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| Identification |
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| Name | Inositol-3-phosphate synthase |
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| Synonyms | - MIP synthase
- Myo-inositol-1-phosphate synthase
- IPS
- MI-1-P synthase
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| Gene Name | INO1 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in inositol-3-phosphate synthase activity |
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| Specific Function | D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate |
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| Cellular Location | Cytoplasm |
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| SMPDB Pathways | |
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| KEGG Pathways | | Inositol phosphate metabolism | ec00562 |  |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00582 | aldehydo-D-glucose 6-phosphate | Show | | YMDB00714 | 1D-myo-inositol 1-phosphate | Show | | YMDB00715 | 1D-myo-inositol 3-phosphate | Show | | YMDB00947 | Glucose 6-phosphate | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| isomerase activity | | intramolecular lyase activity | | inositol-3-phosphate synthase activity | | catalytic activity | | binding | | Process |
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| alcohol metabolic process | | polyol metabolic process | | organophosphate metabolic process | | phospholipid metabolic process | | phospholipid biosynthetic process | | inositol metabolic process | | inositol biosynthetic process | | metabolic process | | small molecule metabolic process |
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| Gene Properties |
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| Chromosome Location | chromosome 10 |
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| Locus | YJL153C |
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| Gene Sequence | >YJL153C INO1 SGDID:S000003689, Chr X from 135933-134332, reverse complement, Verified ORF, "Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phosphol
ATGACAGAAGATAATATTGCTCCAATCACCTCCGTTAAAGTAGTTACCGACAAGTGCACG
TACAAGGACAACGAGCTGCTCACCAAGTACAGCTACGAAAATGCTGTAGTTACGAAGACA
GCTAGTGGCCGCTTCGATGTAACGCCCACTGTTCAAGACTACGTGTTCAAACTTGACTTG
AAAAAGCCGGAAAAACTAGGAATTATGCTCATTGGGTTAGGTGGCAACAATGGCTCCACT
TTAGTGGCCTCGGTATTGGCGAATAAGCACAATGTGGAGTTTCAAACTAAGGAAGGCGTT
AAGCAACCAAACTACTTCGGCTCCATGACTCAATGTTCTACCTTGAAACTGGGTATCGAT
GCGGAGGGGAATGACGTTTATGCTCCTTTTAACTCTCTGTTGCCCATGGTTAGCCCAAAC
GACTTTGTCGTCTCTGGTTGGGACATCAATAACGCAGATCTATACGAAGCTATGCAGAGA
AGTCAAGTTCTCGAATATGATCTGCAACAACGCTTGAAGGCGAAGATGTCCTTGGTGAAG
CCTCTTCCTTCCATTTACTACCCTGATTTCATTGCAGCTAATCAAGATGAGAGAGCCAAT
AACTGCATCAATTTGGATGAAAAAGGCAACGTAACCACGAGGGGTAAGTGGACCCATCTG
CAACGCATCAGACGCGATATCCAGAATTTCAAAGAAGAAAACGCCCTTGATAAAGTAATC
GTTCTTTGGACTGCAAATACTGAGAGGTACGTAGAAGTATCTCCTGGTGTTAATGACACC
ATGGAAAACCTCTTGCAGTCTATTAAGAATGACCATGAAGAGATTGCTCCTTCCACGATC
TTTGCAGCAGCATCTATCTTGGAAGGTGTCCCCTATATTAATGGTTCACCGCAGAATACT
TTTGTTCCCGGCTTGGTTCAGCTGGCTGAGCATGAGGGTACATTCATTGCGGGAGACGAT
CTCAAGTCGGGACAAACCAAGTTGAAGTCTGTTCTGGCCCAGTTCTTAGTGGATGCAGGT
ATTAAACCGGTCTCCATTGCATCCTATAACCATTTAGGCAATAATGACGGTTATAACTTA
TCTGCTCCAAAACAATTTAGGTCTAAGGAGATTTCCAAAAGTTCTGTCATAGATGACATC
ATCGCGTCTAATGATATCTTGTACAATGATAAACTGGGTAAAAAAGTTGACCACTGCATT
GTCATCAAATATATGAAGCCCGTCGGGGACTCAAAAGTGGCAATGGACGAGTATTACAGT
GAGTTGATGTTAGGTGGCCATAACCGGATTTCCATTCACAATGTTTGCGAAGATTCTTTA
CTGGCTACGCCCTTGATCATCGATCTTTTAGTCATGACTGAGTTTTGTACAAGAGTGTCC
TATAAGAAGGTGGACCCAGTTAAAGAAGATGCTGGCAAATTCGAGAACTTTTATCCAGTT
TTAACCTTCTTGAGTTACTGGTTAAAAGCTCCATTAACAAGACCAGGATTTCACCCGGTG
AATGGCTTAAACAAGCAAAGAACCGCCTTAGAAAATTTTTTAAGATTGTTGATTGGATTG
CCTTCTCAAAACGAACTAAGATTCGAAGAGAGATTGTTGTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 533 |
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| Protein Molecular Weight | 59641.60156 |
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| Protein Theoretical pI | 5.71 |
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| PDB File | show |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Inositol-3-phosphate synthase
MTEDNIAPITSVKVVTDKCTYKDNELLTKYSYENAVVTKTASGRFDVTPTVQDYVFKLDL
KKPEKLGIMLIGLGGNNGSTLVASVLANKHNVEFQTKEGVKQPNYFGSMTQCSTLKLGID
AEGNDVYAPFNSLLPMVSPNDFVVSGWDINNADLYEAMQRSQVLEYDLQQRLKAKMSLVK
PLPSIYYPDFIAANQDERANNCINLDEKGNVTTRGKWTHLQRIRRDIQNFKEENALDKVI
VLWTANTERYVEVSPGVNDTMENLLQSIKNDHEEIAPSTIFAAASILEGVPYINGSPQNT
FVPGLVQLAEHEGTFIAGDDLKSGQTKLKSVLAQFLVDAGIKPVSIASYNHLGNNDGYNL
SAPKQFRSKEISKSSVIDDIIASNDILYNDKLGKKVDHCIVIKYMKPVGDSKVAMDEYYS
ELMLGGHNRISIHNVCEDSLLATPLIIDLLVMTEFCTRVSYKKVDPVKEDAGKFENFYPV
LTFLSYWLKAPLTRPGFHPVNGLNKQRTALENFLRLLIGLPSQNELRFEERLL |
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| References |
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| External Links | |
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| General Reference | - Dean-Johnson, M., Henry, S. A. (1989). "Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus." J Biol Chem 264:1274-1283.2642902
- Klig, L. S., Zobel, P. A., Devry, C. G., Losberger, C. (1994). "Comparison of INO1 gene sequences and products in Candida albicans and Saccharomyces cerevisiae." Yeast 10:789-800.7975896
- Katsoulou, C., Tzermia, M., Tavernarakis, N., Alexandraki, D. (1996). "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI." Yeast 12:787-797.8813765
- Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
- Stein, A. J., Geiger, J. H. (2002). "The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase." J Biol Chem 277:9484-9491.11779862
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