAATTGTCACTGCGGCTACCTCTCTGGGAGCTTTG ATTACCAGTATTTTCGCCGGTACTGCAGCTGACATATTTGGTAGGAAACGTTGTTTAATG GGTTCGAATCTGATGTTTGTCATTGGCGCAATCTTACAGGTCTCCGCACACACATTCTGG CAAATGGCTGTTGGTAGACTGATCATGGGTTTCGGTGTCGGTATCGGCTCCTTGATCGCG CCACTTTTCATCAGTGAAATTGCTCCCAAAATGATCAGAGGGAGACTAACTGTCATCAAT TCCTTATGGTTGACTGGTGGTCAATTAGTCGCTTACGGTTGCGGTGCTGGGTTAAACTAC GTCAACAATGGTTGGAGAATTCTTGTTGGATTGTCACTAATTCCCACTGCTGTGCAATTC ACATGCCTGTGCTTTTTACCTGACACTCCAAGATACTACGTTATGAAGGGCGACTTGGCA AGGGCTACTGAGGTGTTGAAGAGAAGTTACACTGACACTTCGGAGGAAATCATTGAACGT AAGGTGGAAGAACTTGTTACTTTGAATCAATCTATTCCTGGTAAGAATGTCCCTGAAAAA GTCTGGAATACCATCAAAGAATTGCACACAGTACCATCTAATCTAAGGGCTTTGATCATT GGTTGTGGTTTACAAGCAATTCAACAGTTTACCGGTTGGAATTCGTTGATGTATTTCTCT GGTACCATCTTCGAAACTGTCGGTTTCAAAAATTCTTCCGCTGTTTCAATCATCGTGTCC GGTACCAATTTTATTTTCACTTTAGTTGCCTTTTTTTCCATTGACAAAATAGGCCGTAGA ACCATATTATTGATTGGATTACCAGGCATGACCATGGCTTTAGTCGTGTGCTCTATTGCT TTCCATTTTCTAGGTATTAAGTTTGATGGCGCTGTCGCTGTGGTGGTTTCCTCCGGTTTC TCCTCTTGGGGTATTGTGATCATCGTATTTATTATCGTATTTGCTGCGTTCTACGCTCTT GGTATCGGTACTGTTCCATGGCAACAATCGGAACTATTCCCCCAAAACGTGAGAGGTATT GGGACTTCATATGCAACTGCTACAAACTGGGCTGGTTCACTGGTTATTGCATCCACATTT TTGACCATGTTACAGAATATCACTCCTGCAGGTACATTTGCCTTTTTCGCGGGATTGTCG TGCTTATCAACCATTTTCTGCTACTTCTGTTATCCAGAATTATCGGGATTGGAGTTAGAA GAGGTACAAACTATTTTGAAGGACGGGTTCAACATCAAAGCCTCGAAAGCTTTGGCCAAG AAGAGAAAACAGCAAGTTGCCAGAGTTCATGAATTGAAATATGAACCAACTCAAGAGATT ATAGAGGATATATAG
Protein Properties
Pfam Domain Function
Protein Residues584
Protein Molecular Weight63569.10156
Protein Theoretical pI6.51
Signalling Regions
  • None
Transmembrane Regions
  • 82-102
  • 130-150
  • 164-184
  • 187-207
  • 216-236
  • 247-267
  • 350-370
  • 377-397
  • 401-421
  • 442-462
  • 487-507
  • 511-531
Protein Sequence>Myo-inositol transporter 1 MGIHIPYLTSKTSQSNVGDAVGNADSVEFNSEHDSPSKRGKITLESHEIQRAPASDDEDR IQIKPVNDEDDTSVMITFNQSLSPFIITLTFVASISGFMFGYDTGYISSALISIGTDLDH KVLTYGEKEIVTAATSLGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFW QMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNY VNNGWRILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLKRSYTDTSEEIIER KVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFS GTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIA FHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPWQQSELFPQNVRGI GTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLELE EVQTILKDGFNIKASKALAKKRKQQVARVHELKYEPTQEIIEDI
References
External Links
ResourceLink
Saccharomyces Genome Database ITR1
Uniprot IDP30605
Uniprot NameITR1_YEAST
GenBank Gene IDD90352
Genebank Protein ID218437
General Reference
  • Nikawa, J., Tsukagoshi, Y., Yamashita, S. (1991). "Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae." J Biol Chem 266:11184-11191.2040626
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
  • Hitchcock, A. L., Auld, K., Gygi, S. P., Silver, P. A. (2003). "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery." Proc Natl Acad Sci U S A 100:12735-12740.14557538
  • Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Mol Cell Proteomics 4:310-327.15665377
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258