Target of rapamycin complex 2 subunit TSC11 (P40061)

Identification
NameTarget of rapamycin complex 2 subunit TSC11
Synonyms
  • TORC2 subunit TSC11
  • Adheres voraciously to TOR2 protein 3
  • Temperature-sensitive CSG2 suppressor protein 11
Gene NameTSC11
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in guanyl-nucleotide exchange factor activity
Specific FunctionEssential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1
Cellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>4293 bp ATGAGCATACCTCACAGTGCAAAACAGAGTAGCCCTCTCTCAAGTCGGCGCCGGTCAGTA ACTAATACTACTCCACTGTTAACCCCTAGACATAGCCGTGATAACTCGAGCACCCAAATA TCAAGCGCCAAGAACATCACCTCCAGCAGCCCATCAACCATAACGAATGAAAGTTCCAAA AGAAATAAACAAAATCTGGTACTCTCGACCTCATTTATCTCCACCAAGAGGCTAGAAAAT AGTGCACCTTCACCGACCAGTCCCTTAATGGCAAGACGAACGAGAAGTACTATGACCAAG GCACTTTTAAATCTTAAAGCAGAAATAAACAACCAATATCAAGAATTAGCTCGATTGCGC AAGAAAAAAGACGATATCGAACATCTTCGGGATTCTACAATATCTGATATATACTCTGGA TCTTACTCTACGAATCATTTACAAAAGCACTCGATGAGGATTAGAGCGAATACTCAACTT AGAGAAATTGACAATTCAATAAAAAGAGTTGAGAAGCATATTTTTGACCTCAAGCAACAG TTCGACAAGAAAAGGCAAAGATCACTCACAACATCCAGCTCAATAAAGGCTGACGTGGGG AGCATCAGGAATGATGATGGCCAAAATAACGATAGTGAAGAATTGGGCGACCATGATAGT TTGACAGATCAAGTTACTCTTGATGATGAATATCTTACGACTCCCACTTCTGGAACTGAG CGTAATAGTCAGCAGAACTTAAATCGTAATAGTACCGTCAACTCACGGAATAACGAAAAT CATTCTACGCTTTCCATTCCAGATTTAGATGGATCTAATAAAGTAAACTTAACCGGTGAT ACTGAAAAAGATCTTGGTGATCTTGAAAACGAAAATCAAATATTCACATCCACAACAACT GAAGCGGCAACATGGCTTGTAAGCGATTATATGCAAAGTTTTCAAGAAAAGAACGTCAAC CCTGATTTCATTGCTCAAAAAGCAAATGGCCTGGTCACCTTATTGAAAGAACATTCAGAG ATAAGAAAAGATCTGGTTTTAACTTCATTCATGTCATCAATTCAAAATCTGCTTCTCAAT GGAAACAAGCTTATAGCAGCATCTGCTTATAGGGTATGTCGTTACCTAATAAATAGCTCG ATTTTCATTGATGAGCTGTTAGAGCTAAGACTGGATGCATTCATAATTATTTCCCTTGCG AAGGATAATTCTTTTCAAATAGAAAGGGAACAAGCCTTAAAAATGGTACGAAGATTCATT GAATACAACAACGGTGTTACTCAAGGCATTATGCAGGCTATAATAAGCTGTGTTGAAAAA CCTGAAGACTCCTTAAGGCACATGGCATTAGAAACTTTGTTGGAACTTTGTTTTGTCGCC CCTGAAATGGTTAAAGAATGCCGTGGTATGAGAGTGATCGAGGGATTTTTACAAGATTAT ACTTCTTTTTCACTCGCATCAGTAATACTTGATACTATTTTACAATTAATGGCTACACAC AAGACAAGGCAACATTTTCTGGAAGATTTCAATGTATCTGTGTTAACCACGGTCTTTTCG GATACAAATACAAAGTCAAACGTTAATGTGGAAAAAATGCAAAACGCTTCTACACTTATC TCAATAACTTTGAACAGCTACAATGGCTTTATGCTTTTTTCTAACAACAATTTCAAACCG TTAAAACAGCTGGTGTCATTCTTCCAAATTCCTATATGCGCCCAATATCTTATCGACATC TTTCTTGATGTTTTGAAAATCAAACCACTACCATACAAGCCAAGGGGCAGACATTCTCAT TCTTTCAAACCAATCCCATCTCAGTACTACAAAGAGTGTATGTCTGTGAATCAACGGCTA GCCTTAATTGTGCTAATTCTGGAGAACTCGGAATTTGTACCCCACCTCCTTGAACTTTTG AACGAAGAAGATAGAGATGATCACTTGGTAGCAAAAGGCAGATATCTTCTTACCGAATAT TTTAATTTAAGAATGAATTTAGTCGATAAAAAGTATACTTCAGTATCAAAACCAATTTAC AAGGAGAACTTCACTTACGTCAATGAAACATTCCAGTTCAAGAAGATCGCTTATAAAATG AATAGAAACAGGAATACAATTGGCATGTCGGGCATTGATTATGCTCAAAATATAAAATCA TTTTCCAAAAATATTAAAGAGAATACTCTTCTCCGCGAAGTAGATGATTTCCGATTTAGA AGAATGGTTTATGACTCTAAAGTTTTGCAAACGAAGGATTTTACGCGATGGAATTGGAAC ATAATTAACGAATTACTTGAAGGACCATTACTAAATAAAAAGCAACTAGAAGAATTAGTT AAATCAACCAAATTCATCAGAAGACTTTTGGTGTTTTACAGACCACTCAGATTGAGATTT TCCAACGTCAATAAAGGCGCAAAATTATCTCAAAAGTATGTACAAGTTGGATGCCAGTTT TTCAAAACACTAACGGCGACTCCAGAAGGAATGAAAATCCTTATGGATGATACAAAAATT ATACCGCAACTGGCGTCTTTAATGTTTAGAGCAATGGAGGGAAATATATCAGGCAACATC TTCAACAAGAATAAACTACGAGAAAAAATAATATTTGGATACTTCAAATTCATCGGAATA TTGACGCAGTCAAAGAATGGGGTTCATATCCTAACGAGGTGGAATTTTTTTACCGTAATC TATAAGATGTTTCAATTTGAATCGAAACTGGGGCTTGAGTTTCTATTATTAACAATACCA GAATTAGATTTGAAATATTCATCACATTGCCGCGTCATTATCGGCAAGGCCCTTGTAGTG GCCAATGAGAAAGTTAGGATTGAGGCTACAAAGCATATAGGCGATAAACTAAAAGAACTG TTATCCACGAAAGAAAGTGATCTTAAGTTAAAAGCGAATAAAGTGAAACTGCAGCAATTC AAAATGGAAATGTTAACAAGGCAACTATACGACCTGAGCCCCAGCGTAGTCGCCGTAGCA GACCAAGCTTTATATGAATGTATTGTCGCGGGCAATGGCTCTGAAGAGCTGGGCACCTCA TTTAGGATGTTTTTAAACCAAATGGTATTCATTAGGTCTCCAATACTTTTCGAGTTATTA AGCCGCCCATACGGGTTCCAGTTGTTGAACGAAATCAATTTTGTGAAGGAGGAAAGGGAT TCGTGGTTATCTAAAAAAAACATTGAGTATGTTCATATTGTGGAGGAATTCCTGAAGAAA AATGAATCAATTAATGCAAAATCCCTCACATTTCAACAAAAGAGTCGCCTGCCATTGCAT TTTTATGAAAGTCTAACGAAAACAGAAGACGGAATATTACTATTAAGCCAAACAGGAGAT TTGGTTACTTTCATGAACGTTATAAAAAAATACGTCAACGGAAACAATATGGCCACAGTA GAAAATGCCAAAGAAATTCTCGACTTAAAAGCAGCATTATGGTGTGTTGGGTTTATCGGA TCCACAGAATTGGGGATAGGTCTACTAGATAACTACTCATTGGTGGAAGATATTATCGAG GTGGCCTACAATGCCAGCGTAACCAGCGTTAGGTTTACAGCATTTTATGTTCTGGGATTA ATCAGCATGACCCGCGAGGGTTGCGAAATTCTAGACGAGATGGGATGGAACTGTTGTGTC AGTGTACAAGATGAGCCTATCGGGATCGCACTACCAAATAGGCTCGATAGATTTCTATCG TATAACGAACACAAATGGTCCGCATTTGGCGAGTATTCTGATGAGATGATTGTTTTTAAT AAAAGCGATGGCGACTTGATAGAAAAATGCTTACCCATCGAATTTGATTTGGACAAACTA CTCAAAGAGAAAGATACCGCAGAGAATCCATTAAATGAAAAAATCATTACTAATAAATAC GACAACGATATCACAAGTCAAACTATCACTGTTTCAGGTGAAAATAGTAGTCTTTTCGCA AACGAAGGCCTTTCTTCTCCCTATGTTACACAATACCGCAATGACGATGACTCCATCGAG AGCAAGGTACTACATATAGTAAGTCAGCTAGGCAATCATATCCTTTCAAATCACGCAGTG AAGGAGATTACAGAAATAAACAATAAATACGGTCCAAGGCTTTTTGAAAACGAGAAAATG TTCTTCAAAGTATTTAATATGATGTCGAAGTATCGGTTTAAGCCACATGTTAGGAAGTTT CTTTGCGGACTATTTATTAACAATAGAGCGCTTGAAAATGTCATCAGGCACGACAACAAA AGGGACAAAAGGCCGGCTAATTTTACACGTTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1430
Protein Molecular Weight164367.0
Protein Theoretical pI8.95
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Target of rapamycin complex 2 subunit TSC11 MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKNITSSSPSTITNESSK RNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLNLKAEINNQYQELARLR KKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREIDNSIKRVEKHIFDLKQQ FDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLTDQVTLDDEYLTTPTSGTE RNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDTEKDLGDLENENQIFTSTTT EAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSEIRKDLVLTSFMSSIQNLLLN GNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISLAKDNSFQIEREQALKMVRRFI EYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCFVAPEMVKECRGMRVIEGFLQDY TSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTTVFSDTNTKSNVNVEKMQNASTLI SITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQYLIDIFLDVLKIKPLPYKPRGRHSH SFKPIPSQYYKECMSVNQRLALIVLILENSEFVPHLLELLNEEDRDDHLVAKGRYLLTEY FNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFKKIAYKMNRNRNTIGMSGIDYAQNIKS FSKNIKENTLLREVDDFRFRRMVYDSKVLQTKDFTRWNWNIINELLEGPLLNKKQLEELV KSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQKYVQVGCQFFKTLTATPEGMKILMDDTKI IPQLASLMFRAMEGNISGNIFNKNKLREKIIFGYFKFIGILTQSKNGVHILTRWNFFTVI YKMFQFESKLGLEFLLLTIPELDLKYSSHCRVIIGKALVVANEKVRIEATKHIGDKLKEL LSTKESDLKLKANKVKLQQFKMEMLTRQLYDLSPSVVAVADQALYECIVAGNGSEELGTS FRMFLNQMVFIRSPILFELLSRPYGFQLLNEINFVKEERDSWLSKKNIEYVHIVEEFLKK NESINAKSLTFQQKSRLPLHFYESLTKTEDGILLLSQTGDLVTFMNVIKKYVNGNNMATV ENAKEILDLKAALWCVGFIGSTELGIGLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGL ISMTREGCEILDEMGWNCCVSVQDEPIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFN KSDGDLIEKCLPIEFDLDKLLKEKDTAENPLNEKIITNKYDNDITSQTITVSGENSSLFA NEGLSSPYVTQYRNDDDSIESKVLHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKM FFKVFNMMSKYRFKPHVRKFLCGLFINNRALENVIRHDNKRDKRPANFTR
References
External Links
ResourceLink
Saccharomyces Genome Database TSC11
Uniprot IDP40061
Uniprot NameTSC11_YEAST
GenBank Gene IDU18839
Genebank Protein ID603331
General Reference
  • Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
  • Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., Hall, M. N. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control." Mol Cell 10:457-468.12408816
  • Wedaman, K. P., Reinke, A., Anderson, S., Yates, J. 3rd, McCaffery, J. M., Powers, T. (2003). "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae." Mol Biol Cell 14:1204-1220.12631735
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Wullschleger, S., Loewith, R., Oppliger, W., Hall, M. N. (2005). "Molecular organization of target of rapamycin complex 2." J Biol Chem 280:30697-30704.16002396
  • Ho, H. L., Shiau, Y. S., Chen, M. Y. (2005). "Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex." Curr Genet 47:273-288.15809876
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956