Target of rapamycin complex 2 subunit AVO1 (Q08236)

Identification
NameTarget of rapamycin complex 2 subunit AVO1
Synonyms
  • TORC2 subunit AVO1
  • Adheres voraciously to TOR2 protein 1
Gene NameAVO1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in phosphatidylinositol-4,5-bisphosphate binding
Specific FunctionComponent of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway
Cellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>3531 bp ATGGACACGGTGACGGTATTAAATGAACTGCGGGCTCAGTTTCTACGAGTGTGTCCGGAG AAAGATCAAATGAAAAGAATAATAAAACCGTACATACCCGTAGATGAATTCAACACAGAG CAGTGCTTAGATTCTTCTATCCGTGAATTATATATGAACTCAGACGGCGTAAGCTTGTTA CCTGAACTAGAGTCTCCACCGGTATCTAAGGATTTTATGGAAAACTATGCTTCATTAGGG AAAATGAGGATAATGAGGGAGAATGAAGGCCAAAAAGGAAAGGCTAACCAGAATTTAATA GGAGCAGAGAAGACTGAAAGAGACGAGGAAGAAACACGAAATTTGCAAGATAAAAGTGCA AAAAATACTCTGATAGTTGAAGAAAATGGAACACTTCGTTATAATCCACTTAATTCATCT GCGTCGAACTCTCTTTTAAATGATGACGACCATACCAGTGGAAAACATCACAAAACTTCC TCAAAGGAAGACTCATATTTAAATAGTTCGATGGAAATGCAGAAGAAATCTAGTAAGAGA TCGTCGCTTCCTTTCGTGAGGATATTCAAAAGTCGAAGGGACCACTCAAATACTTCTGGA AATAAAAATGTCATGAATACAACTAATACAAGAGCAAAATCATCTACTTTGCATCCACCT GGTGCTCGCCATAATAAGAAAGGCAGTAAATTCGATATGAACTTCGATTTCGATGAAAAC TTAGAAGAAGAAGATGATGACGACGACGATGACGAAGAAGGTGACGATATACACTCTCAA TTTTTTCAGTTAGATGATGATTTTGATGCTAAGGGTTCTGGAGCAAGTCCAGCCCACAAA GGCATCAACGGCATGTCCAACAATAAAAACAACACCTACACAAATAACAGAAACAGCATC AGCATTCTTGATGATCGAGAGAGTTCAAATGGCAATATAGGAAGTGCTTCAAGGTTAAAA TCTCATTTCCCCACAAGTCAAAAGGGGAAAATTTTTTTAACTGACAATAAAAATGATGGA CAAAAATCTGATTCACTGAATGCCAATAAAGGTATACATGGAGATGGAAGCAGCGCCAGC GGTAACGGATCGGTGAGTAGGGACGGTTTGACGGAAACGGAAAGCAACAATATTTCCGAT ATGGAATCTTATATCAATGAAAAAGATTTAGATGATTTGAATTTTGATACAGTGACCTCA AACATAAACAAAACAGTATCTGATTTGGGAGGACATGAATCTACAAATGATGGAACGGCG GTCATGAACAGGGATTCAAAAGACAGCCGCAGTAATAGCAATGAATTCAATGCACAAAAT CGTGACCGAATCACTCCTGGCTCATCATATGGGAAGTCCCTTTTAGGATCTGAATATTCC GAAGAACGTTATTCTAATAACGACTCGTCAACCATGGAGAGCGGTGAAATGTCTCTTGAT TCAGACATGCAAACTAATACTATACCCTCTCATTCCATACCAATGTCTATGCAAAAATAT GGCATCTATCATGGCGATGATGACTCTACCTTAAACAATGTCTTCGATAAAGCCGTACTG ACTATGAATTCATCGCGACACCCAAAAGAAAGGCGCGATACTGTTATATCAGGAAAGGAG CCAACATCCTTAACCAGTTCTAATAGAAAATTTTCTGTTAGCTCGAATTTAACTTCAACA AGGTCTCCTCTTTTACGAGGACATGGAAGAACTTCATCGACGGCCAGTAGTGAACACATG AAAGCCCCAAAGGTTTCTGACAGTGTATTGCATAGGGCAAGGAAGAGCACGTTGACGTTA AAGCAGGACCATTCTCAACCTAGTGTTCCATCAAGTGTCCATAAAAGCTCGAAAGAGGGG AACATCCTTATTGAGAAAACCACCGATTATCTAGTGTCGAAACCGAAGGCCTCACAGTTA TCGAATATGTTCAACAAAAAGAAAAAGAGAACAAATACTAATTCTGTAGATGTGTTAGAA TATTTTTCATTTGTTTGCGGAGATAAAGTACCAAATTATGAATCAATGGGTCTCGAAATA TACATTCAAGCTTCCAAAAAATATAAAAGAAATTCCTTCACTACCAAAGTCCGAAAATCG TCTACCATCTTCGAAGTTATTGGATTTGCTTTATTTTTGTATTCTACTGAGAAAAAACCG GACAATTTTGAAGAAGATGGATTGACAGTTGAAGACATTTCTAATCCTAATAACTTCTCT TTGAAAATTGTCGATGAAGACGGTGAACCTTTTGAGGATAACTTTGGTAAACTAGATAGA AAAAGCACTATTCAATCAATTTCGGACAGCGAAGTTGTTTTATGTAAGGTTGATGATGCC GAGAAGTCTCAAAATGAAATTGAAACACCTTTACCATTTGAAACTGGTGGGGGCCTAATG GATGCTTCTACTTTGGATGCTAACAGCAGTCACGATACAACTGACGGAACCATCAACCAA CTAAGTTTCTACAAACCTATTATAGGTAATGAAGACGACATCGATAAGACAAACGGTTCG AAAATCATTGATGTAACAGTATATTTGTATCCTAACGTGAATCCCAAATTTAACTATACT ACCATAAGTGTTTTAGTGACCTCACATATAAACGATATTTTGGTAAAATATTGCAAAATG AAAAATATGGATCCTAATGAATATGCATTAAAAGTTCTAGGAAAGAACTATATACTGGAC TTGAATGATACGGTATTAAGGCTCGATGGTATTAATAAGGTGGAACTCATCTCTAAAAAA GATGCAAGGGAGTTGCATTTGGAAAAAATGAAACCTGACCTAAAGAAGCCCGTTTTGCCA ACGATCCAAAGTAATGATCTAACTCCGTTAACTTTGGAGCCTCTGAACTCTTATCTCAAA GCAGATGCTGGAGGGGCTGTGGCTGCCATTCCTGAAAACACGAAAGTTACATCCAAAGCT AAGAAGATATCCACGAAGTATAAGCTGGGCTTGGCAAAGCAGCATTCGTCATCAAGTGTT GCTAGTGGAAGTGTTTCAACGGCTGGCGGTCTCGCCAATGGAAATGGGTTTTTCAAGAAC AAGAATTCATCCAAATCCTCTTTGCATGGGACACTGCAGTTTCATAATATAAACCGTTCT CAGAGTACGATGGAGCACACGCCTGACACTCCAAATGGAGTTGGAGATAACTTCCAAGAT CTTTTTACCGGAGCGTATCATAAATATAAGGTATGGAGAAGGCAGCAAATGTCATTTATA AACAAGCATGAAAGAACACTAGCCATTGATGGCGACTACATATACATTGTACCCCCGGAG GGACGTATACATTGGCATGATAATGTAAAGACTAAGTCGTTACACATTAGTCAAGTGGTT CTTGTCAAAAAATCCAAAAGAGTCCCTGAGCATTTCAAAATTTTCGTAAGAAGAGAGGGG CAAGATGATATCAAAAGGTACTACTTTGAAGCAGTTTCAGGTCAAGAGTGTACTGAGATC GTGACGCGATTACAAAACTTATTAAGCGCTTATAGAATGAATCATAAATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1176
Protein Molecular Weight131378.0
Protein Theoretical pI6.7
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Target of rapamycin complex 2 subunit AVO1 MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLL PELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSA KNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKR SSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDEN LEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSI SILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSAS GNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTA VMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLD SDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKE PTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTL KQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLE YFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKP DNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDA EKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGS KIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILD LNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLK ADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKN KNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFI NKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREG QDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK
References
External Links
ResourceLink
Saccharomyces Genome Database AVO1
Uniprot IDQ08236
Uniprot NameAVO1_YEAST
GenBank Gene IDZ74820
Genebank Protein ID1419911
General Reference
  • Tzermia, M., Katsoulou, C., Alexandraki, D. (1997). "Sequence analysis of a 33.2 kb segment from the left arm of yeast chromosome XV reveals eight known genes and ten new open reading frames including homologues of ABC transporters, inositol phosphatases and human expressed sequence tags." Yeast 13:583-589.9178509
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., Hall, M. N. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control." Mol Cell 10:457-468.12408816
  • Wedaman, K. P., Reinke, A., Anderson, S., Yates, J. 3rd, McCaffery, J. M., Powers, T. (2003). "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae." Mol Biol Cell 14:1204-1220.12631735
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Wullschleger, S., Loewith, R., Oppliger, W., Hall, M. N. (2005). "Molecular organization of target of rapamycin complex 2." J Biol Chem 280:30697-30704.16002396
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956