Down-regulator of invasive growth 2 (Q03373)

Identification
NameDown-regulator of invasive growth 2
Synonyms
  • Regulator of STE12 protein 2
  • Regulator of sterile twelve 2
Gene NameDIG2
Enzyme ClassNot Available
Biological Properties
General Functionnegative regulation of transcription from RNA polymerase II promoter by pheromones
Specific FunctionDIG2 and DIG1 are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein-protein interaction. DIG2 binds to the DNA binding domain (DBD) of STE12 and thus inhibits transcription when overexpressed.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
nucleus
Ste12p-Dig1p-Dig2p complex
negative regulation of transcription from RNA polymerase II promoter by pheromones
transcription factor binding
negative regulation of invasive growth in response to glucose limitation
negative regulation of pseudohyphal growth
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>972 bp ATGAATAAAGAAGAGCAAGAAGACCCACAGCAAGAGCAAATATCAACTGTTCAGGAAAAT GATCCCAGGAATTTGCAGCAACTGGGAATGCTGTTAGTATCTCCAGGGCTTGATGAAGAC AGATTGAGTGAGAAAATGATTTCGAAGATCAAAAAATCCAGGGATATCGAAAAAAATCAA AAATTGCTCATATCTAGGCTGTCGCAAAAAGAGGAAGATCATAGTGGTAAGCCTCCTACC ATTACGACTTCTCCAGCAGAGAAAACCGTACCCTTTAAGTCGCTGAATCATTCTTTAAAG AGGAAAAGGGTACCTCCAGCGCTAAATTTTTCCGATATACAAGCATCTTCTCATTTGCAT GGATCTAAAAGTGCTCCACCAAACATAACAAGATTTCCGCAGCACAAAAATAGCCTTAGG GTCAGATATATGGGTAGGATGGCTCCTACGAATCAAGATTATCATCCTTCAGTGGCCAAT TCATATATGACAGCAACCTACCCTTATCCATATACTGGACTGCCACCAGTACCATGCTAC CCATATTCTTCAACTCCAACACAAACGCACGCATACGAAGGCTATTATTCCCCGATGTAT CCCGGCCCCTTGTATAATAATGGTATAATACCAGCCGACTACCATGCAAAGAGGAAGAAG TTGGCTGGTAGATCACCACACTTGGAAGATTTGACATCGAGAAAAAGAACCTTTGTCTCC AAACACCACAACGGAGACCCAATCATAAGTAAGACTGATGAAGACATTGAATGCTCTGTC ACGAAAAATTCATTAAGTGAGGGCGCTTCACTTAACGACGATGCCGATGATGACAACGAC AAAGAAAGGATCATTATTGGAGAAATCTCTCTGTATGATGATGTTTTCAAATTTGAAGTT CGCGACGACAAAAATGACTATATGAAAGCATGTGAAACAATCTGGACTGAATGGCATAAC TTGAAGAAATGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues323
Protein Molecular Weight36878.99
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Down-regulator of invasive growth 2 MNKEEQEDPQQEQISTVQENDPRNLQQLGMLLVSPGLDEDRLSEKMISKIKKSRDIEKNQ KLLISRLSQKEEDHSGKPPTITTSPAEKTVPFKSLNHSLKRKRVPPALNFSDIQASSHLH GSKSAPPNITRFPQHKNSLRVRYMGRMAPTNQDYHPSVANSYMTATYPYPYTGLPPVPCY PYSSTPTQTHAYEGYYSPMYPGPLYNNGIIPADYHAKRKKLAGRSPHLEDLTSRKRTFVS KHHNGDPIISKTDEDIECSVTKNSLSEGASLNDDADDDNDKERIIIGEISLYDDVFKFEV RDDKNDYMKACETIWTEWHNLKK
References
External Links
ResourceLink
Saccharomyces Genome Database DIG2
Uniprot IDQ03373
Uniprot NameDIG2
General ReferenceNot Available