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Identification |
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Name | Aminomethyltransferase, mitochondrial |
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Synonyms | - Glycine cleavage system T protein
- GCVT
- Glycine decarboxylase complex subunit T
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Gene Name | GCV1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in aminomethyltransferase activity |
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Specific Function | The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine |
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Cellular Location | Mitochondrion |
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SMPDB Pathways | |
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KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | | Nitrogen metabolism | ec00910 | | One carbon pool by folate | ec00670 | |
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SMPDB Reactions | |
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KEGG Reactions | Not Available |
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Metabolites | YMDB ID | Name | View |
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YMDB00016 | Glycine | Show | YMDB00091 | Ammonia | Show | YMDB00139 | Tetrahydrofolic acid | Show | YMDB00176 | 5,10-Methenyltetrahydrofolic acid | Show | YMDB00260 | 5,10-Methylene-THF | Show | YMDB00298 | N5-Formyl-THF | Show | YMDB00423 | Ammonium | Show | YMDB00890 | water | Show |
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GO Classification | Component |
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cytoplasm | cell part | intracellular part | Function |
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aminomethyltransferase activity | catalytic activity | transferase activity | transferase activity, transferring one-carbon groups | methyltransferase activity | Process |
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serine family amino acid metabolic process | glycine metabolic process | glycine catabolic process | metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 4 |
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Locus | YDR019C |
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Gene Sequence | >1203 bp
ATGTCTATAATCAAAAAAATTGTGTTTAAGAGATTCAACTCAACTTTGAAAAAAACTGCT
CTTCATGACCTTCATGTGTCATTAGGCGGTACAATGGTACCATACGCAGGATATTCCATG
CCCGTACTATACAAGGGACAGACTCATATTGAATCACATAATTGGACCAGGACAAACGCT
GGTTTATTTGATGTTTCTCATATGTTACAAAGTAAGTTATCTGGTCCTCATTCTGTTAAG
TTTCTGCAACGTGTAACGCCCACAGATTTCAATGCCTTGCCTGTTGGGTCAGGGACCTTA
AGTGTTCTATTAAATCCACAGGGAGGCGTGGTAGACGATACCATCATCACTAAAGAAAAC
GATGAGAATGAGTTCTATATTGTGACCAATGCTGGCTGTGCGGAAAGAGACACCGAGTTC
TTTCACGATGAGCTACAAAATGGTTCTACTTTAGATTGTCAATGGAAAATCATTGAAGGT
AGATCACTATTGGCATTGCAGGGTCCTAAAGCAAAAGATGTGTTGGAACCACTTTTATCA
AAAACAGCTCCTGGAAAGGATCTAAAAGAGTTATTTTTTGGACAAAGACATGAATTTGCG
TTAAAGGACGGTTCTTTGGTTCAAATTGCTAGAGGCGGGTACACTGGTGAAGATGGATTT
GAGATAAGCATTGCAAATGAGAAAGCGGTTGAGTTTGCGGAGCAACTCTTGGCCAATCCA
GTAATGAAGCCTATCGGACTGGCTGCTAGAGACAGTTTAAGGTTGGAAGCTGGTATGTGT
TTGTATGGTCATGAATTGGACGAAAGTATCACACCAGTAGAAGCTGCGTTAAACTGGGTG
ATTTCAAAGTCAAGAAGGGACCTAGTAGATCAAAAGTACTGGTTCAATGGCTATGCCAAG
ATAATGGACCAGCTAAACAATAAAACGTATAGCAAGGTACGAGTCGGATTCAAATACTTG
AAAAAGGGGCCAGCTGCCAGAAATGGTGTCAAGATCTTCTTGCCCGATGCCGAAACAGAG
GTCGGCCTTGTTACATCAGGTAGTGCATCTCCAACTTTAAACAACATCAATATTGGACAA
GCTTATGTACAGAAAGGTTACCACAAGAAGGGAACGAAGTTGCTTGTTCAAGTAAGGAAC
AAGTTCTACCCGATTGAACTTGCTAAAATGCCTCTTGTGCCCACACATTACTACAAGCAG
TAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 400 |
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Protein Molecular Weight | 44468.69922 |
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Protein Theoretical pI | 9.23 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Aminomethyltransferase, mitochondrial
MSIIKKIVFKRFNSTLKKTALHDLHVSLGGTMVPYAGYSMPVLYKGQTHIESHNWTRTNA
GLFDVSHMLQSKLSGPHSVKFLQRVTPTDFNALPVGSGTLSVLLNPQGGVVDDTIITKEN
DDNEFYIVTNAGCAERDTEFFHDELQNGSTLDCQWKIIEGRSLLALQGPKAKDVLEPLLS
KTAPGKDLKELFFGQRHEFALKDGSLVQIARGGYTGEDGFEISIANEKAVEFAEQLLANP
VMKPIGLAARDSLRLEAGMCLYGHELDESITPVEAALNWVISKSRRDLVDQKYWFNGYAK
IMDQLNNKTYSKVRVGFKYLKKGPAARNGVKIFLPDAETEVGLVTSGSASPTLNNINIGQ
AYVQKGYHKKGTKLLVQVRNKFYPIELAKMPLVPTHYYKQ |
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References |
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External Links | |
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General Reference | - McNeil, J. B., Zhang, F., Taylor, B. V., Sinclair, D. A., Pearlman, R. E., Bognar, A. L. (1997). "Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae." Gene 186:13-20.9047339
- Eide, L. G., Sander, C., Prydz, H. (1996). "Sequencing and analysis of a 35.4 kb region on the right [corrected] arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames." Yeast 12:1085-1090.8896275
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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