High-affinity nicotinic acid transporter (P53322)

Identification
NameHigh-affinity nicotinic acid transporter
Synonyms
  • Nicotinic acid permease
Gene NameTNA1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transport
Specific FunctionInvolved in the uptake of nicotinic acid
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00224Nicotinic acidShow
GO Classification
Component
Not Available
Function
Not Available
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 7
LocusYGR260W
Gene Sequence>1605 bp ATGAGCAACAAATTTACAATGGAGTCACCTAAGCATTTGGTGGATGATGTGCTTTTCATA TCACCCACCAATGATGGATCAGAAGAAAAGCCTACGGAAGTCACGTTCCAGGAAGATGAA GGCCATGACGCTAGCTTGCATAATCGCAGCCATGACAAGAAGTCGGAACTTGCCACCGAA CGGGAAATTATGGCTACTACCACGGATGATGACGGCATCCCCTCCCCTTCCCATCCAATG GAAAAGCGTGTCTTGCGCAAAATGGATATATACTTGATTCCTCTTATGGGGATGCTATAT TTCCTTTCTAACCTGGATAAATCGAATATTGGTAACGCAGAAGTTGCAGGTCTATCCAAG GATATCCACCTTGTAGGAACGCAATATAACACATGTGTCACAGTTTTTTTCGCGACGTAT GTTCTTTTCGACCCCATAGGTACTAACCTTCTGAAAATTATGGGTCCGCCATTAATGATG AGTATCTGTTTGACCTGTTTCGGTGCTATTTCGCTCGGAACTGCTTGGGTTAAGAATTAT GCTCAATTGATCGTTGTCAGACTACTACTGGGTGCCTTTGAAGGTATGATTTATCCCGCT ATTAACATGTACCTTTCAGTCTGCTATAGAAGAGAACAATATGCTCTGAGGTTCGCTTTT GTCTTCAGTGCAGCCTGTTTGTCTTCATCTTTTGGTGGGCTGATTGCTTATGGTTGTTCC AAAATCAGCGGTTCTCTAAAGGACTGGCAATACATTTACATTGTCGAAGGTTGTATCTCT TTGGGGTTCGTACCATTCTATGCCTTCGGGTTGAGCAAAAATTTGGAGGATTCGTGGTTT TTCAATAAGGAGGAAAAAGAGTACATTTCCGAAAGATACAAGACTATGAACACTTTTGAC CCGGACGAAAAATTTGAATGGTTCCAAGTGTGGCAAGCAGTTAAGGATGTCAAGACTTGG GCTAGTGCTGTGGCATTATTCGGTATCGATTTGACTACTTTTGGTCTAACAGTCTTCTTG CCGATCATCATTACCAGTATGGGGTTCACTAATGTCAGAGCTCAATTAATGACCGTGCCC ATCTATTTCCTTACAGCAATTGTGTTCTTCATTTGTGCCGTTTGGTCTGATCGTATAAAG TTGAGATCTCCATTCATCCTGGGTGCTTGTCTGACGACTTCGATAGGCATAGCTATCGTC CTTGGTTCTCAAGTTCATGGTGTGAGATATTTTGGCGTTTACATTCTTTGTATGGGTATT TACGTTAATGCTGCCTGTAACTGTTTATGGTTAAGTGGTAACACTGGTAATTACTTCAAG AGAGCCACCGCTTTAGGAATTAATCTATTTTTCGGGTCTGGTTCAGGGTTGGTCTCTGGT CAAATTTTTGTTGCCAAAGACAAGCCAAGATATATCAAAGGGCTGTCGATTAGTCTGGCC TTTCAAGTCTTCTCCATATTTATGACGGTTGTGCAAATTTTCCTATACAAGAGGGAAAAC GATAAAAAGAAAGCAATAATAGATCGCTGTAATGAATTGGGAGAGCCTATTCCATACGAC GAAAGGTTAAGCGACAAAAACCCTGAGTTTAAGTACATGTATTAG
Protein Properties
Pfam Domain Function
Protein Residues534
Protein Molecular Weight60134.30078
Protein Theoretical pI6.83
Signalling Regions
  • None
Transmembrane Regions
  • 131-151
  • 153-173
  • 188-208
  • 218-238
  • 251-271
  • 324-344
  • 356-376
  • 385-405
  • 411-431
  • 445-465
  • 475-495
Protein Sequence>High-affinity nicotinic acid transporter MSNKFTMESPKHLVDDVLFISPTNDGSEEKPTEVTFQEDEGHDASLHNRSHDKKSELATE REIMATTTDDDGIPSPSHPMEKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSK DIHLVGTQYNTCVTVFFATYVLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWVKNY AQLIVVRLLLGAFEGMIYPAINMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCS KISGSLKDWQYIYIVEGCISLGFVPFYAFGLSKNLEDSWFFNKEEKEYISERYKTMNTFD PDEKFEWFQVWQAVKDVKTWASAVALFGIDLTTFGLTVFLPIIITSMGFTNVRAQLMTVP IYFLTAIVFFICAVWSDRIKLRSPFILGACLTTSIGIAIVLGSQVHGVRYFGVYILCMGI YVNAACNCLWLSGNTGNYFKRATALGINLFFGSGSGLVSGQIFVAKDKPRYIKGLSISLA FQVFSIFMTVVQIFLYKRENDKKKAIIDRCNELGEPIPYDERLSDKNPEFKYMY
References
External Links
ResourceLink
Saccharomyces Genome Database TNA1
Uniprot IDP53322
Uniprot NameTNA1_YEAST
GenBank Gene IDY07777
Genebank Protein ID1536952
General Reference
  • Clemente, M. L., Sartori, G., Cardazzo, B., Carignani, G. (1997). "Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes." Yeast 13:287-290.9090059
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Llorente, B., Dujon, B. (2000). "Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w)." FEBS Lett 475:237-241.10869563
  • Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258