3-oxoacyl-[acyl-carrier-protein] synthase homolog (P39525)

Identification
Name3-oxoacyl-[acyl-carrier-protein] synthase homolog
Synonyms
  • Beta-ketoacyl-ACP synthase homolog
Gene NameCEM1
Enzyme Class
Biological Properties
General FunctionInvolved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific FunctionPossibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B
Cellular LocationMitochondrion (Potential)
SMPDB Pathways
Fatty acid biosynthesisPW002458 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Fatty acid biosynthesisec00061 Map00061
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00912Carbon dioxideShow
GO Classification
Component
Not Available
Function
catalytic activity
Process
metabolic process
biosynthetic process
Gene Properties
Chromosome Locationchromosome 5
LocusYER061C
Gene Sequence>1329 bp ATGTCAAGAAGAGTGGTTATCACAGGATTGGGCTGTGTAACGCCGTTGGGAAGATCATTA AGTGAGTCATGGGGGAATCTGCTCTCTTCCAAAAATGGACTCACACCAATCACATCTTTG CCCAACTATAATGAGGACTACAAACTCAGAGAAAAAAGTATCCCATCAACGATAACAGTG GGGAAGATTCCAGAGAATTTTCAAAACGAAAATTCAGCCATCAATAAACTGCTGTTCACT AGCCAGGATGAGAGAAGAACCTCAAGCTTTATCAAGCTAGCACTACGTACAACTTATGAA GCGCTTCACAATGCTGGTCTCTTGAACCCAAATGATATAACCATCAATACATCTCTGTGC AATCTGGATCACTTTGGTTGCCTGATAGGTTCTGGTATAGGATCCATTCAAGACATATAC CAAACTTCTCTACAATTCCATAACGACAATAAAAGAATAAATCCATATTTCGTCCCTAAA ATCCTTACAAATATGGCAGCTGGTAATGTTTCCATCAAGTTTAACCTTAGAGGATTATCC CATAGTGTTTCCACAGCATGCGCAACAGGTAATAACTCCATTGGCGATGCATTCAATTTT ATTCGGTTAGGCATGCAAGACATCTGTGTCGCCGGTGCAAGTGAAACGAGTTTGCATCCG TTAAGTTTAGCAGGTTTCATCAGAGCAAAGTCGATTACTACAAACGGGATCTCTAGACCC TTTGATACACAACGTTCTGGATTCGTACTTGGTGAAGGATGCGGAATGATTGTCATGGAA TCGCTAGAACATGCTCAAAAGAGAAATGCAAACATAATTTCTGAGCTCGTGGGCTATGGT TTAAGCAGTGATGCCTGCCATATTACCTCCCCTCCTGCTGATGGAAATGGTGCCAAAAGA GCAATAGAGATGGCTCTAAAAATGGCTAGATTAGAACCAACTGATGTTGACTACGTCAAT GCACATGCTACATCAACTTTACTAGGCGATAAAGCAGAGTGTCTGGCAGTAGCCTCAGCA CTCTTACCAGGAAGATCCAAAAGCAAGCCACTGTACATATCCAGTAACAAAGGTGCAATT GGCCATCTTTTAGGTGCAGCTGGCGCCGTAGAAAGTATATTTACAATTTGTTCCTTGAAG GATGATAAGATGCCGCATACCTTAAACCTGGACAATGTTCTGACTCTAGAAAATAACGAG GCCGATAAGCTACATTTCATAAGAGACAAACCTATTGTGGGAGCTAATCCGAAGTACGCA TTATGCAACAGCTTCGGATTTGGAGGAGTTAACACATCTCTTCTCTTCAAGAAATGGGAA GGGAGTTAA
Protein Properties
Pfam Domain Function
Protein Residues442
Protein Molecular Weight47554.69922
Protein Theoretical pI8.26
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>3-oxoacyl-[acyl-carrier-protein] synthase homolog MSRRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTPITSLPNYNEDYKLREKSIPSTITV GKIPENFQNENSAINKLLFTSQDERRTSSFIKLALRTTYEALHNAGLLNPNDITINTSLC NLDHFGCLIGSGIGSIQDIYQTSLQFHNDNKRINPYFVPKILTNMAAGNVSIKFNLRGLS HSVSTACATGNNSIGDAFNFIRLGMQDICVAGASETSLHPLSLAGFIRAKSITTNGISRP FDTQRSGFVLGEGCGMIVMESLEHAQKRNANIISELVGYGLSSDACHITSPPADGNGAKR AIEMALKMARLEPTDVDYVNAHATSTLLGDKAECLAVASALLPGRSKSKPLYISSNKGAI GHLLGAAGAVESIFTICSLKDDKMPHTLNLDNVLTLENNEADKLHFIRDKPIVGANPKYA LCNSFGFGGVNTSLLFKKWEGS
References
External Links
ResourceLink
Saccharomyces Genome Database CEM1
Uniprot IDP39525
Uniprot NameCEM1_YEAST
GenBank Gene IDU18813
Genebank Protein ID603297
General Reference
  • Harington, A., Herbert, C. J., Tung, B., Getz, G. S., Slonimski, P. P. (1993). "Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae." Mol Microbiol 9:545-555.8412701
  • Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106