Peroxisomal long-chain fatty acid import protein 2 (P41909)

Identification

Name

Peroxisomal long-chain fatty acid import protein 2

Synonyms

Peroxisomal ABC transporter 1

Gene Name

PXA1

Enzyme Class

Not Available

Biological Properties

General Function

Involved in transport

Specific Function

Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix

Cellular Location

Peroxisome membrane; Multi-pass membrane protein

SMPDB Pathways

Not Available

KEGG Pathways

Not Available

SMPDB Reactions

Not Available

KEGG Reactions

Not Available

Metabolites

YMDB ID	Name	View
YMDB00682	stearic acid	Show

GO Classification

Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
binding
primary active transmembrane transporter activity
nucleoside binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
purine nucleoside binding
ATPase activity, coupled to transmembrane movement of substances
adenyl nucleotide binding
pyrophosphatase activity
adenyl ribonucleotide binding
nucleoside-triphosphatase activity
ATP binding
ATPase activity
nucleotide binding
transporter activity
transmembrane transporter activity
active transmembrane transporter activity
Process
transmembrane transport
establishment of localization
transport

Gene Properties

Chromosome Location

chromosome 16

Locus

YPL147W

Gene Sequence

>2613 bp ATGTCAACAACATTAGCAGCACCAGCGAAACTAAAGAGTTTGCTCCTGAATCTACATACT CACTGTATTGGGCTACACGTTAACGATGTCACACCTAAAGTATATTTCAAGTTATTGATA CGGCATCTTCTACAGATATCTAGATCAAACGCTGCTCATCCTAAGCTAAGAAGAAGGGCC CAGATTTTATTGGTATCGCTTTTCCTATCTGGTGTCACACTTTTTTCTGGTGTAACATAT AGTACTTTCAAAATTATTCTAAAATGTTATAAATTTTACAAGTTTCCATGGAAGAGAAGG AATAGGAGACCTTTAATAAGAAGAACAAGATCTCAAATGCAATTAGACAGTGGTGCAAGA ATAATGTATATTCCTGAAGTGGAATTAGTCGACCGCCAGAGTCCCGATGACAACAAATTT ATGAATGCTACAGATAAAAAAAAAAGGAAAAGGATATTTATTCCACCAAAGGATAACGAT GTATATGAACACGATAAGTTTCTTTTTAAAAATGTAGAACTGGAAAGAGCCAAGAATTCG CAGTTATTCTACTCAAAATTTTTAAACCAAATGAACGTCTTGTCTAAAATTTTAATTCCA ACAGTTTTTGACAAAAACTTTCTTCTTTTAACTGCTCAAATTTTTTTCCTGGTGATGAGA ACTTGGCTCTCTTTGTTTGTAGCCAAGCTGGATGGACAAATAGTCAAAAATATAATTGCT GGTAGAGGAAGAAGCTTTCTGTGGGACTTAGGGTGTTGGTTTTTAATTGCTGTCCCTGCT TCTTATACTAATAGTGCTATTAAGCTACTTCAAAGGAAGTTGAGTTTAAACTTTAGGGTA AATTTGACACGTTACATCCATGACATGTATTTGGATAAAAGACTAACATTTTACAAATTA ATTTTTGATGCAAAGGCGTCCAATTCGGTAATCAAGAATATCGACAACTCCATTACTAAT GATGTTGCAAAATTTTGCGATGCGACATGCTCCGTTTTTGCAAACATTGCAAAGCCAGTT ATTGATTTAATATTCTTTTCGGTTTATTTACGTGATAATTTGGGAACTGTGGGAGTAGCA GGTATATTTGTTAATTATTTCATTACTGGGTTTATTTTGAGGAAATACACGCCACCATTA GGTAAATTGGCAGGCGAGAGATCTGCTTCAGACGGCGATTACTACAATTATCATCTAAAC ATGATAAATAATAGCGAAGAGATCGCATTTTACCAAGGAACAGCAGTGGAAAGGACGAAA GTTAAAGAGTTGTATGATGTGCTGATGGAAAAAATGCTGCTGGTTGATAAAGTCAAGTTT GGTTACAATATGTTGGAAGACTATGTTTTAAAATATACATGGTCCGGTTTGGGTTATGTT TTTGCCTCAATCCCTATCGTTATGTCTACCTTAGCGACAGGCATCAATTCAGAGGAAAAA AATATGAAGGAATTTATAGTCAACAAAAGGTTGATGTTGTCGCTTGCAGATGCAGGCTCG AGATTGATGCATTCGATAAAGGACATCTCACAATTGACCGGCTACACTAATAGGATATTT ACTCTGCTTTCCGTCTTACACAGGGTTCACTCTCTGAACTTTAATTACGGCGCTGTTCCT TCAATCCTGTCAATACGTACAGAAGACGCTTCCAGAAATTCCAACTTATTACCCACCACG GATAATTCGCAAGATGCTATTCGTGGTACTATTCAACGCAATTTTAACGGTATTCGGTTA GAAAATATAGACGTAATCATTCCATCAGTAAGGGCGAGCGAAGGCATAAAGCTGATTAAC AAGCTTACATTTCAAATTCCTTTGCATATTGACCCAATAACTTCAAAGTCCAATTCTATA CAAGACTTATCGAAGGCAAATGATATAAAGTTACCATTTTTGCAGGGTTCTGGCTCCAGC CTGTTAATATTAGGGCCAAATGGTTGCGGTAAAAGTTCAATTCAACGCATTATAGCTGAA ATATGGCCAGTGTATAACAAAAATGGATTATTGTCGATTCCTTCAGAAAATAATATTTTT TTTATTCCTCAGAAACCATATTTTAGTAGAGGTGGAACTTTAAGAGACCAAATTATATAC CCCATGTCCTCGGATGAATTCTTTGATAGGGGGTTTAGAGATAAGGAGCTAGTACAGATA TTAGTCGAAGTGAAACTAGATTATCTTTTAAAAAGAGGCGTTGGCTTAACTTACCTAGAT GCCATTGCCGATTGGAAGGACTTATTAAGTGGTGGTGAAAAGCAAAGAGTAAATTTTGCT AGAATCATGTTTCATAAACCACTATACGTAGTATTAGATGAGGCTACAAACGCAATTAGT GTTGACATGGAAGACTATCTGTTCAATCTTTTAAAACGATACAGATTCAATTTCATTTCC ATATCACAAAGACCCACATTAATCAAATATCATGAAATGTTACTAGAGATCGGTGAAAAT CGAGATGGCAAATGGCAATTACAGGCAGTTGGTACCGATGAAGCAATCACGTCGATTGAC AACGAGATTGAGGAATTGGAGAGAAAACTAGAAAGAGTAAAAGGTTGGGAAGATGAGAGG ACGAAGCTACGGGAAAAGCTTGAAATTATTTGA

Protein Properties

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane_2 (PF06472 )

Protein Residues

870

Protein Molecular Weight

100024.0

Protein Theoretical pI

10.0

Signalling Regions

None

Transmembrane Regions

60-80
207-227
247-267
330-350
353-373
455-475

Protein Sequence

>Peroxisomal long-chain fatty acid import protein 2 MSTTLAAPAKLKSLLLNLHTHCIGLHVNDVTPKVYFKLLIRHLLQISRSNAAHPKLRRRA QILLVSLFLSGVTLFSGVTYSTFKIILKCYKFYKFPWKRRNRRPLIRRTRSQMQLDSGAR IMYIPEVELVDRQSPDDNKFMNATDKKKRKRIFIPPKDNDVYEHDKFLFKNVELERAKNS QLFYSKFLNQMNVLSKILIPTVFDKNFLLLTAQIFFLVMRTWLSLFVAKLDGQIVKNIIA GRGRSFLWDLGCWFLIAVPASYTNSAIKLLQRKLSLNFRVNLTRYIHDMYLDKRLTFYKL IFDAKASNSVIKNIDNSITNDVAKFCDATCSVFANIAKPVIDLIFFSVYLRDNLGTVGVA GIFVNYFITGFILRKYTPPLGKLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTK VKELYDVLMEKMLLVDKVKFGYNMLEDYVLKYTWSGLGYVFASIPIVMSTLATGINSEEK NMKEFIVNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVP SILSIRTEDASRNSNLLPTTDNSQDAIRGTIQRNFNGIRLENIDVIIPSVRASEGIKLIN KLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQGSGSSLLILGPNGCGKSSIQRIIAE IWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQI LVEVKLDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAIS VDMEDYLFNLLKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDEAITSID NEIEELERKLERVKGWEDERTKLREKLEII

References

External Links

Resource	Link
Saccharomyces Genome Database	PXA1
Uniprot ID	P41909
Uniprot Name	PXA1_YEAST
GenBank Gene ID	L38491
Genebank Protein ID	1063413

General Reference

Shani, N., Watkins, P. A., Valle, D. (1995). "PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene." Proc Natl Acad Sci U S A 92:6012-6016.7597071
Swartzman, E. E., Viswanathan, M. N., Thorner, J. (1996). "The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae." J Cell Biol 132:549-563.8647887
Purnelle, B., Coster, F., Goffeau, A. (1996). "The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators." Yeast 12:1483-1492.8948103
Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
Hettema, E. H., van Roermund, C. W., Distel, B., van den Berg, M., Vilela, C., Rodrigues-Pousada, C., Wanders, R. J., Tabak, H. F. (1996). "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae." EMBO J 15:3813-3822.8670886