{"ymdb_id":"YMDB00762","created_at":"2011-05-29T18:50:53.000Z","updated_at":"2016-09-08T18:35:52.000Z","name":"Phytosphingosine 1-phosphate","cas":null,"state":null,"melting_point":null,"description":"Phytosphingosine 1-phosphate is an intermediate in sphingolipid metabolism pathway. Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannosyl-diinositol-phosphorylceramide (M(IP)2C). Sphingolipid long chain bases (LCBs) - dihydrosphingosine (DHS) and phytosphingosine (PHS) - are implicated as secondary messengers in vital signaling pathways. [Biocyc SPHINGOLIPID-SYN-PWY] ","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum","synthesis_reference":null,"chebi_id":"46970","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl]oxy}phosphonic acid","traditional_iupac":"phytosphingosine 1-phosphate","logp":"2.5619659304474784","pka":"6.540655024704243","alogps_solubility":"1.71e-02 g/l","alogps_logp":"3.01","alogps_logs":"-4.37","acceptor_count":"6","donor_count":"5","rotatable_bond_count":"18","polar_surface_area":"133.24","refractivity":"103.16379999999997","polarizability":"45.651647235812085","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.371028873380947","pka_strongest_acidic":"1.5142211495907771","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":20160710,"citation":"Cowart, L. A., Shotwell, M., Worley, M. L., Richards, A. J., Montefusco, D. J., Hannun, Y. A., Lu, X. (2010). \"Revealing a signaling role of phytosphingosine-1-phosphate in yeast.\" Mol Syst Biol 6:349."},{"pubmed_id":16730802,"citation":"Dickson, R. C., Sumanasekera, C., Lester, R. L. (2006). \"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae.\" Prog Lipid Res 45:447-465."},{"pubmed_id":10900202,"citation":"Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., Obeid, L. M. (2000). \"Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.\" J Biol Chem 275:31369-31378."}],"proteins":[{"created_at":"2011-05-26T19:42:27.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 4","uniprot_id":"Q12246","uniprot_name":"LCB4_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB4","num_residues":624,"molecular_weight":"69638.60156","theoretical_pi":"6.39","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"Z75078","genbank_protein_id":"1420417","gene_card_id":"LCB4","chromosome_location":"chromosome 15","locus":"YOR171C","synonyms":["LCB kinase 4","Sphinganine kinase 4"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGGTGGTGCAGAAAAAACTTAGGGCTATCTTGACCGATGAAGGTGTATTGATCAAATCGCAATCACACCATATGTTCAATAAGCATGGTCAACTCAGAAGCGGAGATTCTTTATCCTTGTTGAGCTGCTTGTCCTGTCTGGATGATGGAACTTTGAGCTCTGATGGAGGTTCTTTTGATGAGGATGATTCCCTGGAACTGTTGCCTCTTAATACTACCATTCCGTTCAACAGAATTTTGAACGCAAAATATGTGAATGTCGGTCAGAAAGGCTTCAATAATGGCAAAATTTCTTCGAATCCTTTTCAAACGGAAAATCTGAGTTCTTCGTCTGAAAATGACGACGTTGAGAATCATAGTTTGAGCAATGATAAGGCTCCTGTAAGCGAATCACAGTCATTTCCCAAAAAAGACAAGTGGGATACAAAAACGAACACTGTGAAGGTGTCTCCCGATGATTCACAGGATAACTCACCATCTTTAGGGATAAAAGATAATCAACAGTTAATTGAGTTAACTTTTGCTGTACCCAAGGGCCATGATGTTATACCACAAAAATTAACCTTGTTAATAGATCACGTTTCTAGGAAATCGAGAGCAAATACCGGAGAGGAGAACATTTCTTCTGGTACTGTGGAAGAAATCCTGGAAAAAAGTTATGAAAATTCCAAGAGAAACAGATCGATATTAGTCATTATTAATCCCCACGGTGGTAAAGGTACTGCTAAAAATTTATTCCTGACAAAAGCAAGGCCAATACTAGTGGAAAGTGGCTGCAAAATAGAAATTGCATACACAAAATATGCCCGTCACGCCATCGATATTGCCAAAGATTTAGATATCAGCAAATACGATACCATTGCATGTGCCTCGGGTGATGGTATTCCATACGAAGTAATTAATGGGCTTTATAGAAGACCCGACAGAGTGGATGCGTTCAATAAACTAGCCGTAACTCAGCTACCTTGCGGTTCAGGAAATGCTATGAGCATTTCATGTCATTGGACAAATAACCCATCGTACGCCGCTCTGTGCCTTGTCAAATCCATTGAAACAAGAATAGACTTAATGTGTTGTTCCCAACCTTCTTATATGAACGAATGGCCAAGATTATCCTTTTTGAGTCAGACGTACGGCGTTATTGCAGAATCTGATATTAACACTGAATTCATCAGATGGATGGGTCCCGTTAGGTTTAATTTGGGTGTAGCATTCAACATTATCCAAGGTAAGAAATATCCCTGCGAAGTTTTCGTCAAATATGCTGCCAAATCTAAAAAGGAATTAAAAGTTCATTTCTTAGAAAATAAAGATAAAAACAAAGGATGTTTAACCTTCGAACCAAATCCTAGCCCAAACTCTTCGCCGGATTTACTATCTAAAAACAATATCAACAACAGTACAAAAGATGAACTTTCACCGAATTTTCTCAACGAGGACAACTTTAAATTAAAGTATCCGATGACGGAACCAGTACCTAGAGACTGGGAGAAAATGGATTCAGAGCTAACTGATAACTTAACAATCTTTTACACAGGGAAAATGCCGTATATTGCTAAGGACACCAAATTTTTTCCCGCTGCTTTACCAGCGGATGGTACCATTGATTTAGTCATAACGGATGCAAGAATCCCAGTGACAAGAATGACACCAATTTTATTATCCTTGGATAAAGGTTCTCATGTATTAGAGCCAGAAGTTATTCACTCAAAAATATTGGCTTATAAGATTATACCAAAAGTGGAGTCAGGTTTATTTTCAGTGGATGGTGAAAAGTTTCCTTTGGAACCCTTGCAAGTGGAAATAATGCCCATGTTATGCAAGACGTTGCTAAGGAATGGTAGATATATCGATACAGAGTTTGAATCCATGTAG","protein_sequence":"MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM"},{"created_at":"2011-05-26T19:54:39.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 5","uniprot_id":"Q06147","uniprot_name":"LCB5_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB5","num_residues":687,"molecular_weight":"77564.60156","theoretical_pi":"6.86","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"U17244","genbank_protein_id":"577178","gene_card_id":"LCB5","chromosome_location":"chromosome 12","locus":"YLR260W","synonyms":["LCB kinase 5","Sphinganine kinase 5"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACTTTGAAACCTTCAAAGAGACGTAAGGGCAGGTCTCGCCATTCCAGGAAGAAGCAAATAACGTCAGCGATACTGACTGAGGAAGGAATAATGATCAAGGCAAAACCATCAAGTCCTTACACATACGCAAATAGAATGGCAGATAAACGAAGTCGCAGCAGCATTGACAACATCAGTAGAACTAGCTTTCAAAGCAACATCAGTAGAACTAGCTTTCAAAGCAACAGTGATAACAACAGTATATTTGAAACGGCTTCACTAATTAGCTGTGTTACCTGTTTAAGCGATACTGATACAATAGACAGATCGGAAACATCGACAACGGATACAAGTAAAGATGATCTTTCTGCTAATCCAAAACTTCATTATCCTTCGGTGAATGGTCAATTGCCAGCAAACACCGTTATCCCCTATGGACGAATTCTGGATGCCAGATACATTGAAAAGGAACCTCTGCATTATTATGATGCCAATTCATCACCCAGTTCACCTTTAAGCAGCTCAATGAGTAACATTAGTGAAAAGTGTGATCTTGATGAATTAGAGTCTTCCCAAAAAAAAGAAAGGAAGGGCAACTCGCTATCGCGAGGAAGTAACAGTAGTAGTAGCCTCCTGACTTCCAGATCTCCTTTTACGAAACTAGTAGAGGTTATATTTGCTAGGCCAAGACGGCATGACGTTGTACCCAAAAGGGTTTCATTGTATATTGACTATAAACCCCATTCATCTTCTCACTTAAAAGAAGAAGATGACTTGGTTGAGGAGATTTTAAAGAGAAGCTACAAAAACACTAGAAGGAACAAATCCATATTTGTGATCATTAATCCGTTTGGTGGTAAAGGTAAGGCGAAAAAACTGTTTATGACAAAGGCAAAGCCGTTACTATTAGCAAGTCGGTGTTCCATAGAAGTGGTTTATACAAAATACCCTGGTCATGCTATAGAGATCGCGCGGGAAATGGATATTGACAAATATGACACTATTGCTTGCGCTTCGGGAGATGGCATTCCTCATGAGGTGATCAATGGGTTATACCAAAGGCCTGATCATGTCAAAGCATTCAACAATATCGCCATTACAGAAATTCCATGCGGATCAGGTAACGCAATGAGCGTATCCTGCCACTGGACAAACAATCCTTCGTACTCAACTTTATGCTTAATTAAATCGATAGAGACTAGAATTGATTTGATGTGTTGTTCGCAGCCTTCTTATGCAAGAGAGCACCCAAAGTTATCATTTTTAAGTCAAACATATGGTCTCATTGCAGAAACTGACATAAACACTGAATTTATTAGATGGATGGGACCTGCAAGGTTTGAATTGGGTGTAGCCTTCAATATCATACAAAAAAAAAAATATCCTTGTGAGATATATGTAAAGTATGCTGCCAAATCAAAAAACGAGTTAAAAAATCATTACCTGGAACACAAAAATAAAGGGTCGTTAGAATTCCAGCATATTACTATGAACAAAGATAACGAGGATTGTGATAATTACAATTACGAAAATGAATACGAAACCGAAAACGAAGATGAAGATGAAGATGCGGATGCGGATGACGAAGACTCCCACTTGATATCTCGTGATCTGGCAGATTCTAGTGCTGATCAAATTAAAGAGGAAGATTTCAAAATAAAATATCCATTAGATGAAGGTATCCCTAGTGACTGGGAAAGATTGGATCCTAATATTTCGAACAACCTAGGTATCTTCTATACGGGTAAAATGCCATATGTGGCTGCTGACACTAAATTCTTTCCGGCAGCGCTTCCTTCAGATGGTACAATGGATATGGTTATCACCGATGCAAGAACCTCGTTGACGAGGATGGCACCAATCCTGCTGGGACTAGATAAGGGTTCCCATGTTTTACAACCGGAAGTCTTACACTCTAAAATTTTGGCATACAAGATAATACCAAAGCTAGGGAACGGCTTGTTCTCTGTCGATGGCGAGAAATTTCCTCTAGAGCCCCTTCAAGTCGAAATTATGCCACGCTTATGCAAGACGTTACTGAGAAATGGCCGTTATGTGGACACAGATTTCGATTCTATGTGA","protein_sequence":"MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM"},{"created_at":"2011-05-27T02:15:17.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Sphingosine-1-phosphate lyase","uniprot_id":"Q05567","uniprot_name":"SGPL_YEAST","enzyme":true,"transporter":false,"gene_name":"DPL1","num_residues":589,"molecular_weight":"65565.10156","theoretical_pi":"8.15","general_function":"Involved in carboxy-lyase activity","specific_function":"Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine","reactions":[{"id":1895,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1972,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2666,"direction":"\u003e","locations":null,"altext":"Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U51031","genbank_protein_id":"1230658","gene_card_id":"DPL1","chromosome_location":"chromosome 4","locus":"YDR294C","synonyms":["SP-lyase","ySPL","Bestowed of sphingosine tolerance 1","Sphingosine-1-phosphate aldolase"],"enzyme_classes":["4.1.2.27"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Pyridoxal_deC","identifier":"PF00282"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGAGTGGAGTATCAAATAAAACAGTATCAATTAATGGTTGGTATGGCATGCCAATTCATTTACTAAGGGAAGAAGGCGACTTTGCCCAGTTTATGATTCTAACCATCAACGAATTAAAAATAGCCATACATGGTTACCTCAGAAATACCCCATGGTACAACATGTTGAAGGATTATTTGTTTGTGATCTTTTGTTACAAGCTAATAAGTAATTTTTTTTATCTGTTGAAAGTTTATGGGCCGGTGAGGTTAGCAGTGAGAACATACGAGCATAGTTCCAGAAGATTGTTTCGTTGGTTATTGGACTCACCATTTTTGAGGGGTACCGTAGAAAAGGAAGTCACAAAGGTCAAACAATCGATCGAAGACGAACTAATTAGATCGGACTCTCAGTTAATGAATTTCCCACAGTTGCCATCCAATGGGATACCTCAGGATGATGTTATTGAAGAGCTAAATAAATTGAACGACTTGATACCACATACCCAATGGAAGGAAGGAAAGGTCTCTGGTGCCGTTTACCACGGTGGTGATGATTTGATCCACTTACAAACAATCGCATACGAAAAATATTGCGTTGCCAATCAATTACATCCCGATGTCTTTCCTGCCGTACGTAAAATGGAATCCGAAGTGGTTTCTATGGTTTTAAGAATGTTTAATGCCCCTTCTGATACAGGTTGTGGTACCACAACTTCAGGTGGTACAGAATCCTTGCTTTTAGCATGTCTGAGCGCTAAAATGTATGCCCTTCATCATCGTGGAATCACCGAACCAGAAATAATTGCTCCCGTAACTGCACATGCTGGGTTTGACAAAGCTGCTTATTACTTTGGCATGAAGCTACGCCACGTGGAGCTAGATCCAACGACATATCAAGTGGACCTGGGAAAAGTGAAAAAATTCATCAATAAGAACACAATTTTACTGGTCGGTTCCGCTCCAAACTTTCCTCATGGTATTGCCGATGATATTGAAGGATTGGGTAAAATAGCACAAAAATATAAACTTCCTTTACACGTCGACAGTTGTCTAGGTTCCTTTATTGTTTCATTTATGGAAAAGGCTGGTTACAAAAATCTGCCATTACTTGACTTTAGAGTCCCGGGAGTCACCTCAATATCATGTGACACTCATAAATATGGATTTGCACCAAAAGGCTCGTCAGTTATAATGTATAGAAACAGCGACTTACGAATGCATCAGTATTACGTAAATCCTGCTTGGACTGGCGGGTTATATGGCTCTCCTACATTAGCAGGGTCCAGGCCTGGTGCTATTGTCGTAGGTTGTTGGGCCACTATGGTCAACATGGGTGAAAATGGGTACATTGAGTCGTGCCAAGAAATAGTCGGTGCAGCAATGAAGTTTAAAAAATACATCCAGGAAAACATTCCAGACCTGAATATAATGGGCAACCCTAGATATTCAGTCATTTCATTTTCTTCAAAGACCTTGAACATACACGAACTATCTGACAGGTTGTCCAAGAAAGGCTGGCATTTCAATGCCCTACAAAAGCCGGTTGCACTACACATGGCCTTCACGAGATTGAGCGCTCATGTTGTGGATGAGATCTGCGACATTTTACGTACTACCGTGCAAGAGTTGAAGAGCGAATCAAATTCTAAACCATCCCCAGACGGAACTAGCGCTCTATATGGTGTCGCCGGGAGCGTTAAAACTGCTGGCGTTGCAGACAAATTGATTGTGGGATTCCTAGACGCATTATACAAGTTGGGTCCAGGAGAGGATACCGCCACCAAGTAG","protein_sequence":"MSGVSNKTVSINGWYGMPIHLLREEGDFAQFMILTINELKIAIHGYLRNTPWYNMLKDYLFVIFCYKLISNFFYLLKVYGPVRLAVRTYEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQSIEDELIRSDSQLMNFPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEGKVSGAVYHGGDDLIHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLLLACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVKKFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLNIMGNPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQELKSESNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALYKLGPGEDTATK"},{"created_at":"2011-05-27T06:05:18.000Z","updated_at":"2011-05-27T15:01:25.000Z","name":"Dihydrosphingosine 1-phosphate phosphatase LCB3","uniprot_id":"P47013","uniprot_name":"DS1P1_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB3","num_residues":409,"molecular_weight":"47371.30078","theoretical_pi":"9.13","general_function":"Involved in catalytic activity","specific_function":"Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling","reactions":[{"id":1973,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1974,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"87-107;113-133;183-203;208-228;246-266;277-297;316-336;385-405","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"X87371","genbank_protein_id":"854562","gene_card_id":"LCB3","chromosome_location":"chromosome 10","locus":"YJL134W","synonyms":["Long-chain base protein 3","Sphingolipid resistance protein 2"],"enzyme_classes":["3.1.3.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[],"gene_sequence":"ATGGTAGATGGACTGAATACCTCGAACATTAGGAAAAGAGCCAGGACTCTCTCTAACCCCAATGACTTTCAAGAGCCTAATTACTTGCTGGATCCCGGTAATCATCCCTCAGATCATTTTCGAACTCGAATGTCCAAATTTCGGTTTAATATTAGAGAGAAGCTGTTAGTGTTTACCAACAATCAATCATTCACATTAAGCCGCTGGCAAAAGAAGTACCGTTCTGCGTTTAATGATCTCTACTTTACTTATACTTCCTTAATGGGATCGCATACCTTCTATGTTCTGTGTTTACCTATGCCCGTGTGGTTTGGATATTTTGAAACAACAAAAGATATGGTTTATATCTTGGGATATTCTATCTACTTGAGTGGTTTTTTTAAAGATTACTGGTGCTTGCCCAGGCCTAGAGCACCTCCATTACATCGAATTACGTTAAGTGAATATACAACGAAGGAATATGGTGCTCCAAGCTCCCATACAGCAAATGCAACAGGAGTGAGTCTCTTGTTTCTCTACAACATCTGGAGGATGCAAGAATCTTCTGTCATGGTCCAACTATTGTTGTCATGTGTGGTTTTATTTTATTATATGACTTTGGTTTTCGGTAGAATATACTGTGGGATGCATGGCATATTAGATTTAGTAAGCGGTGGGCTCATTGGAATAGTGTGTTTCATTGTTAGGATGTATTTCAAGTACAGGTTTCCGGGTTTACGCATTGAGGAGCATTGGTGGTTTCCTTTGTTTAGTGTGGGATGGGGTCTTCTTCTTTTGTTTAAACATGTTAAGCCCGTAGACGAATGTCCTTGCTTCCAAGATAGTGTTGCGTTCATGGGCGTTGTGTCAGGTATTGAATGCTGTGATTGGTTGGGCAAAGTGTTTGGAGTCACCCTGGTGTACAATTTGGAACCTAACTGTGGCTGGCGGTTAACCTTAGCCAGGCTGCTGGTGGGCCTACCGTGCGTTGTTATCTGGAAGTACGTGATCAGCAAACCGATGATCTACACGTTATTGATCAAAGTTTTCCATCTGAAGGATGACAGAAACGTTGCGGCAAGAAAAAGACTGGAGGCCACGCACAAAGAAGGTGCAAGCAAGTACGAATGTCCATTATATATTGGAGAGCCCAAGATTGACATTCTAGGTAGATTTATTATCTATGCTGGCGTTCCATTCACCGTTGTAATGTGCAGCCCCGTCCTATTTTCCCTCTTAAATATAGCATAA","protein_sequence":"MVDGLNTSNIRKRARTLSNPNDFQEPNYLLDPGNHPSDHFRTRMSKFRFNIREKLLVFTNNQSFTLSRWQKKYRSAFNDLYFTYTSLMGSHTFYVLCLPMPVWFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRITLSEYTTKEYGAPSSHTANATGVSLLFLYNIWRMQESSVMVQLLLSCVVLFYYMTLVFGRIYCGMHGILDLVSGGLIGIVCFIVRMYFKYRFPGLRIEEHWWFPLFSVGWGLLLLFKHVKPVDECPCFQDSVAFMGVVSGIECCDWLGKVFGVTLVYNLEPNCGWRLTLARLLVGLPCVVIWKYVISKPMIYTLLIKVFHLKDDRNVAARKRLEATHKEGASKYECPLYIGEPKIDILGRFIIYAGVPFTVVMCSPVLFSLLNIA"},{"created_at":"2011-05-27T06:05:51.000Z","updated_at":"2011-05-27T15:01:25.000Z","name":"Dihydrosphingosine 1-phosphate phosphatase YSR3","uniprot_id":"P23501","uniprot_name":"DS1P2_YEAST","enzyme":true,"transporter":false,"gene_name":"YSR3","num_residues":404,"molecular_weight":"46487.69922","theoretical_pi":"7.73","general_function":"Involved in catalytic activity","specific_function":"Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling","reactions":[{"id":1973,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1974,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"87-107;114-134;155-176;183-203;216-236;242-262;320-340;380-400","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28278","genbank_protein_id":"486509","gene_card_id":"YSR3","chromosome_location":"chromosome 11","locus":"YKR053C","synonyms":["Long-chain base protein 2","Sphingolipid resistance protein 3"],"enzyme_classes":["3.1.3.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[],"gene_sequence":"ATGACCATTATTCAGACGGTTACTGAATTGGGTGTTACCGAGGACACCATTAAGGTTCAGATGGCTCCTTCCGGCGGCAAACACCTATTGGCAGATCCCGGTAATCATCCAGCGGAGCATTTTGAGAGCCAGATGTCGTGGCTAAGGTTTCAAACAAGGCAGTATCTAACTAGATTCACAGACAACCAATCAGATTTCGTACATTCTTTACAAAAAAAGCACAGAACGCCTTTTAGAGACGTTTATTTCAAATACACTTCGCTTATGGGTTCCCACATGTTTTATGTTATCGTGCTTCCCATGCCTGTGTGGCTTGGATACCGCGATTTAACACGGGACATGATCTACGTTCTTGGTTATTCAATTTATTTGAGTGGCTACTTAAAGGATTATTGGTGCCTACCAAGGCCAAAATCACCGCCAGTTGACAGAATCACACTAAGTGAATACACTACGAAAGAATATGGTGCACCCAGTTCACATTCTGCTAACGCTACTGCGGTAAGTCTATTATTCTTTTGGAGAATATGTTTATCTGACACACTGGTATGGCCAACAAAGCTTCTTTTACTGAGTCTGGTGATATTTTACTACTTAACCCTGGTTTTTGGTAGAGTTTACTGCGGTATGCATGGTATGCTGGATTTATTTAGCGGCGCCGCAGTTGGAGCTATCTGTTTTTTTATAAGAATCTGGGTGGTGCATGCTTTACGAAATTTCCAGATTGGTGAACATCTCTGGTTTCCCCTTTTGAGTGTAGCATGGGGCTTGTTTATTCTGTTTAACCACGTCAGGCCCATTGATGAATGTCCTTGTTTCGAAGATAGCGTAGCGTTCATTGGCGTAGTCAGTGGGCTGGATTGCAGCGACTGGTTAACCGAAAGATACGGATGGAACCTTGTATGTAGTAGGTACGCATCATGTGGTTCTAAGGTGTTCTTGAGGCCTCTGGTAGGTGTCGCTTCTGTGATTGTTTGGAAAGACGTCATTAGCAAGACAGCTGTCTACACGCTGTTAATTAAACTACTCAGATTTCACGATGATAGAAGCGAAAAGGTTCATTTCCATAACGAGACAAGTGAAGAAGAAGAGTGTTTATTGTACAGCGGTGTTTCCAAAGTGGAAATCGTCGGAAGGTTTCTCATATACGCAGGTATACCTACAACCGTCTTTTTGCTATGCCCAGTTTTTTTCACTTGGACAAACTTAAGGTAG","protein_sequence":"MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR"}]}