| Identification |
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| Name | N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial |
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| Synonyms | - tRNA 2,2-dimethylguanosine-26 methyltransferase
- tRNA(guanine-26,N(2)-N(2)) methyltransferase
- tRNA(m(2,2)G26)dimethyltransferase
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| Gene Name | TRM1 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in RNA binding |
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| Specific Function | Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs |
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| Cellular Location | Mitochondrion. Nucleus. Cytoplasm. |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00198 | S-Adenosylhomocysteine | Show | | YMDB00297 | S-Adenosylmethionine | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| transferase activity, transferring one-carbon groups | | methyltransferase activity | | binding | | nucleic acid binding | | RNA binding | | N-methyltransferase activity | | catalytic activity | | tRNA (guanine-N2-)-methyltransferase activity | | transferase activity | | Process |
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| cellular macromolecule metabolic process | | RNA metabolic process | | ncRNA metabolic process | | tRNA metabolic process | | tRNA processing | | metabolic process | | macromolecule metabolic process |
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| Gene Properties |
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| Chromosome Location | chromosome 4 |
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| Locus | YDR120C |
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| Gene Sequence | >1713 bp
ATGGAAGGTTTCTTCAGGATACCCCTCAAGCGGGCAAATTTACACGGAATGTTGAAGGCT
GCTATATCCAAAATTAAAGCGAATTTTACCGCGTATGGTGCACCAAGAATCAATATTGAG
GATTTCAATATAGTCAAGGAAGGAAAAGCAGAAATTCTTTTCCCTAAAAAGGAAACTGTT
TTCTATAATCCCATCCAACAATTTAATAGAGATCTAAGTGTTACATGCATCAAGGCGTGG
GACAACCTATATGGTGAGGAATGTGGCCAAAAGAGAAATAATAAAAAAAGTAAGAAGAAA
AGGTGCGCGGAAACTAACGATGATTCTTCCAAGCGTCAAAAAATGGGAAACGGGTCACCA
AAAGAAGCCGTTGGTAATTCTAATCGAAACGAACCTTATATAAATATTTTGGAAGCATTG
TCAGCCACTGGGTTAAGAGCCATTAGGTATGCTCATGAAATTCCCCATGTGAGGGAAGTT
ATTGCTAACGATTTACTTCCAGAGGCTGTCGAATCTATAAAACGAAACGTTGAATATAAT
AGTGTCGAAAACATTGTCAAGCCAAACCTTGATGATGCTAATGTCTTAATGTACCGTAAC
AAAGCGACGAATAATAAGTTTCACGTCATCGACTTGGATCCTTACGGTACCGTTACACCT
TTTGTAGATGCGGCTATTCAGAGTATTGAGGAGGGTGGTCTAATGCTGGTAACTTGCACT
GATTTATCCGTTTTGGCCGGTAACGGATACCCAGAAAAGTGTTTTGCCTTATATGGTGGT
GCAAATATGGTTTCTCATGAATCAACTCACGAAAGTGCGCTGAGACTAGTATTGAACTTA
CTAAAGCAAACTGCCGCGAAATACAAGAAAACTGTGGAACCGCTTTTGTCGTTGAGCATT
GACTTTTACGTCAGAGTTTTTGTCAAAGTCAAAACAAGCCCGATTGAAGTCAAAAACGTT
ATGTCAAGTACTATGACTACTTACCATTGTTCCCGTTGCGGCTCTTACCACAATCAACCT
CTGGGCAGAATTTCTCAACGCGAAGGTAGGAACAACAAAACATTCACCAAATACTCGGTT
GCGCAAGGGCCTCCGGTTGATACTAAATGTAAGTTCTGCGAGGGGACATACCATTTAGCT
GGTCCAATGTATGCAGGACCTCTACACAACAAGGAGTTCATCGAGGAGGTGTTGAGAATT
AATAAAGAAGAGCATCGTGACCAGGATGATACATATGGAACACGTAAAAGAATTGAAGGT
ATGCTATCTCTAGCTAAGAATGAATTATCCGATTCGCCATTCTATTTCAGTCCTAACCAT
ATTGCATCGGTAATAAAATTACAAGTACCTCCCTTGAAAAAAGTAGTCGCAGGCCTAGGT
TCCCTAGGCTTTGAATGTTCATTGACACATGCCCAACCATCGTCCCTAAAGACTAACGCT
CCATGGGATGCAATCTGGTATGTGATGCAGAAATGTGATGATGAGAAGAAAGACTTAAGC
AAAATGAATCCAAATACTACGGGCTATAAGATTTTATCGGCAATGCCAGGATGGTTGAGT
GGCACTGTCAAATCAGAGTATGACTCAAAGCTGTCGTTCGCACCAAATGAACAAAGCGGT
AATATTGAAAAACTAAGGAAGCTAAAAATTGTGAGATATCAGGAAAATCCAACAAAGAAT
TGGGGCCCAAAAGCCCGTCCCAACACTTCATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 570 |
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| Protein Molecular Weight | 64051.80078 |
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| Protein Theoretical pI | 9.49 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial
MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETV
FYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSP
KEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYN
SVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCT
DLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSI
DFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSV
AQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEG
MLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNA
PWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSG
NIEKLRKLKIVRYQENPTKNWGPKARPNTS |
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| References |
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| External Links | |
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| General Reference | - Ellis, S. R., Hopper, A. K., Martin, N. C. (1987). "Amino-terminal extension generated from an upstream AUG codon is not required for mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferase." Proc Natl Acad Sci U S A 84:5172-5176.3299379
- Liu, J., Liu, J., Straby, K. B. (1998). "Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase." Nucleic Acids Res 26:5102-5108.9801306
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- Liu, J., Zhou, G. Q., Straby, K. B. (1999). "Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity." Gene 226:73-81.10048958
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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