| Identification |
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| Name | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase |
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| Synonyms | Not Available |
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| Gene Name | GPI12 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in N-acetylglucosaminylphosphatidylinositol de |
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| Specific Function | Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol |
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| Cellular Location | Endoplasmic reticulum membrane |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | ec00563 |  |
|
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | | water
+
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
↔
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
+
Acetic acid
+
hydron
|
|
|---|
| Metabolites | | YMDB ID | Name | View |
|---|
| YMDB00056 | Acetic acid | Show | | YMDB00862 | hydron | Show | | YMDB00890 | water | Show |
|
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| GO Classification | Not Available |
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| Gene Properties |
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| Chromosome Location | chromosome 13 |
|---|
| Locus | YMR281W |
|---|
| Gene Sequence | >915 bp
ATGAAGATGTTGAGGCGTACAAAGGTAAATTTTTCAAAATTGCTTTACAAGATTACTAAA
CTAGCAATAGTACTGACGATCCTATATATTTATTTTACGCCCAAAATCGTCTCCCGAAAC
AATGCATCATTGCAGCATATTTTTCCTCATAAATATGGCGATTATGAAATCAATTTGGTC
ATAGCGCACCCTGACGACGAAGTTATGTTTTTTTCCCCCATAATTTCTCAACTGAATTCG
TACTTTCCGAGAACCGTCCCATTTAACATAATCTGCTTATCAAAGGGCAACGCCGAAGGT
CTTGGCGAAACCAGGGTAAGAGAATTAAATGAGTCGGCCGCTTTATTGCTACACAATGAA
AGAGCAGTCTCCGTACAGGTGATGGATTTCCAGGATGGTATGGACGAAATATGGGATATT
GATTCTATAACTTCTTCTCTTTCACAAAAGATAGATATAAAGAATCATAACTTGAACCAG
ATTATCGTTACCTTTGATTCATATGGTGTATCAAATCATATCAACCACAAAAGCTGTTAT
GCTGCCGTTAAAAAGTTGGTGGATGATTATGCTCAACCTAAGACCAAAAGAAATGAACAA
CCACCTCATGTCACTGCGCTTTATTTGAGAAGCTACAAGAACAACATCGTTTTAAAGTAC
AACTCCTTTATTTGGGAAATCCTAAAAATACTTTACGACCTGATTTCTCCATTCCGTAGA
ATAATTCAGGCGCTTCCGCCTAACACAGCCGCCGAAAAAGACAAGCTTTCACTTATGAAT
ACACATGCACAATACGTACTAGCGTTTGCCACTATGCTAAATGCTCACGAATCCCAAGTT
GTGTGGTTTAGATACGGATGGTGGATATTTTCCAGATTTGTCTTCGTTAATGAATTTGAT
GTTTATACATATTAG |
|---|
| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 304 |
|---|
| Protein Molecular Weight | 35445.60156 |
|---|
| Protein Theoretical pI | 9.23 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
MKMLRRTKVNFSKLLYKITKLAIVLTILYIYFTPKIVSRNNASLQHIFPHKYGDYEINLV
IAHPDDEVMFFSPIISQLNSYFPRTVPFNIICLSKGNAEGLGETRVRELNESAALLLHNE
RAVSVQVMDFQDGMDEIWDIDSITSSLSQKIDIKNHNLNQIIVTFDSYGVSNHINHKSCY
AAVKKLVDDYAQPKTKRNEQPPHVTALYLRSYKNNIVLKYNSFIWEILKILYDLISPFRR
IIQALPPNTAAEKDKLSLMNTHAQYVLAFATMLNAHESQVVWFRYGWWIFSRFVFVNEFD
VYTY |
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| References |
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| External Links | |
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| General Reference | - Watanabe, R., Ohishi, K., Maeda, Y., Nakamura, N., Kinoshita, T. (1999). "Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis." Biochem J 339 ( Pt 1):185-192.10085243
- Finnegan, P. M., Payne, M. J., Keramidaris, E., Lukins, H. B. (1991). "Characterization of a yeast nuclear gene, AEP2, required for accumulation of mitochondrial mRNA encoding subunit 9 of the ATP synthase." Curr Genet 20:53-61.1718609
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
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