Mitogen-activated protein kinase SLT2/MPK1 (Q00772)

Identification
NameMitogen-activated protein kinase SLT2/MPK1
Synonyms
  • MAP kinase MPK1
Gene NameSLT2
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction
Specific FunctionSerine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the SLT2/MPK1 kinase which itself then phosphorylates and activates the transcription factor RLM1. Directly phosphorylates BCY1 upon TOR complex 1 (TORC1) inhibition.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
protein serine/threonine kinase activity
cellular bud tip
mating projection tip
regulation of cell size
regulation of fungal-type cell wall organization
protein phosphorylation
signal transduction
MAP kinase activity
pexophagy
mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response
response to acidic pH
mitochondrion
barrier septum assembly
ATP binding
endoplasmic reticulum unfolded protein response
nucleus
fungal-type cell wall biogenesis
cellular bud neck
regulation of transcription factor import into nucleus
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1455 bp ATGGCTGATAAGATAGAGAGGCATACTTTCAAGGTCTTCAATCAAGATTTCAGTGTAGAT AAGAGGTTTCAACTTATCAAAGAAATAGGGCATGGAGCATACGGCATAGTGTGTTCAGCG CGGTTTGCAGAAGCTGCCGAAGATACCACAGTTGCCATCAAGAAAGTGACAAACGTTTTT TCGAAGACCTTACTATGTAAAAGATCCCTACGTGAGCTAAAGCTTTTGAGACATTTCAGA GGCCACAAAAATATTACATGTCTTTATGATATGGATATTGTTTTTTATCCAGACGGGTCT ATCAATGGACTATATCTTTATGAGGAACTTATGGAATGTGATATGCACCAAATCATCAAA TCCGGTCAACCTTTGACGGATGCTCACTATCAAAGTTTCACATACCAAATATTATGTGGT TTAAAGTATATTCATTCTGCAGATGTCTTGCATCGTGATTTGAAGCCCGGCAATTTGCTT GTCAATGCAGATTGTCAATTGAAAATCTGTGATTTTGGGTTAGCTAGAGGTTATTCGGAG AATCCTGTCGAAAACAGTCAATTTTTGACGGAGTACGTGGCCACTAGATGGTATAGAGCT CCGGAAATAATGTTGAGTTACCAAGGATATACCAAGGCGATTGACGTATGGTCAGCTGGC TGTATTTTAGCGGAGTTTCTTGGTGGAAAGCCAATCTTCAAAGGAAAGGATTACGTTAAT CAATTGAATCAAATATTACAAGTTTTAGGGACACCCCCAGACGAAACTTTAAGAAGGATT GGTTCTAAAAATGTTCAGGACTACATACATCAATTAGGTTTCATTCCAAAAGTACCTTTT GTCAATTTATACCCAAATGCCAATTCACAAGCATTAGACTTATTGGAGCAAATGCTCGCG TTTGACCCTCAAAAGAGAATTACCGTGGATGAGGCCCTGGAGCATCCTTACTTGTCTATA TGGCATGATCCAGCTGACGAACCTGTGTGTAGTGAAAAATTCGAATTTAGTTTTGAATCG GTTAATGATATGGAGGACTTAAAACAAATGGTTATACAAGAAGTGCAAGATTTCAGGCTG TTTGTGAGACAACCGCTATTAGAAGAGCAAAGGCAATTACAATTACAGCAGCAGCAACAG CAGCAGCAACAGCAACAGCAACAGCAACAGCAGCCTTCAGATGTGGATAATGGCAACGCC GCAGCGAGTGAAGAAAATTATCCAAAACAGATGGCCACGTCTAATTCTGTTGCGCCACAA CAAGAATCATTTGGTATTCACTCCCAAAATTTGCCAAGGCATGATGCAGATTTCCCACCT CGACCTCAAGAGAGTATGATGGAGATGAGACCTGCCACTGGAAATACCGCAGATATTCCG CCTCAGAATGATAACGGCACGCTTCTAGACCTTGAAAAAGAGCTGGAGTTTGGATTAGAT AGAAAATATTTTTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues484
Protein Molecular Weight55635.555
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Mitogen-activated protein kinase SLT2/MPK1 MADKIERHTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVF SKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIK SGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSE NPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVN QLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLA FDPQKRITVDEALEHPYLSIWHDPADEPVCSEKFEFSFESVNDMEDLKQMVIQEVQDFRL FVRQPLLEEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGNAAASEENYPKQMATSNSVAPQ QESFGIHSQNLPRHDADFPPRPQESMMEMRPATGNTADIPPQNDNGTLLDLEKELEFGLD RKYF
References
External Links
ResourceLink
Saccharomyces Genome Database SLT2
Uniprot IDQ00772
Uniprot NameSLT2
General ReferenceNot Available