GPI transamidase component GAA1 (P39012)

Identification
NameGPI transamidase component GAA1
SynonymsNot Available
Gene NameGAA1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in GPI-anchor transamidase activity
Specific FunctionComponent of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins. Affects endocytosis
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
membrane part
intrinsic to membrane
integral to membrane
macromolecular complex
protein complex
GPI-anchor transamidase complex
cell part
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1845 bp ATGGCCTTATTGGAGAAGTTGCATCGAAGGATTGTTGATATGGGGCTTGTCCCGCGTATA ATCGCCTTATTACCAGTTATTTCCATGCTATGCGCTCTATTTGGGTTTATTTCTATAGCT ATTCTGCCTATGGATGGACAGTACAGAAGAACATACATTTCTGAGAATGCATTGATGCCT TCACAAGCGTATAGTTACTTTAGAGAATCTGAATGGAACATTTTGAGGGGCTATCGATCT CAAATTAAAGAAATGGTAAACATGACTTCTATGGAAAGAAACAATTTGATGGGTTCTTGG TTACAAGAATTTGGTACTAAGACTGCTATTTACGAAAATGAACAATATGGAGAAACATTG TACGGTGTAATGCACGCTCCTAGGGGTGATGGAACAGAAGCGATGGTGCTTGCCGTTCCA TGGTTTAATTCAGATGATGAATTCAATATTGGCGGCGCAGCTTTGGGTGTATCTTTAGCA AGATTTTTCTCACGTTGGCCAGTATGGTCCAAGAATATAATTGTTGTCTTCAGCGAAAAT CCTCGTGCAGCATTAAGATCATGGGTTGAGGCATACCATACTTCCTTAGATTTGACTGGT GGTTCCATTGAAGCTGCTGTTGTGTTGGATTATTCGAGTACGGAAGATTTCTTCGAGTAT GTAGAAATCTCATACGACGGTCTGAATGGTGAGCTGCCCAATTTGGATCTTGTCAACATC GCTATATCCATTACGGAACATGAAGGTATGAAAGTTTCTTTGCACGGTCTACCCAGTGAT CAGTTAACTAATAATAATTTCTGGTCAAGATTAAAAATATTATGCCTGGGAATAAGGGAT TGGGCGTTGTCCGGTGTTAAAAAGCCCCATGGTAACGAGGCATTTAGCGGCTGGAGGATT CAATCTGTAACATTGAAAGCACATGGAAACAGTGGTCATGATATTACTACATTTGGACGT ATACCCGAAGCAATGTTTCGCTCTATTAATAACCTTTTGGAAAAATTTCACCAATCGTTC TTCTTTTATTTGTTATTAGCACCACGTCAGTTCGTATCCATTAGTAGTTATTTGCCAAGC GCTGTGGCTTTATCTATAGCATTCGCCATAAGTTCATTAAATGCATTTATAAACAATGCT TATGCAAATATATCCTTATTTTCCGAGTATAATTTGGTAGCGTTGTTGGTTTGGTTCGTG TCATTGGTGATATCATTTGTTGTTTCACAAGCGTTTCTTCTAATACCTTCATCGGGATTA TTGATGACAATTAGCATGGCATCTTGTTTTTTACCTTTGATACTTTCCAGAAAAATTCAC ATCTCAGAACCACTATCATACAGGTTGAAAAATGTTGCTTTTTTATATTTCAGTTTGGTT TCAACATCTTTGCTAATGATAAACTTTGCAATGGCTTTACTGATCGGCACATTGGCATTT CCTATGACATTTGTGAAGACCATTGTTGAAAGTTCTAGCGAACATGAGGTGACAACTCAA TCCTCTAACCCAATAAAAACTGAGCCGAAAGATGAGATAGAGCTCGTCGAGAATCACATG GATACAACGCCAGCAACCCCCCAACAACAGAAACAAAAACTAAAAAATTTAGTACTATTA ATTTTGACAAATCCATTTATTTCAATAACCTTATTCGGACTATTTTTTGATGATGAATTT CATGGATTTGATATAATAAACAAACTGGTTTCAGCATGGTTGGATTTGAAATGTTGGAGT TGGTTTGTACTTTGTATAGGTTGGCTTCCATGTTGGCTATTGATATTAGCGTCATCGTTT GAATCTAAATCTGTCGTAGTAAGGTCGAAAGAAAAGCAAAGTTAG
Protein Properties
Pfam Domain Function
Protein Residues614
Protein Molecular Weight69220.5
Protein Theoretical pI6.2
Signalling Regions
  • None
Transmembrane Regions
  • 20-40
  • 357-377
  • 395-415
  • 465-485
  • 536-556
  • 578-598
Protein Sequence>GPI transamidase component GAA1 MALLEKLHRRIVDMGLVPRIIALLPVISMLCALFGFISIAILPMDGQYRRTYISENALMP SQAYSYFRESEWNILRGYRSQIKEMVNMTSMERNNLMGSWLQEFGTKTAIYENEQYGETL YGVMHAPRGDGTEAMVLAVPWFNSDDEFNIGGAALGVSLARFFSRWPVWSKNIIVVFSEN PRAALRSWVEAYHTSLDLTGGSIEAAVVLDYSSTEDFFEYVEISYDGLNGELPNLDLVNI AISITEHEGMKVSLHGLPSDQLTNNNFWSRLKILCLGIRDWALSGVKKPHGNEAFSGWRI QSVTLKAHGNSGHDITTFGRIPEAMFRSINNLLEKFHQSFFFYLLLAPRQFVSISSYLPS AVALSIAFAISSLNAFINNAYANISLFSEYNLVALLVWFVSLVISFVVSQAFLLIPSSGL LMTISMASCFLPLILSRKIHISEPLSYRLKNVAFLYFSLVSTSLLMINFAMALLIGTLAF PMTFVKTIVESSSEHEVTTQSSNPIKTEPKDEIELVENHMDTTPATPQQQKQKLKNLVLL ILTNPFISITLFGLFFDDEFHGFDIINKLVSAWLDLKCWSWFVLCIGWLPCWLLILASSF ESKSVVVRSKEKQS
References
External Links
ResourceLink
Saccharomyces Genome Database GAA1
Uniprot IDP39012
Uniprot NameGAA1_YEAST
GenBank Gene IDU53880
Genebank Protein ID1256890
General Reference
  • Hamburger, D., Egerton, M., Riezman, H. (1995). "Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins." J Cell Biol 129:629-639.7730400
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Fraering, P., Imhof, I., Meyer, U., Strub, J. M., van Dorsselaer, A., Vionnet, C., Conzelmann, A. (2001). "The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p." Mol Biol Cell 12:3295-3306.11598210
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258