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Identification |
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Name | Choline/ethanolaminephosphotransferase 1 |
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Synonyms | - ETHPT
- Ethanolaminephosphotransferase 1
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Gene Name | EPT1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in phosphotransferase activity, for other substituted phosphate groups |
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Specific Function | Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl ethanolamine to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the ethanolaminephosphotransferase might participate in the transport process. EPT1 catalyzes both choline- and ethanolamine-phosphotransferase reactions |
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Cellular Location | Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00090 | Citicoline | Show | YMDB00389 | CDP-Ethanolamine | Show | YMDB00406 | Cytidine monophosphate | Show | YMDB00862 | hydron | Show |
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GO Classification | Component |
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cell part | membrane | Function |
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catalytic activity | transferase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, for other substituted phosphate groups | Process |
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metabolic process | organophosphate metabolic process | phospholipid metabolic process | phospholipid biosynthetic process |
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Gene Properties |
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Chromosome Location | chromosome 8 |
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Locus | YHR123W |
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Gene Sequence | >1176 bp
ATGGGATATTTTGTTCCGGATTCACATATCGAAAATCTAAAGTCATATAAATATCAAAGT
GAAGACCGCTCGCTGGTATCGAAGTATTTCTTAAAGCCATTTTGGCAAAGATTTTGTCAC
ATATTTCCCACGTGGATGGCGCCCAACATCATCACATTATCAGGATTTGCTTTTATAGTT
ATCAACGTGTTGACTGTATTCTATTACGATCCAAACCTTAACACAGATACGCCTCGCTGG
ACATATTTTTCTTACGCTTTAGGTGTATTCCTATATCAAACGTTCGTAGGAAGTGATGGT
GTACACGCTCGCCGTATCAATCAATCAGGACCCTTAGGAGAACTATTCGATCATAGTATT
GATGCCATTAATTCTACTCTGTCTATTTTCATCTTCGCATCCGAAACTGGAATGGGATTT
TCGTATAACTTAATGTTATCCCAATTTGCGATGCTGACGAATTTTTACTTAAGTACTTGG
GAAGAGTACCATACACACACATTATACTTAAGTGAGTTTTCTGGACCCGTGGAAGGCATC
CTGATTGTTTGCGTTTCATTGATACTGACAGGTATATACGGAAAACAGGTAATCTGGCAT
ACCTACTTATTTACAATTACAGTTGGTGATAAGGTAATTGATGTAGACACTCTAGATATT
GTTTTTTCCCTAGCTGTTTTCGGTTTGGTTATGAACGCATTGTCTGCGAAAAGAAACGTG
GATAAGTATTATAGAAACAGCACTTCTTCGGCCAACAATATCACGCAAATTGAGCAAGAT
AGTGCTATAAAAGGTCTTTTGCCCTTTTTTGCCTATTATGCAAGCATTGCTTTACTAGTG
TGGATGCAACCAAGCTTTATTACACTCTCTTTCATCCTTTCCGTTGGTTTCACGGGAGCA
TTTACCGTCGGAAGAATAATCGTTTGCCATTTAACTAAGCAGAGCTTTCCCATGTTCAAT
GCACCCATGTTAATTCCTTTGTGCCAGATAGTATTGTACAAAATATGTCTATCCCTTTGG
GGAATTGAGTCTAATAAAATCGTCTTTGCCCTATCTTGGCTTGGGTTCGGTCTCTCACTA
GGTGTTCACATTATGTTTATGAATGACATTATCCATGAATTTACTGAGTACCTGGACGTT
TATGCTTTATCCATCAAGCGCTCCAAGCTGACATAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 391 |
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Protein Molecular Weight | 44559.30078 |
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Protein Theoretical pI | 6.5 |
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Signalling Regions | |
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Transmembrane Regions | - 49-69
- 175-195
- 216-236
- 263-283
- 289-309
- 319-339
- 347-367
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Protein Sequence | >Choline/ethanolaminephosphotransferase 1
MGYFVPDSHIENLKSYKYQSEDRSLVSKYFLKPFWQRFCHIFPTWMAPNIITLSGFAFIV
INVLTVFYYDPNLNTDTPRWTYFSYALGVFLYQTFDGCDGVHARRINQSGPLGELFDHSI
DAINSTLSIFIFASETGMGFSYNLMLSQFAMLTNFYLSTWEEYHTHTLYLSEFSGPVEGI
LIVCVSLILTGIYGKQVIWHTYLFTITVGDKVIDVDTLDIVFSLAVFGLVMNALSAKRNV
DKYYRNSTSSANNITQIEQDSAIKGLLPFFAYYASIALLVWMQPSFITLSFILSVGFTGA
FTVGRIIVCHLTKQSFPMFNAPMLIPLCQIVLYKICLSLWGIESNKIVFALSWLGFGLSL
GVHIMFMNDIIHEFTEYLDVYALSIKRSKLT |
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References |
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External Links | |
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General Reference | - Hjelmstad, R. H., Bell, R. M. (1991). "sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products." J Biol Chem 266:5094-5103.1848238
- Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
- Hjelmstad, R. H., Bell, R. M. (1991). "sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Mixed micellar analysis of the CPT1 and EPT1 gene products." J Biol Chem 266:4357-4365.1847919
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