Signaling mucin HKR1 (P41809)

Identification
NameSignaling mucin HKR1
Synonyms
  • Hansenula MRAKII killer toxin-resistant protein 1
Gene NameHKR1
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction involved in filamentous growth
Specific FunctionPlasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta-glucan synthesis. Overexpression provides resistance to HM-1 killer toxin.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
hyperosmotic response
extracellular region
plasma membrane
cellular bud site selection
fungal-type cell wall organization
cell surface
osmosensory signaling pathway via Sho1 osmosensor
site of polarized growth
osmosensor activity
(1->3)-beta-D-glucan biosynthetic process
integral component of membrane
signal transduction involved in filamentous growth
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>5409 bp ATGGTCTCATTGAAAATAAAAAAAATTTTACTCCTGGTGTCATTGTTAAATGCAATCGAG GCCTATAGTAACGATACAATATATTCAACTTCATACAATAATGGAATAGAAAGCACACCC TCATATTCAACATCCGCGATATCCAGTACCGGATCTAGCAACAAAGAGAATGCAATAACA TCAAGCTCTGAAACCACCACAATGGCTGGCCAATATGGTGAAAGTGGAAGCACAACAATA ATGGATGAACAAGAAACTGGTACGTCCAGCCAGTATATTAGTGTGACGACGACAACGCAA ACTTCTGACACGATGTCATCAGTAAAAAAGTCTACGGAAATAGCGACACCAAGTAGTAGC ATTGTACCCACCCCTTTGCAGTCCTATAGCGATGAATCACAAATATCACAAACGCTTAGT CACAATCCGAAGTCCGTGGCGGAGTCAGATAGCGATACAACCTCCTCGGAATCCTCAAGT AGCGTAATAATATCCACATCCGATAGTTCAGCGGTACCGAGGGAAATAAGTCCAATAATA ACCACAGATTCTCAAATTTCCAAAGAAGAAGGCACATTGGCTCAAACTTCCAGTATCAGT GAAACAACGAGAATTGCACAAATGGTAACCAGAGTTTCACAAATCTCCAGCATAACGGCA GCTTCAACAATAGATGGCTTTAGTAGTGAATCAACACAAACAGATTTTTCCAACACTGTA TCGTTTGAAAATTCAGTCGAAGAAGAATATGCCATGAGCAAATCCCAGCTCTCTGAAAGT TACAGTTCAAGTTCAACCGTCTATTCTGGAGGGGAGTCGACTGCAGACAAGACATCTAGC TCCCCCATTACCAGCTTTTCATCTTCTTATAGCCAAACAACGTCAACTGAAACCTCTGAG AGCAGCCGAGTGGCTGTTGGAGTATCCCGGCCCTCTAGCATAACGCAAACTACATCAATT GATAGTTTTAGTATGAGTGAAGTAGAGCTTTCCACATATTATGACTTAAGTGCTGGCAAC TATCCTGACCAAGAACTGATTGTCGATCGCCCGGCCACTTCTTCCACTGCCGAAACATCT TCAGAGGCAAGTCAAGGTGTAAGCCGTGAATCTAACACTTTCGCAGTATCTTCGATTTCC ACGACAAACTTTATAGTTAGCAGTGCTTCGGATACTGTTGTTTCAACTTCAAGCACCAAT ACAGTGCCATACAGCTCTGTCCATTCAACCTTTGTTCATGCGACTTCCTCGTCGACTTAT ATTTCTTCTTCCCTTTATTCTTCCCCATCCTTATCTGCATCCGTTTCCTCTCACTTTGGC GTTGCTCCTTTTCCATCTGCTTACATATCTTTCTCATCAGTACCCGTTGCAGTATCCTCG ACGTACACGTCTTCACCATCGGCTTCTGTTGTAGTACCTTCTGCCTATGCGTCTTCACCA TCAGTACCCGTTGCAGTATCCTCGACGTACACGTCTTCACCATCAGCACCTGCTGCAATA TCCTCAACGTACACGTCTTCACCATCGGCACCTGTTGCAGTATCCTCGACGTACACGTCT TCACCATCGGCACCTGCTGCAATATCCTCAACGTACACGTCTTCACCATCGGCACCTGTT GCAGTATCCTCGACGTACACGTCTTCACCATCAGCACCTGCTGCAATATCCTCAACGTAC ACGTCTTCACCATCGGCACCTGTTGCAGTATCCTCGACGTACACGTCTTCACCATCAGCA CCTGTTGCAATATCCTCAACGTACACGTCTTCACCATCGGTACCTGTTGCAGTATCCTCG ACGTACACGTCTTCACCATCAGCACCTGCTGCAATATCCTCAACGTACACGTCTTCACCA TCGGCACCCGTTGCAGTATCCTCGACGTACACGTCTTCACCATCAGCACCTGCTGCAATA TCCTCAACGTACACGTCTTCACCATCAGTACCCGTTGCAGTATCCTCGACGTACACGTCT TCACCATCAGCACCTGCTGCAATATCCTCAACGTACACGTCTTCACCATCAGTACCCGTT GCAGTATCCTCGACGTACACGTCTTCACCATCAGCACCTGCTGCAATATCCTCAACGTAC ACGTCTTCACCATCGGCACCCGTTGCAGTATCCTCGACGTACACGTCTTCACCATCAGCA CCTGCTGCAATATCCTCAACGTACACGTCTTCACCATCGGCACCCGTTGCAGTATCCTCG ACGTACACGTCTTCACCATCAGCACCTGCTGCAATATCCTCAACGTACACGTCTTCACCA TCGGCACCTGTTGCAGTATCCTCGACGTACACGTCTTCACCATCGGCTCTTGTTGTCCTG TCATCTACTTCCACATCCTCTCCATATGATATTGTTTACTCTCCATCAACTTTTGCTGCC ATATCATCCGGTTACACGCCTTCACCTTCTGCTTCTGTCGCCATGTCATCTACTTCCTCA TCCTCTCCATATGATATTGTTTACTCTCTATCATCTTCTGCTTCCAGATCGTCCATTGCT ACATATGAATTTTCACCTTCCCCATCTACTTCTTTACCCACCTCTTCTACTTACACATAC TTTTCATCTGCTTATGCGTTTGAATTTTCTTCTGAGCGGTACTCAACAACATCCACAATA GCACCAACTCAAATACATAGCACATTGTCCAGGATTACGGATTTCTTACTGCAGACTTCG ATGGCAATCCAAAGTATAGTCTCTCAGCAAATTTCTACAAGCTCAACTTTAAATGACGAA ATACATTCAAGCGCGCTTTCCGTTTTCAACCCTTCAGCTTCGAATTTGGTTGAAACTTCT CTGATAATTTCATCGACCCAAGCAAGCATAACAAGCCCCAAAAACTCAGCTAAAATTAGT TCACTACAGAGCCAGCTGTCTAGCAGTACAAAAAATCCATACGATACGGCGAACAAGAAT ACTGAGACCAGTGGCAGATCCACAGTTGTTTCGAATTTCCTATACACATCTTCCGCGGCG AAACCAGACAATGAAAAGTTTTCCGCTACTCCTACAGAGATAACTACAATTTCAAGTAGC TCGCACGCATATTCTTTATCTATTCCAAGTTCTCATAATTCTGTGACTGGACTATCACAT AACTTTGTCGATTCGTCAAAAAGTGCAACCTCATTTGGCTACTCATCCTCATCAATATCT TCAATAAAACTTTCAAAAGAAACAATACCTGCAAGTAAATCTGTTTCAAACACACAAGAA AGAATCACAAGCTTTACATCAACATTACGAGCAAATAGTCAGTCTGAAAAATCCGAAGGG AGGAATTCTGTAGGTTCTTTACAAAGTTCACATATTTCATCTAACCCATCGCTCTCCACA AATACAAAGGTTGATTCGAAAAGTTTATCCAGGAAAGTATCGAAAACCATGGGCGAAAAT GGCGAGGAAACCGGCTTAACCACAACAAAGACGCAATACAAAAGTTCTTCTGAAACCAGT GGGTCATATTCTCGGTCTTTTACAAAAATCTCAATTGGACCTGCTACGACTGCAGTTCAA ACTCAGGCAAGCACTAATTCAGTATTCACAGCCCCTGCCTTGTCTACCTATCCTACTACT CCGTACCCCTCTCCAAATAGTTACGCATGGTTACCTACCGCTATTATAGTGGAATCATCC GAAACGGGCCCCACTACCGCATCATTCAATCCGTCAATCACTGGTTCACTTCCCAATGCA ATTGAACCGGCCGTCGCTGTATCGGAACCCATTAACCACACTTTAATTACCATCGGATTC ACGGCCGCTTTGAATTATGTATTTTTGGTTCAAAATCCATTATCTTCGGCTCAAATCTTC AACTTTTTACCTCTCGTTTTGAAGTATCCCTTTTCAAACACCTCATCAGAACTGGACAAT AGTATTGGGGAATTATCCACTTTTATTCTTTCATACCGGTCTGGGAGCAGCACAACTACC CTTTCCCCAAAATCCATATCATCATTATCAGTTGTCAAGAAAAAAAAAAACCAGCAGAAA AAAAATGCCACGAAGTCAACCGAGGACTTACATCCTCCACAAGTCGACACATCCTCAATA GCGGTGAAAAAGATTGTTCCCATGGTAGACTCTTCTAAGGCATACATTGTATCAGTTGCA GAGGTATATTTTCCAACAGAAGCCGTAACATATCTTCAGCAATTAATCCTTGATGAAAAT TCGACTCTTTATAGCAATCCTCAAACCCCACTGCGAAGTTTAGCTGGTCTAATAGATAGT GGGATCCCATTAGGGGGATTGACGTTATATGGCTCTGGAGATGGTGGTTATGTCCCTAGT TTAACCTCATCAAGCGTCTTGGATTCTTCAAAAGGAAATTCCCAAAACATAGATGGAACT TACAAGTATGGAGCTTTGGATGACTTTATCAATTCATTCACAGATTCTGCATCTGCAGGA AAGTATGCTGTAAAAATAATCATCTTTTTGATTGTTTTAACTATTGGCGTACTCTTGTGG TTATTCGTTGCATTTTTTGCTTTCCGTCATAGAAATATATTATTGAAAAGACACCCAAGG AACTGCATAGGGAAAAGCCTCAATAATGAGAGGGAACTTGAAAGTACCGAGCTTTCCCGC TCTTCTTCTGGAAACCAAGTTTATAATGAAAAGCCGCCAGAATCTGAAAATGAAAGTGTT TACTCTGCGGTAGATGATCATTATATTGTGACTGGCGAAAACACAGTCTATAATACTATT CACAGATTACATTATACCATTAATGATGACGGTGATCTATTGTACAGGGACGCAATCCCC CTCGATTTTGATCAAACCAATGGGGATGATGGTTCGGGAATAGACAGTATAGTAAGAGAC TGCGTGTATGACAAAAACCAAGATGCTACGGAAGCCTTCTTGAATGATGAGGAGTCCATA TCAGGCATTCTAGATGTTGATGAAAATGGTGATATTCGATTATACGACAGTTATTCTGAC AATGAAGAGTCAAACAGTTTTCACTTGCCAGACGAAGTTATTGAAAACTATAACAAGAAC CATTTGTGCGAAACTAAACTTCATGGACTAGGCACTGAATCATGTACTACAGATGATCCC GATACTGGAAATCAAATTACGAATGAGTTTTCTACAGGGAGTCAGACATGTTTGCCAAGT ACCGCTTATACCACACCCCTTCATACAAATTCGATTAAACTTCACACATTACGCTACACA GAATCTTCACTACCAAAGCCAAATCAGACTCTTTTCTCTAATCTTGAAGATTTAGAAATA GAGGATATTGACGACAATGGTAGTGTTTCAGATGTACATATCGAGGAGCTGGATGCTTTA GACGAAGAACTTTATAAGAGAATGTCGAAAGTTATAAAACAACAGAACCATCAAACGACA AAAATATAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1802
Protein Molecular Weight188944.995
Protein Theoretical pINot Available
Signalling Regions
  • 1-21
Transmembrane Regions
  • 1486-1506
Protein Sequence>Signaling mucin HKR1 MVSLKIKKILLLVSLLNAIEAYSNDTIYSTSYNNGIESTPSYSTSAISSTGSSNKENAIT SSSETTTMAGQYGESGSTTIMDEQETGTSSQYISVTTTTQTSDTMSSVKKSTEIATPSSS IVPTPLQSYSDESQISQTLSHNPKSVAESDSDTTSSESSSSVIISTSDSSAVPREISPII TTDSQISKEEGTLAQTSSISETTRIAQMVTRVSQISSITAASTIDGFSSESTQTDFSNTV SFENSVEEEYAMSKSQLSESYSSSSTVYSGGESTADKTSSSPITSFSSSYSQTTSTETSE SSRVAVGVSRPSSITQTTSIDSFSMSEVELSTYYDLSAGNYPDQELIVDRPATSSTAETS SEASQGVSRESNTFAVSSISTTNFIVSSASDTVVSTSSTNTVPYSSVHSTFVHATSSSTY ISSSLYSSPSLSASVSSHFGVAPFPSAYISFSSVPVAVSSTYTSSPSASVVVPSAYASSP SVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPV AVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPVAISSTYTSSPSVPVAVSS TYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSVPVAVSSTYTS SPSAPAAISSTYTSSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSA PAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSALVVL SSTSTSSPYDIVYSPSTFAAISSGYTPSPSASVAMSSTSSSSPYDIVYSLSSSASRSSIA TYEFSPSPSTSLPTSSTYTYFSSAYAFEFSSERYSTTSTIAPTQIHSTLSRITDFLLQTS MAIQSIVSQQISTSSTLNDEIHSSALSVFNPSASNLVETSLIISSTQASITSPKNSAKIS SLQSQLSSSTKNPYDTANKNTETSGRSTVVSNFLYTSSAAKPDNEKFSATPTEITTISSS SHAYSLSIPSSHNSVTGLSHNFVDSSKSATSFGYSSSSISSIKLSKETIPASKSVSNTQE RITSFTSTLRANSQSEKSEGRNSVGSLQSSHISSNPSLSTNTKVDSKSLSRKVSKTMGEN GEETGLTTTKTQYKSSSETSGSYSRSFTKISIGPATTAVQTQASTNSVFTAPALSTYPTT PYPSPNSYAWLPTAIIVESSETGPTTASFNPSITGSLPNAIEPAVAVSEPINHTLITIGF TAALNYVFLVQNPLSSAQIFNFLPLVLKYPFSNTSSELDNSIGELSTFILSYRSGSSTTT LSPKSISSLSVVKKKKNQQKKNATKSTEDLHPPQVDTSSIAVKKIVPMVDSSKAYIVSVA EVYFPTEAVTYLQQLILDENSTLYSNPQTPLRSLAGLIDSGIPLGGLTLYGSGDGGYVPS LTSSSVLDSSKGNSQNIDGTYKYGALDDFINSFTDSASAGKYAVKIIIFLIVLTIGVLLW LFVAFFAFRHRNILLKRHPRNCIGKSLNNERELESTELSRSSSGNQVYNEKPPESENESV YSAVDDHYIVTGENTVYNTIHRLHYTINDDGDLLYRDAIPLDFDQTNGDDGSGIDSIVRD CVYDKNQDATEAFLNDEESISGILDVDENGDIRLYDSYSDNEESNSFHLPDEVIENYNKN HLCETKLHGLGTESCTTDDPDTGNQITNEFSTGSQTCLPSTAYTTPLHTNSIKLHTLRYT ESSLPKPNQTLFSNLEDLEIEDIDDNGSVSDVHIEELDALDEELYKRMSKVIKQQNHQTT KI
References
External Links
ResourceLink
Saccharomyces Genome Database HKR1
Uniprot IDP41809
Uniprot NameHKR1
General ReferenceNot Available