You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Identification |
---|
Name | Mitochondrial distribution and morphology protein 12 |
---|
Synonyms | - Mitochondrial inheritance component MDM12
|
---|
Gene Name | MDM12 |
---|
Enzyme Class | Not Available |
---|
Biological Properties |
---|
General Function | protein import into mitochondrial outer membrane |
---|
Specific Function | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids. |
---|
Cellular Location | Not Available |
---|
SMPDB Pathways | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/28:1(11Z)) | PW003519 | | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/28:1(9Z)) | PW003520 | | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/30:0) | PW003521 | | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(9Z)/26:0) | PW003522 | | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(9Z)/26:1(11Z)) | PW003523 | |
|
---|
KEGG Pathways | Not Available |
---|
SMPDB Reactions | Not Available |
---|
KEGG Reactions | Not Available |
---|
Metabolites | |
---|
GO Classification | Function |
---|
mitochondrial outer membrane translocase complex assembly | mitochondrion-ER tethering | phospholipid transport | protein import into mitochondrial outer membrane | mitochondrial outer membrane | mitochondrion inheritance | endoplasmic reticulum membrane | ERMES complex | mitochondrial genome maintenance |
|
---|
Gene Properties |
---|
Chromosome Location | Not Available |
---|
Locus | |
---|
Gene Sequence | >816 bp
ATGTCTTTTGATATTAATTGGAGTACATTGGAATCTGACAATAGACTGAATGATCTTATA
AGAAAACATTTAAATTCATATTTACAAAATACGCAACTACCAAGCTACGTAAGTAATCTT
AGGGTACTAGATTTTGATCTGGGAAAAGTTGGTCCTGCTATAACACTGAAAGAAATAACA
GATCCCCTAGATGAGTTTTATGATTCAATTAGAGAGGAGGCTGATCAAGAGACGGAGGAA
AATAATGACAACAAGGAGGACAGCGAACATATTTGTCCTGATCGTACTATAGCTAATCAT
GAAGGACCTAAAGATGATTTTGAGGCGCCTGTGGTGATGCCATCCCCCAACGATATACAA
TTTTTACTAGAGGTCGAGTACAAGGGTGACTTACTCGTTACGATTGGTGCCGACCTTGTG
CTGAATTATCCCGTAGAAAAATTTATGACTTTGCCAGTAAAACTTTCTATCAGTGATATC
GGTCTCCATTCCCTTTGCATTGTTGCATGTTTATCAAAGCAACTATTTCTTAGCTTTCTG
TGTGATGTTAGTGATCCTGCACTGGATGACAACCAAACTGTTTTAGATCCTAAGGGGCCA
ATTCTGGCAGCTACTAAGCCATTGGAGCGAATATCCATTGTGAGAAGTATGAAGATTGAA
ACCGAAATAGGGGAACAATATCAGGGACAGGGCTCAGTATTAAGAAGTGTTGGAGAACTA
GAACAGTTTTTGTTTACGATATTCAAAGATTTTTTAAGAAAGGAGTTAGCATGGCCAAGT
TGGATTAATCTGGATTTCAACGATGGTGATGAGTAA |
---|
Protein Properties |
---|
Pfam Domain Function | Not Available |
---|
Protein Residues | 271 |
---|
Protein Molecular Weight | 30728.29 |
---|
Protein Theoretical pI | Not Available |
---|
Signalling Regions | Not Available |
---|
Transmembrane Regions | Not Available |
---|
Protein Sequence | >Mitochondrial distribution and morphology protein 12
MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEIT
DPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQ
FLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFL
CDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGEL
EQFLFTIFKDFLRKELAWPSWINLDFNDGDE |
---|
References |
---|
External Links | Resource | Link |
---|
Saccharomyces Genome Database | MDM12 | Uniprot ID | Q92328 | Uniprot Name | MDM12 |
|
---|
General Reference | Not Available |
---|