NAD-dependent deacetylase HST2 (P53686)

Identification
NameNAD-dependent deacetylase HST2
Synonyms
  • Homologous to SIR2 protein 2
Gene NameHST2
Enzyme ClassNot Available
Biological Properties
General FunctionTranscription
Specific FunctionNAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability
Cellular LocationNucleus (Potential)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
NAD + water ↔ hydron + Niacinamide + Adenosine diphosphate ribose
Metabolites
YMDB IDNameView
GO Classification
Function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
nucleotide binding
NAD or NADH binding
hydrolase activity
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
zinc ion binding
catalytic activity
NAD binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Process
protein amino acid deacetylation
biological regulation
regulation of biological process
metabolic process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
cellular process
gene silencing
chromatin silencing
macromolecule modification
macromolecule metabolic process
protein modification process
post-translational protein modification
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1074 bp ATGTCTGTTTCTACCGCCTCTACAGAGATGTCGGTTAGGAAGATCGCTGCTCATATGAAA AGCAACCCCAACGCTAAAGTAATCTTTATGGTGGGTGCCGGGATATCCACTTCTTGTGGG ATACCAGACTTCCGATCTCCGGGAACTGGCCTGTACCATAACTTGGCCAGGTTGAAGTTG CCGTACCCTGAAGCAGTGTTCGATGTCGATTTTTTCCAATCGGATCCTTTGCCATTTTAC ACTTTGGCTAAAGAGTTGTATCCCGGAAATTTCAGACCTTCTAAGTTTCACTATCTTTTG AAATTGTTTCAAGACAAAGACGTTTTGAAGAGAGTATATACCCAGAATATAGACACTTTA GAAAGACAGGCCGGTGTTAAGGATGATCTGATCATCGAGGCCCATGGCAGTTTTGCTCAC TGTCATTGTATCGGATGTGGTAAAGTTTATCCCCCACAGGTTTTCAAATCCAAGCTGGCA GAGCATCCTATAAAGGATTTTGTCAAGTGTGATGTGTGCGGTGAACTGGTAAAGCCGGCA ATAGTTTTTTTTGGCGAAGATCTACCGGATTCCTTTTCGGAAACTTGGTTAAACGATTCA GAGTGGCTTCGTGAAAAAATCACGACATCTGGAAAACATCCTCAGCAGCCTCTTGTCATC GTCGTTGGCACCTCACTAGCCGTTTATCCCTTTGCGTCTCTGCCCGAAGAAATTCCTCGA AAGGTAAAAAGAGTTCTGTGCAATTTGGAAACGGTGGGCGATTTTAAAGCTAACAAGAGG CCTACAGATTTAATAGTTCATCAGTACTCGGATGAGTTTGCCGAGCAACTCGTTGAAGAA TTAGGTTGGCAAGAAGATTTCGAAAAGATACTTACGGCCCAAGGTGGAATGGGGGATAAC TCTAAAGAGCAATTACTTGAAATTGTACATGATTTAGAGAATTTGAGTTTGGATCAATCT GAACATGAGAGTGCAGACAAGAAGGATAAGAAGCTACAGCGTCTCAATGGCCATGACAGC GATGAAGATGGAGCAAGCAACTCCTCTTCTTCACAAAAAGCCGCTAAAGAATAA
Protein Properties
Pfam Domain Function
Protein Residues357
Protein Molecular Weight39979.0
Protein Theoretical pI5.6
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>NAD-dependent deacetylase HST2 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKL PYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTL ERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPA IVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPR KVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDN SKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
References
External Links
ResourceLink
Saccharomyces Genome Database HST2
Uniprot IDP53686
Uniprot NameHST2_YEAST
GenBank Gene IDAY693204
Genebank Protein ID51013859
PDB ID
1Q14
General Reference
  • Brachmann, C. B., Sherman, J. M., Devine, S. E., Cameron, E. E., Pillus, L., Boeke, J. D. (1995). "The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability." Genes Dev 9:2888-2902.7498786
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
  • Zhao, K., Chai, X., Clements, A., Marmorstein, R. (2003). "Structure and autoregulation of the yeast Hst2 homolog of Sir2." Nat Struct Biol 10:864-871.14502267
  • Zhao, K., Harshaw, R., Chai, X., Marmorstein, R. (2004). "Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases." Proc Natl Acad Sci U S A 101:8563-8568.15150415