{"ymdb_id":"YMDB00274","created_at":"2011-05-29T18:01:03.000Z","updated_at":"2016-09-08T18:35:16.000Z","name":"Niacinamide","cas":"98-92-0","state":"Solid","melting_point":"130 oC","description":"Niacinamide (vitamin B3) is an important compound functioning as a component of the coenzyme NAD.","experimental_water_solubility":"500 mg/mL at 25 oC [MERCK INDEX (1996)]","experimental_logp_hydrophobicity":"-0.37 [HANSCH,C ET AL. (1995)]","location":"mitochondrion;nucleus;cytoplasm","synthesis_reference":"Galat, Alexander. Nicotinamide from nicotinonitrile by catalytic hydration. Journal of the American Chemical Society (1948), 70 3945.","chebi_id":"17154","hmdb_id":"HMDB01406","kegg_id":"C00153","pubchem_id":"936","cs_id":"911","foodb_id":null,"wikipedia_link":"Niacinamide","biocyc_id":"NIACINAMIDE","iupac":"pyridine-3-carboxamide","traditional_iupac":"nicotinamide","logp":"-0.3937863166666665","pka":null,"alogps_solubility":"5.01e+01 g/l","alogps_logp":"-0.45","alogps_logs":"-0.39","acceptor_count":"2","donor_count":"1","rotatable_bond_count":"1","polar_surface_area":"55.980000000000004","refractivity":"32.979499999999994","polarizability":"11.711267443233845","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"3.634895404358332","pka_strongest_acidic":"13.38576188771524","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["3-Carbamoylpyridine","3-Pyridinecarboxamide","3-Pyridinecarboxylic acid amide","acid amide","Amid kyseliny nikotinove","Amide PP","Aminicotin","Amixicotyn","Amnicotin","Austrovit PP","b-Pyridinecarboxamide","Benicot","beta-Pyridinecarboxamide","Delonin Amide","Dipegyl","Dipigyl","Endobion","Factor pp","Hansamid","Inovitan PP","m-(Aminocarbonyl)pyridine","Mediatric","NAM","Nandervit-N","Niacevit","Niacinamide","Niamide","Niavit PP","Nicamide","Nicamina","Nicamindon","Nicasir","Nicobion","Nicofort","Nicogen","Nicomidol","Nicosylamide","Nicota","Nicotamide","Nicotilamide","Nicotililamido","Nicotinamida","Nicotinamide","Nicotinamidum","Nicotine acid amide","Nicotine amide","Nicotinic acid amide","Nicotinic amide","Nicotinsaureamid","Nicotol","Nicotylamide","Nicotylamidum","Nicovel","Nicovit","Nicovitina","Nicovitol","Nicozymin","Nictoamide","Niko-tamin","Nikotinamid","Nikotinsaeureamid","Niocinamide","Niozymin","Papulex","Pelmin","Pelmine","Pelonin amide","PP-Faktor","Propamine A","Pyridine-3-carboxylic acid amide","Savacotyl","Vi-Nicotyl","Vi-noctyl","Vitamin B3","Vitamin PP","Witamina PP"],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12736687,"citation":"Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Sinclair, D. A. (2003). \"Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.\" Nature 423:181-185."},{"pubmed_id":17482543,"citation":"Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., Brenner, C. (2007). \"Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.\" Cell 129:473-484."},{"pubmed_id":19889834,"citation":"Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). \"Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.\" Mol Biol Cell 21:198-211."}],"proteins":[{"created_at":"2011-05-26T18:09:25.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Nicotinamidase","uniprot_id":"P53184","uniprot_name":"PNC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PNC1","num_residues":216,"molecular_weight":"24993.19922","theoretical_pi":"6.23","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate","reactions":[{"id":1775,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2511,"direction":"\u003e","locations":"Cytoplasm. Nucleus. Peroxisome.","altext":"Nicotinamide + H(2)O = nicotinate + NH(3).","export":false,"pw_reaction_id":null,"source":null},{"id":4194,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006493","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus. Peroxisome.","genbank_gene_id":"AY558481","genbank_protein_id":"45270852","gene_card_id":"PNC1","chromosome_location":"chromosome 7","locus":"YGL037C","synonyms":["Nicotine deamidase","NAMase"],"enzyme_classes":["3.5.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Isochorismatase","identifier":"PF00857"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAGACTTTAATTGTTGTTGATATGCAAAATGATTTTATTTCACCTTTAGGTTCCTTGACTGTTCCAAAAGGTGAGGAATTAATCAATCCTATCTCGGATTTGATGCAAGATGCTGATAGAGACTGGCACAGGATTGTGGTCACCAGAGATTGGCACCCTTCCAGACATATTTCGTTCGCAAAGAACCATAAAGATAAAGAACCCTATTCAACATACACCTACCACTCTCCAAGGCCAGGCGATGATTCCACGCAAGAGGGTATTTTGTGGCCCGTACACTGTGTGAAAAACACCTGGGGTAGTCAATTGGTTGACCAAATAATGGACCAAGTGGTCACTAAGCATATTAAGATTGTCGACAAGGGTTTCTTGACTGACCGTGAATACTACTCCGCCTTCCACGACATCTGGAACTTCCATAAGACCGACATGAACAAGTACTTAGAAAAGCATCATACAGACGAGGTTTACATTGTCGGTGTAGCTTTGGAGTATTGTGTCAAAGCCACCGCCATTTCCGCTGCAGAACTAGGTTATAAGACCACTGTCCTGCTGGATTACACAAGACCCATCAGCGATGATCCCGAAGTCATCAATAAGGTTAAGGAAGAGTTGAAGGCCCACAACATCAATGTCGTGGATAAATAA","protein_sequence":"MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK"},{"created_at":"2011-05-27T01:45:12.000Z","updated_at":"2011-05-29T05:06:34.000Z","name":"tRNA 2'-phosphotransferase","uniprot_id":"Q12272","uniprot_name":"TPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"TPT1","num_residues":230,"molecular_weight":"26196.19922","theoretical_pi":"9.81","general_function":"Involved in transferase activity, transferring phosphorus-containing groups","specific_function":"Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate","reactions":[{"id":2641,"direction":"\u003e","locations":null,"altext":"2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z48149","genbank_protein_id":"663252","gene_card_id":"TPT1","chromosome_location":"chromosome 15","locus":"YOL102C","synonyms":[],"enzyme_classes":["2.7.1.160"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" RNA processing"},{"category":"Process","description":" RNA splicing"},{"category":"Process","description":" RNA splicing, via endonucleolytic cleavage and ligation"},{"category":"Process","description":" tRNA splicing, via endonucleolytic cleavage and ligation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"}],"pfams":[{"name":"PTS_2-RNA","identifier":"PF01885"}],"pathways":[],"gene_sequence":"ATGCGCCAGGTACTACAAAAAGATAAAAGGGATGTACAGCTTTCCAAAGCTTTATCATATCTGCTTCGACATACAGCGGTGAAAGAAAAGTTGACTATTGACTCAAACGGTTATACACCGCTGAAAGAACTATTGTCTCATAATAGATTGAAAACTCATAAATGTACGGTGGATGATATCCATCGCATTGTTAAGGAAAATGACAAACAACGCTTTCATATAAAAACGTTAGGAGCGGACGAAGAATGGATCTGTGCTACTCAGGGACATTCAATCAAATCGATTCAGCCATCAGATGAGGTTCTCGTACCAATTACTGAAGCGTCGCAGTTACCACAGGAACTAATTCATGGAACAAATCTTCAATCTGTCATAAAGATTATTGAATCCGGAGCAATATCACCAATGAGTAGAAATCATGTCCATTTATCGCCGGGGATGTTGCACGCGAAGGGAGTTATTAGTGGAATGCGTTCTTCAAGTAACGTCTATATTTTCATCGACTGCCATTCTCCATTATTCTTTCAAACTTTGAAAATGTTCAGGTCGCTCAATAATGTTTACTTAAGCAGCAGTATTCCCGTTGAATTGATCCAAAAAGTTGTAGTTAAAGGAAACTTGAAAGATGAGGAGAAGTTAGATACTTTAAGAAGAATTTTACACGAAAGAAACATACCGCTCGAAAAGATATAA","protein_sequence":"MRQVLQKDKRDVQLSKALSYLLRHTAVKEKLTIDSNGYTPLKELLSHNRLKTHKCTVDDIHRIVKENDKQRFHIKTLGADEEWICATQGHSIKSIQPSDEVLVPITEASQLPQELIHGTNLQSVIKIIESGAISPMSRNHVHLSPGMLHAKGVISGMRSSSNVYIFIDCHSPLFFQTLKMFRSLNNVYLSSSIPVELIQKVVVKGNLKDEEKLDTLRRILHERNIPLEKI"},{"created_at":"2011-05-27T03:42:34.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Putative nicotinamide N-methyltransferase","uniprot_id":"Q05874","uniprot_name":"NNT1_YEAST","enzyme":true,"transporter":false,"gene_name":"NNT1","num_residues":261,"molecular_weight":"29632.30078","theoretical_pi":"4.78","general_function":"Involved in nicotinamide N-methyltransferase activity","specific_function":"Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination","reactions":[{"id":1776,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2741,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY693038","genbank_protein_id":"51013527","gene_card_id":"NNT1","chromosome_location":"chromosome 12","locus":"YLR285W","synonyms":[],"enzyme_classes":["2.1.1.1"],"go_classes":[],"pfams":[{"name":"Methyltransf_16","identifier":"PF10294"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGTCAGATATAGAATCATTGGGAGAGGCAGCAGGTTTATTTGAGGAGCCAGAGGATTTTCTTCCTCCTCCACCAAAACCTCATTTTGCAGAATATCAAAGGTCACACATCACAAAAGAGTCCAAATCAGATGTTAAAGACATCAAACTCCGTCTCGTTGGAACGTCACCACTTTGGGGTCATCTCTTGTGGAATGCAGGAATATACACCGCAAATCACTTGGATTCTCATCCAGAATTAATAAAGGGGAAGACTGTTTTAGAATTGGGTGCTGCTGCTGCTTTACCTTCCGTTATTTGTGCTTTGAATGGGGCTCAAATGGTTGTTTCAACTGATTATCCAGATCCTGATTTAATGCAGAACATCGATTATAATATAAAGTCTAACGTTCCTGAAGATTTTAATAATGTCAGTACGGAGGGTTATATTTGGGGAAACGATTATTCTCCATTGTTGGCACATATCGAAAAAATAGGTAACAATAATGGAAAGTTTGACTTAATCATTTTAAGTGATTTAGTCTTCAATCATACGGAACATCACAAATTACTTCAAACAACAAAGGATTTATTAGCTGAGAAAGGTCAGGCGTTGGTAGTATTTTCACCGCATAGACCAAAATTGTTGGAGAAGGATTTAGAATTCTTCGAATTGGCTAAGAACGAGTTCCATTTGGTTCCTCAGCTAATTGAAATGGTTAATTGGAAACCGATGTTTGACGAAGACGAGGAAACAATCGAAGTCAGATCTCGTGTTTATGCGTACTATTTAACACATGAAAAGTAG","protein_sequence":"MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK"},{"created_at":"2011-05-27T17:15:59.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Uridine nucleosidase","uniprot_id":"Q04179","uniprot_name":"URH1_YEAST","enzyme":true,"transporter":false,"gene_name":"URH1","num_residues":340,"molecular_weight":"37960.0","theoretical_pi":"5.07","general_function":"Involved in hydrolase activity, hydrolyzing N-glycosyl compounds","specific_function":"Also acts on cytidine","reactions":[{"id":1269,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1609,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2835,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Uridine + H(2)O = D-ribose + uracil.","export":false,"pw_reaction_id":null,"source":null},{"id":4195,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006494","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"URH1","chromosome_location":"chromosome 4","locus":"YDR400W","synonyms":["Uridine ribohydrolase"],"enzyme_classes":["3.2.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Function","description":" hydrolase activity, hydrolyzing N-glycosyl compounds"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IU_nuc_hydro","identifier":"PF01156"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGTTAGTAAAATACCCATATGGCTAGATTGTGATCCTGGTCATGATGATGCCATAGCCATTTTATTAGGCTGTTTCCATCCAGCTTTCAATCTTCTAGGAATCAGCACGTGTTTTGGTAACGCACCGCCAGAGAATACTGACTACAACGCCCGTTCTCTTTTGACTGCGATGGGCAAAGCACAAGCGATTCCAGTTTATAAAGGCGCACAGAGACCTTGGAAAAGGGAACCTCATTATGCTCCTGACATTCATGGTATATCAGGTTTAGACGGCACTTCTTTGCTACCTAAGCCAACATTTGAGGCAAGAACTGATAAAACGTATATTGAGGCCATTGAAGAGGCGATTCTAGCTAACAATGGAGAGATATCCTTTGTGTCTACTGGTGCACTTACCACATTAGCAACAGTTTTTAGGTGTAAACCATACCTAAAAAAATCTGTCAAATATATTAGCATTATGGGGGGTGGACTCCATGGTCTAGGAAACTGTAACCCAAATCTTTCTGCTGAATTCAACGTTTGGATTGATCCTGACGCAGCGAATTACATATTCCGTGATCCCGATGTAAAGGACAAATGTATAGTAGTTCCTCTAAATTTAACTCACAAGGCCATAGCTACTTACAAGGTTAACGAAATGATATACAACGAAAAGAATAACAGCAAGTTACGAGAATTGTTTTTGGAGCTTTTTCAATTTTTTGCTCATACCTACAAGGATATGCAAGGATTTGAATCGGGCCCACCTATACATGATCCGGTAGCTTTGATGCCGCTTTTGGAATTTTATGGGTGGGATCCATCGTCTGCGGTTGGATTTCGCTACAAGAGAATGGACATATCCTGCATTGATGATGTTTTCAACGAAAACTCAGGGAAAATTATCATTGAAAAAGAATATCCAAATGACAGTGATGTTGGTACAATAATTGGTCTCGATTTGAATATCCAGTACTTTTGGGATCAGATTTTTGAAGCATTAAATAGAGCAGACAAAATGTCAACGATTGGATAA","protein_sequence":"MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG"},{"created_at":"2011-07-22T05:58:28.000Z","updated_at":"2011-07-22T05:58:28.000Z","name":"NAD-dependent histone deacetylase SIR2","uniprot_id":"P06700","uniprot_name":"SIR2_YEAST","enzyme":false,"transporter":false,"gene_name":"SIR2","num_residues":562,"molecular_weight":"63261.30078","theoretical_pi":"8.66","general_function":"Transcription","specific_function":"NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on 'Lys-9' and 'Lys-14' of histone H3 and 'Lys-16' of histone H4 in vitro, such activity is unclear in vivo and may not be essential","reactions":[{"id":1762,"direction":"\u003c\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2861,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Nucleus, nucleolus.;Nucleus.;Nucleus (Potential);Nucleus","altext":"NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.","export":false,"pw_reaction_id":null,"source":null},{"id":4196,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006495","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus, nucleolus.","genbank_gene_id":"X01419","genbank_protein_id":"4470","gene_card_id":"SIR2","chromosome_location":null,"locus":null,"synonyms":["Regulatory protein SIR2","Silent information regulator 2"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"catalytic activity"},{"category":"Function","description":"NAD binding"},{"category":"Function","description":"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":"nucleotide binding"},{"category":"Function","description":"histone deacetylase activity"},{"category":"Function","description":"NAD or NADH binding"},{"category":"Function","description":"NAD-dependent histone deacetylase activity"},{"category":"Function","description":"hydrolase activity"},{"category":"Function","description":"binding"},{"category":"Function","description":"ion binding"},{"category":"Function","description":"cation binding"},{"category":"Function","description":"metal ion binding"},{"category":"Function","description":"transition metal ion binding"},{"category":"Function","description":"zinc ion binding"},{"category":"Process","description":"chromatin silencing"},{"category":"Process","description":"macromolecule metabolic process"},{"category":"Process","description":"macromolecule modification"},{"category":"Process","description":"protein modification process"},{"category":"Process","description":"post-translational protein modification"},{"category":"Process","description":"protein amino acid deacetylation"},{"category":"Process","description":"regulation of transcription, DNA-dependent"},{"category":"Process","description":"biological regulation"},{"category":"Process","description":"regulation of biological process"},{"category":"Process","description":"metabolic process"},{"category":"Process","description":"regulation of metabolic process"},{"category":"Process","description":"regulation of macromolecule metabolic process"},{"category":"Process","description":"regulation of gene expression"},{"category":"Process","description":"regulation of transcription"},{"category":"Process","description":"cellular process"},{"category":"Process","description":"gene silencing"}],"pfams":[{"name":"DUF592","identifier":"PF04574"},{"name":"SIR2","identifier":"PF02146"}],"pathways":[{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACCATCCCACATATGAAATACGCCGTATCAAAGACTAGCGAAAATAAGGTTTCAAATACAGTAAGCCCCACACAAGATAAAGACGCGATCAGAAAACAACCCGATGACATTATAAATAATGATGAACCTTCACATAAGAAGATAAAAGTAGCACAGCCGGATTCCTTGAGGGAAACCAACACAACAGATCCACTTGGGCACACTAAAGCTGCGCTCGGAGAAGTGGCATCGATGGAGCTCAAACCAACTAATGACATGGATCCCTTGGCAGTGTCAGCAGCTTCAGTAGTGTCAATGTCCAATGACGTTTTGAAACCAGAGACGCCCAAGGGGCCAATCATAATCAGTAAAAACCCATCAAATGGTATTTTCTATGGTCCCTCCTTCACTAAACGAGAGTCTCTCAATGCTCGAATGTTTCTGAAATACTATGGTGCACACAAATTTTTAGACACTTACCTCCCCGAGGATTTGAACTCGTTATACATTTACTATCTTATCAAGTTGCTAGGCTTTGAAGTTAAAGATCAAGCGCTTATCGGCACCATCAACAGTATTGTCCATATCAACTCGCAAGAGCGTGTTCAAGATTTGGGAAGTGCAATATCTGTCACAAATGTTGAAGACCCATTGGCAAAAAAGCAAACAGTTCGTCTAATCAAAGATTTGCAAAGAGCAATTAACAAAGTTCTATGTACAAGATTAAGATTATCCAATTTTTTCACTATTGATCATTTTATTCAAAAATTACATACCGCTAGAAAAATTTTGGTCCTGACTGGTGCAGGTGTTTCAACTTCATTAGGGATCCCGGACTTCAGATCTTCTGAGGGGTTCTATTCAAAGATCAAACATTTGGGGCTCGATGATCCCCAAGACGTTTTCAATTACAATATATTTATGCACGACCCCTCTGTTTTCTATAATATTGCCAATATGGTTTTACCTCCAGAAAAAATTTATTCTCCATTGCATAGTTTCATTAAGATGCTACAAATGAAAGGGAAATTATTGAGAAATTATACTCAAAACATTGATAATTTGGAATCTTATGCGGGAATAAGCACAGATAAACTGGTGCAGTGCCATGGCTCTTTTGCTACTGCCACCTGCGTTACCTGCCATTGGAACCTACCCGGTGAGAGGATATTTAATAAAATTAGAAACCTCGAACTTCCACTATGCCCGTACTGTTACAAAAAAAGAAGAGAATATTTCCCAGAGGGATATAATAATAAAGTAGGTGTTGCTGCATCACAGGGTTCAATGTCGGAAAGGCCTCCATATATCCTTAACTCATATGGCGTTCTCAAACCAGATATCACATTCTTTGGCGAAGCACTGCCAAATAAATTTCATAAGAGCATTCGCGAAGATATCTTAGAATGTGATTTGTTGATTTGCATTGGGACAAGTTTAAAAGTAGCGCCAGTGTCTGAAATCGTAAACATGGTTCCTTCCCACGTTCCCCAAGTCCTGATTAATCGTGATCCCGTCAAGCACGCAGAATTTGATTTATCTCTTTTGGGGTACTGTGATGACATTGCAGCTATGGTAGCCCAAAAATGTGGCTGGACGATTCCGCATAAGAAATGGAACGATTTGAAGAACAAGAACTTTAAATGCCAAGAGAAGGATAAGGGCGTGTATGTCGTTACATCAGATGAACATCCCAAAACCCTCTAA","protein_sequence":"MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL"}]}