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Identification |
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Name | Glycine dehydrogenase [decarboxylating], mitochondrial |
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Synonyms | - Glycine cleavage system P protein
- Glycine decarboxylase
- Glycine decarboxylase complex subunit P
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Gene Name | GCV2 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in glycine dehydrogenase (decarboxylating) activity |
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Specific Function | The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein |
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Cellular Location | Mitochondrion |
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SMPDB Pathways | Not Available |
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KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | Not Available |
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Metabolites | YMDB ID | Name | View |
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YMDB00016 | Glycine | Show | YMDB00912 | Carbon dioxide | Show |
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GO Classification | Component |
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Not Available | Function |
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oxidoreductase activity | oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor | glycine dehydrogenase (decarboxylating) activity | catalytic activity | oxidoreductase activity, acting on the CH-NH2 group of donors | Process |
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oxidation reduction | serine family amino acid metabolic process | glycine metabolic process | metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 13 |
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Locus | YMR189W |
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Gene Sequence | >3105 bp
ATGCTTAGGACAAGAGTGACTGCTCTCCTTTGTAGGGCTACTGTCAGGTCAAGCACCAAT
TATGTTTCATTAGCGAGGACTAGATCATTCCATTCTCAATCTATTTTGCTCAAAACAGCC
GCTACAGACATAACGTCTACACAGTACAGCAGGATTTTCAATCCTGACTTGAAAAACATT
GATAGACCGCTAGATACTTTTGCTAGACGTCATTTAGGTCCTTCTCCTAGCGACGTTAAG
AAAATGTTAAAAACAATGGGTTATAGCGATTTAAACGCATTTATAGAAGAGCTCGTTCCT
CCCAATATTTTGAAGAGAAGACCCTTGAAACTAGAAGCTCCTAGTAAGGGATTCTGTGAA
CAAGAAATGCTTCAACATCTAGAAAAGATTGCCAATAAGAACCACTATAAAGTTAAAAAT
TTCATAGGTAAGGGTTACTACGGTACGATTTTACCACCGGTTATACAAAGAAACCTGCTA
GAAAGTCCAGAATGGTATACTTCTTATACGCCCTATCAACCCGAAATTTCTCAAGGTAGG
CTAGAAGCGCTATTAAACTTTCAAACGGTTGTTTCAGATTTGACTGGTTTGCCTGTGGCG
AACGCCTCATTGTTGGATGAGGGTACAGCGGCTGGAGAAGCTATGCTCTTGTCATTCAAT
ATTTCCAGAAAAAAGAAACTAAAATACGTAATAGATAAAAAATTACACCAGCAAACAAAG
AGTGTCCTTCACACCAGAGCCAAGCCGTTCAATATTGAAATTATTGAAGTTGACTGTTCG
GATATCAAGAAAGCTGTGGATGTTTTAAAGAACCCCGACGTATCTGGTTGTTTGGTTCAA
TATCCAGCGACAGATGGTTCAATCTTACCGCCTGACTCGATGAAACAGTTATCTGATGCG
TTACACTCTCACAAGTCTTTGCTCTCTGTGGCCTCAGATTTAATGGCTTTGACACTTCTA
AAACCACCTGCTCATTACGGTGCTGATATCGTCCTGGGTTCCTCTCAACGATTTGGTGTC
CCAATGGGTTATGGTGGTCCTCATGCTGCTTTTTTCGCTGTTATTGATAAATTAAACAGA
AAAATTCCAGGTAGAATTGTCGGTATCTCTAAAGACCGCTTAGGCAAGACGGCCTTGCGG
TTGGCCCTCCAAACAAGAGAACAACATATCAAGCGTGATAAGGCAACTTCAAATATATGT
ACCGCTCAAGCTTTACTGGCTAATGTTGCTTCGAGCTACTGTGTTTATCACGGTCCTAAG
GGCCTACAGAATATTTCCAGGAGGATATTTAGCTTAACATCAATATTGGCAAATGCCATC
GAAAATGACAGTTGCCCTCACGAACTAATTAATAAAACATGGTTTGATACTTTGACTATA
AAGTTAGGTAATGGCATATCCTCCGAGCAGTTATTGGACAAGGCCTTGAAAGAATTTAAT
ATCAATTTGTTTGCCGTGGACACCACCACTATTTCCTTGGCTCTTGATGAAACAACTACA
AAAGCTGATGTTGAAAATCTACTAAAAGTGTTTGACATTGAAAATTCTTCGCAGTTTCTT
TCTGAGGACTATTCTAACAGTTTCCCAAGGGAATTTCAGCGTACTGATGAAATATTGAGG
AACGAAGTCTTTCACATGCACCATAGCGAAACAGCAATGTTGAGATATTTACATAGGTTG
CAATCTCGTGATTTATCTCTTGCTAATTCTATGATTCCTTTAGGTTCCTGTACTATGAAA
TTGAACAGTACTGTTGAAATGATGCCAATCACTTGGCCCCAATTTTCGAATATCCATCCG
TTCCAGCCATCAAACCAAGTCCAAGGATACAAGGAACTAATTACTTCGTTGGAGAAAGAT
TTATGCAGCATTACAGGTTTCGATGGTATTTCTTTACAACCAAATTCAGGTGCTCAAGGT
GAATATACTGGTCTGAGAGTAATCAGATCCTACCTGGAAAGCAAAGGTGAAAATCATCGT
AACGTGTGTTTAATCCCTGTATCCGCTCATGGTACAAATCCGGCTTCTGCCGCTATGGCG
GGTTTAAAAGTTGTTCCTGTCAACTGTTTGCAGGATGGCTCATTAGATCTGGTTGACTTA
AAGAATAAGGCTGAACAACATTCTAAAGAACTAGCCGCCGTAATGATCACCTATCCTTCC
ACTTACGGTTTATTTGAACCAGGCATCCAACATGCTATTGATATCGTACATTCTTTTGGT
GGACAAGTCTATTTGGATGGTGCTAATATGAATGCGCAGGTTGGGCTAACTTCACCCGGA
GATCTTGGTGCAGATGTTTGCCACTTGAATTTACATAAGACATTTTCCATTCCTCATGGT
GGTGGTGGTCCAGCTGGAGCTCCCATTTGCGTCAAATCTCATTTAATACCCCATTTACCT
AAACATGACGTTGTTGATATGATCACTGGAATCGGCGGTAGCAAATCCATCGATTCGGTC
TCCTCTGCTCCATATGGTAATGCTTTAGTGTTACCAATTTCTTATGCCTATATCAAAATG
ATGGGTAATGAGGGATTACCATTTTCTAGTGTGATAGCAATGCTAAATTCAAATTATATG
ATGACAAGATTAAAAGATCATTATAAAATTCTTTTCGTCAATGAAATGAGCACACTAAAA
CACTGCGCTCATGAATTTATAGTTGATCTAAGAGAATACAAAGCTAAAGGTGTTGAAGCT
ATCGATGTTGCCAAGAGATTGCAAGACTACGGATTCCATGCCCCAACGTTGGCCTTCCCT
GTTCCCGGAACTTTGATGATAGAACCAACAGAATCGGAAAACTTGGAAGAATTGGATAGA
TTCTGTGATGCCATGATATCCATCAAAGAAGAAATAAATGCCTTAGTAGCAGGTCAACCA
AAAGGACAGATTTTGAAAAATGCCCCTCATTCATTGGAAGATCTTATTACTTCCTCCAAT
TGGGATACGAGAGGTTATACCCGTGAAGAAGCCGCTTACCCATTACCCTTTTTGAGATAC
AATAAATTCTGGCCTACTGTCGCTAGACTGGATGACACTTATGGTGACATGAATTTAATA
TGTACATGCCCTTCTGTAGAAGAAATTGCGAACGAAACTGAATGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 1034 |
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Protein Molecular Weight | 114450.0 |
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Protein Theoretical pI | 7.26 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Glycine dehydrogenase [decarboxylating], mitochondrial
MLRTRVTALLCRATVRSSTNYVSLARTRSFHSQSILLKTAATDITSTQYSRIFNPDLKNI
DRPLDTFARRHLGPSPSDVKKMLKTMGYSDLNAFIEELVPPNILKRRPLKLEAPSKGFCE
QEMLQHLEKIANKNHYKVKNFIGKGYYGTILPPVIQRNLLESPEWYTSYTPYQPEISQGR
LEALLNFQTVVSDLTGLPVANASLLDEGTAAGEAMLLSFNISRKKKLKYVIDKKLHQQTK
SVLHTRAKPFNIEIIEVDCSDIKKAVDVLKNPDVSGCLVQYPATDGSILPPDSMKQLSDA
LHSHKSLLSVASDLMALTLLKPPAHYGADIVLGSSQRFGVPMGYGGPHAAFFAVIDKLNR
KIPGRIVGISKDRLGKTALRLALQTREQHIKRDKATSNICTAQALLANVASSYCVYHGPK
GLQNISRRIFSLTSILANAIENDSCPHELINKTWFDTLTIKLGNGISSEQLLDKALKEFN
INLFAVDTTTISLALDETTTKADVENLLKVFDIENSSQFLSEDYSNSFPREFQRTDEILR
NEVFHMHHSETAMLRYLHRLQSRDLSLANSMIPLGSCTMKLNSTVEMMPITWPQFSNIHP
FQPSNQVQGYKELITSLEKDLCSITGFDGISLQPNSGAQGEYTGLRVIRSYLESKGENHR
NVCLIPVSAHGTNPASAAMAGLKVVPVNCLQDGSLDLVDLKNKAEQHSKELAAVMITYPS
TYGLFEPGIQHAIDIVHSFGGQVYLDGANMNAQVGLTSPGDLGADVCHLNLHKTFSIPHG
GGGPAGAPICVKSHLIPHLPKHDVVDMITGIGGSKSIDSVSSAPYGNALVLPISYAYIKM
MGNEGLPFSSVIAMLNSNYMMTRLKDHYKILFVNEMSTLKHCAHEFIVDLREYKAKGVEA
IDVAKRLQDYGFHAPTLAFPVPGTLMIEPTESENLEELDRFCDAMISIKEEINALVAGQP
KGQILKNAPHSLEDLITSSNWDTRGYTREEAAYPLPFLRYNKFWPTVARLDDTYGDMNLI
CTCPSVEEIANETE |
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References |
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External Links | |
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General Reference | - Sinclair, D. A., Hong, S. P., Dawes, I. W. (1996). "Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae." Mol Microbiol 19:611-623.8830251
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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