Protein MLP1 (Q02455)

Identification
NameProtein MLP1
Synonyms
  • Myosin-like protein 1
Gene NameMLP1
Enzyme ClassNot Available
Biological Properties
General Functiontranscriptional activation by promoter-terminator looping
Specific FunctionInvolved together with the closely related MLP2 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP1 also recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
telomere tethering at nuclear periphery
transcriptional activation by promoter-terminator looping
nucleoplasm
DNA repair
nuclear envelope
nuclear pore nuclear basket
nucleocytoplasmic transporter activity
ribonucleoprotein complex binding
mitotic spindle assembly checkpoint
negative regulation of protein import into nucleus during spindle assembly checkpoint
nuclear retention of unspliced pre-mRNA at the site of transcription
poly(A)+ mRNA export from nucleus
protein import into nucleus
protein localization to nuclear pore
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>5628 bp ATGTCGGATCATGATACTCCAATGGAAAGCATACAAAATGGTGAAAATTCAGACGAAAGA TTGAACGCCATTGCGTCTTTTTTCGGTTGCTCTTTAGAGCAGGTTAAATCATTTGACGGT GATGTGGTAAAACACCTTAACGATAAACTTTTACAGTTTAATGAACTTAAATCGGAGAAT CTAAAGGTTACCGTCTCATTCGATGAATTGAAGGCTAGTTCTTTAAAGAAAATTGATGGT TTGAAGACAGAAATGGAAAACGTTATAAGAGAAAATGATAAAATCCGAAAAGAGAGGAAT GATACTTTTGTTAAGTTCGAATCTGTAGAAAATGAAAAGATGAAATTATCAAGTGAGCTA GAGTTTGTGAAAAGGAAGCTCGATGATTTAACTGAGGAGAAAAAGGAAACCCAGAGTAAT CAACAGCGAACCCTGAAAATACTGGATGAAAGACTAAAAGAAATAGAATTGGTCAGGGTT GAGAATAATCGCTCCAATAGTGAATGTAAGAAACTACGCTCTACAATAATGGATTTAGAA ACAAAACAACAGGGCTATATTACTAATGACCTGAATTCTAGAACTGAACTGGAAAGAAAA ACACAAGAATTGACTTTATTGCAGTCAAATAATGATTGGCTAGAAAAGGAGCTACGTTCA AAAAATGAACAGTATCTCTCCTACAGACAAAAAACCGACAAAGTAATTCTAGATATCAGG AATGAATTAAATCGTTTAAGGAATGATTTTCAAATGGAAAGAACGAATAATGATGTTTTG AAGCAAAAAAATAACGAATTGTCAAAATCTTTACAAGAAAAACTACTGGAAATCAAGGGT CTATCCGACTCCCTAAATTCCGAAAAGCAAGAATTTTCTGCAGAAATGTCCCTAAAGCAA CGTTTAGTGGACCTTTTAGAATCACAATTGAACGCTGTAAAAGAAGAATTGAACAGTATA AGAGAGTTGAACACTGCAAAGGTAATAGCAGATGATTCAAAAAAACAAACTCCCGAAAAT GAAGACTTACTTAAGGAATTGCAGTTAACGAAAGAAAAATTAGCACAATGCGAAAAAGAA TGTCTACGTTTATCCTCTATAACTGACGAAGCAGATGAAGATAATGAAAATTTATCTGCA AAATCTAGTTCTGATTTTATATTCCTGAAGAAACAATTAATTAAAGAAAGGCGTACCAAG GAACATCTTCAAAATCAAATTGAAACATTCATCGTAGAGTTGGAACATAAAGTGCCCATT ATAAACTCTTTCAAAGAAAGAACTGACATGTTGGAAAACGAATTGAATAACGCTGCATTG TTACTAGAGCATACATCGAACGAGAAGAATGCAAAGGTTAAGGAATTAAATGCCAAAAAC CAAAAGCTAGTGGAATGTGAAAATGATCTTCAAACTTTAACTAAACAACGTCTCGATCTA TGCCGTCAAATACAATACCTTTTAATTACCAATTCTGTTTCTAATGACTCGAAGGGACCC TTACGTAAGGAAGAAATTCAATTTATTCAAAACATTATGCAGGAAGACGATAGTACTATC ACAGAATCTGACTCTCAAAAAGTCGTAACTGAAAGACTAGTTGAATTCAAAAACATTATT CAATTACAAGAAAAAAATGCAGAACTTTTGAAAGTAGTAAGAAACTTAGCCGATAAGTTG GAATCGAAAGAAAAGAAATCTAAACAAAGTCTTCAGAAAATCGAAAGTGAAACAGTAAAT GAGGCTAAAGAGGCTATAATAACTTTAAAGAGTGAAAAAATGGATCTAGAATCAAGAATT GAGGAACTACAGAAAGAGCTTGAAGAATTGAAAACTTCTGTTCCCAACGAAGATGCGTCA TACAGCAATGTAACTATAAAACAGTTAACCGAAACTAAGAGAGACCTCGAATCTCAAGTA CAAGACTTGCAAACTCGTATCTCGCAAATTACTAGGGAGTCTACTGAAAATATGTCACTT TTAAACAAGGAGATACAGGACCTGTATGACAGCAAGAGCGACATATCCATTAAGCTTGGA AAGGAAAAATCATCGAGAATATTGGCAGAGGAACGATTTAAACTACTTTCGAATACGTTA GATCTAACTAAAGCTGAGAACGACCAACTGCGCAAAAGGTTTGATTATTTACAGAATACT ATTTTAAAACAAGATTCCAAAACACACGAGACACTTAATGAATACGTTTCCTGTAAATCT AAGTTAAGCATTGTTGAAACAGAATTATTGAACCTGAAAGAAGAACAGAAATTAAGAGTT CATTTAGAAAAGAACTTGAAACAAGAACTGAATAAACTCTCCCCTGAAAAGGACAGTTTA CGCATCATGGTAACTCAATTACAAACTTTACAAAAGGAGCGTGAAGATCTATTGGAAGAG ACTAGGAAATCATGTCAAAAGAAAATAGATGAACTTGAAGATGCTCTCAGCGAACTTAAA AAGGAAACTTCTCAAAAAGACCATCATATCAAACAGCTGGAAGAAGACAACAATTCAAAT ATAGAATGGTACCAAAATAAAATCGAAGCTTTGAAGAAAGATTATGAATCAGTAATAACT TCTGTAGATAGTAAGCAAACTGACATTGAGAAATTACAATATAAAGTCAAATCACTAGAA AAGGAAATCGAGGAGGACAAGATTCGTTTACATACTTATAATGTTATGGATGAAACAATT AACGATGATTCCCTACGCAAGGAGTTGGAAAAATCCAAGATTAACTTAACTGATGCTTAT TCACAAATCAAAGAATACAAGGATCTCTACGAGACTACCTCTCAGTCTTTGCAGCAAACG AATTCTAAATTGGATGAATCTTTCAAGGACTTTACTAACCAGATTAAAAACCTAACTGAT GAAAAAACTAGTTTGGAGGATAAGATTTCGCTTCTAAAAGAGCAAATGTTTAATTTGAAT AATGAGCTAGATTTGCAGAAAAAAGGGATGGAAAAAGAAAAAGCTGACTTTAAGAAAAGG ATATCAATTTTACAGAACAATAATAAAGAAGTCGAAGCTGTTAAGTCCGAATATGAATCG AAGTTATCAAAAATCCAAAACGACCTTGATCAACAAACTATATATGCTAATACTGCGCAA AACAACTATGAACAAGAACTACAGAAACATGCAGATGTTTCTAAGACGATTAGTGAATTA AGAGAGCAATTACATACGTACAAAGGTCAAGTTAAGACCCTGAACTTATCGCGTGATCAA CTGGAGAATGCTCTGAAAGAAAACGAAAAGAGTTGGTCCTCCCAGAAGGAATCTTTATTA GAACAGCTAGATTTATCGAATTCTCGTATTGAGGATTTATCCTCCCAAAATAAACTATTG TATGATCAAATACAAATCTACACAGCTGCGGACAAAGAAGTCAATAATTCGACAAACGGA CCTGGTTTGAATAATATTTTAATTACACTACGTCGCGAAAGGGATATTCTTGATACAAAA GTGACGGTGGCTGAAAGAGATGCAAAAATGTTGAGACAAAAAATTTCTTTGATGGATGTT GAATTACAAGATGCTCGTACTAAGCTAGATAATTCAAGAGTTGAAAAGGAAAATCATTCT TCCATTATTCAACAGCATGACGACATTATGGAGAAATTAAATCAATTAAATCTATTAAGA GAAAGTAACATAACATTGCGGAATGAGCTGGAAAACAACAATAACAAGAAGAAGGAACTG CAATCTGAATTAGATAAATTGAAGCAAAATGTTGCGCCTATCGAGTCCGAATTGACAGCC TTGAAATATTCTATGCAAGAAAAAGAGCAAGAGCTCAAATTAGCTAAAGAAGAGGTTCAT CGTTGGAAAAAGCGCTCACAAGACATATTGGAGAAACATGAACAATTGAGCTCAAGCGAT TATGAGAAGCTAGAAAGCGAGATAGAAAATTTGAAGGAGGAACTAGAAAATAAGGAGCGT CAAGGAGCGGAAGCCGAGGAAAAATTTAACAGGCTGAGAAGACAAGCGCAAGAGAGATTA AAAACATCAAAACTCTCACAGGACTCATTGACTGAACAAGTAAATAGTCTAAGGGATGCA AAGAACGTGTTGGAAAATTCCTTGAGTGAGGCAAACGCGAGAATCGAAGAGTTACAAAAT GCAAAAGTAGCACAAGGTAACAACCAGTTAGAAGCAATAAGAAAATTACAAGAAGACGCA GAAAAGGCTTCAAGAGAGCTTCAAGCCAAGTTAGAAGAAAGTACGACTTCTTACGAATCT ACGATAAACGGCTTAAATGAAGAGATTACAACATTAAAAGAAGAAATTGAAAAACAAAGG CAAATCCAGCAACAGTTACAAGCTACATCTGCAAATGAACAAAATGACTTATCTAACATA GTTGAGTCTATGAAAAAGTCTTTTGAAGAAGATAAAATCAAATTCATCAAAGAAAAAACC CAAGAAGTTAATGAAAAAATACTCGAGGCCCAAGAAAGGCTAAATCAACCTTCCAATATC AATATGGAGGAGATTAAAAAAAAATGGGAATCTGAGCACGAACAGGAAGTATCTCAAAAG ATTCGCGAAGCTGAGGAAGCCCTCAAAAAGCGAATCAGATTACCCACTGAGGAGAAAATT AATAAGATAATCGAACGAAAGAAGGAGGAATTGGAAAAAGAGTTTGAAGAAAAGGTTGAG GAGAGAATAAAATCAATGGAACAATCTGGAGAAATAGACGTGGTGCTTCGAAAACAGCTA GAAGCTAAGGTTCAAGAGAAACAAAAGGAATTGGAAAACGAGTATAACAAAAAATTACAA GAAGAACTCAAAGATGTACCACACTCAAGTCATATCTCAGATGATGAAAGGGACAAATTA CGAGCAGAAATCGAAAGCAGGTTGAGGGAGGAGTTCAACAATGAACTGCAAGCCATAAAG AAGAAATCCTTCGACGAAGGAAAGCAACAAGCAATGATGAAAACTACCCTTTTGGAAAGA AAACTTGCCAAGATGGAATCTCAATTGTCAGAAACAAAACAAAGTGCCGAGAGTCCTCCG AAATCTGTTAACAATGTACAAAATCCATTACTAGGATTACCTAGGAAAATCGAAGAGAAT TCAAATTCACCATTCAATCCGTTACTTTCCGGTGAAAAACTCTTAAAGCTAAATTCTAAG TCTTCATCAGGTGGATTTAACCCTTTTACCTCGCCATCCCCAAATAAGCACTTACAAAAT GATAATGACAAAAGGGAGTCGTTGGCTAACAAGACAGATCCACCAACTCATTTGGAACCC AGCTTCAACATTCCCGCCTCAAGGGGTCTAATATCTTCATCTTCCACTTTGTCAACTGAT ACAAATGATGAAGAACTTACTAGCAACAATCCTGCCCAAAAGGATTCATCGAACAGAAAT GTTCAATCGGAAGAGGATACAGAAAAAAAGAAAGAGGGAGAACCTGTTAAAAGAGGAGAG GCAATAGAAGAGCAGACGAAATCCAACAAGCGACCTATTGATGAGGTAGGAGAGCTGAAA AATGATGAAGACGACACTACAGAAAACATTAATGAGTCAAAAAAGATCAAGACTGAAGAT GAGGAAGAAAAAGAAACCGATAAGGTGAATGACGAGAACAGTATATAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1875
Protein Molecular Weight218454.4
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Protein MLP1 MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSEN LKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSEL EFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLE TKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIR NELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQ RLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKE CLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPI INSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDL CRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNII QLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRI EELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSL LNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNT ILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSL RIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSN IEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETI NDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTD EKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYES KLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQ LENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNG PGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHS SIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTA LKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKER QGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQN AKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQR QIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNI NMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVE ERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKL RAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPP KSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQN DNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRN VQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTED EEEKETDKVNDENSI
References
External Links
ResourceLink
Saccharomyces Genome Database MLP1
Uniprot IDQ02455
Uniprot NameMLP1
General ReferenceNot Available