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Identification |
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Name | Dihydrosphingosine 1-phosphate phosphatase YSR3 |
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Synonyms | - Long-chain base protein 2
- Sphingolipid resistance protein 3
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Gene Name | YSR3 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in catalytic activity |
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Specific Function | Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling |
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Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
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SMPDB Pathways | Not Available |
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KEGG Pathways | Not Available |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00285 | Phytosphingosine | Show | YMDB00299 | Sphinganine 1-phosphate | Show | YMDB00327 | Sphinganine | Show | YMDB00762 | Phytosphingosine 1-phosphate | Show | YMDB00890 | water | Show |
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GO Classification | Component |
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cell part | membrane | Function |
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catalytic activity | Process |
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Not Available |
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Gene Properties |
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Chromosome Location | chromosome 11 |
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Locus | YKR053C |
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Gene Sequence | >1215 bp
ATGACCATTATTCAGACGGTTACTGAATTGGGTGTTACCGAGGACACCATTAAGGTTCAG
ATGGCTCCTTCCGGCGGCAAACACCTATTGGCAGATCCCGGTAATCATCCAGCGGAGCAT
TTTGAGAGCCAGATGTCGTGGCTAAGGTTTCAAACAAGGCAGTATCTAACTAGATTCACA
GACAACCAATCAGATTTCGTACATTCTTTACAAAAAAAGCACAGAACGCCTTTTAGAGAC
GTTTATTTCAAATACACTTCGCTTATGGGTTCCCACATGTTTTATGTTATCGTGCTTCCC
ATGCCTGTGTGGCTTGGATACCGCGATTTAACACGGGACATGATCTACGTTCTTGGTTAT
TCAATTTATTTGAGTGGCTACTTAAAGGATTATTGGTGCCTACCAAGGCCAAAATCACCG
CCAGTTGACAGAATCACACTAAGTGAATACACTACGAAAGAATATGGTGCACCCAGTTCA
CATTCTGCTAACGCTACTGCGGTAAGTCTATTATTCTTTTGGAGAATATGTTTATCTGAC
ACACTGGTATGGCCAACAAAGCTTCTTTTACTGAGTCTGGTGATATTTTACTACTTAACC
CTGGTTTTTGGTAGAGTTTACTGCGGTATGCATGGTATGCTGGATTTATTTAGCGGCGCC
GCAGTTGGAGCTATCTGTTTTTTTATAAGAATCTGGGTGGTGCATGCTTTACGAAATTTC
CAGATTGGTGAACATCTCTGGTTTCCCCTTTTGAGTGTAGCATGGGGCTTGTTTATTCTG
TTTAACCACGTCAGGCCCATTGATGAATGTCCTTGTTTCGAAGATAGCGTAGCGTTCATT
GGCGTAGTCAGTGGGCTGGATTGCAGCGACTGGTTAACCGAAAGATACGGATGGAACCTT
GTATGTAGTAGGTACGCATCATGTGGTTCTAAGGTGTTCTTGAGGCCTCTGGTAGGTGTC
GCTTCTGTGATTGTTTGGAAAGACGTCATTAGCAAGACAGCTGTCTACACGCTGTTAATT
AAACTACTCAGATTTCACGATGATAGAAGCGAAAAGGTTCATTTCCATAACGAGACAAGT
GAAGAAGAAGAGTGTTTATTGTACAGCGGTGTTTCCAAAGTGGAAATCGTCGGAAGGTTT
CTCATATACGCAGGTATACCTACAACCGTCTTTTTGCTATGCCCAGTTTTTTTCACTTGG
ACAAACTTAAGGTAG |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 404 |
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Protein Molecular Weight | 46487.69922 |
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Protein Theoretical pI | 7.73 |
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Signalling Regions | |
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Transmembrane Regions | - 87-107
- 114-134
- 155-176
- 183-203
- 216-236
- 242-262
- 320-340
- 380-400
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Protein Sequence | >Dihydrosphingosine 1-phosphate phosphatase YSR3
MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFT
DNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGY
SIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSD
TLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNF
QIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNL
VCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETS
EEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR |
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References |
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External Links | |
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General Reference | - Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
- Wiesenberger, G., Link, T. A., von Ahsen, U., Waldherr, M., Schweyen, R. J. (1991). "MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family." J Mol Biol 217:23-37.1703236
- Mao, C., Wadleigh, M., Jenkins, G. M., Hannun, Y. A., Obeid, L. M. (1997). "Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase." J Biol Chem 272:28690-28694.9353337
- Mandala, S. M., Thornton, R., Tu, Z., Kurtz, M. B., Nickels, J., Broach, J., Menzeleev, R., Spiegel, S. (1998). "Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response." Proc Natl Acad Sci U S A 95:150-155.9419344
- Mao, C., Saba, J. D., Obeid, L. M. (1999). "The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses." Biochem J 342 Pt 3:667-675.10477278
- Zanolari, B., Friant, S., Funato, K., Sutterlin, C., Stevenson, B. J., Riezman, H. (2000). "Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae." EMBO J 19:2824-2833.10856228
- Mao, C., Obeid, L. M. (2000). "Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging." Methods Enzymol 311:223-232.10563329
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